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Radiation Pneumonitis

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https://www.readbyqxmd.com/read/27906856/radiation-exposure-and-lung-disease-in-today-s-nuclear-world
#1
Steven D Deas, Nikhil Huprikar, Andrew Skabelund
PURPOSE OF REVIEW: Ionizing radiation poses important health risks. The per capita annual dose rate has increased in the United States and there is increasing concern for the risks posed by low-dose occupational exposure among workers in nuclear industries and healthcare. Recent nuclear accidents and concern for terrorism have heightened concern for catastrophic, high-dose ionizing radiation exposure. This review will highlight recent research into the risks to lung health posed by ionizing radiation exposure and into potential treatments...
November 30, 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27890462/radiation-pneumonitis-following-hepatic-yttrium-90-radioembolization
#2
Horacio Matías Castro, Esteban Javier Wainstein, Joaquin Maritano Furcada
No abstract text is available yet for this article.
November 24, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27846903/prontox-proton-therapy-to-reduce-acute-normal-tissue-toxicity-in-locally-advanced-non-small-cell-lung-carcinomas-nsclc-study-protocol-for-a-randomised-controlled-trial
#3
Sebastian Zschaeck, Monique Simon, Steffen Löck, Esther G C Troost, Kristin Stützer, Patrick Wohlfahrt, Steffen Appold, Sebastian Makocki, Rebecca Bütof, Christian Richter, Michael Baumann, Mechthild Krause
BACKGROUND: Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation pneumonitis limit patients' quality of life, and the latter can be potentially life-threatening. Due to its distinct physical characteristics, proton therapy enables better sparing of normal tissues, which is supposed to translate into a reduction of radiation-induced side effects...
November 15, 2016: Trials
https://www.readbyqxmd.com/read/27845360/pathophysiological-mechanisms-underlying-phenotypic-differences-in-pulmonary-radioresponse
#4
Isabel L Jackson, Yuji Zhang, Søren M Bentzen, Jingping Hu, Angel Zhang, Zeljko Vujaskovic
Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fibrosis to compare and contrast differential gene expression in lungs 24 hours after exposure to a single dose of whole thorax lung irradiation sufficient to cause minor to major morbidity/mortality...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819875/clinical-outcomes-after-lung-stereotactic-body-radiation-therapy-in-patients-with-or-without-a-prior-lung-resection
#5
Ying Hou, Gretchen Hermann, John H Lewis, Hugo J Aerts, Elizabeth H Baldini, Aileen B Chen, Yolonda L Colson, Fred L Hacker, Joseph H Killoran, David E Kozono, Matthew Wagar, Jon O Wee, Raymond H Mak
OBJECTIVES: Tumor control (TC), toxicity and survival, following stereotactic body radiation therapy (SBRT) were compared between patients with and without a prior lung resection (PLR). MATERIALS AND METHODS: The study is comprised of 130 patients with 141 peripheral tumors treated with SBRT at our institution from 2009 to 2013. Primary TC and lobar control (LC) were defined per RTOG 0236. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4...
