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https://www.readbyqxmd.com/read/28807909/development-and-use-of-personalized-bacteriophage-based-therapeutic-cocktails-to-treat-a-patient-with-a-disseminated-resistant-acinetobacter-baumannii-infection
#1
Robert T Schooley, Biswajit Biswas, Jason J Gill, Adriana Hernandez-Morales, Jacob Lancaster, Lauren Lessor, Jeremy J Barr, Sharon L Reed, Forest Rohwer, Sean Benler, Anca M Segall, Randy Taplitz, Davey M Smith, Kim Kerr, Monika Kumaraswamy, Victor Nizet, Leo Lin, Melanie D McCauley, Steffanie A Strathdee, Constance A Benson, Robert K Pope, Brian M Leroux, Andrew C Picel, Alfred J Mateczun, Katherine E Cilwa, James M Regeimbal, Luis A Estrella, David M Wolfe, Matthew S Henry, Javier Quinones, Scott Salka, Kimberly A Bishop-Lilly, Ry Young, Theron Hamilton
Widespread antibiotic use in clinical medicine and the livestock industry has contributed to the global spread of multidrug-resistant (MDR) bacterial pathogens, including Acinetobacter baumannii We report on a method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year old diabetic patient with necrotizing pancreatitis complicated by a MDR A. baumannii infection. Despite multiple antibiotic courses and efforts at percutaneous drainage of a pancreatic pseudocyst, the patient deteriorated over a four-month period...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28799535/hygroscopic-sonographically-detectable-clips-form-characteristic-breast-and-lymph-node-pseudocysts
#2
Moshe Carmon, Sofia Zilber, David Gekhtman, Oded Olsha, Tal Hadar, Eliahu Golomb
The use of hygroscopic sonographically detectable clips (HSDCs) has dramatically increased during the last years, especially in breast cancer patients who undergo neoadjuvant chemotherapy. The aims of this study are to define the appearance of HSDC sites in histopathological specimens, and to enable pathologists to recognize these sites and differentiate them from other lesions. We examined 124 breast cancer specimens in which the application of HSDCs was documented, 88 breast tissues and 36 lymph nodes, and analyzed the appearance of the clip site in these tissues...
August 11, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28796138/predictive-value-of-computed-tomography-scans-and-clinical-findings-for-the-need-of-endoscopic-necrosectomy-in-walled-off-necrosis-from-pancreatitis
#3
Fabian Finkelmeier, Christian Sturm, Mireen Friedrich-Rust, Jörg Bojunga, Christoph Sarrazin, Andrea Tal, Johannes Hausmann, Stefan Zeuzem, Stephan Zangos, Jörg Albert, Harald Farnik
OBJECTIVES: Choosing the best treatment option at the optimal point of time for patients with walled-off necrosis (WON) is crucial. We aimed to identify imaging parameters and clinical findings predicting the need of necrosectomy in patients with WON. METHODS: All patients with endoscopically diagnosed WON and pseudocyst were retrospectively identified. Post hoc analysis of pre-interventional contrast-enhanced computed tomography was performed for factors predicting the need of necrosectomy...
September 2017: Pancreas
https://www.readbyqxmd.com/read/28792798/cholecystopexy-and-pericardial-pseudocyst-removal-in-a-dog-with-a-congenital-peritoneopericardial-diaphragmatic-hernia
#4
Quentin Cabon, Eric Norman Carmel, Julien Cabassu
A 4 mo old spayed female golden retriever was presented with a peritoneopericardial diaphragmatic hernia (PPDH) that was diagnosed during neutering. Echocardiography revealed a fluid-filled structure and parts of the liver in the pericardial cavity. Computed tomography confirmed the existence of the PPDH and the herniation of the right medial liver lobe and the gallbladder. Cystic masses were observed in the pericardial and the peritoneal cavities, possibly communicating through the PPDH. A median laparotomy revealed a single lobulated cystic lesion extending into both the pericardial and peritoneal cavities through the PPDH...
