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Radiation Pneumonitis

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https://www.readbyqxmd.com/read/29228994/survival-and-prognostic-factors-of-non-small-cell-lung-cancer-patients-with-postoperative-locoregional-recurrence-treated-with-radical-radiotherapy
#1
Li Ma, Bo Qiu, Jun Zhang, Qi-Wen Li, Bin Wang, Xu-Hui Zhang, Meng-Yun Qiang, Zhao-Lin Chen, Su-Ping Guo, Hui Liu
BACKGROUND: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical radiotherapy. METHODS: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2012 and February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China)...
December 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29223018/targeting-oxidant-dependent-mechanisms-for-the-treatment-of-respiratory-diseases-and-their-comorbidities
#2
REVIEW
Neil C Thomson
Oxidative stress is implicated in the pathogenesis of respiratory diseases, such as COPD and its comorbidities, asthma, idiopathic pulmonary fibrosis and radiation pneumonitis. Antioxidants drugs, such as small molecule thiols, nuclear erythroid-2 related factor 2 activators and catalytic enzyme mimetics have been developed to target oxidant-dependent mechanisms. The therapeutic effects of antioxidants have been generally disappointing. A small number of antioxidants are approved for clinical use, such as the small molecule thiol N-acetyl-l-cysteine for chronic obstructive pulmonary disease, and in the United States, the superoxide dismutase mimetic AEOL 10150 for severe radiation pneumonitis...
December 6, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29203289/time-and-dose-related-changes-in-lung-perfusion-after-definitive-radiotherapy-for-nsclc
#3
Katherina P Farr, Azza A Khalil, Ditte S Møller, Henrik Bluhme, Stine Kramer, Anni Morsing, Cai Grau
BACKGROUND AND PURPOSE: To examine radiation-induced changes in regional lung perfusion per dose level in 58 non-small-cell lung cancer (NSCLC) patients treated with intensity-modulated radiotherapy (IMRT). MATERIAL AND METHODS: NSCLC patients receiving chemo-radiotherapy (RT) of minimum 60 Gy were included prospectively in the study. Lung perfusion single-photon emission computed tomography (SPECT/CT) was performed before and serially after RT. Changes (relative to baseline, %) in regional lung perfusion were correlated with regional dose...
December 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29197373/health-related-quality-of-life-in-long-term-survivors-of-unresectable-locally-advanced-non-small-cell-lung-cancer
#4
Juntao Ran, Jingbo Wang, Nan Bi, Wei Jiang, Zongmei Zhou, Zhouguang Hui, Jun Liang, Qinfu Feng, Luhua Wang
BACKGROUND: Heath-related quality of life (HRQoL) among survivors with unresectable locally-advanced non-small cell lung cancer (LA-NSCLC) treated with radiotherapy and chemotherapy still is not clear. The current study were performed to determine HRQoL for long-term survivors with unresectable LA-NSCLC and to identify risk factors for poor HRQoL. METHODS: Among patients with LA-NSCLC receiving radiotherapy and chemotherapy between January 2006 and December 2010, 82 long-term survivors beyond 5 years were identified in this cross-sectional study...
December 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29174428/radiation-dose-local-disease-progression-and-overall-survival-in-patients-with-inoperable-non-small-cell-lung-cancer-after-concurrent-chemoradiation-therapy
#5
RongRong Zhou, Ting Xu, Quynh-Nhu Nguyen, Ying Liu, Ju Yang, Ritsuko Komaki, Daniel R Gomez, Zhongxing Liao
PURPOSE: To identify predictors of local control and overall survival (OS) for patients with inoperable non-small cell lung cancer treated with concurrent chemoradiation therapy. METHODS AND MATERIALS: We identified 491 patients with newly diagnosed stage IIIA-IIIB non-small cell lung cancer who had received 60 to 74 Gy (with concurrent chemotherapy) from January 2005 through December 2013 and grouped them by radiation dose received: 60 to 63 Gy, 64 to 66 Gy, 67 to 70 Gy, or 71 to 74 Gy...
