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Radiation Pneumonitis

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https://www.readbyqxmd.com/read/28649248/a-combination-of-podophyllotoxin-and-rutin-alleviates-radiation-induced-pneumonitis-and-fibrosis-through-modulation-of-lung-inflammation-in-mice
#1
Savita Verma, Bhargab Kalita, Sania Bajaj, Hridayesh Prakash, Ajay Kumar Singh, Manju Lata Gupta
Pneumonitis and pulmonary fibrosis are predominant consequences of radiation exposure, whether planned or accidental. The present study, demonstrates radioprotective potential of a formulation, prepared by combining podophyllotoxin and rutin (G-003M), in mice exposed to 11 Gy thoracic gamma radiation (TGR). Treated mice were observed for survival and other symptomatic features. Formation of reactive oxygen species (ROS)/nitric oxide (NO) was measured in bronchoalveolar lavage cells. DNA damage and cell death were assessed in alveolar cells by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28648948/randomized-phase-ii-study-comparing-prophylactic-cranial-irradiation-alone-to-prophylactic-cranial-irradiation-and-consolidative-extra-cranial-irradiation-for-extensive-disease-small-cell-lung-cancer-ed-sclc-nrg-oncology-rtog-0937
#2
Elizabeth M Gore, Chen Hu, Alexander Y Sun, Daniel F Grimm, Suresh S Ramalingam, Neal E Dunlap, Kristin A Higgins, Maria Werner-Wasik, Aaron M Allen, Puneeth Iyengar, Gregory M M Videtic, Russell K Hales, Ronald C McGarry, James J Urbanic, Anthony T Pu, Candice A Johnstone, Volker W Stieber, Rebecca Paulus, Jeffrey D Bradley
INTRODUCTION: RTOG-0937 is a randomized phase-II trial evaluating 1-year OS with PCI or PCI plus consolidative radiation therapy (cRT) to intra-thoracic disease and extracranial metastases for ED-SCLC. METHODS: Patients with 1-4 extracranial metastases were eligible after CR or PR to chemotherapy. Randomization was to PCI or PCI+cRT to the thorax and metastases. Original stratification included PR vs CR after chemotherapy and 1 vs 2-4 metastases; age < 65 vs > 65 was added after an observed imbalance...
June 22, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28642008/concurrent-once-daily-versus-twice-daily-chemoradiotherapy-in-patients-with-limited-stage-small-cell-lung-cancer-convert-an-open-label-phase-3-randomised-superiority-trial
#3
Corinne Faivre-Finn, Michael Snee, Linda Ashcroft, Wiebke Appel, Fabrice Barlesi, Adityanarayan Bhatnagar, Andrea Bezjak, Felipe Cardenal, Pierre Fournel, Susan Harden, Cecile Le Pechoux, Rhona McMenemin, Nazia Mohammed, Mary O'Brien, Jason Pantarotto, Veerle Surmont, Jan P Van Meerbeeck, Penella J Woll, Paul Lorigan, Fiona Blackhall
BACKGROUND: Concurrent chemoradiotherapy is the standard of care in limited-stage small-cell lung cancer, but the optimal radiotherapy schedule and dose remains controversial. The aim of this study was to establish a standard chemoradiotherapy treatment regimen in limited-stage small-cell lung cancer. METHODS: The CONVERT trial was an open-label, phase 3, randomised superiority trial. We enrolled adult patients (aged ≥18 years) who had cytologically or histologically confirmed limited-stage small-cell lung cancer, Eastern Cooperative Oncology Group performance status of 0-2, and adequate pulmonary function...
June 19, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28638799/bilateral-diffuse-grade-5-radiation-pneumonitis-after-intensity-modulated-radiation-therapy-for-localized-lung-cancer
#4
Virginia W Osborn, Andrea Leaf, Anna Lee, Elizabeth Garay, Joseph Safdieh, David Schwartz, David Schreiber
We are reporting a case of fatal radiation pneumonitis that developed six months following chemoradiation for limited stage small cell lung cancer. The patient was a 67-year-old man with a past medical history of Hashimoto's thyroiditis and remote suspicion for CREST, neither of which were active in the years leading up to treatment. He received 6600 cGy delivered in 200 cGy daily fractions via intensity modulated radiation therapy with concurrent cisplatin/etoposide followed by additional chemotherapy with dose-reduced cisplatin/etoposide and carboplatin/etoposide and then received prophylactic cranial irradiation...
