keyword
https://read.qxmd.com/read/38536498/effect-of-vitamin-d3-supplementation-on-blood-parameters-and-liver-gene-expression-in-female-rats
#21
JOURNAL ARTICLE
Maria Oczkowicz, Beata Szymczyk, Małgorzata Świątkiewicz, Alicja Wierzbicka, Anna Steg, Tomasz Szmatoła
BACKGROUND: To better understand the molecular mechanism responsible for the therapeutic potential of vitamin D, we conducted an analysis of the liver transcriptomes of adult female rats. METHODS: Adult female rats (n = 18) were divided into three groups, receiving different doses of vitamin D: group I, 0; group II, 1000 U/kg; and group III, 5000 U/kg. Growth, body weight, the weight of main organs, blood haematological and biochemical parameters were evaluated...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536494/the-role-of-na-coupled-bicarbonate-transporters-ncbt-in-health-and-disease
#22
REVIEW
Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero
Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3 - ) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial...
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38536086/frailty-as-a-comprehensive-health-measure-beyond-seizure-control-in-patients-with-epilepsy-a-cross-sectional-study
#23
JOURNAL ARTICLE
Emanuele Cerulli Irelli, Maria S Borioni, Alessandra Morano, Adolfo Mazzeo, Pierludovico Moro, Biagio Orlando, Enrico M Salamone, Luca Giordano, Alessio Petrungaro, Marco Toccaceli Blasi, Anna T Giallonardo, Marco Canevelli, Carlo Di Bonaventura
OBJECTIVE: Due to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty is increasingly recognized in various medical disciplines as a useful construct to understand differences in susceptibility to adverse outcomes. Here, we develop a frailty index (FI) for patients with epilepsy (PwE) and explore its association with demographic and clinical features. METHODS: In this cross-sectional study, we consecutively enrolled 153 PwE from an outpatient epilepsy clinic...
March 27, 2024: Epilepsia
https://read.qxmd.com/read/38536056/plant-soil-interactions-during-the-native-and-exotic-range-expansion-of-an-annual-plant
#24
JOURNAL ARTICLE
Nicky Lustenhouwer, Tom M R Chaubet, Miranda K Melen, Wim H van der Putten, Ingrid M Parker
Range expansions, whether they are biological invasions or climate change-mediated range shifts, may have profound ecological and evolutionary consequences for plant-soil interactions. Range-expanding plants encounter soil biota with which they have a limited coevolutionary history, especially when introduced to a new continent. Past studies have found mixed results on whether plants experience positive or negative soil feedback interactions in their novel range, and these effects often change over time. One important theoretical explanation is that plants locally adapt to the soil pathogens and mutualists in their novel range...
March 27, 2024: Journal of Evolutionary Biology
https://read.qxmd.com/read/38536012/development-of-a-tannic-acid-and-silicate-ion-functionalized-pva-starch-composite-hydrogel-for-in-situ-skeletal-muscle-repairing
#25
JOURNAL ARTICLE
Longkang Li, Huipeng Li, Zhentian Diao, Huan Zhou, Yanjie Bai, Lei Yang
The repair capacity of skeletal muscle is severely diminished in massive skeletal muscle injuries accompanied by inflammation, resulting in muscle function loss and scar tissue formation. In the current work, we developed a tannic acid (TA)- and silicate ion-functionalized tissue adhesive poly(vinyl alcohol) (PVA)-starch composite hydrogel, referred to as PSTS (PVA-starch-TA-SiO3 2- ). It was formed based on the hydrogen bonding of TA to organic polymers, as well as silicate-TA ligand interaction. PSTS could be gelatinized in minutes at room temperature with crosslinked network formation, making it applicable for injection...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38536003/unconventional-superconducting-diode-effects-via-antisymmetry-and-antisymmetry-breaking
#26
JOURNAL ARTICLE
Chong Li, Yang-Yang Lyu, Wen-Cheng Yue, Peiyuan Huang, Haojie Li, Tianyu Li, Chen-Guang Wang, Zixiong Yuan, Ying Dong, Xiaoyu Ma, Xuecou Tu, Tao Tao, Sining Dong, Liang He, Xiaoqing Jia, Guozhu Sun, Lin Kang, Huabing Wang, Francois M Peeters, Milorad V Milošević, Peiheng Wu, Yong-Lei Wang
Symmetry breaking plays a pivotal role in unlocking intriguing properties and functionalities in material systems. For example, the breaking of spatial and temporal symmetries leads to a fascinating phenomenon: the superconducting diode effect. However, generating and precisely controlling the superconducting diode effect pose significant challenges. Here, we take a novel route with the deliberate manipulation of magnetic charge potentials to realize unconventional superconducting flux-quantum diode effects...