August 9, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28762356/antrochoanal-polyp-arising-from-benign-pseudocyst-of-maxillary-antrum
#5
Neha Keshri, Avi Bansal, Gourav Popli, Arvind Venkatesh, Siddhartha Goel
Antrochoanal polyps (ACPs) are benign lesions that arise from the mucosa of the maxillary antrum, grow into the maxillary sinus, and reach the choana with nasal obstruction being their main symptom. Most of these lesions are small and clinically silent and found as incidental finding, but large cysts which occupy the entire antrum have also been reported in literature. Nasal endoscopy and computer tomography (CT) are the golden standard in the diagnosis of ACPs, and enucleation by Caldwell-Luc approach is the recommended treatment for larger antral cysts...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28754280/-prenatal-diagnosis-and-management-of-two-cases-of-bilateral-ureteroceles-on-simplex-ureters
#6
H Ben Hamouda, H Bouchahda, S Ghanmi, S Wannes, H Soua, H Hamza, M Belghith, A Nouri, M T Sfar
Ureterocele is a rare urologic disorder characterized by pseudocystic dilatation of the terminal submucosal ureter. Most cases of ureteroceles are associated with complete ureteral duplicity and ureterohydronephrosis, whereas ureteroceles on simplex ureters are rarer. The authors report two cases of bilateral ureteroceles on simplex ureters diagnosed prenatally at 30 and 32weeks gestation. Fetal ultrasound had revealed bilateral ureterohydronephrosis. The delivery was made at term and renal function was normal at birth...
July 25, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28736188/asparaginase-associated-pancreatitis-in-childhood-acute-lymphoblastic-leukaemia-an-observational-ponte-di-legno-toxicity-working-group-study
#7
Benjamin O Wolthers, Thomas L Frandsen, André Baruchel, Andishe Attarbaschi, Shlomit Barzilai, Antonella Colombini, Gabriele Escherich, Kathrine Grell, Hiroto Inaba, Gábor Kovacs, Der-Cherng Liang, Marion Mateos, Veerle Mondelaers, Anja Möricke, Tomasz Ociepa, Sujith Samarasinghe, Lewis B Silverman, Inge M van der Sluis, Martin Stanulla, Lynda M Vrooman, Michihiro Yano, Ester Zapotocka, Kjeld Schmiegelow
BACKGROUND: Survival for childhood acute lymphoblastic leukaemia surpasses 90% with contemporary therapy; however, patients remain burdened by the severe toxic effects of treatment, including asparaginase-associated pancreatitis. To investigate the risk of complications and risk of re-exposing patients with asparaginase-associated pancreatitis to asparaginase, 18 acute lymphoblastic leukaemia trial groups merged data for this observational study. METHODS: Patient files from 26 trials run by 18 trial groups were reviewed on children (aged 1·0-17·9 years) diagnosed with t(9;22)-negative acute lymphoblastic leukaemia between June 1, 1996, and Jan 1, 2016, who within 50 days of asparaginase exposure developed asparaginase-associated pancreatitis...
July 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28730147/correlation-between-pain-and-degenerative-bony-changes-on-cone-beam-computed-tomography-images-of-temporomandibular-joints
#8
SunMee Bae, Moon-Soo Park, Jin-Woo Han, Young-Jun Kim
BACKGROUND: The aim of this study was to assess correlation between pain and degenerative bony changes on cone-beam computed tomography (CBCT) images of temporomandibular joints (TMJs). METHODS: Two hundred eighty-three temporomandibular joints with degenerative bony changes were evaluated. Pain intensity (numeric rating scale, NRS) and pain duration in patients with degenerative joint disease (DJD) were also analyzed. We classified condylar bony changes on CBCT into five types: osteophyte (Osp), erosion (Ero), flattening (Fla), subchondral sclerosis (Scl), and pseudocyst (Pse)...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28690904/auricular-pseudocyst-due-to-unusual-repetitive-manipulation-of-the-ears-clinical-approach
#9
Francisco Navarro-Triviño, Ricardo Ruiz-Villaverde
No abstract text is available yet for this article.
