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Contrast induced nephropathy

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https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#1
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
October 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038896/inducible-atf3-nfat-axis-aggravates-podocyte-injury
#2
Hong Zhang, Shun Liang, Yue Du, Ruizhao Li, Chaosheng He, Wenjian Wang, Shuangxin Liu, Zhiming Ye, Xinling Liang, Wei Shi, Bin Zhang
Podocyte injury and loss contribute to proteinuria, glomerulosclerosis, and eventually kidney failure. Activating transcription factor 3 (ATF3) is a stress inducible transcription factor that is transiently expressed following stimulation. However, we show for the first time an induction of ATF3 in podocytes from patients with chronic kidney disease, including minimal change disease, focal segmental glomerulosclerosis, and diabetic nephropathy. The role of ATF3 induction in podocytes under chronic conditions is currently unknown...
October 16, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29035878/resveratrol-ameliorates-contrast-induced-nephropathy-through-the-activation-of-sirt1-pgc-1%C3%AE-foxo1-signaling-in-mice
#3
Yu Ah Hong, So Yeon Bae, Shin Young Ahn, Jieun Kim, Young Joo Kwon, Woon Yong Jung, Gang Jee Ko
BACKGROUND/AIMS: SIRT1 activation promotes the resistance of renal tubular cells to oxidative stress, and resveratrol is known as a SIRT1 activator. METHODS: Resveratrol was injected intraperitoneally with iohexol for 24 hours. NRK-52E cells were pretreated with resveratrol for 24 hours and then exposed to iohexol for 3 hours. Renal function was measured by serum creatinine and cell survival was assessed by MTT assay. We investigated whether resveratrol attenuates oxidative stress and apoptosis in contrast-induced nephropathy (CIN)...
October 13, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29033366/the-bermuda-triangle-chronic-kidney-disease-contrast-induced-nephropathy-and-atrial-fibrillation
#4
Ahmed Shawky Elserafy
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29024304/efficacy-of-alprostadil-in-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention-a-multicenter-prospective-randomized-controlled-trial
#5
Min Liang, Shicheng Yang, Naikuan Fu, Chengzhi Lu, Fengshi Tian, Xiaochun Xing, Wenhua Lin, Jingjing Liu
BACKGROUND: The role of alprostadil on the prevention of contrast-induced nephropathy (CIN) still remains controversial. The purpose of this study was to examine the effects of short-term alprostadil on the incidence of CIN in patients undergoing elective percutaneous coronary intervention (PCI). METHODS: A total of 480 patients with coronary heart disease undergoing PCI were enrolled in our study and randomly assigned to two groups. The control group (n = 240) was given only hydration therapy and the alprostadil group (n = 240) received intravenous administration of 20 ug/day (diluted with 100 ml normal saline) from 0...
October 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28986810/recent-advances-in-chinese-medicine-for-contrast-induced-nephropathy
#6
Xue-Zhong Gong
No abstract text is available yet for this article.
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28986808/contrast-induced-nephropathy-time-for-western-medicine-and-chinese-medicine-to-team-up
#7
Svante Norgren, Xue-Zhong Gong
No abstract text is available yet for this article.
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28980300/cha2ds2-vasc-score-predicts-contrast-induced-nephropathy-in-patients-with-st-segment-elevation-myocardial-infarction-who-were-undergoing-primary-percutaneous-coronary-intervention
#8
Gokhan Cicek, Ersin Yıldırım
BACKGROUND: We aimed to investigate the predictive value of the CHA₂DS₂-VASc score in the development of Contrast Induced Nephropathy (CIN). METHODS: A total of 2972 patients who had been diagnosed with ST elevation-MI and who had undergone primary coronary angioplasty were included in the study. The patients were divided into 3 groups according to the CHA₂DS₂-VASc score as low risk (1 point), intermediate risk (2 points) and high risk (≥3 points). The groups were followed-up with regard to CIN development...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28974245/dose-escalation-study-of-intravenous-and-intra-arterial-n-acetylcysteine-for-the-prevention-of-oto-and-nephrotoxicity-of-cisplatin-with-a-contrast-induced-nephropathy-model-in-patients-with-renal-insufficiency
#9
Edit Dósa, Krisztina Heltai, Tamás Radovits, Gabriella Molnár, Judit Kapocsi, Béla Merkely, Rongwei Fu, Nancy D Doolittle, Gerda B Tóth, Zachary Urdang, Edward A Neuwelt
BACKGROUND: Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, and overall quality of life. The blood-labyrinth barrier is somewhat permeable to cisplatin, and sensory hair cells and cochlear supporting cells are highly sensitive to this toxic drug. Several chemoprotective agents such as N-acetylcysteine (NAC) were utilized experimentally to avoid these potentially serious and life-long side effects, although no clinical phase I trial was performed before...
