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Developmental reflex

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https://www.readbyqxmd.com/read/29290148/who-do-we-think-we-are-disrupting-notions-of-quality-in-qualitative-research
#1
Jennifer Mitchell, Nicholas Boettcher-Sheard, Camille Duque, Bonnie Lashewicz
The purpose of this article is to illuminate our troubles with, and troubling of, the trustworthiness dimension of balancing subjectivity and reflexivity, in qualitative research. This article evolved from debriefing sessions between three novice researchers working on a qualitative research study aimed at building understandings of the relational dynamics between adults with developmental disability diagnoses (ADevD) and their caregiving families. Following data collection, coauthors discussed interview experiences they had personally found challenging...
December 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29275446/distinct-expression-of-phenotypic-markers-in-placodes-and-neural-crest-derived-afferent-neurons-innervating-the-rat-stomach
#2
Alzbeta Trancikova, Eva Kovacova, Fei Ru, Kristian Varga, Mariana Brozmanova, Milos Tatar, Marian Kollarik
BACKGROUND: Visceral pain is initiated by activation of primary afferent neurons among which the capsaicin-sensitive (TRPV1-positive) neurons play an important role. The stomach is a common source of visceral pain. Similar to other organs, the stomach receives dual spinal and vagal afferent innervation. Developmentally, spinal dorsal root ganglia (DRG) and vagal jugular neurons originate from embryonic neural crest and vagal nodose neurons originate from placodes. In thoracic organs the neural crest- and placodes-derived TRPV1-positive neurons have distinct phenotypes differing in activation profile, neurotrophic regulation and reflex responses...
December 23, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29275070/parent-participation-in-the-neonatal-intensive-care-unit-predictors-and-relationships-to-neurobehavior-and-developmental-outcomes
#3
Roberta Pineda, Joy Bender, Bailey Hall, Lisa Shabosky, Anna Annecca, Joan Smith
OBJECTIVE: To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS: Eighty-one preterm infants born ≤32weeks estimated gestational age were prospectively enrolled within one week of life in a level III-IV NICU. Parent (maternal and paternal) presence and holding (including holding in arms and skin-to-skin care) were tracked throughout NICU hospitalization...
December 21, 2017: Early Human Development
https://www.readbyqxmd.com/read/29274882/neurodevelopment-and-behavior-in-neonatal-oxys-rats-with-genetically-determined-accelerated-senescence
#4
Tatyana N Igonina, Diana S Ragaeva, Maria A Tikhonova, Olga M Petrova, Yuri E Herbeck, Irina N Rozhkova, Tamara G Amstislavskaya, Sergey Ya Amstislavsky
Study of the developmental characteristics and mechanisms of senescence is an important field in brain aging research. The OXYS strain was selected from Wistar rats in Novosibirsk, and it serves as a rat model of accelerated aging. Previously, neurodegenerative processes and aberrant behavior were reported in experiments with adult OXYS rats. In our study, neurodevelopmental reflexes, neuronal density in the prefrontal cortex and hippocampus, and global DNA methylation in the hippocampus are compared between OXYS and WAG (Wistar Albino Glaxo) neonatal pups...
December 21, 2017: Brain Research
https://www.readbyqxmd.com/read/29219953/specific-retinal-phenotype-in-early-iqcb1-related-disease
#5
A Vincent, A AlAli, H MacDonald, C VandenHoven, E Héon
PurposeTo describe the ocular and systemic phenotype in IQCB1-related disease.MethodsFour cases (3 males, 1 female) with molecularly confirmed IQCB1-related disease underwent ophthalmological examination including best-corrected visual acuity (BCVA) measurement, fundus evaluation, electroretinography (ERG), and spectral-domain optical coherence tomography (SD-OCT). Systemic evaluation including abdominal ultrasound was performed in all cases.ResultsBCVA ranged from perception of light (Case-2; 1 year) to 20/125 (Case-1; 9 years)...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29199884/congenital-cavitary-optic-disc-anomaly-and-axenfeld-s-anomaly-in-wolf-hirschhorn-syndrome-a-case-report-and-review-of-the-literature
#6
Mohsin H Ali, Nathalie F Azar, Vinay Aakalu, Felix Y Chau, Javaneh Abbasian, Pete Setabutr, Irene H Maumenee
BACKGROUND: Wolf-Hirschhorn syndrome is a rare genetic syndrome caused by a heterozygous deletion on chromosome 4p16.3 and is characterized by a "Greek warrior helmet" facies, hypotonia, developmental delay, seizures, structural central nervous system defects, intrauterine growth restriction, sketelal anomalies, cardiac defects, abnormal tooth development, and hearing loss. A variety of ocular manifestations may occur in up to 40% of patients. MATERIALS/METHODS: We report the genetic testing results, systemic findings, and complete ophthalmologic examination findings in a patient with Wolf-Hirschhorn syndrome, including external photography, RetCam3 (Clarity Medical Systems, Pleasonton, CA) goniography, and fundus photography...
