keyword
MENU ▼
Read by QxMD icon Read
search

Radiation Pneumonitis

keyword
https://www.readbyqxmd.com/read/29050127/-immune-related-pneumonitis-caused-by-programmed-death-1-inhibitor-pembrolizumab-a-case-report-and-literature-review
#1
Y L Chen, J Zhao, R Jia, H Y Wang, J Zheng, C Q Bai, M Z Wang, J M Xu
Objective: To investigate the risk factors, clinical manifestations, radiological features, diagnosis, treatment and prognosis of immune-related pneumonitis caused by programmed death-1(PD-1)/PD-L1 inhibitors. Methods: The clinical data of immune-related pneumonitis caused by PD-1 inhibitor Pembrolizumab in a patient with advanced esophageal carcinoma admitted to the 307(th) Hospital of Chinese People's Liberation Army was retrospectively analyzed and the related literatures were reviewed. We searched Medline database using the keywords"PD-1 inhibitor","PD-L1 inhibitor","Pembrolizumab","Nivolumab","Atezolizumab"combined with"Pneumonitis"by Mar 31, 2017...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29034482/deep-reinforcement-learning-for-automated-radiation-adaptation-in-lung-cancer
#2
Huan-Hsin Tseng, Yi Luo, Sunan Cui, Jen-Tzung Chien, Randall K Ten Haken, Issam El Naqa
PURPOSE: To investigate deep reinforcement learning (DRL) based on historical treatment plans for developing automated radiation adaptation protocols for non-small cell lung cancer (NSCLC) patients that aim to maximize tumor local control at reduced rates of radiation pneumonitis grade 2 (RP2). METHODS: In a retrospective population of 114 NSCLC patients who received radiotherapy, a 3-component neural networks framework was developed for deep reinforcement learning (DRL) of dose fractionation adaptation...
October 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/29017827/subjective-global-assessment-sga-score-could-be-a-predictive-factor-for-radiation-pneumonitis-in-lung-cancer-patients-with-normal-pulmonary-function-treated-by-intensity-modulated-radiation-therapy-and-concurrent-chemotherapy
#3
Li Ma, WenFeng Ye, QiWen Li, Bin Wang, GuangYu Luo, ZhaoLin Chen, SuPing Guo, Bo Qiu, Hui Liu
INTRODUCTION: To investigate the relationship between malnutrition and the severity of radiation pneumonitis (RP) in patients with lung cancer with normal baseline pulmonary function and lungs' V20 < 35% treated by intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy. MATERIALS AND METHODS: A total of 150 patients with lung cancer who received definitive IMRT (≥ 60 Gy) and concurrent chemotherapy were enrolled. In the condition of normal baseline pulmonary function and strict constraints of the irradiation dose to normal lung tissues, we recorded Eastern Cooperative Oncology Group score; concurrent chemotherapy; clinical stage; the level of albumin (ALB), hemoglobin, and C-reactive protein; Subjective Global Assessment (SGA) scores; radiation esophagitis grade; V20 of lungs; and mean lung dose...
September 19, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28981731/efficacy-and-safety-of-stereotactic-body-radiotherapy-using-cyberknife-in-stage-i-primary-lung-tumor
#4
Nobuyasu Awano, Soichiro Ikushima, Takehiro Izumo, Mari Tone, Kensuke Fukuda, Shingo Miyamoto, Yuan Bae, Toshio Kumasaka, Yuriko Terada, Yoshiaki Furuhata, Ryutaro Nomura, Kengo Sato
Background: CyberKnife® (CK) is a new, advanced radiotherapy technique. This study aimed to evaluate its efficacy and toxicity in Japanese patients with early-stage primary lung tumor who were medically unfit and inoperable. Methods: This retrospective study investigated patients who received CK treatment for medically inoperable Stage І primary lung tumor at the Japanese Red Cross Medical Center between June 2011 and September 2016. Each patient received a total of 36-48 Gy (median, 43 Gy) administered by CK in 4-5 fractions...
October 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28969651/exclusion-of-emphysematous-lung-from-dose-volume-estimates-of-risk-improves-prediction-of-radiation-pneumonitis
#5
Yasuki Uchida, Takuya Tsugawa, Sachiko Tanaka-Mizuno, Kazuo Noma, Ken Aoki, Wataru Shigemori, Hiroaki Nakagawa, Daisuke Kinose, Masafumi Yamaguchi, Makoto Osawa, Emiko Ogawa, Yasutaka Nakano
BACKGROUND: The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of RP, but the most accurate dosimetric parameter has not been established. We hypothesized that the total lung volume irradiated without emphysema would influence the onset of RP. METHODS: We retrospectively evaluated 100 patients who received radiotherapy for lung cancer...
