Daniel A Jones, Anne-Marie Beirne, Matthew Kelham, Lucinda Wynne, Mervyn Andiapen, Krishnaraj S Rathod, Tipparat Parakaw, Jessica Adams, Annastazia Learoyd, Kamran Khan, Thomas Godec, Paul Wright, Sotiris Antoniou, Andrew Wragg, Muhammad Yaqoob, Anthony Mathur, Amrita Ahluwalia
BACKGROUND AND AIMS: Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-risk patients and remains a significant unmet need. In pre-clinical studies inorganic nitrate, which is chemically reduced in vivo to nitric oxide, is renoprotective but this observation is yet to be translated clinically. In this study, the efficacy of inorganic nitrate in the prevention of CIN in high-risk patients presenting with acute coronary syndromes (ACS) is reported...
March 21, 2024: European Heart Journal