keyword
https://read.qxmd.com/read/38487473/developing-and-evaluating-a-predictive-model-for-neonatal-hyperbilirubinemia-based-on-ugt1a1-gene-polymorphism-and-clinical-risk-factors
#1
JOURNAL ARTICLE
Zhaoyang Cui, Wensheng Shen, Xuetong Sun, Yan Li, Ying Liu, Zhiyong Sun
BACKGROUND: Neonatal hyperbilirubinemia (NHB) is one of the most common diseases in the neonatal period. Without timely diagnosis and treatment, it can lead to long-term complications. In severe cases, it may even result in fatality. The UGT1A1 gene and clinical risk factors play important roles in the development and progression of NHB. METHODS: In this study, we conducted a cohort study and analyzed 3258 newborns from the Jilin Women And Children Health Hospital in northern China, including 372 children with hyperbilirubinemia...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38476806/novel-two-infusion-pump-technique-for-exchange-transfusion-in-a-hyperbilirubinemic-neonate
#2
Naramreddy Sudheesh Reddy, Aditi Rawat, Sagar Karotkar, Ashish Varma, Amar Taksande, Revat J Meshram, Chaitanya Kumar Javvaji, SreeHarsha Damam
Neonatal hyperbilirubinemia is a common concern in newborns, with ABO blood group incompatibility serving as a significant risk factor for severe jaundice. This case report outlines the successful management of a 2.5 kg female infant born to a primigravida mother with ABO incompatibility-induced hyperbilirubinemia. The neonate, born at 38.4 weeks via lower segment cesarean section, exhibited signs of jaundice at 91 hours of life, prompting screening and subsequent confirmation of serum bilirubin levels 26...
February 2024: Curēus
https://read.qxmd.com/read/38368497/skin-color-influences-transcutaneous-bilirubin-measurements-a-systematic-in-vitro-evaluation
#3
JOURNAL ARTICLE
Alida J Dam-Vervloet, Claudia F Morsink, Marleen E Krommendijk, Ingrid M Nijholt, Henrica L M van Straaten, Lieke Poot, Nienke Bosschaart
OBJECTIVE: Concerns have been raised about the effect of skin color on the accuracy of transcutaneous bilirubin (TcB) measurements, a widely used method for hyperbilirubinemia diagnosis in newborns. Literature is inconclusive, with both reported under- and overestimations of the TcB with increasing skin pigmentation. Therefore, the influence of skin color on TcB measurements was systematically evaluated in a controlled, in vitro setting. METHODS: A bilirubin meter (JM-105) was evaluated on layered phantoms that mimic neonatal skin with varying dermal bilirubin concentrations (0-250 µmol/L) and varying epidermal melanosome volume fractions (0-40%; light-dark skin color)...
February 17, 2024: Pediatric Research
https://read.qxmd.com/read/38146169/accuracy-of-transcutaneous-bilirubinometry-in-term-infants-after-phototherapy-a-prospective-observational-study
#4
JOURNAL ARTICLE
Charissa Joy, Taya A Collyer, Kathryn McMahon
OBJECTIVE: To test the accuracy of transcutaneous bilirubinometry (TcB) in neonates 12 h after discontinuing phototherapy. STUDY DESIGN: In a prospective study of 91 neonates at ≥35 weeks of gestation, paired measurements of total serum bilirubin (TSB) and TcB were obtained 12 h after discontinuation of phototherapy. TcB measurements were obtained on the uncovered skin of the sternum and the covered skin of the lower abdomen. Bland-Altman plots were used to evaluate agreement between TSB and TcB...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/38054187/demystifying-non-invasive-approaches-for-screening-jaundice-in-low-resource-settings-a-review
#5
REVIEW
Umme Abiha, Dip Sankar Banerjee, Saptarshi Mandal
All national and international pediatric guidelines universally prescribe meticulous bilirubin screening for neonates as a critical measure to mitigate the incidence of acute bilirubin encephalopathy (ABE) and Kernicterus. The prevailing gold standard for jaundice detection in neonates necessitates invasive blood collection, followed by subsequent biochemical testing. While the invasive procedure provides dependable bilirubin measurements and continues to be the sole gold standard diagnostic method for assessing bilirubin concentration...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38002910/early-term-neonates-demonstrate-a-higher-likelihood-of-requiring-phototherapy-compared-to-those-born-full-term
#6
JOURNAL ARTICLE
Teck-Jin Tan, Wan-Ju Chen, Wan-Chun Lin, Ming-Chun Yang, Ching-Chung Tsai, Yung-Ning Yang, San-Nan Yang, Hsien-Kuan Liu
Early-term neonates (with a gestational age (GA) of 37 and 0/7 weeks to 38 and 6/7 weeks) face higher morbidities, including respiratory and neurodevelopmental issues, than full-term (39 and 0/7 weeks to 40 and 6/7 weeks) infants. This study explores whether hyperbilirubinemia necessitating phototherapy also differs between these groups. A retrospective study was conducted on neonates born from January 2021-June 2022, excluding those with specific conditions. Evaluated factors included GA, birth weight, bilirubin levels, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and feeding type, with phototherapy given as per AAP guidelines...