June 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28618180/neutrophil-lymphocyte-ratio-and-a-dosimetric-factor-for-predicting-symptomatic-radiation-pneumonitis-in-non-small-cell-lung-cancer-patients-treated-with-concurrent-chemoradiotherapy
#5
Yun Hee Lee, Hoon-Sik Choi, Hojin Jeong, Ki Mun Kang, Jin Ho Song, Won Sup Lee, Gyeong-Won Lee, Haa-Na Song, Hoon-Gu Kim, Myoung Hee Kang, Dong Yoon Rhee, Bae Kwon Jeong
OBJECTIVES: To identify the factors that predict the progression of radiological radiation pneumonitis (RP) to symptomatic RP, and to evaluate the usefulness of the neutrophil-lymphocyte ratio (NLR) as a marker of RP severity and prognosis in stage III non-small cell lung cancer (NSCLC) patients treated with definitive concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: We retrospectively reviewed 61 patients treated between January 2010 and December 2015...
June 15, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28609013/polydatin-alleviated-radiation-induced-lung-injury-through-activation-of-sirt3-and-inhibition-of-epithelial-mesenchymal-transition
#6
Kun Cao, Xiao Lei, Hu Liu, Hainan Zhao, Jiaming Guo, Yuanyuan Chen, Yang Xu, Ying Cheng, Cong Liu, Jianguo Cui, Bailong Li, Jianming Cai, Fu Gao, Yanyong Yang
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti-inflammation and anti-oxidative capacities in other diseases. In this study, we demonstrated that PD-mitigated acute inflammation and late fibrosis caused by irradiation. PD treatment inhibited TGF-β1-Smad3 signalling pathway and epithelial-mesenchymal transition...
June 13, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28602412/definitive-chemoradiation-therapy-for-esophageal-cancer-in-the-elderly-clinical-outcomes-for-patients-exceeding-80%C3%A2-years-old
#7
Cai Xu, Mian Xi, Amy Moreno, Yutaka Shiraishi, Brian P Hobbs, Meilin Huang, Ritsuko Komaki, Steven H Lin
PURPOSE: The optimal treatment approach for patients ≥80 years ("elderly") with esophageal cancer is not well established. We assessed the clinical outcomes in elderly patients treated with definitive chemoradiation therapy (CCRT) at our institution. METHODS AND MATERIALS: 56 consecutive patients ≥80 years with esophageal cancer treated with conventional CCRT between 2001 and 2016 were propensity score matched 1:2 to generate 2 younger patient cohorts treated with CCRT without surgery: "intermediate" (65-79 years, n=112) and "younger" (<65 years, n=112)...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28596060/-medical-prevention-and-treatment-of-radiation-induced-pulmonary-complications
#8
A Vallard, C Rancoule, H Le Floch, J-B Guy, S Espenel, C Le Péchoux, É Deutsch, N Magné, C Chargari
Radiation-induced lung injuries mainly include the (acute or sub-acute) radiation pneumonitis, the lung fibrosis and the bronchiolitis obliterans organizing pneumonia (BOOP). The present review aims at describing the diagnostic process, the current physiopathological knowledge, and the available (non dosimetric) preventive and curative treatments. Radiation-induced lung injury is a diagnosis of exclusion, since clinical, radiological, or biological pathognomonic evidences do not exist. Investigations should necessarily include a thoracic high resolution CT-scan and lung function tests with a diffusing capacity of the lung for carbon monoxide...
June 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28589434/outcome-and-toxicity-of-intensity-modulated-radiotherapy-with-simultaneous-integrated-boost-in-locally-advanced-non-small-cell-lung-cancer-patients
#9
A Fondevilla Soler, J L López-Guerra, M Dzugashvili, P Sempere Rincón, A Sautbaet, P Castañeda, J M Díaz, J M Praena-Fernandez, E Rivin Del Campo, I Azinovic
PURPOSE: The aim of this study was to assess the feasibility and treatment outcome of intensity modulated radiation therapy with simultaneous integrated boost (SIB-IMRT) in locally advanced non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS: A total of 64 NSCLC patients with stage IIB (3%), IIIA (36%), and IIIB (61%) were treated with concomitant (N = 47; 73%) or sequential (N = 9; 14%) chemotherapy between February 2009 and January 2014. Eight patients (13%) received RT alone...
