keyword
https://read.qxmd.com/read/38403464/3d-qsar-pharmacophore-modeling-virtual-screening-molecular-docking-md-simulations-in-vitro-and-in-vivo-studies-to-identify-potential-anti-hyperplasia-drugs
#1
JOURNAL ARTICLE
Muhammad Zafar Irshad Khan, Dildar Khan, Muhammad Yasir Akbar, Hao Wang, Ihsan-Ul Haq, Jian-Zhong Chen
Psoriasis is a common immune-mediated skin condition characterized by aberrant keratinocytes and cell proliferation. The purpose of this study was to explore the FDA-approved drugs by 3D-QSAR pharmacophore model and evaluate their efficiency by in-silico, in vitro, and in vivo psoriasis animal model. A 3D-QSAR pharmacophore model was developed by utilizing HypoGen algorithm using the structural features of 48 diaryl derivatives with diverse molecular patterns. The model was validated by a test set of 27 compounds, by cost analysis method, and Fischer's randomization test...
February 2024: Biotechnology Journal
https://read.qxmd.com/read/38353013/-development-of-selective-method-for-mebeverine-detection-in-blood
#2
JOURNAL ARTICLE
P S Vikman, O L Balabanova, O Yu Strelova, A N Grebenyuk
OBJECTIVE: To develop the method of biological fluids' sample processing and mebeverine detection to exclude false results' receiving when diagnosing drug intoxication. MATERIAL AND METHODS: The study was carried out using «Mebeverine» (NJCO «North star», Russia) medicine and hydrolysis by enzymes, namely papain, chymotrypsin, trypsin, chymopsin and hyaluronidase, was applied for sample processing. The extractions were analyzed by methods of HPLC-MS/MS on Nexera XR modular liquid chromatograph with LCMS-8050 (Shimadzu) tandem mass spectrometer and GC-MS on gas chromatograph connected with QP-2020 (Shimadzu, Japanese) mono quadrupole mass spectrometer...
2024: Sudebno-meditsinskaia Ekspertiza
https://read.qxmd.com/read/38321448/molecular-docking-as-a-tool-for-the-discovery-of-novel-insight-about-the-role-of-acid-sphingomyelinase-inhibitors-in-sars-cov-2-infectivity
#3
REVIEW
Samar Sami Alkafaas, Abanoub Mosaad Abdallah, Mai H Hassan, Aya Misbah Hussien, Sara Samy Elkafas, Samah A Loutfy, Abanoub Mikhail, Omnia G Murad, Mohamed I Elsalahaty, Mohamed Hessien, Rami M Elshazli, Fatimah A Alsaeed, Ahmed Ezzat Ahmed, Hani K Kamal, Wael Hafez, Mohamed T El-Saadony, Khaled A El-Tarabily, Soumya Ghosh
Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, caused > 6 million deaths. Symptoms included respiratory strain and complications, leading to severe pneumonia. SARS-CoV-2 attaches to the ACE-2 receptor of the host cell membrane to enter. Targeting the SARS-CoV-2 entry may effectively inhibit infection. Acid sphingomyelinase (ASMase) is a lysosomal protein that catalyzes the conversion of sphingolipid (sphingomyelin) to ceramide. Ceramide molecules aggregate/assemble on the plasma membrane to form "platforms" that facilitate the viral intake into the cell...
February 6, 2024: BMC Public Health
https://read.qxmd.com/read/38251100/photocatalytic-degradation-of-pharmaceutical-residues-from-water-and-sewage-effluent-using-different-tio-2-nanomaterials
#4
JOURNAL ARTICLE
Amir Hossein Navidpour, Mohammad Boshir Ahmed, John L Zhou
Pharmaceuticals are widely used and often discharged without metabolism into the aquatic systems. The photocatalytic degradation of pharmaceutical compounds propranolol, mebeverine, and carbamazepine was studied using different titanium dioxide nanostructures suspended in water under UV and UV-visible irradiation. Among three different photocatalysts, the degradation was most effective by using Degussa P25 TiO2 , followed by Hombikat UV100 and Aldrich TiO2 . The photocatalytic performance was dependent on photocatalyst dosage, with an optimum concentration of 150 mg L-1 ...