October 3, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28964467/safety-of-contrast-material-use-in-children
#10
REVIEW
Bruno P Soares, Maarten H Lequin, Thierry A G M Huisman
Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity...
November 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28956474/effect-of-atrial-fibrillation-on-contrast-induced-nephropathy-development-in-patients-with-non-st-segment-elevation-myocardial-infarction
#11
Bariş Düzel, Sadik Volkan Emren, Rida Berilgen
We investigated the relationship between atrial fibrillation (AF) and contrast-induced nephropathy (CIN) in patients with non-ST-segment elevation myocardial infarction (NSTEMI); 1045 consecutive patients undergoing percutaneous coronary interventions were enrolled. Risk factors for CIN were investigated. Baseline characteristics, except oral anticoagulant use, were similar between patients with and without AF. Patients with CIN show higher presence of diabetes mellitus (DM), coronary artery bypass graft surgery history, Mehran score, baseline creatinine levels, baseline glomerular filtration rate (GFR), peak troponin levels, left ventricular ejection fraction (LVEF), and presence of AF ( P < ...
November 2017: Angiology
https://www.readbyqxmd.com/read/28951244/tyrosines-740-751-of-pdgfr%C3%AE-contribute-to-the-activation-of-akt-hif1%C3%AE-tgf%C3%AE-nexus-to-drive-high-glucose-induced-glomerular-mesangial-cell-hypertrophy
#12
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Glomerular mesangial cell hypertrophy contributes to the complications of diabetic nephropathy. The mechanism by which high glucose induces mesangial cell hypertrophy is poorly understood. Here we explored the role of the platelet-derived growth factor receptor-β (PDGFRβ) tyrosine kinase in driving the high glucose-induced mesangial cell hypertrophy. We show that high glucose stimulates the association of the PDGFRβ with PI 3 kinase leading to tyrosine phosphorylation of the latter. High glucose-induced Akt kinase activation was also dependent upon PDGFRβ and its tyrosine phosphorylation at 740/751 residues...
September 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28950711/effect-of-nicorandil-administration-on-preventing-contrast-induced-nephropathy-a-meta-analysis
#13
Biming Zhan, Xiao Huang, Long Jiang, Huihui Bao, XiaoShu Cheng
Several studies have investigated the effect of nicorandil on contrast-induced nephropathy (CIN) in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). However, the final results of these trials are not identical. This meta-analysis evaluated the role of nicorandil administration on CIN prevention. We searched databases to find randomized controlled trial (RCT) comparing nicorandil with hydration versus conventional hydration therapy on preventing CIN. Finally, 5 articles (805 patients) were included in our meta-analysis; the data showed that nicorandil was related to significant reduction in the risk of CIN (risk ratio = 0...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28946776/complications-and-perioperative-management-of-patients-undergoing-thoracic-endovascular-aortic-repair
#14
Anna P Sattah, Michael H Secrist, Shawn Sarin
Endovascular treatments have become increasingly common for patients with a variety of thoracic aortic pathologies. Although considered less invasive than traditional open surgical approaches, they are nonetheless complex procedures. Patients undergo manipulation of an often calcified aorta near the origin of the carotid and subclavian vessels and have stents placed in a curved vessel adjacent to a perpetually beating heart. These stents can obstruct blood flow to the spinal cord, induce an inflammatory response, and in rare cases erode into the adjacent trachea or esophagus...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28946773/response-to-the-letter-to-the-editor-n-acetylcysteine-and-contrast-induced-nephropathy
#15
Xi-Peng Sun, Jing Li, Wei-Wei Zhu, Dong-Bao Li, Hui Chen, Hong-Wei Li, Wen-Ming Chen, Qi Hua
No abstract text is available yet for this article.
