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Radiation Pneumonitis

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https://www.readbyqxmd.com/read/29661254/the-risk-and-predictors-for-severe-radiation-pneumonitis-in-lung-cancer-patients-treated-with-thoracic-reirradiation
#1
Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang, Guang Li
BACKGROUND: Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictors for severe RP in patients receiving thoracic re-RT. METHODS: Sixty seven patients with lung cancer received thoracic re-RT for recurrent or metastatic disease. Three-dimensional conformal radiotherapy (3D-CRT)/intensity modulated radiotherapy (IMRT) was used for 60 patients, and stereotactic body radiation therapy (SBRT) was used in 7 patients...
April 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29659324/montelukast-attenuates-radioactive-i131-induced-pulmonary-damage-on-rats
#2
Arif Osman Tokat, Aylin Akbulut, Deniz Billur, Gokhan Koca, Pinar Bayram, Serdar Kuru, Sezgin Karasu, Suheyla Aydogmus, Hüseyin Cakmak, Sengul Ozmert, Meliha Korkmaz
PURPOSE: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas, however, I131 also accumulates in non-thyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29651875/is-severe-emphysema-as-defined-by-quantitative-ct-measurement-a-negative-risk-factor-of-radiation-pneumonitis
#3
Tatsuhiko Saito, Hidetsugu Nakayama, Takafumi Yamada, Sachica Shiraishi, Koichi Tokuuye
OBJECTIVES: To investigate whether patients with emphysema, as evaluated by quantitative CT image measurement, are at risk of developing radiation pneumonitis (RP) after radiotherapy for non-small cell lung cancer (NSCLC). METHODS: Between March 2011 and June 2015, 68 consecutive patients with stage INSCLC treated with a radiotherapy a dose of 75 Gy given in 30 fractions were enrolled. The median age was 79 years and there were 45 males and 23 females. The numbers of patients with T1 and T2 were 49 and 19, respectively...
April 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29618353/efficacy-of-virtual-block-objects-in-reducing-the-lung-dose-in-helical-tomotherapy-planning-for-cervical-oesophageal-cancer-a-planning-study
#4
Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi, Takeshi Kodaira
BACKGROUND: Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique that avoids the lungs has never been examined due to the high difficulty of dose optimization. In this study, we examined the efficacy of helical tomotherapy that can restrict beamlets passing virtual blocks during dose optimization computing (block plan) in reducing the lung dose...
April 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29608606/lung-density-change-after-sabr-a-comparative-study-between-tri-co-60-magnetic-resonance-guided-system-and-linear-accelerator
#5
Eunji Kim, Hong-Gyun Wu, Jong Min Park, Jung-In Kim, Hak Jae Kim, Hyun-Cheol Kang
Radiation-induced lung damage is an important treatment-related toxicity after lung stereotactic ablative radiotherapy (SABR). After implementing a tri-60Co magnetic-resonance image guided system, ViewRayTM, we compared the associated early radiological lung density changes to those associated with a linear accelerator (LINAC). Eight patients treated with the tri-60Co system were matched 1:1 with patients treated with LINAC. Prescription doses were 52 Gy or 60 Gy in four fractions, and lung dose-volumetric parameters were calculated from each planning system...