January 6, 2024: Nanomaterials
https://read.qxmd.com/read/37788098/pharmacotherapy-for-gastric-and-intestinal-cramping-pain-%C3%A2-current-and-emerging-therapies
#5
REVIEW
Taraneh Mousavi, Mohammadhossein Sharifnia, Shekoufeh Nikfar, Mohammad Abdollahi
INTRODUCTION: Acute gastrointestinal cramping pain (GICP) is a debilitating condition that affects many people worldwide, significantly reducing their quality of life. As such, prompt treatment is crucial. AREAS COVERED: This article will explore relevant literature from databases such as PubMed, Scopus, Google Scholar, Cochrane Library, and Web of Science. Additionally, we searched ClinicalTrials.gov and the WHO ICTRP database for the latest clinical trials. EXPERT OPINION: Consensus dictates that antispasmodics such as hyoscine-N-butyl bromide and mebeverine should be the primary treatment for GICP...
October 3, 2023: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/37371688/drug-loaded-silver-nanoparticles-a-tool-for-delivery-of-a-mebeverine-precursor-in-inflammatory-bowel-diseases-treatment
#6
JOURNAL ARTICLE
Mina Todorova, Miglena Milusheva, Lidia Kaynarova, Deyana Georgieva, Vassil Delchev, Stanislava Simeonova, Bissera Pilicheva, Stoyanka Nikolova
Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery systems in the pharmaceutical industry. The goal of the current study is to synthesize drug-loaded Ag NPs using a previously described 3-methyl-1-phenylbutan-2-amine, as a mebeverine precursor (MP). Methods: A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented...
May 30, 2023: Biomedicines
https://read.qxmd.com/read/37167114/-irritable-bowel-syndrome-in-the-russian-federation-results-of-the-romerus-multicenter-observational-study
#7
JOURNAL ARTICLE
I V Maev, O Z Okhlobystina, I L Khalif, D N Andreev
BACKGROUND: Irritable bowel syndrome (IBS) is one of the most common functional disorders of the gastrointestinal tract. According to Russian guidelines, a standard examination using laboratory and instrumental evaluation methods, including colonoscopy, should be performed to establish the diagnosis of IBS. AIM: To characterize the Russian population of IBS patients. MATERIALS AND METHODS: A multicenter observational prospective study ROMERUS was conducted at 35 clinical centers in the Russian Federation...
February 24, 2023: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/36903341/prospective-of-agro-waste-husks-for-biogenic-synthesis-of-polymeric-based-ceo-2-nio-nanocomposite-sensor-for-determination-of-mebeverine-hydrochloride
#8
JOURNAL ARTICLE
Gamal A E Mostafa, Maha F El-Tohamy, Haitham Alrabiah
BACKGROUND: The remarkable properties of nickel oxide (NiO) and cerium oxide (CeO2 ) nanostructures have attracted considerable interest in these nanocomposites as potential electroactive materials for sensor construction. METHODS: The mebeverine hydrochloride (MBHCl) content of commercial formulations was determined in this study using a unique factionalized CeO2 /NiO-nanocomposite-coated membrane sensor. RESULTS: Mebeverine-phosphotungstate (MB-PT) was prepared by adding phosphotungstic acid to mebeverine hydrochloride and mixing with a polymeric matrix (polyvinyl chloride, PVC) and plasticizing agent o -nitrophenyl octyl ether...
February 23, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36831141/in-silico-in-vitro-and-ex-vivo-biological-activity-of-some-novel-mebeverine-precursors
#9
JOURNAL ARTICLE
Miglena Milusheva, Vera Gledacheva, Iliyana Stefanova, Mina Pencheva, Rositsa Mihaylova, Yulian Tumbarski, Paraskev Nedialkov, Emiliya Cherneva, Mina Todorova, Stoyanka Nikolova
UNLABELLED: Irritable bowel syndrome (IBS) is a functional gastroenterological disorder with complex pathogenesis and multifaceted therapy approaches, aimed at alleviating clinical symptoms and improving the life quality of patients. Its treatment includes dietary changes and drugs from various pharmacological groups such as antidiarrheals, anticholinergics, serotonin receptor antagonists, targeting chloride ion channels, etc. The present article is focused on the synthesis and biological evaluation of some mebeverine precursors as potential antispasmodics...
February 17, 2023: Biomedicines
https://read.qxmd.com/read/36719313/-ways-to-solve-the-problem-of-cross-reactions-during-immunochromatographic-examination-of-biological-objects
#10
JOURNAL ARTICLE
P S Vikman, A S Zhuravleva, O Yu Strelova, A N Grebenyuk
The purpose of this review is to study the causes of cross-reactions of a number of drugs (mebeverine, phenibut, tropicamide, ramipril, metoprolol, phenylephrine, sertraline, chloropyramine and diphenhydramine) during the preliminary stage of laboratory diagnostics by immunochromatographic method and to propose a possible algorithm for solving this problem. Conducting a hair study in order to identify the fact of the use of psychoactive substances will increase the reliability of analytical diagnostics and reduce the likelihood of false positive results of the analysis...