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28689243/giant-intrastromal-cleft-in-corneal-hydrops
#10
Virgilio Galvis, Alejandro Tello, Marcela F Cianci, Luis Carlos Escaf, M Margarita Parra
A 15-year-old male patient with corneal hydrops and a giant intrastromal cleft (pseudocyst) successfully received medical treatment with topical prednisolone, hypertonic saline solution and ocular hypotensive eyedrops. Anterior segment optical coherence tomography (OCT) was used as an auxiliary tool for assessing the response to treatment during follow-up time (33 months).
July 8, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28683898/color-doppler-ultrasound-study-of-glomuvenous-malformations-with-its-clinical-and-histologic-correlations
#11
X Wortsman, F Millard, L Aranibar
Glomuvenous malformations are hamartomatous lesions characterized by the presence of glomus cells in the vascular smooth muscle. We present the clinical and color Doppler ultrasound features of a series of 13 cases of histologically confirmed glomuvenous malformations. In all cases, the ultrasound study revealed moderately delimited superficial dermal and hypodermal pseudonodular structures of mixed echogenicity, with hypoechoic and heterogeneous areas and anechoic, pseudocystic tubular and lacunar zones. Arterial and venous vessels, mainly with a low flow (≤ 15cm/s) were observed in 85% of patients, but no arteriovenous shunts were present...
July 3, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28678954/occurrence-of-dermoid-cyst-in-the-floor-of-the-mouth-the-importance-of-differential-diagnosis-in-pediatric-patients
#12
Edela Puricelli, Bernardo Ottoni Braga Barreiro, Alexandre Silva Quevedo, Deise Ponzoni
Lesions in the floor of the mouth can be a challenging diagnosis due to the variety of pathological conditions that might be found in this area. Within a broad range of lesions, attention has to be addressed to those that require specific management, such as a dermoid cyst (DC) and a ranula. Especially in pediatric patients, in whom the failure of diagnosis can postpone the correct treatment and cause sequelae later in life. DC, a developmental anomaly, is managed primarily by surgical resection. On the other hand, ranula is a pseudocyst that may be treated by marsupialization...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28676624/recurrent-pleural-effusion-secondary-to-a-pancreatic-pleural-fistula-treated-endoscopically
#13
Marco Antonio Bustamante Bernal, Jose Lisandro Gonzalez Martinez, Arleen Ortiz, Marc J Zuckerman
BACKGROUND Pancreatic-pleural fistula (PPF) is an uncommon complication of pancreatitis. Pleural effusions secondary to PPF are caused by fistulization of pancreatic secretions to the thorax derived from the rupture or leakage of a pseudocyst. CASE REPORT We describe the case of a 44-year-old male with recurrent right-sided pleural effusions and alcoholic pancreatitis who presented with epigastric pain and shortness of breath. Pleural fluid analysis revealed an amylase of 7002 U/lt. MRCP showed segmental narrowing and stricture of the proximal main pancreatic duct and an area of walled-off necrosis...
July 5, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28673238/report-of-an-unsual-case-of-anophthalmia-and-craniofacial-cleft-in-a-newborn-with-toxoplasma-gondii-congenital-infection
#14
Gabriel Emmanuel Arce-Estrada, Valeria Gómez-Toscano, Carlos Cedillo-Peláez, Ana Luisa Sesman-Bernal, Vanessa Bosch-Canto, José Luis Mayorga-Butrón, José Antonio Vargas-Villavicencio, Dolores Correa
BACKGROUND: We present one unusual case of anophthalmia and craniofacial cleft, probably due to congenital toxoplasmosis only. CASE PRESENTATION: A two-month-old male had a twin in utero who disappeared between the 7(th) and the 14(th) week of gestation. At birth, the baby presented anophthalmia and craniofacial cleft, and no sign compatible with genetic or exposition/deficiency problems, like the Wolf-Hirschhorn syndrome or maternal vitamin A deficiency. Congenital toxoplasmosis was confirmed by the presence of IgM abs and IgG neo-antibodies in western blot, as well as by real time PCR in blood...