June 6, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28588712/maximum-standardized-uptake-value-on-fdg-pet-predicts-survival-in-stage-i-non-small-cell-lung-cancer-following-carbon-ion-radiotherapy
#10
Katsuyuki Shirai, Takanori Abe, Jun-Ichi Saitoh, Tatsuji Mizukami, Daisuke Irie, Yosuke Takakusagi, Shintaro Shiba, Naoko Okano, Takeshi Ebara, Tatsuya Ohno, Takashi Nakano
The present study (University Hospital Medical Information Network study no. UMIN000003797) aimed to evaluate whether the maximum standardized uptake value (SUVmax) of pretreatment (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is prognostic factor for stage I non-small cell lung cancer (NSCLC) treated with carbon ion radiotherapy (C-ion RT). Patients treated between June 2010 and June 2013 at Gunma University Heavy Ion Medical Center (Maebashi, Japan) on a prospective protocol were included in the present study...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28584268/pulmonary-emphysema-is-a-risk-factor-for-radiation-pneumonitis-in-nsclc-patients-with-squamous-cell-carcinoma-after-thoracic-radiation-therapy
#11
Ziyang Zhou, Xiao Song, Ailu Wu, Hui Liu, Hongyu Wu, Qiongya Wu, Yu Liu, Yefei Li, Yong Cai, Shixiong Liang
Pulmonary emphysema (PE) has been demonstrated to have a high prevalence in patients with locally advanced non-small cell lung cancer (NSCLC). A total of 153 patients with locally advanced NSCLC were enrolled in this study to investigate the association between PE and radiation pneumonitis (RP) after definitive thoracic radiation therapy (TRT). The incidence of RP in Grade 2, 3 and 5 were 11.1%, 9.8% and 0.7%, respectively. Univariate analysis revealed that age, PE, forced vital capacity (FVC), arterial partial pressure of oxygen (PO2) and mean lung dose (MLD) were significantly associated with the risk of Grade ≥2 or Grade ≥3 RP in patients with squamous cell carcinoma (SCC, P < 0...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28581403/plasma-levels-of-il-8-and-tgf-%C3%AE-1-predict-radiation-induced-lung-toxicity-in-non-small-cell-lung-cancer-a-validation-study
#12
Shulian Wang, Jeff Campbell, Matthew H Stenmark, Jing Zhao, Paul Stanton, Martha M Matuszak, Randall K Ten Haken, Feng-Ming Spring Kong
PURPOSE AND OBJECTIVES: We previously reported that the combination of mean lung dose (MLD) and inflammatory cytokines interleukin-8 (IL-8) and transforming growth factor-β1 (TGF-β1) may provide a more accurate model for radiation-induced lung toxicity (RILT) prediction in 58 patients with non-small cell lung cancer (NSCLC). This study is to validate the previous findings with new patients and to explore new models with more cytokines. METHODS AND MATERIALS: One hundred forty-two patients with stage I-III NSCLC treated with definitive radiation therapy (RT) from prospective studies were included...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28577952/stereotactic-body-radiotherapy-for-operable-early-stage-non-small-cell-lung-cancer
#13
Takahisa Eriguchi, Atsuya Takeda, Naoko Sanuki, Yuichiro Tsurugai, Yousuke Aoki, Yohei Oku, Yu Hara, Takeshi Akiba, Naoyuki Shigematsu
PURPOSE: To analyze outcomes of stereotactic body radiotherapy (SBRT) for operable patients with early-stage non-small cell lung cancer (NSCLC) and to evaluate factors associated with outcomes. METHODS: We retrospectively analyzed operable patients with NSCLC, staged as cT1-2N0M0, treated with SBRT between 2006 and 2015. Both biopsy-proven and clinically diagnosed NSCLC were included. Local control and survival rates were calculated and compared between subsets of patients...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28574846/polymorphisms-in-bmp2-bmp4-with-estimates-of-mean-lung-dose-predict-radiation-pneumonitis-among-patients-receiving-definitive-radiotherapy-for-non-small-cell-lung-cancer
#14
Ju Yang, Ting Xu, Daniel R Gomez, Xianglin Yuan, Quynh-Nhu Nguyen, Melenda Jeter, Yipeng Song, Stephen Hahn, Zhongxing Liao
Single nucleotide polymorphisms (SNPs) in TGFβ1 can predict the risk of radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) after definitive radiotherapy. Here we investigated whether SNPs in TGFβ superfamily members BMP2 and BMP4 are associated with RP in such patients. In total, we retrospectively analyzed 663 patients given ≥ 60 Gy for NSCLC. We randomly assigned 323 patients to the training cohort and 340 patients to the validation cohort. Potentially functional and tagging SNPs of BMP2 (rs170986, rs1979855, rs1980499, rs235768, rs3178250) and BMP4 (rs17563, rs4898820, rs762642) were genotyped...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28558766/prognostic-analysis-of-radiation-pneumonitis-carbon-ion-radiotherapy-in-patients-with-locally-advanced-lung-cancer
#15
Kazuhiko Hayashi, Naoyoshi Yamamoto, Masataka Karube, Mio Nakajima, Naruhiro Matsufuji, Hiroshi Tsuji, Kazuhiko Ogawa, Tadashi Kamada
BACKGROUND: Carbon-ion radiotherapy (CIRT) is a promising treatment for locally advanced non-small-cell lung cancer, especially for patients with inoperable lung cancer. Although the incidence of CIRT-induced radiation pneumonitis (RP) ≥ grade 2 ranges from 2.5 to 9.9%, the association between CIRT-induced RP and dosimetric parameters is not clear. Herein, we identified prognostic factors associated with symptomatic RP after CIRT for patients with non-small-cell lung cancer. METHODS: Clinical results of 65 patients treated with CIRT between 2000 and 2015 at the National Institute of Radiological Sciences were retrospectively analyzed...