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28944925/autophagy-is-activated-to-protect-renal-tubular-epithelial-cells-against-iodinated-contrast-media%C3%A2-induced-cytotoxicity
#16
Na Liu, Rong Lei, Mi-Mi Tang, Wei Cheng, Min Luo, Qian Xu, Shao-Bin Duan
With the steady increase in the use of various contrast‑related technologies in recent years, contrast‑induced nephropathy has received significant attention from clinicians and researchers. The present study aimed to determine the potential role of autophagy in iodinated contrast media (CM)‑induced cell injury and apoptosis in human proximal renal tubular epithelial HK‑2 cells. The present study used the iodinated CM iohexol (200 mg iodine/ml) to treat HK‑2 cells for 6 h, in order to establish a damaged cell model...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944839/alteration-of-oxidative-stress-and-inflammatory-cytokines-induces-apoptosis-in-diabetic-nephropathy
#17
Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
Diabetic nephropathy (DN) is one of the most significant long‑term complications in terms of morbidity and mortality for diabetic patients; however, the exact cause remains unknown. To address this, the DN model was established, and oxidative stress indexes, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px), and inflammatory cytokines, includinginterleukin‑6 (IL‑6), tumor necrosis factor‑alpha (TNF‑α) and transforming growth factor‑beta (TGF‑β), were examined by ELISA...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28939956/radial-access-protects-from-contrast-media-induced-nephropathy-after-cardiac-catheterization-procedures
#18
Thorsten Feldkamp, Maya Luedemann, Martina E Spehlmann, Sandra Freitag-Wolf, Julia Gaensbacher, Kevin Schulte, Amer Bajrovic, Dieter Hinzmann, Hans-Joerg Hippe, Ulrich Kunzendorf, Norbert Frey, Mark Luedde
OBJECTIVES: To assess, whether cardiac catheterization via radial access prevents contrast-induced nephropathy. BACKGROUND: Contrast-induced nephropathy (CIN) is a major clinical problem which accounts for more than 10% of acute kidney injury cases in hospitalized patients. Protective measures such as the infusion of isotonic saline solution or acetylcysteine have not consistently been proven to prevent acute kidney injury (AKI). However, there is growing evidence that radial access for coronary angiography and coronary intervention is associated with a lower incidence of AKI compared to femoral access...
September 22, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28914202/statins-and-contrast-induced-nephropathy-a-systematic-review-and-meta-analysis
#19
Alexandros Briasoulis, Mohan Pala, Tesfaye Telila, Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi, Evangelos Oikonomou, Dimitris Tousoulis
Contrast-induced nephropathy (CIN) is a type of acute kidney injury associated with intravascular administration of iodinated contrast, usually reversible. Contrast agents are an essential component of invasive and noninvasive coronary angiography. These agents have been modified over time to enhance patient safety and tolerability, but adverse reactions still occur. CIN has been variably defined, as a rise in serum creatinine of 0.5 mg/dl, or a 25% increase in serum creatinine above baseline within 24-72 hours after the procedure...
September 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28912882/atorvastatin-alleviates-iodinated-contrast-media-induced-cytotoxicity-in-human-proximal-renal-tubular-epithelial-cells
#20
Gai-Ling Liu, Rong Lei, Shao-Bin Duan, Mi-Mi Tang, Min Luo, Qian Xu
Contrast media (CM)-induced nephropathy (CIN) is a serious complication of intravascularly applied radiocontrast media. At present, no drugs have been approved for the prevention of CIN. The present study aimed to explore the effects and potential mechanisms of atorvastatin on iodinated CM-induced cytotoxicity in the human proximal renal tubular epithelial cells. The cytotoxic effect of iohexol (50, 100 and 200 mg I/ml) and the protective effect of atorvastatin pretreatment (1, 20 and 40 µM) were assessed...
October 2017: Experimental and Therapeutic Medicine
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