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Radiation Pneumonitis

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https://www.readbyqxmd.com/read/28103970/-a-phase-i-ii-study-of-chemotherapy-concurrent-with-twice-daily-radiotherapy-%C3%A2-schedules-by-intensity-modulated-radiation-therapy-using-simultaneous-integrated-boost-for-limited-stage-small-cell-lung-cancer
#1
Jing You, Huiming Yu, Maxiaowei Song, Chen Shi, Xiaohang Wang, Ye Zheng, Rong Yu, Anhui Shi, Guangying Zhu
BACKGROUND: Twice-daily radiation concurrent with chemotherapy is one of the standard methods for limited-stage small cell lung cancer. The study was to evaluate the feasibility of chemotherapy concurrent with dose-escalating twice-daily radiotherapy by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) approach in patients with limited-stage small cell lung cancer. METHODS: Patients with limited-stage small cell lung cancer were included, treated with twice-daily radiotherapy by SIB-IMRT concurrent with chemotherapy of etoposide plus cisplatin...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28057036/clinical-outcomes-of-stage-i-and-iia-non-small-cell-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy-using-a-real-time-tumor-tracking-radiotherapy-system
#2
Norio Katoh, Itaru Soda, Hiroyasu Tamamura, Shotaro Takahashi, Yusuke Uchinami, Hiromichi Ishiyama, Kiyotaka Ota, Tetsuya Inoue, Rikiya Onimaru, Keiko Shibuya, Kazushige Hayakawa, Hiroki Shirato
PURPOSE: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. MATERIALS AND METHODS: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner...
January 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28053021/first-in-human-phase-1-study-of-the-oral-inhibitor-of-indoleamine-2-3-dioxygenase-1-epacadostat-incb024360-in-patients-with-advanced-solid-malignancies
#3
Gregory L Beatty, Peter J O'Dwyer, Jason Clark, Jack G Shi, Kevin J Bowman, Peggy Scherle, Robert C Newton, Richard Schaub, Janet Maleski, Lance Leopold, Thomas F Gajewski
PURPOSE: Indoleamine 2,3-dioxygenase-1 (IDO1) catalyzes the degradation of tryptophan to N-formyl-kynurenine. Overexpressed in many solid malignancies, IDO1 can promote tumor escape from host immunosurveillance. This first-in-human phase 1 study investigated the maximum tolerated dose, safety, pharmacokinetics, pharmacodynamics, and antitumor activity of epacadostat (INCB024360), a potent and selective inhibitor of IDO1. PATIENTS AND METHODS: Fifty-two patients with advanced solid malignancies were treated with epacadostat (50 mg once daily or 50, 100, 300, 400, 500, 600, or 700 mg twice daily [BID]) in a dose-escalation 3 + 3 design and evaluated in 28-day cycles...
January 4, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28052649/prognostic-impact-of-elective-supraclavicular-nodal-irradiation-for-patients-with-n1-breast-cancer-after-lumpectomy-and-anthracycline-plus-taxane-based-chemotherapy-krog-1418-a-multicenter-case-controlled-study
#4
Haeyoung Kim, Won Park, Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Yeon-Joo Kim, Eun Sook Lee, Keun Seok Lee, Han-Sung Kang, In Hae Park, Kyung Hwan Shin, Chan Woo Wee, Kyubo Kim, Kyung Ran Park, Yong Bae Kim, Sung Ja Ahn, Jong Hoon Lee, Jin Hee Kim, Mison Chun, Hyung-Sik Lee, Jung Soo Kim, Jihye Cha
Purpose: This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy. Materials and Methods: We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching...
