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Marios K Georgakis, Rainer Malik, Natalie R Hasbani, Gabrielle Shakt, Alanna C Morrison, Noah L Tsao, Renae Judy, Braxton D Mitchell, Huichun Xu, May E Montasser, Ron Do, Eimear E Kenny, Ruth J F Loos, James G Terry, John Jeffrey Carr, Joshua C Bis, Bruce M Psaty, W T Longstreth, Kendra A Young, Sharon M Lutz, Michael H Cho, Jai Broome, Alyna T Khan, Fei Fei Wang, Nancy Heard-Costa, Sudha Seshadri, Ramachandran S Vasan, Nicholette D Palmer, Barry I Freedman, Donald W Bowden, Lisa R Yanek, Brian G Kral, Lewis C Becker, Patricia A Peyser, Lawrence F Bielak, Farah Ammous, April P Carson, Michael E Hall, Laura M Raffield, Stephen S Rich, Wendy S Post, Russel P Tracy, Kent D Taylor, Xiuqing Guo, Michael C Mahaney, Joanne E Curran, John Blangero, Shoa L Clarke, Jeffrey W Haessler, Yao Hu, Themistocles L Assimes, Charles Kooperberg, Scott M Damrauer, Jerome I Rotter, Paul S de Vries, Martin Dichgans
BACKGROUND: The CCL2/CCR2 axis governs monocyte trafficking and recruitment to atherosclerotic lesions. Human genetic analyses and population-based studies support an association between circulating CCL2 levels and atherosclerosis. Still, it remains unknown whether pharmacological targeting of CCR2, the main CCL2 receptor, would provide protection against human atherosclerotic disease. METHODS: In whole-exome sequencing data from 454,775 UK Biobank participants (40-69 years), we identified predicted loss-of-function (LoF) or damaging missense (REVEL score >0...
August 16, 2023: medRxiv
#22
JOURNAL ARTICLE
Lingqiong Meng, Xiangbing Wang, Jeffrey L Carson, Yvette Schlussel, Sue A Shapses
CONTEXT: Hip fracture is a serious injury that can lead to increased morbidity and mortality. Vitamin D binding protein (DBP) could be a prognostic indicator of outcomes since it is important for actin scavenging and inflammation after tissue injury. OBJECTIVE: To determine whether circulating DBP is associated with mobility or mortality after hip fracture and its association with acute tissue injury markers. DESIGN AND PARTICIPANTS: A post-hoc analysis of a prospective study of 260 patients with hip fracture and mobility at 30-d and 60-d and mortality at 60-d after repair surgery...
August 26, 2023: Journal of Clinical Endocrinology and Metabolism
#23
JOURNAL ARTICLE
Amena Keshawarz, Helena Bui, Roby Joehanes, Jiantao Ma, Chunyu Liu, Tianxiao Huan, Shih-Jen Hwang, Brandon Tejada, Meera Sooda, Paul Courchesne, Peter J Munson, Cumhur Y Demirkale, Chen Yao, Nancy L Heard-Costa, Achilleas N Pitsillides, Honghuang Lin, Ching-Ti Liu, Yuxuan Wang, Gina M Peloso, Jessica Lundin, Jeffrey Haessler, Zhaohui Du, Michael Cho, Craig P Hersh, Peter Castaldi, Laura M Raffield, Jia Wen, Yun Li, Alexander P Reiner, Mike Feolo, Nataliya Sharopova, Ramachandran S Vasan, Dawn L DeMeo, April P Carson, Charles Kooperberg, Daniel Levy
Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood DNA methylation and RNA sequencing gene expression data in 2115 Framingham Heart Study participants. We identified 70,047 significant cis CpG-transcript pairs at p < 1E-7 where the top most significant eGenes (i.e., gene transcripts associated with a CpG) were enriched in biological pathways related to cell signaling, and for 1208 clinical traits (enrichment false discovery rate [FDR] ≤ 0...
August 10, 2023: Scientific Reports
#24
JOURNAL ARTICLE
Abigail J S Armstrong, Daniel B Horton, Tracy Andrews, Patricia Greenberg, Jason Roy, Maria Laura Gennaro, Jeffrey L Carson, Reynold A Panettieri, Emily S Barrett, Martin J Blaser
BACKGROUND: The clinical outcomes of SARS-CoV-2 infection vary in severity, potentially influenced by the resident human microbiota. There is limited consensus on conserved microbiome changes in response to SARS-CoV-2 infection, with many studies focusing on severely ill individuals. This study aimed to assess the variation in the upper respiratory tract microbiome using saliva specimens in a cohort of individuals with primarily mild to moderate disease. METHODS: In early 2020, a cohort of 831 adults without known SARS-CoV-2 infection was followed over a six-month period to assess the occurrence and natural history of SARS-CoV-2 infection...
