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cold knife conization

Yanming Jiang, Changxian Chen, Li Li
OBJECTIVE: The objective of this systematic review was to conduct a more comprehensive literature search and meta-analysis of original studies to evaluate the efficacy and safety of the loop electrosurgical excision procedure (LEEP) versus cold-knife conization (CKC) in conservative surgical treatment of cervical adenocarcinoma in situ (ACIS) for women who have not completed childbearing. METHODS: Systematic searches were conducted in the PUBMED, EMBASE, Cochrane, and China National Knowledge Infrastructure (CNKI) databases to identify all potential studies involving patients with ACIS treated with LEEP versus CKC published until December 2015...
2017: PloS One
Chumnan Kietpeerakool, Bandit Chumworathayi, Jadsada Thinkhamrop, Butsakorn Ussahgij, Pisake Lumbiganon
BACKGROUND: Excision of the transformation zone of the cervix is the most commonly used approach to treat cervical precancerous lesions (cervical intraepithelial neoplasia (CIN)) to reduce the risk of developing cervical cancer. As the excision of the transformation zone leaves a raw area on the cervix, there is a risk of infection following the procedure. The incidence of infection after cold knife conization (CKC) is 36%, whereas the incidence for large loop excision of the transformation zone (LLETZ, also known as loop electrical excision procedure (LEEP)) is much lower (0...
January 21, 2017: Cochrane Database of Systematic Reviews
Guorui Zhang, Jinghe Lang, Keng Shen, Lan Zhu, Yang Xiang
OBJECTIVE: To investigate high-risk human papillomavirus (HPV) infection clearance rates following successful cold knife conization and factors predictive of HPV clearance among patients with cervical intraepithelial neoplasm grade 3. METHOD: The present retrospective study analyzed clinical data from patients aged at least 45 years with cervical intraepithelial neoplasm grade 3 who had undergone successful cold knife conization and attended regular follow-up at Peking Union Medical College Hospital, China, between January 1, 2002 and December 31, 2012...
January 2017: International Journal of Gynaecology and Obstetrics
Caio Augusto Hartman, Julio Cesar Teixeira, Sergio Bruno Barbosa, Stephanye Mariano Figueiredo, Liliana Aparecida Lucci De Angelo Andrade, Joana Froes Bragança Bastos
OBJECTIVE: The aim of this study was to evaluate the prognosis and recurrence of microinvasive squamous cervical (MIC) cancer stage IA1 in women treated conservatively or by hysterectomy, and followed-up to 20 years. METHODS: It was studied in a cohort of 139 women with MIC, 41 definitively managed by conization and 98 by hysterectomy from January 1994 to December 2003 and followed-up until 2013. The definitive treatment, age, conization technique (loop electrosurgical excision procedure or cold knife conization), cone margin, residual disease in hysterectomy specimen, and the association with recurrence (intraepithelial cervical neoplasia grade 3/intraepithelial vaginal neoplasia grade 3 or worse, and microinvasive or worse) were analyzed...
February 2017: International Journal of Gynecological Cancer
Sherif A El-Nashar, Sherif A Shazly, Matthew R Hopkins, Jamie N Bakkum-Gomez, Abimbola O Famuyide
OBJECTIVES: This meta-analysis compared loop electrosurgical excision procedure (LEEP) with cold-knife conization (CKC) for treating cervical intraepithelial neoplasia (CIN) in patients with unsatisfactory colposcopic examinations. MATERIAL AND METHODS: A literature search on MEDLINE, EMBASE, Cochrane Systematic Reviews, CENTRAL, Web of Science, and Scopus databases was conducted from inception until April 2015. We included clinical trials and cohort studies comparing CKC with LEEP for treating CIN...
December 13, 2016: Journal of Lower Genital Tract Disease
Tone Bjørge, Gry B Skare, Line Bjørge, Ameli Tropé, Stefan Lönnberg
OBJECTIVE: To explore associations between specific treatments for intraepithelial or early invasive cervical lesions and adverse pregnancy outcomes. METHODS: We conducted a population-based cohort study in which treatment data from the Cancer Registry of Norway were linked to the Medical Birth Registry of Norway to identify adverse pregnancy outcomes. All women (n=545,243) with singleton births (N=943,321) in Norway during 1998-2014 were included; 9,554 of births were in women treated before delivery...