December 4, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29197524/mercuric-resistant-bacteria-aeromonas-exhibits-neurologic-toxic-effects-on-the-developmental-motor-reflexes-and-brain-oxidative-stress-in-mice-offspring
#7
Mohammad Ahmad
Mercury and its derivatives even in small concentration may cause a major human health problem. Though not reported in detail, there are various aquatic bacterial species that produce small quantities of methyl mercury (MM) growing under aerobic conditions. Consumption of food derived from sources contaminated with such bacteria within therapeutic doses and exposure to different forms of MM compounds through such sources may induce substantial toxic effects. In the present study, the perinatal oral exposure of pregnant mice to two strains of mercury resistant bacteria (MRB), Aeromonas KSU5 MRB and KSU6 MRB resulted in a significant reduction in postnatal body weight gain, delays in the opening of the eyes and appearance in the body hair fuzz, and deficits in the developing sensory motor reflexes in the mice pups during their weaning period on post-natal day (PD)7, PD14 and PD21...
November 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29178965/a-child-with-distal-type-1-renal-tubular-acidosis-presenting-with-progressive-gross-motor-developmental-regression-and-acute-paralysis
#8
Randula Ranawaka, Kavinda Dayasiri, Manoji Gamage
BACKGROUND: Distal (Type 1) renal tubular acidosis (dRTA) is characterized by inability to secrete hydrogen irons from the distal tubule. The aetiology of dRTA is diverse and can be either inherited or acquired. Common clinical presentations of dRTA in the paediatric age group include polyuria, nocturia, failure to thrive, constipation, abnormal breathing and nephrolithiasis. Though persistent hypokalemia is frequently seen in dRTA, hypokalemic muscular paralysis is uncommon and rarely described in children...
November 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29136012/regional-knockdown-of-ndufs4-implicates-a-thalamocortical-circuit-mediating-anesthetic-sensitivity
#9
Renjini Ramadasan-Nair, Jessica Hui, Pavel I Zimin, Leslie S Itsara, Philip G Morgan, Margaret M Sedensky
Knockout of the mitochondrial complex I protein, NDUFS4, profoundly increases sensitivity of mice to volatile anesthetics. In mice carrying an Ndufs4lox/lox gene, adeno-associated virus expressing Cre recombinase was injected into regions of the brain postulated to affect sensitivity to volatile anesthetics. These injections generated otherwise phenotypically wild type mice with region-specific, postnatal inactivation of Ndufs4, minimizing developmental effects of gene loss. Sensitivities to the volatile anesthetics isoflurane and halothane were measured using loss of righting reflex (LORR) and movement in response to tail clamp (TC) as endpoints...
2017: PloS One
https://www.readbyqxmd.com/read/29069391/dimensions-and-intensity-of-inter-professional-teamwork-in-primary-care-evidence-from-five-international-jurisdictions
#10
Jean-Frederic Levesque, Mark F Harris, Cathie Scott, Benjamin Crabtree, William Miller, Lisa M Halma, William E Hogg, Jan-Willem Weenink, Jenny R Advocat, Jane Gunn, Grant Russell
Background: Inter-professional teamwork in primary care settings offers potential benefits for responding to the increasing complexity of patients' needs. While it is a central element in many reforms to primary care delivery, implementing inter-professional teamwork has proven to be more challenging than anticipated. Objective: The objective of this study was to better understand the dimensions and intensity of teamwork and the developmental process involved in creating fully integrated teams...