July 22, 2023: EBioMedicine
#25
REVIEW
Sanjay Jain, Liming Pei, Jeffrey M Spraggins, Michael Angelo, James P Carson, Nils Gehlenborg, Fiona Ginty, Joana P Gonçalves, James S Hagood, John W Hickey, Neil L Kelleher, Louise C Laurent, Shin Lin, Yiing Lin, Huiping Liu, Alexandra Naba, Ernesto S Nakayasu, Wei-Jun Qian, Andrea Radtke, Paul Robson, Brent R Stockwell, Raf Van de Plas, Ioannis S Vlachos, Mowei Zhou, Katy Börner, Michael P Snyder
The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale spatial atlas of the healthy human body at single-cell resolution by applying advanced technologies and disseminating resources to the community. As the HuBMAP moves past its first phase, creating ontologies, protocols and pipelines, this Perspective introduces the production phase: the generation of reference spatial maps of functional tissue units across many organs from diverse populations and the creation of mapping tools and infrastructure to advance biomedical research...
August 2023: Nature Cell Biology
#26
Yuxuan Wang, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Jacob A Holdcraft, Donna K Arnett, Joshua C Bis, John Blangero, Eric Boerwinkle, Donald W Bowden, Brian E Cade, Jenna C Carlson, April P Carson, Yii-Der Ida Chen, Joanne E Curran, Paul S de Vries, Susan K Dutcher, Patrick T Ellinor, James S Floyd, Myriam Fornage, Barry I Freedman, Stacey Gabriel, Soren Germer, Richard A Gibbs, Xiuqing Guo, Jiang He, Nancy Heard-Costa, Bertha Hildalgo, Lifang Hou, Marguerite R Irvin, Roby Joehanes, Robert C Kaplan, Sharon Lr Kardia, Tanika N Kelly, Ryan Kim, Charles Kooperberg, Brian G Kral, Daniel Levy, Changwei Li, Chunyu Liu, Don Lloyd-Jone, Ruth Jf Loos, Michael C Mahaney, Lisa W Martin, Rasika A Mathias, Ryan L Minster, Braxton D Mitchell, May E Montasser, Alanna C Morrison, Joanne M Murabito, Take Naseri, Jeffrey R O'Connell, Nicholette D Palmer, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Dabeeru C Rao, Susan Redline, Alexander P Reiner, Stephen S Rich, Muagututi'a Sefuiva Ruepena, Wayne H-H Sheu, Jennifer A Smith, Albert Smith, Hemant K Tiwari, Michael Y Tsai, Karine A Viaud-Martinez, Zhe Wang, Lisa R Yanek, Wei Zhao, Jerome I Rotter, Xihong Lin, Pradeep Natarajan, Gina M Peloso
Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions. Large-scale whole genome sequencing (WGS) studies and new statistical methods for variant set tests now provide an opportunity to assess the associations between rare variants in lncRNA genes and complex traits across the genome. In this study, we used high-coverage WGS from 66,329 participants of diverse ancestries with blood lipid levels (LDL-C, HDL-C, TC, and TG) in the National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) program to investigate the role of lncRNAs in lipid variability...
June 29, 2023: medRxiv
#27
JOURNAL ARTICLE
Daniel Y Chu, Nagesh Adluru, Veena A Nair, Timothy Choi, Anusha Adluru, Camille Garcia-Ramos, Kevin Dabbs, Jedidiah Mathis, Andrew S Nencka, Carson Gundlach, Lisa Conant, Jeffrey R Binder, Mary E Meyerand, Andrew L Alexander, Aaron F Struck, Bruce Hermann, Vivek Prabhakaran
OBJECTIVE: Social determinants of health, including the effects of neighborhood disadvantage, impact epilepsy prevalence, treatment, and outcomes. This study characterized the association between aberrant white matter connectivity in temporal lobe epilepsy (TLE) and disadvantage using a US census-based neighborhood disadvantage metric, the Area Deprivation Index (ADI), derived from measures of income, education, employment, and housing quality. METHODS: Participants including 74 TLE patients (47 male, mean age=39...