2023: Sudebno-meditsinskaia Ekspertiza
https://read.qxmd.com/read/36686904/potentiometric-determination-of-mebeverine-hydrochloride-antispasmodic-drug-based-on-molecular-docking-with-different-ionophores-host-guest-inclusion-as-a-theoretical-study
#11
JOURNAL ARTICLE
Ahmed M Abdel-Raoof, Manal M Fouad, Noha S Rashed, Noha Y Z Hosni, Ahmed Elsonbaty, Ashraf Abdel-Fattah
The scientific community has continued to pay particular attention to potentiometric sensors based on ion-selective membrane sensors as an energy-efficient, easy-to-use method suitable for microfabrication. To this end, potentiometric ion-selective sensors were used as an alternative green analytical instrument. Three distinct sensors relying on various ionophores were built and assessed. A cationic exchanger, tetra phenyl borate, was used in the polyvinyl chloride polymeric plasticized matrix using di octyl phthalate, where α, β, and γ cyclodextrins were utilized as ionophores...
January 3, 2023: RSC Advances
https://read.qxmd.com/read/36286741/-the-effectiveness-of-a-probiotic-containing-bifidobacterium-longum-bb-46-and-enterococcus-faecium-encfa-68-in-the-treatment-of-post-infectious-irritable-bowel-syndrome-prospective-randomized-comparative-study
#12
RANDOMIZED CONTROLLED TRIAL
E P Yakovenko, T V Strokova, A N Ivanov, A V Iakovenko, I Z Gioeva, M A Aldiyarova
BACKGROUND: In the treatment of post-infectious irritable bowel syndrome (PI-IBS), the leading role belongs to the normalization of the composition of the intestinal microbiome, the disturbances of which are associated with previous intestinal infections. AIM: To study the effectiveness of the drug Bifiform in the treatment of PI-IBS. MATERIALS AND METHODS: An open, prospective, comparative, randomized study included 62 patients with PI-IBS...
February 15, 2022: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/35456677/application-and-multi-stage-optimization-of-daylight-polymer-3d-printing-of-personalized-medicine-products
#13
JOURNAL ARTICLE
Jolanta Pyteraf, Adam Pacławski, Witold Jamróz, Aleksander Mendyk, Marian Paluch, Renata Jachowicz
Additive technologies have undoubtedly become one of the most intensively developing manufacturing methods in recent years. Among the numerous applications, the interest in 3D printing also includes its application in pharmacy for production of small batches of personalized drugs. For this reason, we conducted multi-stage pre-formulation studies to optimize the process of manufacturing solid dosage forms by photopolymerization with visible light. Based on tests planned and executed according to the design of the experiment (DoE), we selected the optimal quantitative composition of photocurable resin made of PEG 400, PEGDA MW 575, water, and riboflavin, a non-toxic photoinitiator...
April 12, 2022: Pharmaceutics
https://read.qxmd.com/read/35444453/a-potential-role-of-ethosuximide-and-pentoxifylline-in-relieving-abdominal-pain-in-irritable-bowel-syndrome-patients-treated-with-mebeverine-a-randomized-double-blind-placebo-controlled-trial-retraction
#14
https://read.qxmd.com/read/35440055/green-hplc-method-with-time-programming-for-the-determination-of-the-co-formulated-eye-drops-of-tafluprost-and-timolol-in-their-challengeable-ratio
#15
JOURNAL ARTICLE
Walaa Nabil Abd-AlGhafar, Fatma Ahmed Aly, Zeinab Awad Sheribah, Samar Saad
A new, simple and selective HPLC method was implemented for the simultaneous estimation of tafluprost (TFL) and timolol (TIM) in their new anti-glaucoma combination in the challengeable ratio of 3 and 1000 for TFL and TIM, respectively. Separation was achieved using a BDS Hypersil phenyl column and a mobile phase made up of acetonitrile: 0.015 M phosphate buffer (50:50 v/v, pH 3.5) delivered at 1 mL min-1 and the separation was completed in less than 6 min. UV detection was time programmed at 220 nm for the first 4...