October 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28963717/bio-300-a-nanosuspension-of-genistein-mitigates-pneumonitis-fibrosis-following-high-dose-radiation-exposure-in-the-c57l-j-murine-model
#6
Isabel L Jackson, Andrew Zodda, Ganga Gurung, Radmila Pavlovic, Michael D Kaytor, Michael A Kuskowski, Zeljko Vujaskovic
BACKGROUND AND PURPOSE: BIO 300 nanosuspension (Humanetics Corporation) is being developed as a medical countermeasure (MCM) for the mitigation of the delayed effects of acute radiation exposure (DEARE), specifically pneumonitis and fibrosis of the lung. The objective of this study was to determine the best dose and treatment duration of BIO 300 to mitigate lung injury and improve the likelihood for survival in C57L/J mice exposed to whole thorax lung irradiation (WTLI). EXPERIMENTAL APPROACH: Age and sex-matched C57L/J mice received a single dose of 11...
September 30, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28957436/is-serum-level-of-cc-chemokine-ligand-18-a-biomarker-for-the-prediction-of-radiation-induced-lung-toxicity-rilt
#7
Eleni Gkika, Werner Vach, Sonja Adebahr, Tanja Schimeck-Jasch, Anton Brenner, Thomas Baptist Brunner, Klaus Kaier, Antje Prasse, Joachim Müller-Quernheim, Anca-Ligia Grosu, Gernot Zissel, Ursula Nestle
The CC chemokine ligand 18 (CCL18) is produced by alveolar macrophages in patients with fibrosing lung disease and its concentration is increased in various fibrotic lung diseases. Furthermore CCL18 is elevated in several malignancies as it is produced by tumor associated macrophages. In this study we aimed to analyze the role of CCL18 as a prognostic biomarker for the development of early radiation induced lung toxicity (RILT), i.e. radiation pneumonitis after thoracic irradiation and its significance in the course of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28943927/measurement-of-exhaled-nitric-oxide-and-serum-surfactant-protein-d-levels-for-monitoring-radiation-pneumonitis-following-thoracic-radiotherapy
#8
Hideya Yamazaki, Norihiro Aibe, Satoaki Nakamura, Naomi Sasaki, Gen Suzuki, Ken Yoshida, Kei Yamada, Masahiko Koizumi, Taichiro Arimoto, Yoshinobu Iwasaki, Yoshiko Kaneko, Koichi Takayama
The present study aimed to examine the role of exhaled nitric oxide (eNO) and serum surfactant protein D (SP-D) level in the determination of radiation pneumonitis (RP) after thoracic radiotherapy (RT). The study included 34 treatments for 33 patients, including 16 three-dimensional conformal and 18 stereotactic body RT treatments. eNO levels were measured prior to RT, immediately subsequent to RT, every week during the RT course and at 1, 3, 6, 9 and 12 months following the treatment. The therapy reduced the eNO from 24...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28941961/survival-impact-of-cardiac-dose-following-lung-stereotactic-body-radiotherapy
#9
Olive Y Wong, Vivian Yau, Julie Kang, Daniel Glick, Patricia Lindsay, Lisa W Le, Alexander Sun, Andrea Bezjak, B C John Cho, Andrew Hope, Meredith Giuliani
INTRODUCTION: The purpose of this study was to determine the impact of radiation dose to substructures of the heart in lung stereotactic body radiotherapy (SBRT) patients on non-cancer-related deaths. METHODS: Patients treated with lung SBRT at a single institution from 2005 to 2013 were included. The heart and its substructures were contoured, and dose was calculated including mean, max, and max 10 cc dose. Clinical variables including stage, histology, age, gender, Charlson comorbidity index (CCI), preexisting cardiac disease, pulmonary function (forced expiratory volume in 1 second, diffusion capacity), and smoking status were explored for association with non-cancer-related deaths in univariable (UVA) and multivariable (MVA) analyses...