March 27, 2024: Nano Letters
https://read.qxmd.com/read/38535921/microarray-and-functional-pathway-analyses-revealed-significantly-elevated-gene-expressions-associated-with-metabolic-resistance-to-oxamyl-vydate-in-lygus-lineolaris
#27
JOURNAL ARTICLE
Yu-Cheng Zhu, Yuzhe Du, Xiaofen Liu, Maribel Portilla, Jian Chen, Yanhua Wang
The tarnished plant bug (TPB, Lygus lineolaris ) remains a major pest for a variety of crops. Frequent sprays on row crops, especially cotton, prompted resistance development in field populations. To maintain chemical control as an effective tool against the pest, knowledge of global gene regulations is desirable for better understanding and managing the resistance. Novel microarray expressions of 6688 genes showed 685 significantly upregulated and 1382 significantly downregulated genes in oxamyl-selected TPBs (Vyd1515FF[R]) from a cotton field...
February 28, 2024: Toxics
https://read.qxmd.com/read/38535825/comprehensive-analysis-of-bufadienolide-and-protein-profiles-of-gland-secretions-from-medicinal-bufo-species
#28
JOURNAL ARTICLE
Yunge Fang, Liangmian Chen, Pengfei Wang, Yating Liu, Yuxiu Wang, Zhimin Wang, Yue Ma, Huimin Gao
Toad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeared on the market, posing challenges to its quality control. In order to develop an efficient, feasible, and comprehensive approach to evaluate TV quality, a thorough analysis and comparison of chemical compounds among legal species BgC and BmS, as well as the main confusion species B...
March 20, 2024: Toxins
https://read.qxmd.com/read/38535824/dietary-exposure-and-risk-assessment-of-multi-mycotoxins-afb1-afm1-ota-otb-don-t-2-and-ht-2-in-the-lebanese-food-basket-consumed-by-adults-findings-from-the-updated-lebanese-national-consumption-survey-through-a-total-diet-study-approach
#29
JOURNAL ARTICLE
Maha Hoteit, Zahraa Abbass, Rouaa Daou, Nikolaos Tzenios, Lamis Chmeis, Joyce Haddad, Mohamad Chahine, Elham Al Manasfi, Abdulrahman Chahine, Omasyarifa Binti Jamal Poh, André El Khoury
Mycotoxins have been linked to adverse health impacts, including liver cancer and kidney diseases. The objectives of the current study were to evaluate the dietary exposure of Lebanese adults to multi-mycotoxins (aflatoxin B1 (AFB1), aflatoxin M1 (AFM1), ochratoxin A (OTA), ochratoxin B (OTB), deoxynivalenol (DON), T-2 and HT-2) and to assess their associated health risks. Hence, a nationally representative sample of 449 participants aged 18-64 years old were interviewed to obtain their socio-demographic characteristics, food consumption data and exposure estimates...
March 19, 2024: Toxins
https://read.qxmd.com/read/38535823/paradoxical-exception-to-island-tameness-increased-defensiveness-in-an-insular-population-of-rattlesnakes
#30
JOURNAL ARTICLE
William K Hayes, Carl E Person, Gerad A Fox, Julie L King, Erick Briggs, Eric C K Gren
Island tameness results largely from a lack of natural predators. Because some insular rattlesnake populations lack functional rattles, presumably the consequence of relaxed selection from reduced predation, we hypothesized that the Santa Catalina Island, California, USA, population of the southern Pacific rattlesnake ( Crotalus helleri , which possesses a functional rattle), would exhibit a decrement in defensive behavior relative to their mainland counterparts. Contrary to our prediction, rattlesnakes from the island not only lacked tameness compared to mainland snakes, but instead exhibited measurably greater levels of defensiveness...
March 18, 2024: Toxins
https://read.qxmd.com/read/38535820/the-effects-of-t-2-toxin-deoxynivalenol-and-fumonisin-b1-on-oxidative-stress-related-genes-in-the-kidneys-of-laying-hens
#31
JOURNAL ARTICLE
Benjamin Kövesi, Szabina Kulcsár, Zsolt Ancsin, Márta Erdélyi, Erika Zándoki, Patrik Gömbös, Krisztián Balogh, Miklós Mézes
In the context of nephrotoxic risks associated with environmental contaminants, this study focused on the impact of mycotoxin exposure on the renal health of laying hens, with particular attention to oxidative stress pathways. Sixty laying hens were assigned to three groups-a control group (CON), a low-dose mycotoxin group (LOW), and a high-dose mycotoxin group (HIGH)-and monitored for 72 h. Mycotoxin contamination involved T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, and FB1 at their EU-recommended levels (low mix) and at double doses (high mix)...
