keyword
MENU ▼
Read by QxMD icon Read
search

biological control

keyword
https://www.readbyqxmd.com/read/29684898/isotopic-evidence-for-enhanced-fossil-fuel-sources-of-aerosol-ammonium-in-the-urban-atmosphere
#1
Yuepeng Pan, Shili Tian, Dongwei Liu, Yunting Fang, Xiaying Zhu, Meng Gao, Jian Gao, Greg Michalski, Yuesi Wang
The sources of aerosol ammonium (NH4 + ) are of interest because of the potential of NH4 + to impact the Earth's radiative balance, as well as human health and biological diversity. Isotopic source apportionment of aerosol NH4 + is challenging in the urban atmosphere, which has excess ammonia (NH3 ) and where nitrogen isotopic fractionation commonly occurs. Based on year-round isotopic measurements in urban Beijing, we show the source dependence of the isotopic abundance of aerosol NH4 + , with isotopically light (-33...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684873/seabird-colonies-as-relevant-sources-of-pollutants-in-antarctic-ecosystems-part-1-trace-elements
#2
C V Z Cipro, P Bustamante, M V Petry, R C Montone
Global distillation is classically pointed as the biggest responsible for contaminant inputs in Polar ecosystems. Mercury (Hg) and other trace elements (TEs) also present natural sources, whereas the biologically mediated input is typically ignored. However, bioaccumulation and biomagnification combined with the fact that seabirds gather in large numbers into large colonies and excrete on land might represent an important local TEs input. A previous work suggested these colonies as sources of not only nutrients, but also organic contaminants...
March 24, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684857/microrna-449a-functions-as-a-tumor-suppressor-in-pancreatic-cancer-by-the-epigenetic-regulation-of-atdc-expression
#3
Feng Li, Jing Liang, Lu Bai
A growing body of evidence has suggested that microRNAs (miRNAs) play a pivotal role in the development and progression of pancreatic cancer. miRNA-449a (miR-449a) has attracted particular interest due to its critical role in regulating cancer biology in numerous cancer types. However, whether miR-449a is involved in the regulation of pancreatic cancer development and progression remains unknown. In this study, we aimed to investigate the expression pattern and potential biological function of miR-449a in pancreatic cancer...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684766/characterization-and-competitive-ability-of-non-aflatoxigenic-aspergillus-flavus-isolated-from-the-maize-agro-ecosystem-in-argentina-as-potential-aflatoxin-biocontrol-agents
#4
María Silvina Alaniz Zanon, María Paz Clemente, Sofía Noemí Chulze
Aspergillus flavus is an opportunistic pathogen and may produce aflatoxins in maize, one of the most important crops in Argentina. A promising strategy to reduce aflatoxin accumulation is the biological control based on competitive exclusion. In order to select potential biocontrol agents among isolates from the maize growing region in Argentina, a total of 512 A. flavus strains were isolated from maize kernels and soil samples. Thirty-six per cent of the isolates from maize kernels did not produce detectable levels of aflatoxins, while 73% of the isolates from soil were characterized as non-aflatoxin producers...
April 13, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29684688/layer-by-layer-hollow-photosensitizer-microcapsule-design-via-a-manganese-carbonate-hard-template-for-photodynamic-therapy-in-cells
#5
Andreza Ribeiro Simioni, Priscila Costa Carvalho de Jesus, Antonio Claudio Tedesco
BACKGROUND: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. In this paper, we describe a novel drug delivery system for loading photosensitizer drugs into hollow multilayered microcapsules for photoprocess applications...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29684673/exercise-as-a-therapeutic-intervention-to-optimize-fetal-weight
#6
REVIEW
Laura M Reyes, Margie H Davenport
The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. It is generally recommended that women accumulate at least 150 minutes per week of moderate-intensity exercise...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29684467/vitamin-c-for-the-treatment-of-sepsis-the-scientific-rationale
#7
REVIEW
Paul E Marik
Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with widespread endothelial, cellular and mitochondrial injury leading to progressive organ failure. Sepsis is associated with an acute deficiency of vitamin C. In experimental sepsis models, intravenous vitamin C reduces organ injury and improves survival...
