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https://www.readbyqxmd.com/read/29730049/cafeteria-diet-during-the-gestation-period-programs-developmental-and-behavioral-courses-in-the-offspring
#1
Ana Cláudia Alves Freire Ribeiro, Tatiane Helena Batista, Vanessa Barbosa Veronesi, Alexandre Giusti-Paiva, Fabiana Cardoso Vilela
The objective of this study was to investigate the effect of exposure to maternal consumption of a hyperenergetic, highly palatable diet, known as the cafeteria diet, during the gestation period on the development and behavior of offspring. For this, we used pregnant female mice that were fed a normal or a cafeteria diet during the gestation period. The evaluation of maternal behavior in lactating dams was performed from the second to the eighth day postpartum (PND 2 - 8). Weight gain, feed intake, and energy intake were recorded during the gestation period...
May 3, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29714461/the-brazelton-neonatal-behavioral-assessment-scale-a-validity-and-reliability-study-in-a-turkish-sample
#2
Öznur Başdaş, Emine Erdem, Ferhan Elmalı, Selim Kurtoğlu
Background/aim: The aim of the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) is to gather a comprehensive profile of neonatal functioning by describing the full range of neonatal behavior, including competencies and strengths, as well as difficulties or deviations. This instrument has proved to be of great clinical value by detecting infants at risk for later developmental problems. This work was conducted methodologically with the aim of a Turkish validity and reliability study of the BNBAS. Materials and methods: The study was conducted in a large tertiary hospital in Turkey...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29696051/are-there-neurological-symptoms-in-type-1-of-gaucher-disease
#3
Mohammadreza Alaei, Narjes Jafari, Farzaneh Rohani, Farzad Ahmadabadi, Rezvan Azadi
Objective: Gaucher disease (GD) is a rare inborn error of metabolism, classified as a lipid storage disorders. This disease is caused by a deficiency in glucocerebrosidase enzyme. It has been classified according to the presence or absence of neurological symptoms into the following types: type 1 non-neuropathic, type 2 acute infantile neuropathic and type 3 or chronic neuropathic. We evaluated neurological symptoms in patients with GD1 and GD3 and compared both of these groups. Materials & Methods: Eleven patients were identified according to their clinical presentation and the presence of disease confirmed by genetic testing, from 2006-2016, at the Mofid Children Hospital Clinic, Tehran, Iran...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29605507/developmental-dysgraphia-is-often-associated-with-minor-neurological-dysfunction-in-children-with-developmental-coordination-disorder-dcd
#4
Clémence Lopez, Cherhazad Hemimou, Bernard Golse, Laurence Vaivre-Douret
OBJECTIVES: Children with developmental coordination disorder (DCD) are particularly affected by handwriting disorders, which remain poorly understood and are not clearly defined. The aim of our study is to provide a better understanding of handwriting disorders, and specifically of dysgraphia in children with DCD. METHODS: Sixty-five children with DCD (5-15 years), enrolled according to DSM-5, were assessed with handwriting testing and standardized assessments of neuropsychological, neurovisual, MRI and neuropsychomotor functions, with special attention paid to muscular tone examination...
March 28, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29602144/weird-laughing-in-hyperekplexia-a-new-phenotype-associated-with-a-novel-mutation-in-the-glra1-gene
#5
Zhi Huang, Yajun Lian, Hongliang Xu, Haifeng Zhang
Hyperekplexia (HPX) or startle disease is a rare hereditary neurological disorder characterized by generalized stiffness, excessive startle reflex to unexpected stimuli and a short period of generalized stiffness following the startle response, and can be complicated by umbilical or inguinal hernia, developmental delay and apnea spell. HPX is caused mainly by mutations in the GLRA1 gene, and has a good response to clonazepam. In this short communication we describe an 11-year-old girl with excessive startle reflex, weird laughing and developmental delay since early infancy...
March 20, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29576117/a-neurosteroid-analogue-with-t-type-calcium-channel-blocking-properties-is-an-effective-hypnotic-but-is-not-harmful-to-neonatal-rat-brain
#6
N Atluri, S M Joksimovic, A Oklopcic, D Milanovic, J Klawitter, P Eggan, K Krishnan, D F Covey, S M Todorovic, V Jevtovic-Todorovic
BACKGROUND: More than 4 million children are exposed annually to sedatives and general anaesthetics (GAs) in the USA alone. Recent data suggest that common GAs can be detrimental to brain development causing neurodegeneration and long-term cognitive impairments. Challenged by a recent US Food and Drug Administration (FDA) warning about potentially neurotoxic effects of GAs in children, there is an urgent need to develop safer GAs. METHODS: Postnatal Day 7 (P7) rat pups of both sexes were exposed to six (repeated every 2 h) injections of equipotent hypnotic doses of ketamine or the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) for 12 h...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29575996/soleus-h-reflex-and-its-modulation-with-vibration-in-idiopathic-toe-walkers-and-typically-developing-children
#7
Essi Marttinen Rossi, Päivi Nevalainen, Helena Mäenpää, Leena Lauronen
Idiopathic toe walking is a relatively common developmental condition often leading to secondary problems such as pain and muscle contractures in the lower extremities. The cause of idiopathic toe walking is unknown, which hinders the development of treatment strategies. To test whether children with idiopathic toe walking have functional alterations in their spinal motor circuits, we studied the properties of the soleus H-reflex and its modulation with vibration in 26 idiopathic toe walkers and 16 typically developing children...