March 16, 2024: Toxins
https://read.qxmd.com/read/38535819/botulinum-toxin-for-pain-relief-in-cancer-patients-a-systematic-review-of-randomized-controlled-trials
#32
REVIEW
Lorenzo Lippi, Alessandro de Sire, Alessio Turco, Martina Ferrillo, Serdar Kesikburun, Alessio Baricich, Stefano Carda, Marco Invernizzi
Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, their role in these patients is still debated. Thus, this systematic review of randomized controlled trials aimed at assessing the effects of BoNT treatment for cancer pain to guide physicians in an evidence-based approach integrating BoNT in cancer care. Out of 5824 records, 10 RCTs satisfied our eligibility criteria and were included in the present work for a total of 413 subjects with several cancer types (breast, head and neck, esophageal, and thoracic/gastric cancers)...
March 15, 2024: Toxins
https://read.qxmd.com/read/38535815/integration-of-multi-omics-histological-and-biochemical-analysis-reveals-the-toxic-responses-of-nile-tilapia-liver-to-chronic-microcystin-lr-exposure
#33
JOURNAL ARTICLE
Yichao Li, Huici Yang, Bing Fu, Gen Kaneko, Hongyan Li, Jingjing Tian, Guangjun Wang, Mingken Wei, Jun Xie, Ermeng Yu
Microcystin-LR (MC-LR) is a cyanobacterial metabolite produced during cyanobacterial blooms and is toxic to aquatic animals, and the liver is the main targeted organ of MC-LR. To comprehensively understand the toxicity mechanism of chronic exposure to environmental levels of MC-LR on the liver of fish, juvenile Nile tilapia were exposed to 0 μg/L (control), 1 μg/L (M1), 3 μg/L (M3), 10 μg/L (M10), and 30 μg/L (M30) MC-LR for 60 days. Then, the liver hepatotoxicity induced by MC-LR exposure was systematically evaluated via histological and biochemical determinations, and the underlying mechanisms were explored through combining analysis of biochemical parameters, multi-omics (transcriptome and metabolome), and gene expression...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535810/environmental-toxin-biliatresone-induced-biliary-atresia-like-abnormal-cilia-and-bile-duct-cell-development-of-human-liver-organoids
#34
JOURNAL ARTICLE
Yue Hai-Bing, Menon Sudheer Sivasankaran, Babu Rosana Ottakandathil, Wu Zhong-Luan, So Man-Ting, Chung Patrick Ho-Yu, Wong Kenneth Kak-Yuen, Tam Paul Kwong-Hang, Lui Vincent Chi-Hang
Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns. Biliatresone, a plant toxin, causes BA-like syndrome in some animals, but its relevance in humans is unknown. To validate the hypothesis that biliatresone exposure is a plausible BA disease mechanism in humans, we treated normal human liver organoids with biliatresone and addressed its adverse effects on organoid development, functions and cellular organization. The control organoids (without biliatresone) were well expanded and much bigger than biliatresone-treated organoids...
March 11, 2024: Toxins
https://read.qxmd.com/read/38535807/inhibition-of-aflatoxin-production-in-aspergillus-flavus-by-a-klebsiella-sp-and-its-metabolite-cyclo-l-ala-gly
#35
JOURNAL ARTICLE
Shohei Sakuda, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa
During an experiment where we were cultivating aflatoxigenic Aspergillus flavus on peanuts, we accidentally discovered that a bacterium adhering to the peanut strongly inhibited aflatoxin (AF) production by A. flavus . The bacterium, isolated and identified as Klebsiella aerogenes , was found to produce an AF production inhibitor. Cyclo(l-Ala-Gly), isolated from the bacterial culture supernatant, was the main active component. The aflatoxin production-inhibitory activity of cyclo(l-Ala-Gly) has not been reported...
March 8, 2024: Toxins
https://read.qxmd.com/read/38535800/insecticidal-effects-of-transgenic-maize-bt-cry1ab-bt-vip3aa-and-bt-cry1ab-vip3aa-against-the-oriental-armyworm-mythimna-separata-walker-in-southwest-china
#36
JOURNAL ARTICLE
Zhenghao Zhang, Xianming Yang, Wenhui Wang, Kongming Wu
The oriental armyworm, Mythimna separata (Walker), an important migratory pest of maize and wheat, is posing a severe threat to maize production in Asian countries. As source areas of spring-summer emigratory populations, the control of M. separata in southwestern China is of great significance for East Asian maize production. To assess the toxicity of Bt maize against the pest, bioassays of Bt-(Cry1Ab+Vip3Aa) maize (event DBN3601T), Bt-Cry1Ab maize (event DBN9936), and Bt-Vip3Aa maize (event DBN9501) were conducted in Yunnan province of southwest China...