October 23, 2017: Family Practice
https://www.readbyqxmd.com/read/29036732/predictors-of-poor-outcome-in-neonates-with-pyogenic-meningitis-in-a-level-three-neonatal-intensive-care-unit-of-developing-country
#11
Mala Kumar, Shalini Tripathi, Himanshu Kumar, S N Singh
Background: The mortality of neonatal pyogenic meningitis is reduced to 10-15%, but morbidity is unchanged. Methods: Primary objective is to determine the outcome, i.e. death or abnormal neurological examination (NE) at discharge and abnormal developmental quotient (DQ) at 3 months. Secondary objective is to find predictors of poor outcome. Results: In all, 89 neonates enrolled, 10 expired and 24 neonates had abnormal NE at discharge. A total of 59 neonates came for follow up, 13 had DQ < 70...
September 26, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29035974/altered-ultrasonic-vocalization-in-neonatal-sapap3-deficient-mice
#12
Natalya S Tesdahl, Danielle K King, Latisha N McDaniel, Andrew A Pieper
Ultrasonic vocalizations (USVs) in neonatal mice provide a means of modeling communication deficits in neurodevelopmental disorders. Mature mice deficient in SAP90/PSD95-associated protein 3 (SAPAP3) display compulsive grooming and anxiety-like behavior, conditions that are often associated with neurodevelopmental disorders. To date, however, aspects of neurodevelopment have not been investigated in SAPAP3-deficient mice. Here, we examined whether neonatal SAPAP3-deficient mice display altered USVs. We recorded USVs from 5-day-old sapap3 and sapap3 mice, and also monitored developmental reflexes in these mice during the early postnatal period...
December 6, 2017: Neuroreport
https://www.readbyqxmd.com/read/29020454/the-absence-of-brain-specific-link-protein-bral2-in-perineuronal-nets-hampers-auditory-temporal-resolution-and-neural-adaptation-in-mice
#13
J Popelář, M Díaz Gómez, J Lindovský, N Rybalko, J Burianová, T Oohashi, J Syka
Brain-specific link protein Bral2 represents a substantial component of perineuronal nets (PNNs) enwrapping neurons in the central nervous system. To elucidate the role of Bral2 in auditory signal processing, the hearing function in knockout Bral2(-/-) (KO) mice was investigated using behavioral and electrophysiological methods and compared with wild type Bral2(+/+) (WT) mice. The amplitudes of the acoustic startle reflex (ASR) and the efficiency of the prepulse inhibition of ASR (PPI of ASR), produced by prepulse noise stimulus or gap in continuous noise, was similar in 2-week-old WT and KO mice...
October 11, 2017: Physiological Research
https://www.readbyqxmd.com/read/29017960/upper-respiratory-tract-nociceptor-stimulation-and-stress-response-following-acute-and-repeated-cyfluthrin-inhalation-in-normal-and-pregnant-rats-physiological-rat-specific-adaptions-can-easily-be-misunderstood-as-adversities
#14
Juergen Pauluhn
This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroexcitatory afferent sensory stimulus from peripheral nociceptors in the upper respiratory tract is likely to be perceived as a transient stimulus triggering annoyance and/or avoidance by both rats and humans...