April 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29571948/neurological-outcome-at-6-and-12-months-corrected-age-in-hospitalised-late-preterm-infants-a-prospective-study
#8
Ilias Chatziioannidis, Maria Kyriakidou, Sotiria Exadaktylou, Evangelia Antoniou, Dimitrios Zafeiriou, Nikolaos Nikolaidis
Late preterm infants (34-0/7 to 36-6/7 weeks" gestation) account for 10-20% of NICU admissions and are at increased risk for morbidity and mortality. Although they are prone to developmental delays, reports on neurological outcome during the first 2 years of life are scarce. The aim of the study was to assess neurological/neuromotor outcome in high risk late preterm infants at 6 and 12 months corrected age and the change in neurological scores over time, and to identify factors associated with the neurological outcome...
March 6, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29571543/dysphagia-in-children
#9
Kimberly L Duffy
Speech-Language Pathologists (SLP) play an integral role in evaluating and treating pediatric patients with dysphagia related to aerodigestive disorders. Non-supportive anatomy, cardio-respiratory and medical status, state control, neurologic functioning, postural stability and control, gastrointestinal functioning, hunger and satiation, developmental abilities, oral-motor skills, oral/pharyngeal reflexes, airway protection and secretion management can create barriers to successful oral feeding. Swallowing is broken down into four phases and difficulties can occur during any phase or in combination with another phase of swallowing...
March 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29560119/hcn-channels-contribute-to-the-sensitivity-of-intravenous-anesthetics-in-developmental-mice
#10
Jie Gao, Zhiqiang Hu, Liwei Shi, Na Li, Yeling Ouyang, Shaofang Shu, Shanglong Yao, Xiangdong Chen
It is widely accepted that the induction dose of anesthetics is higher in infants than in adults, although the relevant molecular mechanism remains elusive. We previously showed neuronal hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to hypnotic actions of propofol and ketamine. Interestingly, the expression of HCN channels in neocortex significantly changes during postnatal periods. Thus, we postulated that changes in HCN channels expression might contribute to sensitivity to intravenous anesthetics...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29501972/reactive-balance-performance-and-neuromuscular-and-cognitive-responses-to-unpredictable-balance-perturbations-in-children-with-developmental-coordination-disorder
#11
Yoyo T Y Cheng, William W N Tsang, Catherine Mary Schooling, Shirley S M Fong
Developmental coordination disorder (DCD) is a common motor disorder affecting balance performance. However, few studies have investigated reactive balance performance and the underlying mechanisms in children with DCD. This study aimed to compare the reactive balance performance, lower limb muscle reflex contraction latency and attention level in response to unpredictable balance perturbations between 100 typically developing children and 120 children with DCD (with and without comorbid autism spectrum disorder) aged 6-9 years...
March 1, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29457651/progressive-recruitment-of-contralesional-cortico-reticulospinal-pathways-drives-motor-impairment-post-stroke
#12
Jacob G McPherson, Albert Chen, Michael D Ellis, Jun Yao, C J Heckman, Julius P A Dewald
KEY POINTS: Activation of the shoulder abductor muscles in the arm opposite a unilateral brain injury causes involuntary increases in elbow, wrist and finger flexion in the same arm, a phenomenon referred to as the flexion synergy. It has been proposed that flexion synergy expression is related to reduced output from ipsilesional motor cortex and corticospinal pathways. In this human subjects study, we provide evidence that the magnitude of flexion synergy expression is instead related to a progressive, task-dependent recruitment of contralesional cortex...
April 1, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29437246/early-movement-restriction-leads-to-enduring-disorders-in-muscle-and-locomotion
#13
Maxime Delcour, Vicky S Massicotte, Michaël Russier, Hélène Bras, Julie Peyronnet, Marie-Hélène Canu, Florence Cayetanot, Mary F Barbe, Jacques-Olivier Coq
Motor control and body representation in the central nervous system (CNS) as well as musculoskeletal architecture and physiology are shaped during development by sensorimotor experience and feedback, but the emergence of locomotor disorders during maturation and their persistence over time remain a matter of debate in the absence of brain damage. By using transient immobilization of the hind limbs, we investigated the enduring impact of postnatal sensorimotor restriction (SMR) on gait and posture on treadmill, age-related changes in locomotion, musculoskeletal histopathology and Hoffmann reflex in adult rats without brain damage...