December 2016: Obstetrics and Gynecology
J Hong, K A So, J W Kim
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Murat Öz, Nilüfer Çetinkaya, Elmas Korkmaz, Kerem Doğa Seçkin, Mehmet Mutlu Meydanlı, Tayfun Güngör
OBJECTIVE: To determine the optimal cone size to achieve a reliable sensitivity and specificity for clear surgical margins after cold knife conization (CKC). MATERIAL AND METHODS: The medical reports of patients who had high-grade cervical intraepithelial lesions, carcinoma in situ, or stage 1A1 microinvasive carcinoma in their CKC specimens between June 2008 and January 2015 were reviewed retrospectively. RESULTS: In total, 315 women fulfilled the inclusion criteria...
2016: Journal of the Turkish German Gynecological Association
Yan-Ming Jiang, Chang-Xian Chen, Li Li
OBJECTIVE: This meta-analysis aimed to compare the superiority of loop electrosurgical excision procedure (LEEP) or large loop excision of the transformation zone (LLETZ) versus cold-knife conization (CKC) in the surgical treatment of cervical intraepithelial neoplasia (CIN). METHODS: Systematic searches were performed in the MEDLINE, EMBASE, Cochrane databases, and the China National Knowledge Infrastructure Databases to identify all potential articles involving patients with CIN treated with LEEP/LLETZ or CKC published up to February 2016...
2016: OncoTargets and Therapy
Y X Sun, Q Liu, K J Liu, P Q Li, Z J Hu
OBJECTIVE: To explore the outcomes of the oncology, the fertility and pregnancy on patients with early-stage cervical cancer after undergoing fertility-sparing treatments, and to investigate its value on clinical treatment. METHODS: A total of 29 patients with cervical cancer (stage Ⅰa2-Ⅰb1) who had undergone the fertility- sparing treatments in Renji Hospital, School of Medicine, Shanghai Jiaotong University from February 2010 to September 2015 were analyzed retrospectively...
June 25, 2016: Zhonghua Fu Chan Ke za Zhi
Francesco Sopracordevole, Jacopo DI Giuseppe, Francesca Mancioli, Giovanni DE Piero, Monica Buttignol, Andrea Ciavattini
BACKGROUND: The recent evolution of surgical techniques, anesthesia and treatment strategies has led to a decrease in the number of cervical conization procedures performed in ordinary hospitalization or with anesthetics other than local infiltration anesthesia of the cervix. Conization should be as least invasive as possible, favor women's compliance and resumption of normal daily activities after surgery. We evaluated various aspects of patient care revolving around conization (technical, healthcare, and administrative aspects) in the clinical practice of 26 Italian colposcopy units...
April 2016: Minerva Ginecologica
A S M Wong, W H Li, T H Cheung
OBJECTIVE: To identify predictive factors for residual disease in hysterectomy specimens after a loop electrical excision procedure (LEEP) or cold knife conization in early-stage cervical cancer. STUDY DESIGN: A retrospective review was undertaken of the clinical records and pathology reports of 108 consecutive patients who were diagnosed with early invasive cervical cancer stage IA1 to IB1 by cold knife conization or LEEP, and underwent subsequent hysterectomy or radical hysterectomy at the Gynae-oncology Unit, Queen Elizabeth Hospital between 2000 and 2012...
April 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Nancy Santesso, Reem A Mustafa, Holger J Schünemann, Marc Arbyn, Paul D Blumenthal, Joanna Cain, Michael Chirenje, Lynette Denny, Hugo De Vuyst, Linda O'Neal Eckert, Sara E Forhan, Eduardo L Franco, Julia C Gage, Francisco Garcia, Rolando Herrero, José Jeronimo, Enriquito R Lu, Silvana Luciani, Swee Chong Quek, Rengaswamy Sankaranarayanan, Vivien Tsu, Nathalie Broutet
BACKGROUND: It is estimated that 1%-2% of women develop cervical intraepithelial neoplasia grade 2-3 (CIN 2-3) annually worldwide. The prevalence among women living with HIV is higher, at 10%. If left untreated, CIN 2-3 can progress to cervical cancer. WHO has previously published guidelines for strategies to screen and treat precancerous cervical lesions and for treatment of histologically confirmed CIN 2-3. METHODS: Guidelines were developed using the WHO Handbook for Guideline Development and the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach...