July 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28664407/combined-use-of-electron-microscopy-and-intravital-imaging-captures-morphological-and-functional-features-of-podocyte-detachment
#15
REVIEW
James L Burford, Georgina Gyarmati, Isao Shirato, Wilhelm Kriz, Kevin V Lemley, János Peti-Peterdi
The development of podocyte injury and albuminuria in various glomerular pathologies is still incompletely understood due to technical limitations in studying the glomerular filtration barrier (GFB) in real-time. We aimed to directly visualize the early morphological and functional changes of the GFB during the development of focal segmental glomerulosclerosis (FSGS) using a combination of transmission electron microscopy (TEM) and in vivo multiphoton microscopy (MPM) in the rat puromycin aminonucleoside (PAN) model...
August 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28637548/pancreatic-pseudocyst-induced-gastric-varices-a-rare-case-of-extrahepatic-portal-hypertension
#16
Neal Cooper, Jason D Sciarretta, Ayolola Onayemi, John Davis
No abstract text is available yet for this article.
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28637114/diffuse-large-b-cell-lymphoma-a-rare-complication-of-an-abdominal-csf-pseudocyst
#17
Cathal Hannan, Aaron Niblock, Jeremy Hamilton, H Neil Simms
Abdominal CSF pseudocysts are an uncommon complication of ventriculo-peritoneal shunting. We report the case of a 35 year old man with a myelomenigocele, associated Chiari 2 malformation, and VP shunt developing a Diffuse Large B-Cell Lymphoma within the lining of an abdominal CSF pseuodcyst. This diagnosis should be considered in those with recurrent pseudocysts, or those associated with a swinging pyrexia and high C-Reactive protein, in the absence of infection.
March 2, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28633941/pancreatic-cyst-fluid-vascular-endothelial-growth-factor-a-and-carcinoembryonic-antigen-a-highly-accurate-test-for-the-diagnosis-of-serous-cystic-neoplasm
#18
Rosalie A Carr, Michele T Yip-Schneider, Scott Dolejs, Bradley A Hancock, Huangbing Wu, Milan Radovich, C Max Schmidt
BACKGROUND: Accurate differentiation of pancreatic cystic lesions is important for pancreatic cancer early detection and prevention as well as avoidance of unnecessary surgical intervention. Serous cystic neoplasms (SCN) have no malignant potential, but may mimic premalignant mucinous cystic lesions: mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm (IPMN). We recently identified vascular endothelial growth factor (VEGF)-A as a novel pancreatic fluid biomarker for SCN...
May 18, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28630665/fronto-orbital-mucocele-with-intracranial-extension-a-case-report
#19
Rocco Severino, Paolo Severino
Frontal sinus mucoceles are benign, pseudocystic lesion deriving from the obliteration of the sinus ostium, resulting in a continuous mucous accumulation. The growing process of a mucocele leads to a progressive enlargement of the sinus cavity, thickening and eroding its bony walls up to invading the surrounding tissues. The surgical procedure through an endoscopic endonasal approach is the current treatment option for such conditions, but in cases with an extensive bone erosion and intracranial or intraorbital extension, a transcranial approach should be preferred...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28621297/endoscopic-ultrasound-with-or-without-fine-needle-aspiration-has-a-meaningful-impact-on-clinical-care-in-the-pediatric-population
#20
Amit Raina, Maire A Conrad, Benjamin Sahn, Alireza Sedarat, Gregory G Ginsberg, Nuzhat A Ahmad, Vinay Chandrasekhara, Petar Mamula, Michael L Kochman
BACKGROUND AND OBJECTIVES: The safety and utility of endoscopic ultrasound (EUS) for the evaluation and management of gastrointestinal (GI) tract disorders among adults has been established. The literature on safety and efficacy in a pediatric referral population (under 21 years of age) is limited. We hypothesized that EUS is safe and useful in the pediatric population. We reviewed the pediatric EUS experience at a single tertiary-care system. We describe the indications, findings, safety, technical success rate, and impact on clinical outcomes...
May 2017: Endoscopic Ultrasound
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