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aripiprazole hyperprolactinemia

Keiko Naono-Nagatomo, Hisao Naono, Hiroshi Abe, Ryuichiro Takeda, Hideki Funahashi, Daisuke Uchimura, Yasushi Ishida
AIM: Aripiprazole (ARP) is a popular antipsychotic drug that has demonstrated ameliorative effects on hyperprolactinemia. However, no study to date has studied the utility of ARP in patients with a long history of schizophrenia and antipsychotic treatment. We therefore examined the effect of partial antipsychotic regimen replacement with ARP on hyperprolactinemia induced by chronic antipsychotic use in patients with schizophrenia. METHODS: Sixteen patients with a schizophrenia diagnosis (F2) based on the International Classification of Diseases (version 10) were recruited...
February 2017: Asian Journal of Psychiatry
Ángel L Montejo, Celso Arango, Miquel Bernardo, José L Carrasco, Benidicto Crespo-Facorro, Juan J Cruz, Javier Del Pino-Montes, Miguel A García-Escudero, Clemente García-Rizo, Ana González-Pinto, Ana I Hernández, Manuel Martín-Carrasco, Fermín Mayoral-Cleries, Jaqueline Mayoral-van Son, M Teresa Mories, Isabella Pachiarotti, Jesús Pérez, Salvador Ros, Eduard Vieta
Hyperprolactinemia is an underappreciated/unknown adverse effects of antipsychotics. The consequences of hyperprolactinemia compromise therapeutic adherence and can be serious. We present the consensus recommendations made by a group of experts regarding the management of antipsychotic-induced hyperprolactinemia. The current consensus was developed in 3 phases: 1, review of the scientific literature; 2, subsequent round table discussion to attempt to reach a consensus among the experts; and 3, review by all of the authors of the final conclusions until reaching a complete consensus...
April 2017: Frontiers in Neuroendocrinology
Benedicto Crespo-Facorro, Victor Ortiz-Garcia de la Foz, Paula Suarez-Pinilla, Elsa M Valdizan, Rocío Pérez-Iglesias, Jose Antonio Amado-Señaris, M Teresa Garcia-Unzueta, Javier Labad, Christopher Correll, Rosa Ayesa-Arriola
RATIONALE: Hyperprolactinemia is considered a troubling adverse effect of antipsychotics. Direct comparisons among second generation antipsychotics are scant in clinical practice. We hypothesize prolactin-sparing second-generation antipsychotics may have differential effects on prolactin levels and that they may be influenced by sex. OBJECTIVES: To explore the differential effect of three widely used prolactin-sparing antipsychotics, aripiprazole, quetiapine and ziprasidone, on prolactin plasma levels in first episode non-affective psychosis during a 1year of treatment...
February 17, 2017: Schizophrenia Research
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
Feng-Rong An, Rui Yang, Zhi-Min Wang, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Ping-Ping Wu, Xin Jin, Lu Li, Grace K I Lok, Yu-Tao Xiang
PURPOSE: To examine the frequency of hyperprolactinemia and the socio-demographic, clinical, and quality of life (QOL) correlates. The frequency of prolactin-related side effects and associated subjective experiences were also examined. METHODS: A cohort of 1364 psychiatric inpatients were consecutively recruited and evaluated. Basic socio-demographic and clinical data were collected. Psychopathology, prolactin-related side effects were measured using standardized instruments...
November 2016: Comprehensive Psychiatry
Hui Woo Yoon, Jung Suk Lee, Sang Jin Park, Seon-Koo Lee, Won-Jung Choi, Tae Yong Kim, Chang Hyung Hong, Jeong-Ho Seok, Il-Ho Park, Sang Joon Son, Daeyoung Roh, Bo-Ra Kim, Byung Ook Lee
OBJECTIVES: Hyperprolactinemia is an important but often overlooked adverse effect of antipsychotics. Several studies have shown that switching to or adding aripiprazole normalizes antipsychotic-induced hyperprolactinemia. However, no study has directly compared the effectiveness and safety of the 2 strategies. METHODS: A total of 52 patients with antipsychotic-induced hyperprolactinemia were recruited. Aripiprazole was administered to patients with mild hyperprolactinemia (serum prolactin level < 50 ng/mL)...
November 2016: Clinical Neuropharmacology
Sam Padamadan Joseph
Hyperprolactinemia is a common adverse effect of antipsychotic medication. Switching over to aripiprazole or adjunctive aripiprazole has been advocated for optimal management of antipsychotic-induced hyperprolactinemia. Adjunctive treatment with aripiprazole has been shown to normalize prolactin levels without affecting already achieved improvements in psychotic symptoms. However, here, we present the case of a 36 year old female with delusional disorder who developed symptomatic hyperprolactinemia while on aripiprazole treatment...