2018: PloS One
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#6
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29600055/clarithromycin-mitigates-radiation-pneumonitis-in-patients-with-lung-cancer-treated-with-stereotactic-body-radiotherapy
#7
Atsuya Takeda, Yuichiro Tsurugai, Naoko Sanuki, Tatsuji Enomoto, Masaharu Shinkai, Tomikazu Mizuno, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Yu Hara, Etsuo Kunieda
Background: Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and are used to treat respiratory inflammatory diseases. Radiation pneumonitis has similar pathology to them. Adverse reactions to macrolides are few and self-limited. We thus administered CAM to patients with high-risk factors for radiation pneumonitis, and retrospectively investigated whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29594201/association-of-lung-fluorodeoxyglucose-uptake-with-radiation-pneumonitis-after-concurrent-chemoradiation-for-non-small-cell-lung-cancer
#8
Jinbo Yue, Matthew McKeever, Terence T Sio, Ting Xu, Jinhai Huo, Qiuling Shi, Quynh-Nhu Nguyen, Ritsuko Komaki, Daniel R Gomez, Tinsu Pan, Xin Shelley Wang, Zhongxing Liao
Background: Increased uptake of fluorodeoxyglucose (FDG) by lung tissue could reflect inflammatory changes related to radiation pneumonitis (RP). In this secondary analysis of a clinical trial, we examined potential associations between posttreatment lung FDG uptake and RP severity in patients with non-small cell lung cancer (NSCLC) for up to 12 months after concurrent chemoradiation (CRT). Methods: Subjects were 152 patients with NSCLC who had received concurrent CRT as part of the prospective trial NCT00915005...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29565649/risk-factors-for-radiation-pneumonitis-after-stereotactic-radiation-therapy-for-lung-tumours-clinical-usefulness-of-the-planning-target-volume-to-total-lung-volume-ratio
#9
Tomoko Ueyama, Takeshi Arimura, Koji Takumi, Fumihiko Nakamura, Ryutaro Higashi, Soichiro Ito, Yoshihiko Fukukura, Tomokazu Umanodan, Masanori Nakajo, Chihaya Koriyama, Takashi Yoshiura
OBJECTIVES: To identify risk factors for symptomatic radiation pneumonitis (RP) after stereotactic radiation therapy (SRT) for lung tumours. Methods We retrospectively evaluated 68 lung tumours in 63 patients treated with SRT between 2010 and 2015. RP was graded according to the National Cancer Institute-Common Terminology Criteria for Adverse Events version 4.0. SRT was delivered at 7.0-12.0 Gy per each fraction, once daily, to a total of 48-64 Gy (median, 50 Gy). Univariate analysis was performed to assess patient- and treatment-related factors, including age, sex, smoking index, pulmonary function, tumour location, serum Krebs von den Lungen-6 value, dose-volume metrics (V5, V10, V20, V30, V40, and VS5), homogeneity index of the planning target volume (PTV), PTV dose, mean lung dose (MLD), contralateral MLD and V2, PTV volume, lung volume and the PTV/lung volume ratio (PTV/Lung)...
March 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29556391/radiation-recall-pneumonitis-induced-by-ifosfamide-for-malignant-soft-tissue-tumor-arising-from-the-chest-wall-a-case-report
#10
Hiroaki Murata, Kenzou Koyama, Yasunobu Takezawa, Yasunori Nishigaki
The present study reports a rare case of radiation recall pneumonitis attributed to ifosfamide that was used as a single antitumor agent for a recurrent malignant soft tissue tumor, arising from the chest wall. A 74-year-old man, who had a mass in his right upper chest wall, underwent surgical excision under the diagnosis of chronic expanding hematoma. He was referred to the present hospital with a recurrent tumor as the excised tumor was diagnosed as undifferentiated high-grade sarcoma. The extension of the tumor following previous surgery was aggressive and the tumor margins were unclear on magnetic resonance imaging...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29556330/gstp1-ile105val-polymorphism-might-be-associated-with-the-risk-of-radiation-pneumonitis-among-lung-cancer-patients-in-chinese-population-a-prospective-study
#11
Lehui Du, Wei Yu, Xiang Huang, Nana Zhao, Fang Liu, Fang Tong, Sujing Zhang, Baolong Niu, Xiaoliang Liu, Shouping Xu, Yurong Huang, Xiangkun Dai, Chuanbin Xie, Gaoxiang Chen, Xiaohu Cong, Baolin Qu
Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between functional SNPs and risk of RP. Methods: We recruited a total of 149 lung cancer patients who had received intensity modulated radiation therapy (IMRT)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29552767/toxicity-and-efficacy-of-a-hypofractionated-3-weekly-fractions-of-850c-gy-irradiation-schedule-for-stage-iiib-iv-non-small-cell-lung-cancer-elderly-patients-with-low-performance-status-and-unfit-for-chemotherapy
#12
Vassilis Kouloulias, Evridiki Patriki, Eftychia Mosa, Kalliopi Platoni, John Georgakopoulos, Anna Zygogianni, Maria Dilvoi, George Patatoukas, Christos Antypas, Christina Armpilia, Nikolaos Trogkanis, Eyfrosini Kypraiou, Stella Nikoloudi, George Giannakouras, Efstathios Efstathopoulos, Nikolaos Kelekis, John Kouvaris
PURPOSE: To evaluate in an observational way the clinical impact of a hypofractionated irradiation schedule in patients with unresectable non-small cell lung cancer (NSCLC). METHODS: Forty elderly patients (24 men/16 women) diagnosed with unresectable stage IIIb/IV NSCLC unfit for chemotherapy, were treated with once-a-week hypofractionation schedule. All patients had a poor performance status. A dose of 255 Gy in 3 weekly fractions was prescribed while a 3D conformal technique (3D-CRT) was used for irradiation...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29549533/patient-reported-lung-symptoms-as-an-early-signal-of-impending-radiation-pneumonitis-in-patients-with-non-small-cell-lung-cancer-treated-with-chemoradiation-an-observational-study
#13
Jinbo Yue, Qiuling Shi, Ting Xu, Melenda Jeter, Ting-Yu Chen, Ritsuko Komaki, Daniel R Gomez, Tinsu Pan, Charles S Cleeland, Zhongxing Liao, Xin Shelley Wang
PURPOSE: Clinician ratings of concurrent chemoradiation (CRT)-induced radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) are based on both imaging and patient-reported lung symptoms. We compared the value of patient-reported outcomes versus normal-lung uptake of18 F-fluoro-2-deoxyglucose in positron emission computed tomography (FDG PET/CT) during the last week of treatment, for indicating the development of grade ≥ 2 RP within 4 months of CRT completion...
March 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29526532/fatal-radiation-pneumonitis-in-patients-with-subclinical-interstitial-lung-disease
#14
Joshua R Niska, Steven E Schild, William G Rule, Thomas B Daniels, James R Jett
No abstract text is available yet for this article.
February 17, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29520071/hsp27-inhibitor-attenuates-radiation-induced-pulmonary-inflammation
#15
Jee-Youn Kim, Yong-Min An, Byeong Rok Yoo, Jin-Mo Kim, Song Yee Han, Younghwa Na, Yun-Sil Lee, Jaeho Cho
Radiation therapy has been used to treat over 70% of thoracic cancer; however, the method usually causes radiation pneumonitis. In the current study, we investigated the radioprotective effects of HSP27 inhibitor (J2) on radiation-induced lung inflammation in comparison to amifostine. In gross and histological findings, J2 treatment significantly inhibited immune cell infiltration in lung tissue, revealing anti-inflammatory potential of J2. Normal lung volume, evaluated by micro-CT analysis, in J2-treated mice was higher compared to that in irradiated mice...
March 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29519614/posttreatment-immune-parameters-predict-cancer-control-and-pneumonitis-in-stage-i-non-small-cell-lung-cancer-patients-treated-with-stereotactic-ablative-radiotherapy
#16
Ye Zheng, Anhui Shi, Weihu Wang, Huiming Yu, Rong Yu, Dongming Li, Bo Xu, Huimin Ma, Jing You, Dan Zhao, Leilei Jiang, Jianhao Geng, Guangying Zhu
PURPOSE: Stereotactic ablative body radiotherapy (SABR) represents an exciting, tolerable, and highly effective form of radiotherapy. Ongoing investigations into the interactions between radiotherapy and the immune system have uncovered new mechanisms that can be exploited to improve efficacy. We determined whether baseline or posttreatment immune parameters could predict disease control and toxicity in stage I non-small-cell lung cancer (NSCLC) patients treated with SABR. PATIENTS AND METHODS: Peripheral blood samples were collected from 62 patients 24 hours before treatment and within 4 weeks after treatment for lymphocyte subset count analysis...