October 12, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29159011/proton-therapy-for-malignant-pleural-mesothelioma-a-three-case-series-describing-the-clinical-and-dosimetric-advantages-of-proton-based-therapy
#6
Howard Lee, Jing Zeng, Stephen R Bowen, Ramesh Rengan
Malignant pleural mesothelioma (MPM) is a malignancy of the pleural cavity that typically presents at an advanced stage. Due to its large, circumferential clinical target volume (CTV) and proximity to major structures, including the heart and contralateral lung, delivering hemithoracic intensity-modulated radiotherapy (IMRT) with photon therapy to achieve loco-regional control following macroscopic complete resection is challenging. Intensity-modulated proton therapy (IMPT) has been shown to be a method for achieving higher therapeutic doses while limiting exposure to organs at risk (OARs), but patient outcomes after treatment have yet to be reported...
September 20, 2017: Curēus
https://www.readbyqxmd.com/read/29151967/new-clinical-features-and-dosimetric-predictor-identification-for-symptomatic-radiation-pneumonitis-after-tangential-irradiation-in-breast-cancer-patients
#7
Ge Wen, Yu-Ting Tan, Xiao-Wen Lan, Zhi-Chun He, Jiang-Hua Huang, Jun-Tian Shi, Xiao Lin, Xiao-Bo Huang
Background: Tangential irradiation is the most popular postoperative radiotherapy technique for breast cancer. However, irradiation has been related to symptomatic radiation pneumonitis (SRP), which decreases the quality of life of patients. This study investigated the clinical features and dosimetric parameters related to SRP of the ipsilateral lung to identify risk factors for SRP in breast cancer patients after three-dimensional conformal radiation therapy (3D-CRT) with tangential fields. Material and Methods: A total of 515 breast cancer patients were evaluated and divided into two groups: the local-regional irradiation group (259 patients) and the simple local irradiation group (256 patients)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29136066/unsuspected-lymphomatoid-granulomatosis-in-a-patient-with-antisynthetase-syndrome
#8
Stephanie L Skala, Alexandra C Hristov, Johann E Gudjonsson, May P Chan
Clinical diagnosis of lymphomatoid granulomatosis (LYG) often is difficult, especially in patients with multiple comorbidities. We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. Her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. Computed tomography showed ground-glass opacities and nodular infiltrates in all lung lobes, raising concern for radiation pneumonitis and drug toxicity...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29132803/high-dose-irradiation-after-pleurectomy-decortication-or-biopsy-for-pleural-mesothelioma-treatment
#9
E Parisi, A Romeo, A Sarnelli, G Ghigi, S R Bellia, E Neri, S Micheletti, B Dipalma, D Arpa, G Furini, M A Burgio, G Genestreti, C Gurioli, S Sanna, P Bovolato, F Rea, G Storme, E Scarpi, C Arienti, A Tesei, R Polico
PURPOSE: The role played by radiation therapy after pleurectomy/decortication or surgical biopsy in malignant pleural mesothelioma is uncertain. We treated patients with accelerated hypofractionated radiotherapy using helical tomotherapy and intensity-modulated arc therapy in an attempt to keep lung toxicity to a minimum. The present study reports the feasibility and toxicity of this approach. MATERIAL AND METHODS: Between 2008 and 2012, 36 patients with malignant pleural mesothelioma underwent accelerated hypofractionated radiotherapy to the hemithorax after pleurectomy/decortication (19 patients) or biopsy (17 patients)...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29128934/radiobiological-analysis-of-stereotactic-body-radiation-therapy-for-an-evidence-based-planning-target-volume-of-the-lung-using-multiphase-ct-images-obtained-with-a-pneumatic-abdominal-compression-apparatus-a-case-study
#10
Arun Chairmadurai, Harish Chandra Goel, Sandeep Kumar Jain, Pawan Kumar
This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose-volume parameters...