November 16, 2023: Children
https://read.qxmd.com/read/37990609/transcutaneous-bilirubin-accuracy-before-during-and-after-phototherapy-a-meta-analysis
#7
JOURNAL ARTICLE
Lisa Ten Kate, Tiemen van Oorschot, Jessica Woolderink, Sarah Teklenburg-Roord, Jolita Bekhof
CONTEXT: Transcutaneous bilirubinometry (TcB) is used as a valid screening to identify neonates requiring measurement of total serum bilirubin (TSB) before phototherapy. Its use during and after phototherapy is not advised yet because of unknown reliability. OBJECTIVES: To determine the agreement of TcB and TSB measurements before, during, and after phototherapy. DATA SOURCES: PubMed Medline, Cochrane Library, and references of eligible studies were searched...
December 1, 2023: Pediatrics
https://read.qxmd.com/read/37915398/measuring-and-imaging-of-transcutaneous-bilirubin-hemoglobin-and-melanin-based-on-diffuse-reflectance-spectroscopy
#8
JOURNAL ARTICLE
Masafumi Minakawa, Md Abdul Wares, Kazuya Nakano, Hideaki Haneishi, Yoshihisa Aizu, Yoshio Hayasaki, Tetsuo Ikeda, Hajime Nagahara, Izumi Nishidate
SIGNIFICANCE: Evaluation of biological chromophore levels is useful for detection of various skin diseases, including cancer, monitoring of health status and tissue metabolism, and assessment of clinical and physiological vascular functions. Clinically, it is useful to assess multiple different chromophores in vivo with a single technique or instrument. AIM: To investigate the possibility of estimating the concentration of four chromophores, bilirubin, oxygenated hemoglobin, deoxygenated hemoglobin, and melanin from diffuse reflectance spectra in the visible region...
October 2023: Journal of Biomedical Optics
https://read.qxmd.com/read/37854578/noninvasive-transcutaneous-bilirubin-measurement-in-adults-using-skin-diffuse-reflectance
#9
JOURNAL ARTICLE
Chia-Te Chen, Sheng-Hao Tseng, Bing-Hsuan Sung, Ying-Yu Chen, Hsiu-Chi Cheng
Accurate measurement of bilirubin concentration in adults is crucial for the diagnosis and management of liver and biliary tract diseases. Traditional methods relying on central laboratory testing pose challenges such as invasiveness, patient discomfort, and time consumption. Non-invasive alternatives have been explored, but their applicability to adult populations remains uncertain. This study aimed to develop and validate a portable non-invasive optical system based on spatially resolved diffuse reflectance spectroscopy (DRS) specifically tailored for adult transcutaneous bilirubin measurement...
October 1, 2023: Biomedical Optics Express
https://read.qxmd.com/read/37722208/transcutaneous-bilirubin-measured-on-protected-skin-during-phototherapy-in-term-and-preterm-neonates
#10
JOURNAL ARTICLE
Fatih İşleyen, İstemi Han Çelik, Nihal Demirel, Nihan Özel Erçel, Dilek Ulubaş Işık, Ahmet Yağmur Baş
BACKGROUND: Transcutaneous bilirubin (TCB) measurement is a simple, painless, and time-saving alternative for the assessment of TSB (total serum bilirubin) levels. However, TCB measurements obtained during phototherapy can yield inaccurate results. We evaluated the effectiveness of TCB measurements obtained from protected skin areas in patients who underwent phototherapy. METHODS: This prospective study included neonates delivered at a gestational age of ≥340/7 weeks...