March 4, 2024: Toxins
https://read.qxmd.com/read/38535795/detection-of-anatoxins-in-human-urine-by-liquid-chromatography-triple-quadrupole-mass-spectrometry-and-elisa
#37
JOURNAL ARTICLE
Brady R Cunningham, Sarah R Lagon, William A Bragg, Donna Hill, Elizabeth I Hamelin
Harmful cyanobacterial blooms are becoming more common and persistent around the world. When in bloom, various cyanobacterial strains can produce anatoxins in high concentrations, which, unlike other cyanobacterial toxins, may be present in clear water. Potential human and animal exposures to anatoxins occur mainly through unintentional ingestion of contaminated algal mats and water. To address this public health threat, we developed and validated an LC-MS/MS method to detect anatoxins in human urine to confirm exposures...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535788/assessment-of-the-impact-of-humic-acids-on-intestinal-microbiota-gut-integrity-ileum-morphometry-and-cellular-immunity-of-turkey-poults-fed-an-aflatoxin-b-1-contaminated-diet
#38
JOURNAL ARTICLE
Jesús A Maguey-González, Jing Liu, Guolong Zhang, Juan D Latorre, Juan O Hernández-Ramírez, María de Jesús Nava-Ramírez, Roberto Senas-Cuesta, Sergio Gómez-Rosales, María de Lourdes Ángeles, Andressa Stein, Bruno Solís-Cruz, Daniel Hernández-Patlán, Rubén Merino-Guzmán, Xochitl Hernandez-Velasco, Inkar Castellanos-Huerta, Santiago Uribe-Diaz, Alma Vázquez-Durán, Abraham Méndez-Albores, Victor M Petrone-Garcia, Guillermo Tellez, Billy M Hargis, Guillermo Téllez-Isaías
A recent study published data on the growth performance, relative weights of the organs of the gastrointestinal tract, liver histology, serum biochemistry, and hematological parameters for turkey poults fed an experimental diet contaminated with aflatoxin B1 (AFB1 ) and humic acids (HA) extracted from vermicompost. The negative effects of AFB1 (250 ng AFB1 /g of feed) were significantly reduced by HA supplementation (0.25% w / w ), suggesting that HA might be utilized to ameliorate the negative impact of AFB1 from contaminated diets...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535787/alleviative-effect-of-rutin-on-zearalenone-induced-reproductive-toxicity-in-male-mice-by-preventing-spermatogenic-cell-apoptosis-and-modulating-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis
#39
JOURNAL ARTICLE
Hira Sayed, Qiongqiong Zhang, Yu Tang, Yanan Wang, Yongpeng Guo, Jianyun Zhang, Cheng Ji, Qiugang Ma, Lihong Zhao
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin found in many agricultural products and can cause reproductive disorders, mainly affecting spermatogenesis in male animals. Rutin (RUT) is a natural flavonoid compound recognized for its significant antioxidant, anti-inflammatory and estrogenic properties. The present study aimed to determine the protective role of RUT against ZEN-induced reproductive toxicity in male mice. Twenty-four adult Kunming male mice were divided into four groups: control, RUT (500 mg/kg RUT), ZEN (10 mg/kg ZEN), ZEN + RUT (500 mg/kg RUT + 10 mg/kg ZEN), with six replicates per treatment...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535784/association-of-urinary-mycotoxins-with-sperm-quality-a-case-control-study-in-southern-nigeria
#40
JOURNAL ARTICLE
Friday Ebhodaghe Okonofua, Lorretta Favour Chizomam Ntoimo, Emmanuel Iyayi Unuabonah, Titus Afred Makudali Msagati, Oladiran Ayodeji, Michael Aziken, Akhere Omonkhua, Victor Ohenhen, Celestina Olafusi, Moses O Alfred
The objective of this study was to determine the association between mycotoxins and the quality of spermatozoa in Nigeria. We designed a prospective case-control study involving 136 men diagnosed with reduced sperm count and quality in five infertility clinics in southwest Nigeria and 154 normal fertile controls. Sperm analysis was conducted in accordance with the recommendations of the World Health OrganizationWHO, while Liquid Chromatography-Mass Spectrometry was used to assay three metabolites of mycotoxins (zearalenone, ochratoxin A, and deoxyvinelol) in the urine samples of cases and controls...
February 29, 2024: Toxins
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