August 31, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28931214/baicalin-alleviates-radiation-induced-epithelial-mesenchymal-transition-of-primary-type-ii-alveolar-epithelial-cells-via-tgf-%C3%AE-and-erk-gsk3%C3%AE-signaling-pathways
#10
Jinhua Lu, Yazhen Zhong, Zechen Lin, Xianlei Lin, Zhaohui Chen, Xuping Wu, Nan Wang, Haiqiao Zhang, Siyu Huang, Yuan Zhu, Yuanyuan Wang, Shengyou Lin
BACKGROUND: Radiation therapy is commonly used to treat thoracic malignancies. However, it may lead to severe lung pneumonitis and ultimately fibrosis. Irradiation has been reported to increase epithelial-mesenchymal transition (EMT) of type II alveolar epithelial cells (AEC), which play an important role in pulmonary fibrosis. The transforming growth factor-β (TGF-β) and ERK/glycogen synthase kinase 3β (GSK3β) pathways are critically involved in radiation-induced EMT. In the present study, we investigated whether baicalin was a novel therapeutic candidate for radiation-induced EMT in type II AEC...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28919004/stereotactic-body-radiotherapy-for-lung-cancer-patients-with-idiopathic-interstitial-pneumonias
#11
Yuichiro Tsurugai, Atsuya Takeda, Naoko Sanuki, Tatsuji Enomoto, Takeshi Kaneko, Yu Hara, Tomikazu Mizuno, Noriyuki Saeki, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Etsuo Kunieda
PURPOSE: To compare toxicity and survival after stereotactic body radiotherapy (SBRT) between lung cancer patients with or without idiopathic interstitial pneumonias (IIPs), and to investigate the potential value of SBRT for the patients. METHODS: Among lung cancer patients receiving SBRT between 2005 and 2016, we evaluated those treated with a total dose of 40-60Gy in five fractions with curative intent who either were staged as cT1-4N0M0 or experienced postoperative isolated local recurrence...
September 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28912510/the-th1-th17-balance-dictates-the-fibrosis-response-in-murine-radiation-induced-lung-disease
#12
Alexandra Paun, Marie-Eve Bergeron, Christina K Haston
Radiotherapy can result in lung diseases pneumonitis or fibrosis dependent on patient susceptibility. Herein we used inbred and genetically altered mice to investigate whether the tissue adaptive immune response to radiation injury influences the development of radiation-induced lung disease. Six inbred mouse strains were exposed to 18 Gy whole thorax irradiation and upon respiratory distress strains prone to pneumonitis with fibrosis presented an increased pulmonary frequency of Thelper (Th)17 cells which was not evident in strains prone solely to pneumonitis...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893300/stereotactic-body-radiotherapy-for-stage-i-non-small-cell-lung-cancer-using-higher-doses-for-larger-tumors-results-of-the-second-study
#13
Akifumi Miyakawa, Yuta Shibamoto, Fumiya Baba, Yoshihiko Manabe, Taro Murai, Chikao Sugie, Takeshi Yanagi, Taiki Takaoka
BACKGROUND: Efficacy of stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer (NSCLC) has almost been established. In Japan, the protocol of 48 Gy in 4 fractions over 4 days has been most often employed, but higher doses may be necessary to control large tumors. Previously, we conducted a clinical study using SBRT for stage I NSCLC employing different doses depending on tumor diameter, which was closed in 2008. Thereafter, a new study employing higher doses has been conducted, which is reported here...
September 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28886981/-lung-dose-constraints-for-normo-fractionated-radiotherapy-and-for-stereotactic-body-radiation-therapy
#14
REVIEW
E Blais, B Pichon, A Mampuya, M Antoine, P Lagarde, G Kantor, C Breton-Callu, C Lefebvre, M Gerard, A Aamarcha, M Ozsahin, J Bourhis, P Maingon, I Troussier, N Pourel
Radiation-induced lung disease (RILD) is common after radiation therapy and represents cornerstone toxicities after treatment of thoracic malignancies. From a review of literature, the objective of this article was to summarize clinical and non-clinical parameters associated with the risk of RILD in the settings of normo-fractionated radiotherapy and stereotactic body radiation therapy (SBRT). For the treatment of lung cancers with a normo-fractionated treatment, the mean lung dose (MLD) should be below 15-20Gy...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28885561/acute-and-late-toxicities-of-concurrent-chemoradiotherapy-for-locally-advanced-non-small-cell-lung-cancer
#15
REVIEW
Vivek Verma, Charles B Simone, Maria Werner-Wasik
For patients with unresectable locally-advanced non-small cell lung cancer (LA-NSCLC), concurrent chemoradiotherapy improves overall survival as compared to sequential chemotherapy and radiation therapy, but is associated with higher rates of toxicities. Acute, clinically significant esophagitis or pneumonitis can occur in one in five patients. The risks of esophagitis and pneumonitis can impact the decision to deliver concurrent therapy and limit the total dose of radiation therapy that is delivered. Hematologic toxicities and emesis are common toxicities from systemic therapies for LA-NSCLC and can result in delaying chemotherapy dosing or chemotherapy dose reductions...
