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https://www.readbyqxmd.com/read/27824756/adverse-pregnancy-outcomes-after-treatment-for-cervical-intraepithelial-neoplasia
#1
Tone Bjørge, Gry B Skare, Line Bjørge, Ameli Tropé, Stefan Lönnberg
OBJECTIVE: To explore associations between specific treatments for intraepithelial or early invasive cervical lesions and adverse pregnancy outcomes. METHODS: We conducted a population-based cohort study in which treatment data from the Cancer Registry of Norway were linked to the Medical Birth Registry of Norway to identify adverse pregnancy outcomes. All women (n=545,243) with singleton births (N=943,321) in Norway during 1998-2014 were included; 9,554 of births were in women treated before delivery...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27679120/comparison-of-clinical-outcomes-of-bovie-blade-versus-cold-knife-conization-as-a-treatment-modality-of-high-grade-cervical-intraepithelial-neoplasia
#2
J Hong, K A So, J W Kim
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27651725/optimal-cone-size-to-predict-positive-surgical-margins-after-cold-knife-conization-ckc-and-the-risk-factors-for-residual-disease
#3
Murat Öz, Nilüfer Çetinkaya, Elmas Korkmaz, Kerem Doğa Seçkin, Mehmet Mutlu Meydanlı, Tayfun Güngör
OBJECTIVE: To determine the optimal cone size to achieve a reliable sensitivity and specificity for clear surgical margins after cold knife conization (CKC). MATERIAL AND METHODS: The medical reports of patients who had high-grade cervical intraepithelial lesions, carcinoma in situ, or stage 1A1 microinvasive carcinoma in their CKC specimens between June 2008 and January 2015 were reviewed retrospectively. RESULTS: In total, 315 women fulfilled the inclusion criteria...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27418835/meta-analysis-of-cold-knife-conization-versus-loop-electrosurgical-excision-procedure-for-cervical-intraepithelial-neoplasia
#4
Yan-Ming Jiang, Chang-Xian Chen, Li Li
OBJECTIVE: This meta-analysis aimed to compare the superiority of loop electrosurgical excision procedure (LEEP) or large loop excision of the transformation zone (LLETZ) versus cold-knife conization (CKC) in the surgical treatment of cervical intraepithelial neoplasia (CIN). METHODS: Systematic searches were performed in the MEDLINE, EMBASE, Cochrane databases, and the China National Knowledge Infrastructure Databases to identify all potential articles involving patients with CIN treated with LEEP/LLETZ or CKC published up to February 2016...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27356480/-a-retrospective-study-on-the-outcomes-of-the-oncology-fertility-and-pregnancy-in-patients-with-early-stage-cervical-cancer-after-undergoing-the-fertility-sparing-treatments
#5
Y X Sun, Q Liu, K J Liu, P Q Li, Z J Hu
OBJECTIVE: To explore the outcomes of the oncology, the fertility and pregnancy on patients with early-stage cervical cancer after undergoing fertility-sparing treatments, and to investigate its value on clinical treatment. METHODS: A total of 29 patients with cervical cancer (stage Ⅰa2-Ⅰb1) who had undergone the fertility- sparing treatments in Renji Hospital, School of Medicine, Shanghai Jiaotong University from February 2010 to September 2015 were analyzed retrospectively...
June 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27008241/procedures-of-cervical-conization-a-national-survey-among-italian-colposcopy-units
#6
Francesco Sopracordevole, Jacopo DI Giuseppe, Francesca Mancioli, Giovanni DE Piero, Monica Buttignol, Andrea Ciavattini
BACKGROUND: The recent evolution of surgical techniques, anesthesia and treatment strategies has led to a decrease in the number of cervical conization procedures performed in ordinary hospitalization or with anesthetics other than local infiltration anesthesia of the cervix. Conization should be as least invasive as possible, favor women's compliance and resumption of normal daily activities after surgery. We evaluated various aspects of patient care revolving around conization (technical, healthcare, and administrative aspects) in the clinical practice of 26 Italian colposcopy units...
April 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/26894378/predictive-factors-for-residual-disease-in-hysterectomy-specimens-after-conization-in-early-stage-cervical-cancer
#7
A S M Wong, W H Li, T H Cheung
OBJECTIVE: To identify predictive factors for residual disease in hysterectomy specimens after a loop electrical excision procedure (LEEP) or cold knife conization in early-stage cervical cancer. STUDY DESIGN: A retrospective review was undertaken of the clinical records and pathology reports of 108 consecutive patients who were diagnosed with early invasive cervical cancer stage IA1 to IB1 by cold knife conization or LEEP, and underwent subsequent hysterectomy or radical hysterectomy at the Gynae-oncology Unit, Queen Elizabeth Hospital between 2000 and 2012...