November 4, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27805837/dosimetric-factors-predicting-radiation-pneumonitis-after-cyberknife-stereotactic-body-radiotherapy-for-peripheral-lung-cancer
#6
Masaki Nakamura, Hideki Nishimura, Masao Nakayama, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryohei Sasaki
OBJECTIVE: The aims of this study were to investigate the frequency of symptomatic radiation pneumonitis (RP) after CyberKnife lung stereotactic body radiotherapy (SBRT) and to evaluate predictive factors of symptomatic RP. METHODS: 56 patients with peripheral non-small-cell lung cancer were treated using the CyberKnife(®) VSI(™) System (Accuracy Inc., Sunnyvale, CA) between May 2013 and September 2015. Total radiation doses ranged from 48 to 56 Gy, as delivered in four equal fractions...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27798931/radiation-pneumonitis-changes-over-time-after-stereotactic-body-radiation-therapy-for-lung-tumors-post-treatment-cavity-sunny-side-up-egg-like-changes
#7
Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Tsutomu Sato, Jiro Kawamori, Yoshiaki Tanaka
BACKGROUND: Stereotactic body radiation therapy (SBRT) is a viable treatment option for stage I non-small cell lung carcinoma (NSCLC) in non-surgical candidates. Although treatment with a 100 Gy biological effective dose is considered to carry a low risk of local recurrence, only a few reports have focused on changes in tumors or surrounding intact portions of the lung after SBRT. Such changes are assessed using diagnostic imaging specifically for radiation pneumonitis, which can be difficult to distinguish from local tumor recurrence...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27787567/patient-s-quality-of-life-after-high-dose-radiation-therapy-for-thoracic-carcinomas-changes-over-time-and-influence-on-clinical-outcome
#8
Christina Schröder, Rita Engenhart-Cabillic, Hilke Vorwerk, Michael Schmidt, Winfried Huhnt, Eyck Blank, Dietrich Sidow, André Buchali
PURPOSE: Quality of life (QoL) is an important factor in patient care. This analysis is focused on QoL before and after radio(chemo)therapy in patients with thoracic carcinomas, as well as on its influence on clinical follow-up and survival, and the correlation with treatment-related toxicities. MATERIALS AND METHODS: The analysis included 81 patients with intrathoracic carcinoma receiving radio(chemo)therapy. For analysis of QoL, the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the lung cancer-specific supplement (EORTC QLQ-LC13) were used...
October 27, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27742539/does-bleomycin-lung-toxicity-increase-the-risk-of-radiation-pneumonitis-in-hodgkin-lymphoma
#9
Zeinab Abou Yehia, George N Mikhaeel, Grace Smith, Chelsea C Pinnix, Sarah A Milgrom, Chad Tang, Wen Jiang, Michelle A Fanale, Yasuhiro Oki, JoAnn H Shank, Trisha Horace, Jay Reddy, Mani Akhtari, Jillian R Gunther, Tina Suki, Pamela K Allen, Shryll Turner, Osama Mawlawi, Bouthaina S Dabaja
PURPOSE: Bleomycin pulmonary toxicity (BPT) is a well-known complication of treatment in patients with Hodgkin lymphoma (HL). We undertook the present study to investigate the risk of radiation pneumonitis (RP) in the setting of BPT and to determine the need for delay or omission of radiation therapy (RT) in these patients. METHODS AND MATERIALS: We identified 123 HL patients treated with ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) followed by RT to the chest from January 2009 to December 2014...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27741355/multi-institutional-experience-of-stereotactic-body-radiotherapy-for-large-%C3%A2-5-centimeters-non-small-cell-lung-tumors
#10
Vivek Verma, Valerie K Shostrom, Sameera S Kumar, Weining Zhen, Christopher L Hallemeier, Steve E Braunstein, John Holland, Matthew M Harkenrider, Adrian S Iskhanian, Hanmanth J Neboori, Salma K Jabbour, Albert Attia, Percy Lee, Fiori Alite, Joshua M Walker, John M Stahl, Kyle Wang, Brian S Bingham, Christina Hadzitheodorou, Roy H Decker, Ronald C McGarry, Charles B Simone
BACKGROUND: Stereotactic body radiotherapy (SBRT) is the standard of care for patients with nonoperative, early-stage non-small cell lung cancer (NSCLC) measuring < 5 cm, but its use among patients with tumors measuring ≥5 cm is considerably less defined, with the existing literature limited to small, single-institution reports. The current multi-institutional study reported outcomes evaluating the largest such population reported to date. METHODS: Clinical/treatment characteristics, outcomes, toxicities, and patterns of failure were assessed in patients with primary NSCLC measuring ≥5 cm without evidence of distant/lymph node metastasis who underwent SBRT using ≤5 fractions...