September 12, 2023: Early Human Development
https://read.qxmd.com/read/37702683/accuracy-and-reproducibility-of-bilicare%C3%A2-transcutaneous-bilirubin-device
#11
JOURNAL ARTICLE
Yu Chen, Susan Lake, Kate Scott
BACKGROUND: The aim of this study was to evaluate the analytical performance of a new transcutaneous bilirubin (TcB) device - BiliCareTM (Gerium Medical, Yavne, Israel). METHODS: The neonatal TcB measurements were compared between BiliCareTM and the existing BiliChekTM systems (n = 40). TcB measured by BiliCareTM were also compared with total serum bilirubin (TSB) using a Roche Cobas702 chemistry analyzer (n = 31) and whole blood bilirubin using a Radiometer ABL 835 (n = 11)...
September 1, 2023: Clinical Laboratory
https://read.qxmd.com/read/37658617/current-status-of-neonatal-jaundice-management-in-japan
#12
JOURNAL ARTICLE
Kazuya Honbe, Masahiro Hayakawa, Ichiro Morioka, Hiroshi Arai, Yoshihiro Maruo, Takashi Kusaka, Tetsuya Kunikata, Sota Iwatani, Akihisa Okumura
BACKGROUND: This nationwide survey aimed to determine the status of jaundice management in Japan. METHODS: A questionnaire about bilirubin level measurements and neonatal jaundice treatment was sent to 330 institutions providing neonatal care. The responses were analyzed according to institution level. RESULTS: Of 330 institutions, 172 responded (52.1% response rate). Total bilirubin levels were measured in the central laboratory using spectrophotometry at 134 institutions and a blood gas analyzer at 81 institutions...
2023: Pediatrics International: Official Journal of the Japan Pediatric Society
https://read.qxmd.com/read/37647914/comparison-of-transcutaneous-and-total-serum-bilirubin-measurements-at-five-different-sites-in-newborns-before-and-after-phototherapy
#13
JOURNAL ARTICLE
Seda Eken, Ozkan Ilhan, Nilay Hakan
OBJECTIVE: This study aims to examine the accuracy of transcutaneous bilirubin (TcB) in estimating the total serum bilirubin (TSB) level at five different sites before and immediately after phototherapy. METHODS: This study prospectively enrolled infants with a gestational age of 34 to 416/7 weeks who were clinically diagnosed with neonatal jaundice and required phototherapy within 28 days after birth. TcB levels were measured on the uncovered four areas (forehead, mid-sternum, abdomen, and interscapular site) and covered hipbone by using the Dräger JM-103 Jaundice Meter before phototherapy and at 0 min after discontinuing phototherapy...
August 30, 2023: Klinische Pädiatrie
https://read.qxmd.com/read/37599136/readmission-reduction-for-hyperbilirubinemia-in-infants-%C3%A2-35-weeks-estimated-gestational-age-using-a-standardized-protocol
#14
JOURNAL ARTICLE
Dakota K Tomasini, Michael G Guindon, Rasheda J Vereen, Caitlin M Drumm, Adharsh P Ponnapakkam
BACKGROUND: Most newborns experience hyperbilirubinemia. Monitoring and treatment must be balanced with the risk of unintended harm, including readmission to the birth hospital. From January 2019 to April 2021, the average rate of inborn readmission for all causes was 2.09% at the study hospital; hyperbilirubinemia accounted for 91% of these readmissions. The aim of this project was to decrease readmission rate for hyperbilirubinemia by 60% within eight months of protocol implementation...
July 9, 2023: Joint Commission Journal on Quality and Patient Safety
https://read.qxmd.com/read/37538974/the-accuracy-of-transcutaneous-bilirubin-as-a-screening-test-in-preterm-infants
#15
JOURNAL ARTICLE
Yunfai Ng, Timothy Maul, Sreekanth Viswanathan, Caroline Chua
OBJECTIVE: To determine the accuracy of transcutaneous bilirubin (TcB) to predict total serum bilirubin (TSB) in preterm infants across gestational age (GA) ranges and to calculate the cost-effectiveness of TcB as the primary screening test of choice for neonatal jaundice in neonatal intensive care unit (NICU) settings. METHODS: Single-center retrospective study of infants aged ≤ seven days admitted to the NICU over a six-month period with a paired TSB and TcB, with or without phototherapy as part of their routine clinical care...