April 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26868062/world-health-organization-guidelines-for-treatment-of-cervical-intraepithelial-neoplasia-2-3-and-screen-and-treat-strategies-to-prevent-cervical-cancer
#8
Nancy Santesso, Reem A Mustafa, Holger J Schünemann, Marc Arbyn, Paul D Blumenthal, Joanna Cain, Michael Chirenje, Lynette Denny, Hugo De Vuyst, Linda O'Neal Eckert, Sara E Forhan, Eduardo L Franco, Julia C Gage, Francisco Garcia, Rolando Herrero, José Jeronimo, Enriquito R Lu, Silvana Luciani, Swee Chong Quek, Rengaswamy Sankaranarayanan, Vivien Tsu, Nathalie Broutet
BACKGROUND: It is estimated that 1%-2% of women develop cervical intraepithelial neoplasia grade 2-3 (CIN 2-3) annually worldwide. The prevalence among women living with HIV is higher, at 10%. If left untreated, CIN 2-3 can progress to cervical cancer. WHO has previously published guidelines for strategies to screen and treat precancerous cervical lesions and for treatment of histologically confirmed CIN 2-3. METHODS: Guidelines were developed using the WHO Handbook for Guideline Development and the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach...
March 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26863789/-colposcopy-assisted-laser-microsurgery-for-cervical-pathology
#9
I Karagyozov
AIM: A short presentation of the method--laser microsurgery and analysis of the achieved results. MATERIALS AND METHODS: 631 laser procedures were done for 3 years (2008- 2011) at Tokuda hospital outpatient department. These procedures were divided as follows: 607 laser vaporizations and 24 laser conisations. Indications for vaporizations were: CINI-114 patients, CIN II--26 patients, CIN III (without invasion of the cervical os) -26 patients and 422 patients were done laser vaporization for different reasons-papiloma, leucoplakia, atypical vessels and so on...
2015: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/26643302/systematic-reviews-and-meta-analyses-of-benefits-and-harms-of-cryotherapy-leep-and-cold-knife-conization-to-treat-cervical-intraepithelial-neoplasia
#10
REVIEW
Nancy Santesso, Reem A Mustafa, Wojtek Wiercioch, Rohan Kehar, Shreyas Gandhi, Yaolong Chen, Adrienne Cheung, Jessica Hopkins, Rasha Khatib, Bin Ma, Ahmad A Mustafa, Nancy Lloyd, Darong Wu, Nathalie Broutet, Holger J Schünemann
BACKGROUND: Cervical intraepithelial neoplasia (CIN) stage 2-3 is a premalignant lesion that can progress to cervical cancer in 10-20 years if untreated. OBJECTIVES: To conduct systematic reviews of randomized and nonrandomized studies for effects of cryotherapy, loop electrosurgical excision procedure (LEEP), and cold knife conization (CKC) as treatment for CIN 2-3. SEARCH STRATEGY: Medline, Embase, and other databases were searched to February 2012 for benefits, and to July 2012 for harms...
March 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26461233/multiple-papillomavirus-infection-and-size-of-colposcopic-lesions-among-women-with-cervical-intraepithelial-neoplasia
#11
Arsenio Spinillo, Barbara Gardella, Anna Daniela Iacobone, Stefania Cesari, Paola Alberizzi, Enrico Maria Silini
OBJECTIVE: The aim of the study was to evaluate the association between the size of cervical lesions as detected by colposcopy and multiple human papillomavirus (HPV) infection in subjects with cervical intraepithelial neoplasia (CIN). METHODS: A case series of 898 subjects with CIN diagnosed by histopathology and infected by high-risk HPV. Human papillomavirus genotypes were identified using the INNO-LIPA genotyping system. RESULTS: The rates of CIN 1, CIN 2, and CIN 3+ lesions were 53...
January 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/26418271/an-analysis-of-the-outcomes-of-cervical-cone-biopsies-performed-in-a-low-resource-setting
#12
COMPARATIVE STUDY
C A Okonkwo, D O Selo-Ojeme
Following skills transfer to this low resource setting, we carried out a descriptive analysis of the outcomes of all cone biopsies performed for women with cervical intra-epithelial neoplasia 3 (CIN 3). We also compared two methods of cone biopsy. All the women had follow-up smear tests at 6 and 18 months. There were no cases of CIN 3 at follow-up. 80% had normal smears at 18 months and 20% had CIN 1. Compared with knife cone biopsy, women who had an electric knife (hand-held diathermy blade) cone biopsy had a significantly smaller volume of mean blood loss (55...
2015: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/25951466/correlating-preoperative-cytology-and-colposcopic-biopsy-with-final-histology-after-conization-of-the-cervix
#13
H E Cejtin, F T Chronopoulos, P M Meyer, L S Massad
OBJECTIVES: We set out to evaluate the predictive value of preoperative cytology and colposcopic histology in determining final pathology after conization of the cervix in the era of the Bethesda system. METHODS: A retrospective review of the charts of 280 patients who had cold-knife conization was undertaken. Preoperative cytology and colposcopic biopsy histology were compared to the cone biopsy histology. The Spearman's correlation coefficient was used to determine the correlation between both preoperative cytology and histology and histology of the cone biopsy...