May 2016: Indian Journal of Psychological Medicine
Rintaro Sogawa, Yuki Shimomura, Chikako Minami, Joji Maruo, Yutaka Kunitake, Yoshito Mizoguchi, Toshiro Kawashima, Akira Monji, Hideo Hara
BACKGROUND: The increase in prolactin (PRL) levels is a common adverse effect that occurs when using conventional and atypical antipsychotic drugs. Aripiprazole (ARI) is beneficial for antipsychotic-associated hyperprolactinemia but has been reported to decrease PRL secretion. Therefore, we investigated blood levels of PRL in patients who had taken ARI alone or in combination with other antipsychotics. METHODS: Retrospective information was obtained from 25 psychiatric patients who were prescribed ARI, and the blood levels of PRL were measured...
August 2016: Journal of Clinical Psychopharmacology
Rebecca L Curran, Ismail A Badran, Virginia Peppers, Ernest V Pedapati, Christoph U Correll, Melissa P DelBello
No abstract text is available yet for this article.
June 2016: Journal of Child and Adolescent Psychopharmacology
Young-Min Park, Seung-Hwan Lee, Bun-Hee Lee, Kyu Young Lee, Kye-Seong Lee, Seung-Gul Kang, Hwa-Young Lee, Won Kim
The aims of this study were to clarify whether atypical antipsychotics can elevate serum levels of both macroprolactin and prolactin, and whether the macroprolactin levels differ according to the type of atypical antipsychotic being taken. In total, 245 subjects were enrolled consecutively in 6 hospitals. Serum prolactin and macroprolactin levels were measured at a single time point during maintenance antipsychotic monotherapy. The mean total serum prolactin levels including macroprolactin were 11.91, 20.73, 16...
May 30, 2016: Psychiatry Research
S S Potanin, D S Burminsky, M A Morozova, A I Platova, N V Baymeeva, I I Miroshnichenko
OBJECTIVE: To study a relationship between plasma levels of antipsychotics (AP) and severity of side-effects (SE) during the treatment of inpatients with exacerbation of schizophrenia. MATERIAL AND METHODS: The study included 39 patients treated with risperidone, haloperidol, zuclopenthixol, clozapine, aripiprazole or olanzapine as monotherapy or in combination of two AP. Blood sampling to measure the AP plasma level was performed twice (at 7-10 and 26-30 day from start of treatment), the levels of prolactin and glucose were determined once (at 26-30 day from start of treatment)...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
D Mété, C Dafreville, V Paitel, P Wind
INTRODUCTION: Aripiprazole, an atypical or second-generation antipsychotic, is usually well tolerated. It is an approved treatment for schizophrenia and mania in bipolar disorder type 1. Unlike the other antipsychotics, it has high affinity agonist properties for dopamine D2 and D3 receptors. It has also 5-HT1A partial agonist and 5-HT2A antagonist properties. Aripiprazole is a first or second line treatment frequently used because it has reduced side effects such as weight gain, sleepiness, dyslipidemia, insulin resistance, hyperprolactinemia and extrapyramidal symptoms...
June 2016: L'Encéphale
Ying Qiao, Fuzhong Yang, Chunbo Li, Qian Guo, Hui Wen, Suoyu Zhu, Qiong Ouyang, Weidi Shen, Jianhua Sheng
This study investigated the effects of a low-dose aripiprazole adjunctive treatment for risperidone- or paliperidone-induced hyperprolactinemia in Han Chinese women with schizophrenia. After 4 weeks of risperidone or paliperidone treatment, 60 out of 66 patients improved significantly and experienced hyperprolactinemia. They were randomly assigned to the treatment group (aripiprazole adjunctive treatment) (n=30) or control group (non-adjunctive treatment) (n=30). The dosage of risperidone and paliperidone were maintained; and aripiprazole was maintained at 5mg/day during the 8-week study period...
March 30, 2016: Psychiatry Research
Martina Meduri, Giorgia Gregoraci, Valentina Baglivo, Matteo Balestrieri, Miriam Isola, Paolo Brambilla
BACKGROUND: Aripiprazole (ARP) has been shown to be effective in the treatment of bipolar disorder (BD). However, no prior investigation considered both randomized clinical trials (RCTs) and non-RCTs. We here evaluated the efficacy and safety of ARP compared with placebo (PCB) and other drugs at 3- and 12-weeks in adult and pediatric population including, for the first time, both observational and controlled studies. METHODS: All studies were systematically located by searching electronic sources (EMBASE, MEDLINE, CINHAIL, PsychINFO, Cochrane Central Register of Controlled Trials, Scopus and ClinicalTrials...