January 4, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28048563/we-ab-207b-05-correlation-of-normal-lung-density-changes-with-dose-after-stereotactic-body-radiotherapy-sbrt-for-early-stage-lung-cancer
#5
Q Wu, S Devpura, K Feghali, C Liu, M Ajlouni, B Movsas, I Chetty
PURPOSE: To investigate correlation of normal lung CT density changes with dose accuracy and outcome after SBRT for patients with early stage lung cancer. METHODS: Dose distributions for patients originally planned and treated using a 1-D pencil beam-based (PB-1D) dose algorithm were retrospectively recomputed using algorithms: 3-D pencil beam (PB-3D), and model-based METHODS: AAA, Acuros XB (AXB), and Monte Carlo (MC). Prescription dose was 12 Gy × 4 fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048506/we-ab-207b-12-prospective-study-of-the-relationship-between-dose-volume-clinical-toxicity-and-patient-reported-outcomes-in-lung-cancer-patients-treated-with-sbrt
#6
E Mayyas, S Vance, S Brown, J Liu, J Kim, S Zhen, S Devpura, M Ajlouni, S Salim, I Chetty, B Movsas
PURPOSE: To determine in a prospective study, the correlation between radiation dose/volume, clinical toxicities and patient-reported, quality of life (QOL) resulting from lung SBRT. METHODS: For 106 non-small cell lung cancer (NSCLC) patients receiving SBRT (12 Gy × 4), symptoms including cough, dyspnea, fatigue and pneumonitis were measured at baseline (before treatment), after treatment and 3, 6, and 12 months post-treatment. Toxicity was graded from zero to five...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048474/we-ab-202-01-evaluating-the-toxicity-reduction-with-ct-ventilation-functional-avoidance-radiation-therapy
#7
Y Vinogradskiy, Y Miyasaka, N Kadoya, R Castillo, E Castillo, T Guerrero, T Yamamoto
PURPOSE: CT-ventilation is an exciting new imaging modality that uses 4DCTs to calculate lung ventilation. Studies have proposed to use 4DCT-ventilation imaging for functional avoidance radiotherapy which implies designing treatment plans to spare functional portions of the lung. Although retrospective studies have been performed to evaluate the dosimetric gains to functional lung; no work has been done to translate the dosimetric gains to an improvement in pulmonary toxicity. The purpose of our work was to evaluate the potential reduction in toxicity for 4DCT-ventilation based functional avoidance...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048445/su-c-207a-07-cumulative-18f-fdg-uptake-histogram-relative-to-radiation-dose-volume-histogram-of-lung-after-imrt-or-pspt-and-their-association-with-radiation-pneumonitis
#8
N Shusharina, Z Liao, R Mohan, N Choi, T Bortfeld
PURPOSE: To determine whether the difference in cumulative 18F-FDG uptake histogram of lung treated with either IMRT or PSPT is associated with radiation pneumonitis (RP) in patients with inoperable stage II and III NSCLC. METHODS: We analyzed 24 patients from a prospective randomized trial to compare IMRT (n=12) with vs. PSPT (n=12) for inoperable NSCLC. All patients underwent PET-CT imaging between 35 and 88 days post-therapy. Post-treatment PET-CT was aligned with planning 4D CT to establish a voxel-to-voxel correspondence between post-treatment PET and planning dose images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048415/su-f-p-52-a-meta-analysis-of-controlled-clinical-trials-comparing-elective-nodal-irradiation-with-involved-field-irradiation-for-conformal-or-intensity-modulated-radiotherapy-in-patients-with-esophageal-cancer
#9
W Bai, R Zhang, Z Zhou, X Qiao
PURPOSE: To compare elective nodal irradiation with involved-field irradiation for three-dimensional conformal radiotherapy or intensity-modulated radiotherapy in patients with esophageal cancer by a metaanalysis. METHODS: Wanfang, CNKI, VIP, CBM databases, PubMed, Embase and Cochrane Library were searched to identify the controlled clinical trials of elective nodal irradiation with involved-field irradiation for three-dimensional conformal radiotherapy or intensity-modulated radiotherapy in patients with esophageal cancer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048125/su-f-r-31-identification-of-robust-normal-lung-ct-texture-features-for-the-prediction-of-radiation-induced-lung-disease
#10
W Choi, S Riyahi, W Lu
PURPOSE: Normal lung CT texture features have been used for the prediction of radiation-induced lung disease (radiation pneumonitis and radiation fibrosis). For these features to be clinically useful, they need to be relatively invariant (robust) to tumor size and not correlated with normal lung volume. METHODS: The free-breathing CTs of 14 lung SBRT patients were studied. Different sizes of GTVs were simulated with spheres placed at the upper lobe and lower lobe respectively in the normal lung (contralateral to tumor)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047826/we-ab-207b-02-a-bayesian-network-approach-for-joint-prediction-of-tumor-control-and-radiation-pneumonitis-rp-in-non-small-cell-lung-cancer-nsclc