November 11, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29119941/targeting-of-inflammation-for-radiation-protection-and-mitigation
#11
Rasoul Yahyapour, Peyman Amini, Saeed Rezapoor, Abolhasan Rezaeyan, Bagher Farhood, Mohsen Cheki, Hengameh Fallah, Masoud Najafi
Inflammation is the response of the immune system that guards the body against several harmful stimuli in normal conditions. However, in response to ionizing radiation that leads to a massive cell death and DNA aberrations, this phenomenon causes various side effects in normal tissues. Inflammation is involved in various side effects such as gastrointestinal toxicity, mucositis, skin reactions, nervous system damage, pneumonitis, fibrosis and so on. Observations have proposed that inflammatory mediators are involved in the toxic effect of ionizing radiation on non-irradiated cells via a phenomenon named bystander effect...
November 8, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29118857/analysis-of-predictive-parameters-for-the-development-of-radiation-induced-pneumonitis
#12
Toru Yamagishi, Norio Kodaka, Yoshiyuki Kurose, Kayo Watanabe, Chihiro Nakano, Kumiko Kishimoto, Takeshi Oshio, Kumiko Niitsuma, Hiroto Matsuse
INTRODUCTION: Prevention and effective treatment of radiation-induced pneumonitis (RP) could facilitate greater use of radiation therapy (RT) for lung cancer. The purpose of this study was to determine clinical parameters useful for early prediction of RP. METHODS: Blood sampling, pulmonary function testing, chest computed tomography, and bronchoalveolar lavage (BAL) were performed in patients with pathologically confirmed lung cancer who had completed ≥60 Gy of RT, at baseline, shortly after RT, and at 1 month posttreatment...
October 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29114599/dosimetric-and-clinical-outcomes-after-volumetric-modulated-arc-therapy-for-carcinoma-of-the-thoracic-esophagus
#13
Cai Xu, Mian Xi, Ritsuko Komaki, Peter A Balter, Meilin Huang, Brian P Hobbs, Luhua Wang, Steven H Lin
Purpose: The efficiency of radiation delivery via volumetric modulated arc therapy (VMAT) is indisputable, but outcomes after VMAT for thoracic esophageal carcinoma are largely unknown. Methods and materials: We retrospectively analyzed 65 patients with thoracic esophageal cancer who received VMAT to 50.4 Gy (range, 45-50.4 Gy) with concurrent chemotherapy from November 2012 to March 2016 at a single tertiary cancer center. We then used propensity score matching to match these 65 patients with 130 other patients treated with step-and-shoot intensity modulated radiation therapy (ssIMRT) and concurrent chemotherapy...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114598/long-term-survival-and-toxicity-outcomes-of-intensity-modulated-radiation-therapy-for-the-treatment-of-esophageal-cancer-a-large-single-institutional-cohort-study
#14
Anhui Shi, Zhongxing Liao, Pamela K Allen, Linus Ho, Mariela Blum Murphy, Dipen M Maru, Stephen G Swisher, Wayne L Hofstetter, Reza J Mehran, James D Cox, Ritsuko Komaki, Steven H Lin
Purpose: In patients with esophageal cancer (EC), intensity modulated radiation therapy (IMRT) improves dose sparing to the heart and lung, with some evidence showing clinical benefit. Herein, we report our cumulative clinical experience with the use of IMRT for EC. Methods and materials: This is a retrospective analysis of 587 patients with nonmetastatic EC who were treated consecutively with IMRT from January 2004 to June 30, 2013. All patients with stage I-IVA (American Joint Committee on Cancer 2002) received concurrent chemoradiation therapy either preoperatively or definitively...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113195/advances-in-targeting-the-transforming-growth-factor-%C3%AE-1-signaling-pathway-in-lung-cancer-radiotherapy
#15
Zhonghua Lu, Yiting Tang, Judong Luo, Shuyu Zhang, Xifa Zhou, Lei Fu
Lung cancer was demonstrated to be the most lethal type of malignant tumor amongst humans in the global cancer statistics of 2012. As one of the primary treatments, radiotherapy has been reported to induce remission in, and even cure, patients with lung cancer. However, the side effects of radiotherapy may prove lethal in certain patients. In past decades, the transforming growth factor β1 (TGFB1) signaling pathway has been revealed to serve multiple functions in the control of lung cancer progression and the radiotherapy response...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110732/normal-lung-sparing-tomotherapy-technique-in-stage-iii-lung-cancer
#16
Chae-Seon Hong, Sang Gyu Ju, Yong Chan Ahn, Gyu Sang Yoo, Jae Myoung Noh, Dongryul Oh, Kwangzoo Chung, Hongryull Pyo, Kwanghyun Jo
PURPOSE: Radiation pneumonitis (RP) has been a challenging obstacle in treating stage III lung cancer patients. Beam angle optimization (BAO) technique for Tomotherapy was developed to reduce the normal lung dose for stage III non-small cell lung cancer (NSCLC). Comparative analyses on plan quality by 3 different Intensity-modulated radiation therapy (IMRT) methods with BAO were done. MATERIALS AND METHODS: Ten consecutive stage IIIB NSCLC patients receiving linac-based static IMRT (L-IMRT) with total 66 Gy in 33 fractions to the PTV were selected...