February 2016: Journal of Affective Disorders
Lisa Burback
UNLABELLED: A previously healthy 32-year-old woman developed cyclical mood swings after being prescribed cabergoline for a pituitary microprolactinoma. These mood swings persisted for over 2 years, at which point she developed an acute manic episode with psychotic features and was admitted to a psychiatry unit. Cabergoline was discontinued and replaced with aripiprazole 10 mg/day. Her manic episode quickly resolved, and she was discharged within 6 days of admission. The aripiprazole suppressed her prolactin levels for over 18 months of follow-up, even after the dose was lowered to 2 mg/day...
2015: Endocrinology, Diabetes & Metabolism Case Reports
Jingyuan Zhao, Xueqin Song, Xiaoqing Ai, Xiaojing Gu, Guangbiao Huang, Xue Li, Lijuan Pang, Minli Ding, Shuang Ding, Luxian Lv
OBJECTIVE: The present study aimed to evaluate the efficacy and safety of adjunctive aripiprazole treatment in schizophrenia patients with risperidone-induced hyperprolactinemia. METHODS: One hundred and thirteen patients who were receiving a stable dose of risperidone were randomly assigned to either adjunctive aripiprazole treatment (10 mg/day) (aripiprazole group) or no additional treatment (control group) at a 1:1 ratio for 8 weeks. Schizophrenia symptoms were measured using the Positive and Negative Syndrome Scale (PANSS)...
2015: PloS One
Jing-Xu Chen, Yun-Ai Su, Qing-Tao Bian, Li-He Wei, Rong-Zhen Zhang, Yan-Hong Liu, Christoph Correll, Jair C Soares, Fu-De Yang, Shao-Li Wang, Xiang-Yang Zhang
Hyperprolactinemia is an unwanted adverse effect associated with several antipsychotics. The addition of partial dopamine receptor agonist aripiprazole may attenuate antipsychotic-induced hyperprolactinemia effectively. However, the ideal dosing regimen for this purpose is unknown. We aimed to evaluate the dose effects of adjunctive treatment with aripiprazole on prolactin levels and hyperprolactinemia in schizophrenia patients. Stable subjects 18-45 years old with schizophrenia and hyperprolactinemia (i.e...
August 2015: Psychoneuroendocrinology
Isabella Pacchiarotti, Andrea Murru, Georgios D Kotzalidis, C Mar Bonnin, Lorenzo Mazzarini, Francesc Colom, Eduard Vieta
Drug-induced changes in serum prolactin (sPrl) levels constitute a relevant issue due to the potentially severe consequences on physical health of psychiatric patients such as sexual dysfunctions, osteoporosis and Prl-sensitive tumors. Several drugs have been associated to sPrl changes. Only antipsychotics have been extensively studied as sPrl-elevating agents in schizophrenia, but the extent to which bipolar disorder (BD) treatments affect sPrl levels is much less known. The objective of this systematic review is to summarize the evidence of the effects of drugs used in BD on Prl...
August 2015: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Meiling Meng, Wei Li, Shaowei Zhang, Hongyan Wang, Jianhua Sheng, Jijun Wang, Chunbo Li
BACKGROUND: Hyperprolactinemia (HPL) is a common side effect of antipsychotic medications. Recent reports suggest that aripiprazole can ameliorate antipsychotic-induced HPL, but results are inconsistent and the single available systematic review only considered five studies. AIM: Conduct an updated meta-analysis of all randomized controlled trials (RCTs) about the efficacy and safety of aripiprazole as an adjunctive treatment for antipsychotic-induced hyperprolactinemia...
February 25, 2015: Shanghai Archives of Psychiatry
Fatemeh Ranjbar, Homayoun Sadeghi-Bazargani, Parisa Niari Khams, Asghar Arfaie, Azim Salari, Mostafa Farahbakhsh
BACKGROUND: Antipsychotics have been used for more than 50 years in the treatment of schizophrenia and many other psychiatric disorders. Prolactin levels usually increase in patients treated with risperidone. Aripiprazole, which has a unique effect as an antipsychotic, is a D2 receptor partial agonist. It is an atypical antipsychotic with limited extrapyramidal symptoms. Since it acts as an antagonist in hyperdopaminergic conditions and as an agonist in hypodopaminergic conditions, it does not have adverse effects on serum prolactin levels...
2015: Neuropsychiatric Disease and Treatment
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