March 2016: International Journal of Gynaecology and Obstetrics
I Karagyozov
AIM: A short presentation of the method--laser microsurgery and analysis of the achieved results. MATERIALS AND METHODS: 631 laser procedures were done for 3 years (2008- 2011) at Tokuda hospital outpatient department. These procedures were divided as follows: 607 laser vaporizations and 24 laser conisations. Indications for vaporizations were: CINI-114 patients, CIN II--26 patients, CIN III (without invasion of the cervical os) -26 patients and 422 patients were done laser vaporization for different reasons-papiloma, leucoplakia, atypical vessels and so on...
2015: Akusherstvo i Ginekologii︠a︡
Nancy Santesso, Reem A Mustafa, Wojtek Wiercioch, Rohan Kehar, Shreyas Gandhi, Yaolong Chen, Adrienne Cheung, Jessica Hopkins, Rasha Khatib, Bin Ma, Ahmad A Mustafa, Nancy Lloyd, Darong Wu, Nathalie Broutet, Holger J Schünemann
BACKGROUND: Cervical intraepithelial neoplasia (CIN) stage 2-3 is a premalignant lesion that can progress to cervical cancer in 10-20 years if untreated. OBJECTIVES: To conduct systematic reviews of randomized and nonrandomized studies for effects of cryotherapy, loop electrosurgical excision procedure (LEEP), and cold knife conization (CKC) as treatment for CIN 2-3. SEARCH STRATEGY: Medline, Embase, and other databases were searched to February 2012 for benefits, and to July 2012 for harms...
March 2016: International Journal of Gynaecology and Obstetrics
Arsenio Spinillo, Barbara Gardella, Anna Daniela Iacobone, Stefania Cesari, Paola Alberizzi, Enrico Maria Silini
OBJECTIVE: The aim of the study was to evaluate the association between the size of cervical lesions as detected by colposcopy and multiple human papillomavirus (HPV) infection in subjects with cervical intraepithelial neoplasia (CIN). METHODS: A case series of 898 subjects with CIN diagnosed by histopathology and infected by high-risk HPV. Human papillomavirus genotypes were identified using the INNO-LIPA genotyping system. RESULTS: The rates of CIN 1, CIN 2, and CIN 3+ lesions were 53...
January 2016: Journal of Lower Genital Tract Disease
C A Okonkwo, D O Selo-Ojeme
Following skills transfer to this low resource setting, we carried out a descriptive analysis of the outcomes of all cone biopsies performed for women with cervical intra-epithelial neoplasia 3 (CIN 3). We also compared two methods of cone biopsy. All the women had follow-up smear tests at 6 and 18 months. There were no cases of CIN 3 at follow-up. 80% had normal smears at 18 months and 20% had CIN 1. Compared with knife cone biopsy, women who had an electric knife (hand-held diathermy blade) cone biopsy had a significantly smaller volume of mean blood loss (55...
2015: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
H E Cejtin, F T Chronopoulos, P M Meyer, L S Massad
OBJECTIVES: We set out to evaluate the predictive value of preoperative cytology and colposcopic histology in determining final pathology after conization of the cervix in the era of the Bethesda system. METHODS: A retrospective review of the charts of 280 patients who had cold-knife conization was undertaken. Preoperative cytology and colposcopic biopsy histology were compared to the cone biopsy histology. The Spearman's correlation coefficient was used to determine the correlation between both preoperative cytology and histology and histology of the cone biopsy...
April 1998: Journal of Lower Genital Tract Disease
N Husseinzadeh, W L Retting
OBJECTIVES: To compare the double-LEEP cone procedure with cold-knife conization to treat cervical intraepithelial neoplasia; to evaluate the specimen adequacy regarding resection margins and residual disease. METHODS AND MATERIALS: Of 137 patients with cervical intraepithelial neoplasia, 60 patients had cold-knife cone and 77 had double-LEEP cone procedure. The indications were the same for both groups. The average follow-up time was 6 months. RESULTS: Therapeutic failure (incomplete excision) rate was 14% for double-LEEP cone procedure and 13% for cold-knife conization (p = 0...
April 2000: Journal of Lower Genital Tract Disease
M S Seltzer, D A Habermehl, T M Julian
BACKGROUND: The purpose of this study is to compare loop electrosurgical excision, laser ablation, and coldknife conization for accuracy of excision in a model simulating the nulliparous uterine cervix. METHODS: Twenty obstetrics and gynecology residents excised or ablated specimens (n = 300) by using loop electrosurgical excision, laser, and scalpel. Preprepared specimens (bologna) were cut to simulate the adult, nulliparous cervix. These specimens were marked with templates to simulate cervical lesions...
April 1997: Journal of Lower Genital Tract Disease
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