June 27, 2023: Epilepsia
#28
JOURNAL ARTICLE
Kyra O'Brien, Rui Feng, Frederick Sieber, Edward R Marcantonio, Ann Tierney, Jay Magaziner, Jeffrey L Carson, Derek Dillane, Daniel I Sessler, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S Schwenk, Mitchell Marshall, J Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A Hoeft, Jason Karlawish, Samir Mehta, Derek J Donegan, Annamarie Horan, Susan S Ellenberg, Mark D Neuman
INTRODUCTION: The effect of spinal versus general anesthesia on the risk of postoperative delirium or other outcomes for patients with or without cognitive impairment (including dementia) is unknown. METHODS: Post hoc secondary analysis of a multicenter pragmatic trial comparing spinal versus general anesthesia for adults aged 50 years or older undergoing hip fracture surgery. RESULTS: Among patients randomized to spinal versus general anesthesia, new or worsened delirium occurred in 100/295 (33...
May 12, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#29
EDITORIAL
Nareg H Roubinian, Jeffrey L Carson
No abstract text is available yet for this article.
May 2023: Blood Transfusion
#30
JOURNAL ARTICLE
Andrea E Glassmire, Walter P Carson, Angela M Smilanich, Lora A Richards, Christopher S Jeffrey, Craig D Dodson, Casey S Philbin, Garcia L Humberto, Lee A Dyer
Intraspecific phytochemical variation across a landscape can cascade up trophic levels, potentially mediating the composition of entire insect communities. Surprisingly, we have little understanding of the processes that regulate and maintain phytochemical variation within species, likely because these processes are complex and operate simultaneously both temporally and spatially. To assess how phytochemistry varies within species, we tested the degree to which resource availability, contrasting soil type, and herbivory generate intraspecific chemical variation in growth and defense of the tropical shrub, Piper imperiale (Piperaceae)...
April 12, 2023: Oecologia
#31
JOURNAL ARTICLE
Joshua S Carson, Jeffrey E Carter, William L Hickerson, Lisa Rae, Syed F Saquib, Lucy A Wibbenmeyer, Russell V Becker, Jeremiah A Sparks, Thomas P Walsh
BACKGROUND: Autologous skin cell suspension (ASCS) is a treatment for acute thermal burn injuries associated with significantly lower donor skin requirements than conventional split-thickness skin grafts (STSG). Projections using the BEACON model suggest that among patients with small burns (total body surface area [TBSA]<20 %), use of ASCS± STSG leads to a shorter length of stay (LOS) in hospital and cost savings compared with use of STSG alone. This study evaluated whether data from real-world clinical practice corroborate these findings...
December 5, 2022: Burns
#32
JOURNAL ARTICLE
Panos Kougias, Zhibao Mi, Min Zhan, Jeffrey L Carson, Hasan Dosluoglu, Peter Nelson, George A Sarosi, Shipra Arya, L Erin Norman, Sherene Sharath, Alexandra Scrymgeour, Jade Ollison, Lawrence A Calais, Kousick Biswas
BACKGROUND: There is substantial uncertainty regarding the effects of restrictive postoperative transfusion among patients who have underlying cardiovascular disease. The TOP Trial's objective is to compare adverse outcomes between liberal and restrictive transfusion strategies in patients undergoing vascular and general surgery operations, and with a high risk of postoperative cardiac events. METHODS: A two-arm, single-blinded, randomized controlled superiority trial will be used across 15 Veterans Affairs hospitals with expected enrollment of 1520 participants...
March 2023: Contemporary Clinical Trials
#33
JOURNAL ARTICLE
Mark D Neuman, Susan S Ellenberg, Jeffrey L Carson, Frederick E Sieber
No abstract text is available yet for this article.
January 2023: Annals of Internal Medicine
#34
JOURNAL ARTICLE
Matthew C Mauck, Jeffrey Lotz, Matthew A Psioda, Timothy S Carey, Daniel J Clauw, Sharmila Majumdar, William S Marras, Nam Vo, Ayleen Aylward, Anna Hoffmeyer, Patricia Zheng, Anastasia Ivanova, Micah McCumber, Christiane Carson, Kevin J Anstrom, Anton E Bowden, Diane Dalton, Leslie Derr, Jonathan Dufour, Aaron J Fields, Julie Fritz, Afton L Hassett, Steven E Harte, Trisha F Hue, Roland Krug, Marco L Loggia, Prasath Mageswaran, Samuel A McLean, Ulrike H Mitchell, Conor O'Neill, Valentina Pedoia, David Adam Quirk, Daniel I Rhon, Viola Rieke, Lubdha Shah, Gwendolyn Sowa, Brennan Spiegel, Ajay D Wasan, Hsiao-Ying Monica Wey, Lisa LaVange
In 2019, the National Health Interview survey found that nearly 59% of adults reported pain some, most, or every day in the past 3 months, with 39% reporting back pain, making back pain the most prevalent source of pain, and a significant issue among adults. Often, identifying a direct, treatable cause for back pain is challenging, especially as it is often attributed to complex, multifaceted issues involving biological, psychological, and social components. Due to the difficulty in treating the true cause of chronic low back pain (cLBP), an over-reliance on opioid pain medications among cLBP patients has developed, which is associated with increased prevalence of opioid use disorder and increased risk of death...