September 8, 2017: Cancers
https://www.readbyqxmd.com/read/28877030/radiation-mitigating-properties-of-intranasally-administered-kl4-surfactant-in-a-murine-model-of-radiation-induced-lung-damage
#16
Melpo Christofidou-Solomidou, Ralph A Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, Robert Segal
The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced lung disease can manifest with an acute radiation pneumonitis and/or delayed effects leading to pulmonary fibrosis. As prior warning of radiation exposure is unlikely, medical countermeasures (MCMs) to mitigate radiation-induced lung disease that can be given in mass-casualty situations many hours or days postirradiation are needed to prevent both early and late lung damage...
September 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28871994/inclusion-of-incidental-radiation-dose-to-the-cardiac-atria-and-ventricles-does-not-improve-the-prediction-of-radiation-pneumonitis-in-advanced-stage-non-small-cell-lung-cancer-patients-treated-with-intensity-modulated-radiation-therapy
#17
Robin Wijsman, Frank J W M Dankers, Esther G C Troost, Aswin L Hoffmann, Erik H F M van der Heijden, Lioe-Fee de Geus-Oei, Johan Bussink
PURPOSE: To evaluate whether inclusion of incidental radiation dose to the cardiac atria and ventricles improves the prediction of grade ≥3 radiation pneumonitis (RP) in advanced-stage non-small cell lung cancer (AS-NSCLC) patients treated with intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT). METHODS AND MATERIALS: Using a bootstrap modeling approach, clinical parameters and dose-volume histogram (DVH) parameters of lungs and heart (assessing atria and ventricles separately and combined) were evaluated for RP prediction in 188 AS-NSCLC patients...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871982/evaluating-the-toxicity-reduction-with-computed-tomographic-ventilation-functional-avoidance-radiation-therapy
#18
Austin M Faught, Yuya Miyasaka, Noriyuki Kadoya, Richard Castillo, Edward Castillo, Yevgeniy Vinogradskiy, Tokihiro Yamamoto
PURPOSE: Computed tomographic (CT) ventilation imaging is a new modality that uses 4-dimensional (4D) CT information to calculate lung ventilation. Although retrospective studies have reported on the reduction in dose to functional lung, no work to our knowledge has been published in which the dosimetric improvements have been translated to a reduction in the probability of pulmonary toxicity. Our work estimates the reduction in toxicity for CT ventilation-based functional avoidance planning...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871103/lipidomic-dysregulation-within-the-lung-parenchyma-following-whole-thorax-lung-irradiation-markers-of-injury-inflammation-and-fibrosis-detected-by-maldi-msi
#19
Claire L Carter, Jace W Jones, Ann M Farese, Thomas J MacVittie, Maureen A Kane
Radiation-induced lung injury (RILI) is a delayed effect of acute radiation exposure that can limit curative cancer treatment therapies and cause lethality following high-dose whole-thorax lung irradiation (WTLI). To date, the exact mechanisms of injury development following insult remain ill-defined and there are no FDA approved pharmaceutical agents or medical countermeasures. Traditionally, RILI development is considered as three phases, the clinically latent period, the intermediate acute pneumonitis phase and the later fibrotic stage...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870955/correlation-of-radiation-pneumonitis-history-before-nivolumab-with-onset-of-interstitial-lung-disease-and-progression-free-survival-of-patients-with-pre-treated-advanced-non-small-cell-lung-cancer
#20
Akihiro Tamiya, Motohiro Tamiya, Kenji Nakahama, Yoshihiko Taniguchi, Takayuki Shiroyama, Shun-Ichi Isa, Takako Inoue, Kyoichi Okishio, Kazumi Nishino, Toru Kumagai, Hidekazu Suzuki, Tomonori Hirashima, Fumio Imamura, Shinji Atagi
BACKGROUND/AIM: Nivolumab has a promising efficacy for patients with non-small-cell lung cancer (NSCLC) as second-line or later treatment, and after radiotherapy as abscopal effect. However, the effects of radiation pneumonitis history before nivolumab have not been clarified. Therefore, we retrospectively analyzed the correlation of a history of radiation pneumonitis before nivolumab with onset of interstitial lung disease (ILD) and progression-free survival (PFS) after nivolumab treatment in patients with previously treated NSCLC...
September 2017: Anticancer Research
keyword
keyword
11286
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"