April 1998: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/25950891/double-leep-cone-procedure-as-an-alternative-to-cold-knife-conization-in-management-of-cervical-intraepithelial-neoplasia
#14
N Husseinzadeh, W L Retting
OBJECTIVES: To compare the double-LEEP cone procedure with cold-knife conization to treat cervical intraepithelial neoplasia; to evaluate the specimen adequacy regarding resection margins and residual disease. METHODS AND MATERIALS: Of 137 patients with cervical intraepithelial neoplasia, 60 patients had cold-knife cone and 77 had double-LEEP cone procedure. The indications were the same for both groups. The average follow-up time was 6 months. RESULTS: Therapeutic failure (incomplete excision) rate was 14% for double-LEEP cone procedure and 13% for cold-knife conization (p = 0...
April 2000: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/25950878/a-comparison-of-loop-electrosurgical-excision-laser-ablation-and-cold-knife-conization-in-relation-to-precise-specimen-removal-in-an-inanimate-model
#15
M S Seltzer, D A Habermehl, T M Julian
BACKGROUND: The purpose of this study is to compare loop electrosurgical excision, laser ablation, and coldknife conization for accuracy of excision in a model simulating the nulliparous uterine cervix. METHODS: Twenty obstetrics and gynecology residents excised or ablated specimens (n = 300) by using loop electrosurgical excision, laser, and scalpel. Preprepared specimens (bologna) were cut to simulate the adult, nulliparous cervix. These specimens were marked with templates to simulate cervical lesions...
April 1997: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/25950306/sutureless-technique-for-cold-knife-conization-a-report-of-seventy-four-consecutive-cases
#16
I Benjamin, S Y Segel, S C Rubin
No abstract text is available yet for this article.
January 1999: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/25950098/predicting-risk-factors-for-suboptimal-excision-in-women-undergoing-cold-knife-cone-biopsy
#17
L S Massad, F T Chronopoulos, P M Meyer, H E Cejtin
OBJECTIVE: Our goal was to identify risk factors for suboptimal excision in relation to a positive endocervical curettage (ECC) after conization or positive specimen margin. MATERIALS AND METHODS: A retrospective review of referral cy-tology and colposcopy results for 280 women undergoing conization at two urban teaching centers was performed. Mann-Whitney or Pearson's chi-square test was used to de-termine significant associations between preoperative variables and positive cone margin, positive intraoperative ECC, and either positive margin or positive intraoperative ECC...
July 1998: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/25937157/randomized-clinical-trial-comparing-cold-knife-conization-of-the-cervix-with-and-without-lateral-hemostatic-sutures
#18
RANDOMIZED CONTROLLED TRIAL
Letícia Rossi Bueno, Marcia Binda, Heleusa Monego, Roberta Luísa Scherer, Karen Machado Rolim, Alessandra Leal Bottini, José H T G Fregnani, Ricardo dos Reis
OBJECTIVE: Compare blood loss during cold knife conization of the cervix with and without lateral hemostatic sutures in the cervical branches of the uterine arteries. DESIGN: Randomized clinical trial. SETTING: Hospital de Clínicas de Porto Alegre (HCPA). POPULATION: 102 patients that underwent cold knife conization. METHODS: Women that underwent cold knife conization of the cervix were randomized to undergo the procedure with or without lateral hemostatic sutures...
June 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/25769659/comparison-of-cold-knife-cone-biopsy-and-loop-electrosurgical-excision-procedure-in-the-management-of-cervical-adenocarcinoma-in-situ-what-is-the-gold-standard
#19
COMPARATIVE STUDY
A Munro, Y Leung, K Spilsbury, C J R Stewart, J Semmens, J Codde, V Williams, P O'Leary, N Steel, P Cohen
OBJECTIVE: To compare the outcomes of patients with cervical adenocarcinoma in situ (ACIS) treated with cold knife cone (CKC) biopsy or loop electrosurgical excision procedure (LEEP) for the treatment of cervical adenocarcinoma in situ (ACIS). STUDY DESIGN: This is a retrospective, population-based cohort study of Western Australian patients with ACIS diagnosed between 2001 and 2012. Outcomes included pathological margin status and the incidence of persistent or recurrent endocervical neoplasia (ACIS and adenocarcinoma) during follow-up (<12 months) and surveillance (≥12 months) periods...
May 2015: Gynecologic Oncology
https://www.readbyqxmd.com/read/25742569/surgical-treatment-of-microinvasive-cervical-cancer-analysis-of-pathologic-features-with-implications-on-radicality
#20
Juliana Yoko Yoneda, Joana Froes Braganca, Luis Otavio Sarian, Patrícia Patury Borba, Jose Carlos J Conceição, Luiz Carlos Zeferino
OBJECTIVES: To evaluate pathologic features with implications on surgical radicality in women treated with radical hysterectomy and pelvic lymphadenectomy for cervical cancer stage IA1 with lymph vascular space invasion (LVSI) and stage IA2 by correlating findings in conization and hysterectomy specimens. METHODS: Women with cervical cancer stage IA1 with LVSI and stage IA2 diagnosed by loop electrosurgical excisional procedure or cold knife conization were treated with radical hysterectomy and pelvic lymphadenectomy from January 1999 to December 2011 in 2 institutions...
May 2015: International Journal of Gynecological Cancer
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