November 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29106573/endobronchial-brachytherapy-with-curative-intent-the-impact-of-reference-points-setting-according-to-the-bronchial-diameter
#17
Yoshihito Nomoto, Noriko Ii, Shuichi Murashima, Yasufumi Yamashita, Satoru Ochiai, Akinori Takada, Yutaka Toyomasu, Tomoko Kawamura, Hajime Sakuma
Endobronchial brachytherapy (EBB) is an effective treatment for endobronchial tumors. However, bronchial toxicity caused by over-irradiation remains problematic. To decrease bronchial toxicity, we developed a source-centralizing applicator for EBB. The purpose of the present study was to assess the efficacy and safety of EBB with varying reference dose points according to the bronchial diameter, using a source-centralizing applicator. We reviewed 15 patients with endobronchial carcinoma who were treated with curative intent using a combination of external beam radiotherapy (EBRT) and high-dose-rate EBB between 2005 and 2014...
July 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29102264/radiation-toxicity-in-patients-with-collagen-vascular-disease-and-intrathoracic-malignancy-treated-with-modern-radiation-techniques
#18
Kevin Diao, Yu-Hui Chen, Paul J Catalano, Stephanie Lee, Nastaran Milani, Joseph H Killoran, Elizabeth H Baldini, Aileen B Chen, David E Kozono, Raymond H Mak
BACKGROUND AND PURPOSE: There is concern that patients with collagen vascular disease (CVD) are at higher risk of developing radiation toxicity. We analyzed radiation toxicities in patients with intrathoracic malignancy and CVD treated using modern radiotherapy. MATERIALS AND METHODS: This single-institution retrospective study included 31 patients with CVD and 825 patients without CVD treated from 1998 to 2014. Radiation esophagitis (RE) and radiation pneumonitis (RP) were scored by RTOG scales...
October 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29096667/temporal-and-spatial-dose-distribution-of-radiation-pneumonitis-after-concurrent-radiochemotherapy-in-stage-iii-non-small-cell-cancer-patients
#19
Mohammed Alharbi, Stefan Janssen, Heiko Golpon, Michael Bremer, Christoph Henkenberens
BACKGROUND AND PURPOSE: Radiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are associated with a distinct risk of symptomatic RP. The aim of this study was to assess the spatial dose distribution of the RP volume from first occurence to maximum volume expansion of RP. MATERIAL AND METHODS: Between 2007 and 2015, 732 patients with lung cancer were treated in an institution...
November 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29089078/-nlrp3-inflammasome-induces-pyroptosis-in-lung-tissues-of-radiation-induced-lung-injury-in-mice
#20
Rong Han, Dongming Wu, Shihua Deng, Teng Liu, Ting Zhang, Ying Xu
Objective To establish a radiation-induced lung injury model and investigate the role of caspase-1-dependent programmed cell death (pyroptosis) in the pathogenesis of radiation pneumonitis. Methods BALB/c mice were sacrificed after receiving 5-day 15 Gy X-ray irradiation at chest cavity. The pathological changes of pulmonary tissues were observed by HE staining. The apoptosis of lung tissues cells after irradiation was detected by TUNEL assay. The expressions of γ-H2AX, ki67, NLR family pyrin domain containing 3 (NLRP3), caspase-1, apoptosis-associated speck-like protein containing a CARD (ASC/TMS-1) were detected by Western blot analysis...
September 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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