October 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28959195/prenatal-exposure-to-paint-thinner-alters-postnatal-development-and-behavior-in-mice
#15
Hanaa Malloul, Ferdaousse M Mahdani, Mohammed Bennis, Saadia Ba-M'hamed
Occupational exposure and sniffing of volatile organic solvents continue to be a worldwide health problem, raising the risk for teratogenic sequelae of maternal inhalant abuse. Real life exposures usually involve simultaneous exposures to multiple solvents, and almost all the abused solvents contain a mixture of two or more different volatile compounds. However, several studies examined the teratogenicity due to industrial exposure to a single volatile solvent but investigating the teratogenic potential of complex chemical mixture such as thinner remains unexplored...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28955085/menkes-disease-a-rare-disorder
#16
Sidra Kaleem Jafri, Raman Kumar, Shazia Kulsoom Lashari, Prem Chand
Menkes disease (MD) (OMIM: 309400) is also known as kinky hair disease, trichopoliodystrophy, and steely hair. A 7-months-old, male infant presented to our outpatient department in June 2016 with history of developmental delay and seizures. Seizures started at 3 months of age and worsened progressively to clusters of extensor spasms. Physical examination showed sparse and kinky hair. Neurological examination revealed a central hypotonia with marked decrease in muscle power with normal deep tendon reflexes. The serum ceruloplasmin level and serum copper level were decreased...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28931039/abnormalities-in-substance-p-neurokinin-1-receptor-binding-in-key-brainstem-nuclei-in-sudden-infant-death-syndrome-related-to-prematurity-and-sex
#17
Fiona M Bright, Robert Vink, Roger W Byard, Jhodie R Duncan, Henry F Krous, David S Paterson
Sudden infant death syndrome (SIDS) involves failure of arousal to potentially life threatening events, including hypoxia, during sleep. While neuronal dysfunction and abnormalities in neurotransmitter systems within the medulla oblongata have been implicated, the specific pathways associated with autonomic and cardiorespiratory failure are unknown. The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including regulation of respiratory rhythm generation, integration of cardiovascular control, and modulation of the baroreceptor reflex and mediation of the chemoreceptor reflex in response to hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28889966/safety-evaluation-of-supratherapeutic-dose-of-maytenus-ilicifolia-mart-ex-reissek-extracts-on-fertility-and-neurobehavioral-status-of-male-and-pregnant-rats
#18
Assis Ecker, Carla Giane Loss, Stephen A Adefegha, Aline Augusti Boligon, Silvane Souza Roman
Maytenus ilicifolia Mart. ex Reissek is a plant commonly used in folklore medicine in the management of gastric diseases in South America. This study explores the effects of a supratherapeutic dose of aqueous and ethanol extracts of M. ilicifolia (1360 mg/kg) on fertility and neurobehavioral status in male and pregnant rats. A battery of sensory-motor developmental endpoints was carried out to assess impairments on pups of dams orally treated with the aqueous extract of M. ilicifolia during the organogenesis period of pregnancy (GD 9 through GD 14)...
September 7, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28879461/perinatal-exposure-to-the-cyanotoxin-%C3%AE-n-m%C3%A3-thylamino-l-alanine-bmaa-results-in-long-lasting-behavioral-changes-in-offspring-potential-involvement-of-dna-damage-and-oxidative-stress
#19
Anthony Laugeray, Asma Oummadi, Clément Jourdain, Justyne Feat, Géraldine Meyer-Dilhet, Arnaud Menuet, Karen Plé, Marion Gay, Sylvain Routier, Stéphane Mortaud, Gilles J Guillemin
We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like symptoms in offspring later in life. In the present study, we aimed to investigate whether perinatal exposure to another glutamate-related toxicant, the cyanobacterial amino acid β-N-methylamino-L-alanine (BMAA), might also trigger neurodevelopmental disturbances. With this aim, female mice were intranasally exposed to low doses of BMAA, 50 mg kg(-1) three times a week from embryonic days 7-10 to postnatal day 21...
September 6, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28763098/cross-species-comparison-of-behavioral-neurodevelopmental-milestones-in-the-common-marmoset-monkey-and-human-child
#20
Karla K Ausderau, Caitlin Dammann, Kathy McManus, Mary Schneider, Marina E Emborg, Nancy Schultz-Darken
The common marmoset (Callithrix jacchus) is an increasingly popular non-human primate species for developing transgenic and genomic edited models of neurological disorders. These models present an opportunity to assess from birth the impact of genetic mutations and to identify candidate predictive biomarkers of early disease onset. In order to apply findings from marmosets to humans, a cross-species comparison of typical development is essential. Aiming to identify similarities, differences, and gaps in knowledge of neurodevelopment, we evaluated peer-reviewed literature focused on the first 6 months of life of marmosets and compared to humans...
November 2017: Developmental Psychobiology
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