#11
Y Luo, D McShan, M Matuszak, S Hobson, S Jolly, R Ten Haken, I El Naqa
PURPOSE: NSCLC radiotherapy treatment is a trade-off between controlling the tumor while limiting radiation-induced toxicities. Here we identify hierarchical biophysical relationships that could simultaneously influence both local control (LC) and RP by using an integrated Bayesian Networks (BN) approach. METHODS: We studied 79 NSCLC patients treated on prospective protocol with 56 cases of LC and 21 events of RP. Beyond dosimetric information, each patient had 193 features including 12 clinical factors, 60 circulating blood cytokines before and during radiotherapy, 62 microRNAs, and 59 single-nucleotide polymorphisms (SNPs)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047740/su-g-brc-08-evaluation-of-dose-mass-histogram-as-a-more-representative-dose-description-method-than-dose-volume-histogram-in-lung-cancer-patients
#12
J Liu, A Eldib, M Lin, J Li, G Mora, C Ma
PURPOSE: Dose-volume-histogram (DVH) is widely used for plan evaluation in radiation treatment. The concept of dose-mass-histogram (DMH) is expected to provide a more representative description as it accounts for heterogeneity in tissue density. This study is intended to assess the difference between DVH and DMH for evaluating treatment planning quality. METHODS: 12 lung cancer treatment plans were exported from the treatment planning system. DVHs for the planning target volume (PTV), the normal lung and other structures of interest were calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047298/tu-h-campus-tep2-01-a-comparison-of-noninvasive-techniques-to-assess-radiation-induced-lung-damage-in-mice
#13
A Rubinstein, C Kingsley, A Melancon, R Tailor, J Pollard, M Guindani, D Followill, J Hazle, L Court
PURPOSE: To evaluate the use of post-irradiation changes in respiratory rate and CBCT-based morphology as predictors of survival in mice. METHODS: C57L/J mice underwent whole-thorax irradiation with a Co-60 beam to four different doses [0Gy (n=3), 9Gy (n=5), 11Gy (n=7), and 13Gy (n=5)] in order to induce varying levels of pneumonitis. Respiratory rate measurements, breath-hold CBCTs, and free-breathing CBCTs were acquired pre-irradiation and at six time points between two and seven months post-irradiation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046930/we-h-bra-02-radiobiological-modeling-of-tumor-control-probability-tcp-and-radiation-induced-pneumonitis-rp-for-lung-cancer-patients-treated-with-monte-carlo-based-lung-sbrt
#14
D Pokhrel, S Sood, X Shen, R Badkul, C McClinton, H Jiang, M Mitchell, C Lominska, F Wang
PURPOSE: To present radiobiological modeling of TCP using tumor size-adjusted BED(s-BED)and PTV(D99) to lung SBRT patients treated with X-ray Voxel Monte Carlo(XVMC) algorithm, apply parameterized Lyman-NTCP model to predict grade-2 RP and subsequently, compare with clinical outcomes/observations. METHODS: Dosimetric parameters and clinical follow-up for XVMC-based lung-SBRT patients were retrospectively evaluated. Patients were treated at Novalis-TX with hybrid(2 non-coplanar partial-arcs plus 3-6 static-beams)plan using HD-MLC/6MV-SRS-beam...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046029/genetic-variants-in-mthfr-gene-predict-%C3%A2-2-radiation-pneumonitis-in-esophageal-squamous-cell-carcinoma-patients-treated-with-thoracic-radiotherapy
#15
Yang Zhang, Zongjuan Li, Jian Zhang, Hongsheng Li, Yumei Qiao, Chengsuo Huang, Baosheng Li
Reactive oxygen species (ROS), formed as an indirect production of radiotherapy (RT), could cause DNA damage of normal tissues. Meanwhile, our body possesses the ability to restore the damage by DNA repair pathways. The imbalance between the two systems could finally result in radiation injury. Therefore, in this prospective cohort study, we explored the association of genetic variants in ROS metabolism and DNA repair pathway-related genes with radiation pneumonitis (RP). A total of 265 locally advanced esophageal squamous cell carcinoma (ESCC) patients receiving RT in Chinese Han population were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28041813/target-volume-delineation-for-radical-radiotherapy-of-early-oesophageal-carcinoma-in-elderly-patients
#16
J Su, S Zhu, Z Liu, Y Zhao, C Song
PURPOSE: To compare the prognosis of elderly patients with early oesophageal carcinoma between radical elective nodal prophylactic irradiation and involved-field irradiation and to estimate the failure modes and adverse effects, then to provide the patients the safe and individual therapeutic regimens. MATERIAL AND METHODS: The charts of 96 patients aged 65 and over with early stage oesophageal carcinoma receiving radical radiotherapy in our department were retrospectively analysed...