January 4, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29518913/post-irradiation-treatment-with-a-superoxide-dismutase-mimic-mntnhex-2-pyp-5-mitigates-radiation-injury-in-the-lungs-of-non-human-primates-after-whole-thorax-exposure-to-ionizing-radiation
#17
John Mark Cline, Greg Dugan, John Daniel Bourland, Donna L Perry, Joel D Stitzel, Ashley A Weaver, Chen Jiang, Artak Tovmasyan, Kouros Owzar, Ivan Spasojevic, Ines Batinic-Haberle, Zeljko Vujaskovic
Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; however, studies in humans or large animals are lacking. We hypothesized that post-exposure treatment with the lipophilic mitochondrial superoxide dismutase mimetic, MnTnHex-2-PyP5+ (hexyl), would reduce radiation-induced pneumonitis and fibrosis in the lungs of nonhuman primates...
March 7, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29498145/feasibility-of-carbon-ion-radiotherapy-for-re-irradiation-of-locoregionally-recurrent-metastatic-or-secondary-lung-tumors
#18
Kazuhiko Hayashi, Naoyoshi Yamamoto, Masataka Karube, Mio Nakajima, Hiroshi Tsuji, Kazuhiko Ogawa, Tadashi Kamada
Intrathoracic recurrence after carbon-ion radiotherapy for primary or metastatic lung tumors remains a major cause of cancer-related deaths. However, treatment options are limited. Herein, we report on the toxicity and efficacy of re-irradiation with carbon-ion radiotherapy for locoregionally recurrent, metastatic, or secondary lung tumors. Data of 95 patients with prior intrathoracic carbon-ion radiotherapy who were treated with re-irradiation with carbon-ion radiotherapy at our institution between 2006 and 2016 were retrospectively analyzed...
March 2, 2018: Cancer Science
https://www.readbyqxmd.com/read/29487024/phase-1-study-of-accelerated-hypofractionated-radiation-therapy-with-concurrent-chemotherapy-for-stage-iii-non-small-cell-lung-cancer-calgb-31102-alliance
#19
James J Urbanic, Xiaofei Wang, Jeffrey A Bogart, Thomas E Stinchcombe, Lydia Hodgson, Steven E Schild, Lyudmila Bazhenova, Olwen Hahn, Ravi Salgia, Everett E Vokes
PURPOSE: To investigate the safety of accelerated hypofractionated radiation therapy (AHRT) with concurrent chemotherapy (CT) for inoperable stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: The primary objectives were to define the maximally tolerable course of accelerated radiation therapy and to describe toxicities of therapy. Total radiation therapy remained at 60 Gy. The number of once-daily fractions in each successive cohort was reduced as follows: cohort 1, 60 Gy in 27 fractions; cohort 2, 60 Gy in 24 fractions; cohort 3, 60 Gy in 22 fractions; and cohort 4, 60 Gy in 20 fractions...
January 31, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29455424/hypo-fractionated-stereotactic-radiation-therapy-for-lung-malignancies-by-means-of-helical-tomotherapy-report-of-feasibility-by-a-single-center-experience
#20
Vanessa Figlia, Rosario Mazzola, Francesco Cuccia, Filippo Alongi, Gianluca Mortellaro, Daniela Cespuglio, Teresa Cucchiara, Giuseppina Iacoviello, Vito Valenti, Massimo Molino, Francesco Verderame, Domenica Matranga, Antonio Lo Casto, Giuseppe Ferrera
BACKGROUND: Several experiences in the literature report SBRT as an effective treatment option for medically inoperable early stage non-small cell lung cancer (NSCLC) and oligometastatic disease. The optimal fractionation schedules and total dose remain controversial. In this study, we evaluated the safety in terms of toxicity and efficacy of using of 8-10 fractions schedules with Helical Tomotherapy (HT) for primary and metastatic lung lesions. METHODS: Between March 2014 and May 2016, a total of 39 patients (median age 72 years, range 26-91) were treated with HT-SBRT for malignant lung lesions: 22 patients with early stage NSCLC, 17 with oligometastases...
February 17, 2018: La Radiologia Medica
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