January 9, 2023: Pain Medicine
#35
JOURNAL ARTICLE
Jeffrey L Carson
No abstract text is available yet for this article.
December 2022: Transfusion
#36
JOURNAL ARTICLE
Jeffrey L Carson, Maria Mori Brooks, Bernard R Chaitman, John H Alexander, Shaun G Goodman, Marnie Bertolet, J Dawn Abbott, Howard A Cooper, Sunil V Rao, Darrell J Triulzi, Dean A Fergusson, William J Kostis, Helaine Noveck, Tabassome Simon, Philippe Gabriel Steg, Andrew P DeFilippis, Andrew M Goldsweig, Renato D Lopes, Harvey White, Caroline Alsweiler, Erin Morton, Paul C Hébert, On-Behalf-Of-The-Mint-Investigators
BACKGROUND: Accumulating evidence from clinical trials suggests that a lower (restrictive) hemoglobin threshold (<8% g/dL) for red blood cell (RBC) transfusion, compared with a higher (liberal) threshold (≥10 g/dL) is safe. However, in anemic patients with acute myocardial infarction (MI), maintaining a higher hemoglobin level may increase oxygen delivery to vulnerable myocardium resulting in improved clinical outcomes. Conversely, RBC transfusion may result in increased blood viscosity, vascular inflammation, and reduction in available nitric oxide resulting in worse clinical outcomes...
November 20, 2022: American Heart Journal
#37
COMMENT
Chintan V Dave, Gary M Brittenham, Jeffrey L Carson, Soko Setoguchi
No abstract text is available yet for this article.
November 2022: Annals of Internal Medicine
#38
JOURNAL ARTICLE
Jeffrey L Carson, Gary M Brittenham
Severe anemia is commonly treated with red blood cell transfusion. Clinical trials have demonstrated that a restrictive transfusion strategy of 7 to 8 g/dL is as safe as a liberal transfusion strategy of 9 to 10 g/dL in many clinical settings. Evidence is lacking for subgroups of patients, including those with preexisting coronary artery disease, acute myocardial infarction, congestive heart failure, and myelodysplastic neoplasms. We present 3 clinical vignettes that highlight the clinical challenges in caring for patients with coronary artery disease with gastrointestinal bleeding, congestive heart failure, or myelodysplastic neoplasms...
August 31, 2023: Blood
#39
JOURNAL ARTICLE
Connor Yanchus, Kristen L Drucker, Thomas M Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B De Lorenzo, Asma Ali, Paul A Decker, Matt L Kosel, Arijit Panda, Khalid N Al-Zahrani, Lingyan Jiang, Jared W L Browning, Chris Lowden, Michael Geuenich, J Javier Hernandez, Jessica T Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Daniel J Murphy, Liguo Wang, Alexej Abyzov, James W Dennis, Philipp G Maass, Kieran Campbell, Michael D Wilson, Daniel H Lachance, Margaret Wrensch, John Wiencke, Tak Mak, Len A Pennacchio, Diane E Dickel, Axel Visel, Jeffrey Wrana, Michael D Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M Ida, Evgeny Z Kvon, Robert B Jenkins, Daniel Schramek
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) -mutant low-grade glioma (LGG). We reveal that rs55705857 itself is the causal variant and is associated with molecular pathways that drive LGG. Mechanistically, we show that rs55705857 resides within a brain-specific enhancer, where the risk allele disrupts OCT2/4 binding, allowing increased interaction with the Myc promoter and increased Myc expression...
October 7, 2022: Science
#40
JOURNAL ARTICLE
Jeffrey E Carter, Joshua S Carson, William L Hickerson, Lisa Rae, Syed F Saquib, Lucy A Wibbenmeyer, Russell V Becker, Thomas P Walsh, Jeremiah A Sparks
INTRODUCTION: Autologous skin cell suspension (ASCS) significantly reduces donor skin requirements versus conventional split-thickness skin grafts (STSG) for thermal burn treatment. In analyses using the Burn-medical counter measure Effectiveness Assessment Cost Outcomes Nexus (BEACON) model, ASCS was associated with shorter hospital length of stay (LOS) and cost savings versus STSG. This study hypothesized that daily practice data from the USA would support these findings. METHODS: Electronic medical record data from 500 healthcare facilities (January 2019-August 2020) were used to match adult patients who received inpatient burn treatment with ASCS (± STSG) to patients treated with STSG alone on the basis of sex, age, percent total body surface area (TBSA), and comorbidities...
September 14, 2022: Advances in Therapy
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