October 14, 2016: Cancer
https://www.readbyqxmd.com/read/27721877/radiation-pneumonitis-in-association-with-internal-mammary-node-irradiation-in-breast-cancer-patients-an-ancillary-result-from-the-krog-08-06-study
#11
Jinhyun Choi, Yong Bae Kim, Kyung Hwan Shin, Sung-Ja Ahn, Hyung-Sik Lee, Won Park, Su Ssan Kim, Jin Hee Kim, Kyu Chan Lee, Dong Won Kim, Hyun Suk Suh, Kyung Ran Park, Hyun Soo Shin, Chang-Ok Suh
PURPOSE: The aim of this study is to present the incidence of radiation pneumonitis (RP) reported within 6 months after treatment for breast cancer with or without internal mammary node irradiation (IMNI). METHODS: In the Korean Radiation Oncology Group (KROG) 08-06 phase III randomized trial, patients who were node-positive after surgery were randomly assigned to receive radiotherapy either with or without IMNI. A total of 747 patients were enrolled, and three-dimensional treatment planning with computed tomography simulation was performed for all patients...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27717315/a-phase-i-study-of-nedaplatin-pemetrexed-and-thoracic-intensity-modulated-radiotherapy-for-inoperable-stage-iii-lung-adenocarcinoma
#12
Yiyu Lu, Weiguang Gu, Jin Deng, Hua Yang, Wen Yang
BACKGROUND: Concurrent chemotherapy and radiation is the standard treatment for unresectable stage III Lung adenocarcinoma. However, no optimal concurrent chemotherapeutic regimen has been described. This study aimed to assess concurrent pemetrexed, nedaplatin and thoracic intensity-modulated radiotherapy followed by consolidation pemetrexed/nedaplatin for unresectable Stage IIIA/B lung adenocarcinoma. METHODS: Patients with unresectable stage III lung adenocarcinoma received thoracic intensity-modulated radiotherapy at 60-64 Gy in 30-32 fractions, concurrently with two cycles of 500 mg/m(2) pemetrexed, with nedaplatin doses escalating from 60 mg/m(2) (level 1) to 70 mg/m(2) (level 2) and 80 mg/m(2) (level 3)...
October 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27709077/correlation-between-pneumonitis-risk-in-radiation-oncology-and-lung-density-measured-with-x-ray-computed-tomography
#13
Abdulhamid Chaikh, Jacques Balosso
BACKGROUND: The risk of toxicity with radiation oncology for lung cancer limits the maximal radiation dose that can be delivered to thoracic tumors. This study aims at investigating the correlation between normal tissue complication probability (NTCP) and physical lung density by analyzing the computed tomography (CT) scan imaging used for radiotherapy dose planning. METHODS: Data from CT of lung cancer patients (n=10), treated with three dimensional radiotherapy, were selected for this study...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27675983/the-expression-of-cxcl16-during-lung-irradiation-may-lead-to-radiation-pneumonitis-and-fibrosis-through-inducing-neutrophil-and-macrophage-infiltration-in-lung-tissue
#14
Y H Chen, C H Chou, C T Shun, M F Wei, S H Kuo
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675707/dosimetric-predictors-of-radiation-pneumonitis-after-hemithoracic-pleural-intensity-modulated-radiation-treatment
#15
E D Yorke, A Ojo, L Kuo, A Jackson, A J Wu, M Yan, A Rimner
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675603/risk-factor-study-of-radiation-pneumonitis-focused-on-subclinical-interstitial-lung-disease-in-definitive-radiation-therapy-for-non-small-cell-lung-cancer-a-single-institution-experience
#16
Y Li, S Liang, Z Zhou, Y Cai, Y Chen, F Li
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675601/risk-factors-associated-with-fatal-radiation-pneumonitis-after-concurrent-chemoradiation-therapy-for-non-small-cell-lung-cancer
#17
K Tsujino, H Kubota, H Kawaguchi, Y Matsumoto, Y Ota, T Soejima
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675575/combined-ventilation-and-perfusion-imaging-correlates-with-the-dosimetric-parameters-of-radiation-pneumonitis-in-radiation-therapy-planning-for-lung-cancer
#18
T Kimura, T Nakashima, A Saito, Y Takeuchi, I Takahashi, I Nishibuchi, Y Murakami, T Nishio, Y Nagata
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675370/influence-of-respiratory-motion-management-technique-on-radiation-pneumonitis-risk-in-lung-stereotactic-body-radiation-therapy
#19
C H Chapman, C McGuinness, A R Gottschalk, S S Yom, A A Garsa, S Braunstein, A Sudhyadhom, P Keall, M Descovich
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675171/radiation-pneumonitis-dose-response-after-photon-or-proton-radiation-therapy-assessed-by-18-f-fdg-uptake
#20
N Shusharina, Z Liao, R Mohan, N C Choi, T Bortfeld
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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