May 30, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28548957/involvement-of-p38-%C3%AE-trcp-tristetraprolin-tnf%C3%AE-axis-in-radiation-pneumonitis
#16
Pranathi Meda Krishnamurthy, Shirish Shukla, Paramita Ray, Rohit Mehra, Mukesh K Nyati, Theodore S Lawrence, Dipankar Ray
Early release of tumor necrosis factor-alpha (TNF-α) during radiotherapy of thoracic cancers plays an important role in radiation pneumonitis, whose inhibition may provide lung radioprotection. We previously reported radiation inactivates Tristetraprolin (TTP), a negative regulator of TNF-α synthesis, which correlated with increased TNF-α release. However, the molecular events involved in radiation-induced TTP inactivation remain unclear. To determine if eliminating Ttp in mice resulted in a phenotypic response to radiation, Ttp-null mice lungs were exposed to a single dose of 15 Gy, and TNF-α release and lung inflammation were analyzed at different time points post-irradiation...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28522279/-stereotactic-lung-radiotherapy-technical-setting-up-on-novalis-tx-%C3%A2-and-single-centre-prospective-study-of-the-100-first-malignant-pulmonary-nodules-treated-at-centre-jean-perrin
#17
A Bellière-Calandry, G Dupic, F Magnier, V Chassin, V Dedieu, M Lapeyre
PURPOSE: Description of the treatment technique of stereotactic lung radiotherapy on Novalis Tx(®) and prospective study of the first 100 pulmonary nodules treated at centre Jean-Perrin (France). MATERIAL AND METHODS: From October 2012 to December 2015, 100 inoperable pulmonary nodules (62 stage I non-small-cell lung cancer and 38 metastases) of 90 patients with a mean age of 68.2 years (range: 46-89 years) were prospectively treated with dynamic arctherapy on Novalis Tx(®)...
May 15, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28512460/immunological-aspect-of-radiation-induced-pneumonitis-current-treatment-strategies-and-future-prospects
#18
REVIEW
Anup Kainthola, Teena Haritwal, Mrinialini Tiwari, Noopur Gupta, Suhel Parvez, Manisha Tiwari, Hrideysh Prakash, Paban K Agrawala
Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of treatment and leading to fibrosis later. Several cytokines and inflammatory molecules interplay in the vicinity of the tissue developing radiation injury leading to pneumonitis and fibrosis. While certain cytokines may be exploited as biomarkers, they also appear to be a potent target of intervention at transcriptional level...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28506589/the-relationship-between-dosimetric-factors-side-effects-and-survival-in-patients-with-non-small-cell-lung-cancer-treated-with-definitive-radiotherapy
#19
Dilruba Okumus, Sureyya Sarihan, Sema Gozcu, Deniz Sigirli
The patients with non-small cell lung cancer (NSCLC) treated with definitive conformal radiotherapy (RT) were evaluated in terms of side effects and survival. Normal tissue complication probability (NTCP) was calculated for 68 patients treated between 2009 and 2012. Clinical and dosimetric factors were analyzed. The median dose of 63 Gy (range: 54 to 70 Gy) was given with conformal RT with blocks (n = 37), 3-dimensional conformal RT (3DCRT) (n = 11), or intensity-modulated RT (IMRT) (n = 20)...
May 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28499662/-acute-toxicity-of-breast-cancer-irradiation-with-modulated-intensity-by-tomotherapy-%C3%A2
#20
N Aoulad, C Massabeau, B de Lafontan, L Vieillevigne, G Hangard, C Ciprian, L Chaltiel, É Moyal, F Izar
PURPOSE: Helical radiation intensity modulated by tomotherapy improves dose distribution to complex and large volumes. The aim of the study was to assess acute toxicity of this technique during breast cancer irradiation after conserving surgery or mastectomy. PATIENTS AND METHODS: Cutaneous toxicities, lung and oesophageal side effects, and breast lymphedema were retrospectively collected according to the Common Terminology Criteria for Adverse Events Version 4...
May 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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