April 19, 2022: BMC chemistry
https://read.qxmd.com/read/34969608/clinical-evaluation-of-the-effect-of-zataria-multiflora-boiss-and-trachyspermum-copticum-l-on-the-patients-with-irritable-bowel-syndrome
#16
RANDOMIZED CONTROLLED TRIAL
Hossein Jamalizadeh, Bijan Ahmadi, Fariba Shariffar, Mehdi Ansari, Mohammad Setayesh, Armita Shahesmaeili, Haleh Tajadini
BACKGROUND AND AIM: Irritable Bowel Syndrome (IBS) is the most common gastrointestinal dysfunction characterized by abdominal pain or discomfort, as well as changes in bowel movements and stool shape. Given the global trend towards the increased use of complementary and alternative medicine (CAM), the high prevalence of IBS, the lack of a standard treatment for all IBS subtypes, and patients' willingness to use CAM treatments, investigations into CAM treatments are needed. Accordingly, the present study aimed to investigate the effect of a mix of two herbal medicines (Zataria-Trachyspermum, ZT) on the clinical symptoms of patients with IBS...
May 2022: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/34941040/buspirone-in-the-management-of-refractory-irritable-bowel-syndrome-a-case-report
#17
JOURNAL ARTICLE
Mustafa Abdul Karim, Nadeen Al-Baz, Peter M Haddad, Shuja M Reagu, Majid Alabdulla
RATIONALE: Irritable bowel syndrome (IBS) is a chronic and debilitating functional disorder of the gastrointestinal tract manifested by abdominal pain and bowel habit dysregulation. The pathophysiology is complex and management targets symptom resolution. Therapeutic interventions range from dietary modification, psychological interventions, exercise, to the use of antispasmodics, antibiotics, and antidepressants. Anecdotal reports have suggested that buspirone may be beneficial in the treatment of functional dyspepsia and IBS and its physiological effect of reducing gastric tone provides a rational for its benefit...
December 23, 2021: Medicine (Baltimore)
https://read.qxmd.com/read/34877323/management-of-pouch-related-symptoms-in-patients-who-underwent-ileal-pouch-anal-anastomosis-surgery-for-adenomatous-polyposis
#18
JOURNAL ARTICLE
Ophir Gilad, Guy Rosner, Eli Brazowski, Revital Kariv, Nathan Gluck, Hana Strul
BACKGROUND: Adenomatous polyposis syndromes (APS) patients with ileal pouch anal anastomosis (IPAA) suffer frequent symptoms with scarce signs of inflammation, distinct from ulcerative colitis patients. While the management of pouchitis in ulcerative colitis patients is well established, data regarding response to treatment modalities targeting pouch-related disorders in APS patient population is scarce. AIM: To assess clinical, endoscopic and histologic response to various treatment modalities employed in the therapy of pouch related disorders...
November 16, 2021: World Journal of Clinical Cases
https://read.qxmd.com/read/34791058/explainable-multimodal-machine-learning-model-for-classifying-pregnancy-drug-safety
#19
JOURNAL ARTICLE
Guy Shtar, Lior Rokach, Bracha Shapira, Elkana Kohn, Matitiahu Berkovitch, Maya Berlin
MOTIVATION: Teratogenic drugs can cause severe fetal malformation and therefore have critical impact on the health of the fetus, yet the teratogenic risks are unknown for most approved drugs. This article proposes an explainable machine learning model for classifying pregnancy drug safety based on multimodal data and suggests an orthogonal ensemble for modeling multimodal data. To train the proposed model, we created a set of labeled drugs by processing over 100 000 textual responses collected by a large teratology information service...
January 27, 2022: Bioinformatics
https://read.qxmd.com/read/34775240/pentoxifylline-a-nonselective-phosphodiesterase-inhibitor-in-adjunctive-therapy-in-patients-with-irritable-bowel-syndrome-treated-with-mebeverine
#20
RANDOMIZED CONTROLLED TRIAL
Sahar M El-Haggar, Sahar K Hegazy, Sherief M Abd-Elsalam, Mostafa M Bahaa
BACKGROUND: Irritable bowel syndrome (IBS) is a functional gastrointestinal condition marked by chronic bowel pain or discomfort, as well as changes in abdominal motility. Despite its worldwide prevalence and clinical impact, the cause of IBS is unknown. Inflammation could play a fundamental role in the development of IBS. The aim of this study was to examine whether pentoxifylline, a competitive nonselective phosphodiesterase inhibitor, is useful in alleviating abdominal pain in IBS patients treated with mebeverine...
January 2022: Biomedicine & Pharmacotherapy
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