August 2023: Curēus
https://read.qxmd.com/read/37538268/the-use-of-transcutaneous-bilirubin-nomograms-for-the-prevention-of-bilirubin-neurotoxicity-in-the-neonates
#16
JOURNAL ARTICLE
Lucia Casnocha Lucanova, Jana Zibolenova, Katarina Matasova, Katarina Matasova, Mirko Zibolen
PURPOSE: Although neonatal jaundice is a ubiquitous and predominantly benign phenomenon, the risk of neurotoxicity exists in a number of infants with unconjugated hyperbilirubinemia. Plotting bilirubin values on nomograms enables clinicians to employ an anticipatory and individualized approach with the goal of avoiding excessive hyperbilirubinemia and preventing acute bilirubin encephalopathy and its progression to kernicterus. We aimed to construct nomograms for White term infants based on transcutaneous bilirubin (TcB) measurements using a JM-105 device...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37476881/the-predictive-significance-of-umbilical-cord-bilirubin-and-bilirubin-albumin-ratio-for-neonatal-jaundice-in-healthy-term-newborns
#17
JOURNAL ARTICLE
Handan Şahan, Selvi Gülaşı, Mustafa Kurthan Mert, Eren Kale Çekinmez
BACKGROUND: The aim of this study is to determine the value of the questions asked in routine follow-up, the cord blood bilirubin (CBB) and bilirubin/albumin (B/A) ratio in estimating the risk of developing hyperbilirubinemia. METHODS: Term and healthy 217 newborns whose CBB and albumin could be obtained and whose needed to be measured bilirubin level at the 24thand 72nd hours of life were included. Nutrition, sex and nationality, consanguinity between parents, jaundice in the sibling (s), mother's medications were questioned...
April 2023: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/37368007/performance-of-smartphone-application-to-accurately-quantify-hyperbilirubinemia-in-neonates-a-systematic-review-with-meta-analysis
#18
JOURNAL ARTICLE
Deeparaj Hegde, Chandra Rath, Sathika Amarasekara, Chitra Saraswati, Sanjay Patole, Shripada Rao
Neonatal jaundice is a common clinical condition that can progress to severe hyperbilirubinemia if identification and intervention are delayed. In this study, we aimed to analyze the current evidence on the accurate performance of smartphone applications to quantify bilirubin levels. PubMed, Embase, Emcare, MEDLINE, the Cochrane Library, and Google Scholar were searched from inception until July 2022. Grey literature was searched on "OpenGrey" and "MedNar" databases. We included prospective and retrospective cohort studies that recruited infants with a gestation of ≥ 35 weeks and reported paired total serum bilirubin (TSB) and smartphone app-based bilirubin (ABB) levels...
June 27, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37252231/characteristics-of-intestinal-microbiota-in-infants-with-late-onset-breast-milk-jaundice
#19
JOURNAL ARTICLE
Qianying Guo, Xinran Liu, Mingxuan Cui, Xuening Li, Chen Yang, Shilong Zhao, Lina Pan, Xiaoyu Peng, Linlin Wang, Peng Liu
INTRODUCTION: In this paper, microbiota analysis was determined to analyze the structure and difference of intestinal microbiota between LBMJ (late-onset breast milk jaundice) infants and healthy individuals. METHODS: We collected fresh fecal samples from 13 infants with LBMJ and 13 healthy individuals, then determined the intestinal microbiota by 16 s rRNA sequencing. The differences of microbiota structure, diversity and functional characteristics between the two groups were analyzed, and the correlation between dominant genus and TcB (transcutaneous bilirubin) value was calculated...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37158489/transcutaneous-bilirubinometry-versus-total-serum-bilirubin-measurement-for-newborns
#20
REVIEW
Charles I Okwundu, Abiola Olowoyeye, Olalekan A Uthman, Johan Smith, Charles S Wiysonge, Vinod K Bhutani, Michelle Fiander, Kanekal S Gautham
BACKGROUND: Jaundice is a very common condition in newborns, affecting up to 60% of term newborns and 80% of preterm newborns in the first week of life. Jaundice is caused by increased bilirubin in the blood from the breakdown of red blood cells. The gold standard for measuring bilirubin levels is obtaining a blood sample and processing it in a laboratory. However, noninvasive transcutaneous bilirubin (TcB) measurement devices are widely available and used in many settings to estimate total serum bilirubin (TSB) levels...
May 9, 2023: Cochrane Database of Systematic Reviews
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