December 29, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28034064/impact-of-intensity-modulated-radiation-therapy-technique-for-locally-advanced-non-small-cell-lung-cancer-a-secondary-analysis-of-the-nrg-oncology-rtog-0617-randomized-clinical-trial
#17
Stephen G Chun, Chen Hu, Hak Choy, Ritsuko U Komaki, Robert D Timmerman, Steven E Schild, Jeffrey A Bogart, Michael C Dobelbower, Walter Bosch, James M Galvin, Vivek S Kavadi, Samir Narayan, Puneeth Iyengar, Clifford G Robinson, Raymond B Wynn, Adam Raben, Mark E Augspurger, Robert M MacRae, Rebecca Paulus, Jeffrey D Bradley
Purpose Although intensity-modulated radiation therapy (IMRT) is increasingly used to treat locally advanced non-small-cell lung cancer (NSCLC), IMRT and three-dimensional conformal external beam radiation therapy (3D-CRT) have not been compared prospectively. This study compares 3D-CRT and IMRT outcomes for locally advanced NSCLC in a large prospective clinical trial. Patients and Methods A secondary analysis was performed to compare IMRT with 3D-CRT in NRG Oncology clinical trial RTOG 0617, in which patients received concurrent chemotherapy of carboplatin and paclitaxel with or without cetuximab, and 60- versus 74-Gy radiation doses...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28018357/the-role-of-lymphocytes-in-radiotherapy-induced-adverse-late-effects-in-the-lung
#18
REVIEW
Florian Wirsdörfer, Verena Jendrossek
Radiation-induced pneumonitis and fibrosis are dose-limiting side effects of thoracic irradiation. Thoracic irradiation triggers acute and chronic environmental lung changes that are shaped by the damage response of resident cells, by the resulting reaction of the immune system, and by repair processes. Although considerable progress has been made during the last decade in defining involved effector cells and soluble mediators, the network of pathophysiological events and the cellular cross talk linking acute tissue damage to chronic inflammation and fibrosis still require further definition...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28011047/multi-institutional-experience-of-stereotactic-ablative-radiation-therapy-for-stage-i-small-cell-lung-cancer
#19
Vivek Verma, Charles B Simone, Pamela K Allen, Sameer R Gajjar, Chirag Shah, Weining Zhen, Matthew M Harkenrider, Christopher L Hallemeier, Salma K Jabbour, Chance L Matthiesen, Steve E Braunstein, Percy Lee, Thomas J Dilling, Bryan G Allen, Elizabeth M Nichols, Albert Attia, Jing Zeng, Tithi Biswas, Peter Paximadis, Fen Wang, Joshua M Walker, John M Stahl, Megan E Daly, Roy H Decker, Russell K Hales, Henning Willers, Gregory M M Videtic, Minesh P Mehta, Steven H Lin
PURPOSE: For inoperable stage I (T1-T2N0) small cell lung cancer (SCLC), national guidelines recommend chemotherapy with or without conventionally fractionated radiation therapy. The present multi-institutional cohort study investigated the role of stereotactic ablative radiation therapy (SABR) for this population. METHODS AND MATERIALS: The clinical and treatment characteristics, toxicities, outcomes, and patterns of failure were assessed in patients with histologically confirmed stage T1-T2N0M0 SCLC...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28005209/the-effect-of-consolidation-chemotherapy-after-concurrent-chemoradiotherapy-on-the-survival-of-patients-with-locally-advanced-non-small-cell-lung-cancer-a-meta-analysis
#20
REVIEW
Xinshuai Wang, Xuezhen Ding, Dejiu Kong, Li Zhang, Yibo Guo, Jing Ren, Xiaochen Hu, Junqiang Yang, Shegan Gao
Whether consolidation chemotherapy (CCT) after chemoradiotherapy (CRT) helps in the treatment of locally advanced non-small cell lung cancer (LA-NSCLC) is controversial. The aim of this meta-analysis was to evaluate the impact of CCT on overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities in patients with inoperable LA-NSCLC. PubMed, Embase, The Cochrane Library, WanFang, VIP, and CNKI were searched to identify any relevant publications. After screening the literature and completing quality assessment and data extraction, the meta-analysis was performed using RevMan5...
December 22, 2016: International Journal of Clinical Oncology
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