February 13, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29421768/developmental-neurotoxicity-in-the-progeny-after-maternal-gavage-with-chlorpyrifos
#14
Bérengère Laporte, Jérôme Gay-Quéheillard, Véronique Bach, Anne-Sophie Villégier
Today, developmental intellectual disorders affect one out of six children in industrialised countries. Intensively used in agriculture, the neurotoxicant pesticide chlorpyrifos (CPF) is known for its environmental persistence and bioaccumulation. Its role has not yet been established in the aetiology of intellectual impairments. Here we assessed whether maternal ingestion of low CPF dose in rats could impair the cerebral function of their progeny. Rat dams received daily CPF exposures (1 mg/kg, per os) during gestation and lactation...
March 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29379379/cardamom-elettaria-cardamomum-perinatal-exposure-effects-on-the-development-behavior-and-biochemical-parameters-in-mice-offspring
#15
Gasem Mohammad Abu-Taweel
Cardamom is a strong antioxidant plant, so it is called the queen of spices. In the present study, we explored the potentials of cardamom on developmental, learning ability and biochemical parameters of mice offspring. Thirty pregnant mice were allocated to three groups of ten animals in each. Groups Π and Ш received pilsbury's Diet containing 10 and 20% of cardamom (w/w) respectively, whereas Group I used as control. Cardomom was administered from the first day of pregnancy and was continued until post-natal day 15 (PD 15) and thereafter the mothers were switched to plain pilsbury's Diet...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29377096/delayed-myelination-and-neurodevelopment-in-male-seizure-prone-versus-seizure-resistant-rats
#16
Pragati Sharma, Kim L Powell, Mary E Wlodek, Terence J O'Brien, Krista L Gilby
OBJECTIVE: Aberrant myelination and developmental delay have been reported in epilepsy. However, it is unclear whether these are linked to intrinsic mechanisms that support a predisposition toward seizures and the development of epilepsy. Thus, we compared rates of myelination and neurodevelopment in male rats selectively bred for enhanced susceptibility to kindling epileptogenesis (FAST) with male rats bred for resistance (SLOW). METHODS: Myelin-specific gene expression was compared in the brainstem, cerebellum, and cerebral hemisphere of FAST and SLOW rats on postnatal days (PNDs) 5, 11, 17, 23, and 90 to determine strain-specific myelination rates...
April 2018: Epilepsia
https://www.readbyqxmd.com/read/29364251/swarmsight-real-time-tracking-of-insect-antenna-movements-and-proboscis-extension-reflex-using-a-common-preparation-and-conventional-hardware
#17
Justas Birgiolas, Christopher M Jernigan, Richard C Gerkin, Brian H Smith, Sharon M Crook
Many scientifically and agriculturally important insects use antennae to detect the presence of volatile chemical compounds and extend their proboscis during feeding. The ability to rapidly obtain high-resolution measurements of natural antenna and proboscis movements and assess how they change in response to chemical, developmental, and genetic manipulations can aid the understanding of insect behavior. By extending our previous work on assessing aggregate insect swarm or animal group movements from natural and laboratory videos using the video analysis software SwarmSight, we developed a novel, free, and open-source software module, SwarmSight Appendage Tracking (SwarmSight...
December 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29290148/who-do-we-think-we-are-disrupting-notions-of-quality-in-qualitative-research
#18
Jennifer Mitchell, Nicholas Boettcher-Sheard, Camille Duque, Bonnie Lashewicz
The purpose of this article is to illuminate our troubles with, and troubling of, the trustworthiness dimension of balancing subjectivity and reflexivity, in qualitative research. This article evolved from debriefing sessions between three novice researchers working on a qualitative research study aimed at building understandings of the relational dynamics between adults with developmental disability diagnoses (ADevD) and their caregiving families. Following data collection, coauthors discussed interview experiences they had personally found challenging...
March 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29275446/distinct-expression-of-phenotypic-markers-in-placodes-and-neural-crest-derived-afferent-neurons-innervating-the-rat-stomach
#19
Alzbeta Trancikova, Eva Kovacova, Fei Ru, Kristian Varga, Mariana Brozmanova, Milos Tatar, Marian Kollarik
BACKGROUND: Visceral pain is initiated by activation of primary afferent neurons among which the capsaicin-sensitive (TRPV1-positive) neurons play an important role. The stomach is a common source of visceral pain. Similar to other organs, the stomach receives dual spinal and vagal afferent innervation. Developmentally, spinal dorsal root ganglia (DRG) and vagal jugular neurons originate from embryonic neural crest and vagal nodose neurons originate from placodes. In thoracic organs the neural crest- and placodes-derived TRPV1-positive neurons have distinct phenotypes differing in activation profile, neurotrophic regulation and reflex responses...
February 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29275070/parent-participation-in-the-neonatal-intensive-care-unit-predictors-and-relationships-to-neurobehavior-and-developmental-outcomes
#20
Roberta Pineda, Joy Bender, Bailey Hall, Lisa Shabosky, Anna Annecca, Joan Smith
OBJECTIVE: To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS: Eighty-one preterm infants born ≤32weeks estimated gestational age were prospectively enrolled within one week of life in a level III-IV NICU. Parent (maternal and paternal) presence and holding (including holding in arms and skin-to-skin care) were tracked throughout NICU hospitalization...
February 2018: Early Human Development
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