April 20, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29684436/foxo-transcription-factors-in-t-cell-biology-and-tumor-immunity
#8
REVIEW
Chong T Luo, Ming O Li
The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells...
April 20, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29684167/reproduction-in-domestic-ruminants-during-the-past-50-years-discovery-to-application
#9
Michael F Smith, Rodney D Geisert, John J Parrish
The study of reproductive physiology in domestic ruminants has progressed from the whole animal to the molecular level in an amazingly short period of time. The volume of information on this subject is enormous; therefore, we have focused on domestic ruminants, with an emphasis on cattle. To date, artificial insemination (AI) is perhaps the most powerful technique that reproductive physiologists and geneticists have provided the livestock industry for genetic improvement. Early efforts to establish AI as a tool were initiated in Russia around 1899 and since that time major advances in methods of semen collection, evaluation of male fertility, cryopreservation of sperm, sex-sorted semen, and estrous cycle control have occurred...
April 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29684098/binquasi-a-peak-detection-method-for-chip-sequencing-data-with-biological-replicates
#10
Emily Goren, Peng Liu, Chao Wang, Chong Wang
Motivation: ChIP-seq experiments that are aimed at detecting DNA-protein interactions require biological replication to draw inferential conclusions, however there is no current consensus on how to analyze ChIP-seq data with biological replicates. Very few methodologies exist for the joint analysis of replicated ChIP-seq data, with approaches ranging from combining the results of analyzing replicates individually to joint modeling of all replicates. Combining the results of individual replicates analyzed separately can lead to reduced peak classification performance compared to joint modeling...
April 19, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29683921/effects-of-exercise-on-asc-methylation-and-il-1-cytokines-in-heart-failure
#11
Brittany Butts, Javed Butler, Sandra B Dunbar, Elizabeth Corwin, Rebecca A Gary
INTRODUCTION/PURPOSE: Inflammation contributes to heart failure (HF) progression and the interleukin (IL)-1 cytokine IL-1β is implicated in this process. The adaptor protein ASC is necessary for inflammasome activation of IL-1β. Lower ASC methylation is associated with worse outcomes in HF. The purpose of this study was to examine the effects of exercise on changes in ASC methylation and activation of the interleukin-1 family cytokine IL-1β in persons with HF. METHODS: Participants (N=54) were randomized to receive exercise intervention (n=38) or attention control (n=16) for 3 months...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683499/the-role-of-androgens-on-periodontal-repair-in-female-rats
#12
João Paulo Steffens, Luis Carlos Leal Santana, Jonleno Coutinho Paiva Pitombo, Daniel Olivio Ribeiro, Maria Carolina Costa Albaricci, Stephanie von Stein Cubas Warnavin, Alpdogan Kantarci, Luis Carlos Spolidorio
BACKGROUND: Testosterone replacement enhances cognitive function and musculoskeletal health in postmenopausal women. However, the biological role of testosterone on inflammation and bone metabolism in females is not well understood. Our objective was to measure the impact of androgens and their receptors on periodontal tissues during periodontal repair in female rats. METHODS: Seventy female Holtzman rats were divided into seven groups (n = 10/group): negative control; repair control; androgen receptor antagonist (flutamide, 50 mg/kg, every other day); estrogen receptor antagonist (fulvestrant, 1...
April 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29683435/phospholipid-signaling-in-innate-immune-cells
#13
Valerie B O'Donnell, Jamie Rossjohn, Michael Jo Wakelam
Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents a highly controlled cellular signaling network that is essential for mounting an effective innate immune response. Phospholipids in innate cells are subject to dynamic regulation by enzymes, whose activities are highly responsive to activation status. Along with their metabolic products, they regulate multiple aspects of innate immune cell biology, including shape change, aggregation, blood clotting, and degranulation...
April 23, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29683396/reduced-peripheral-availability-of-tryptophan-and-increased-activation-of-the-kynurenine-pathway-and-cortisol-correlate-with-major-depression-and-suicide
#14
Amel Messaoud, Mensi Rym, Wahiba Douki, Fadoua Neffati, Mohamed Fadhel Najjar, Gabriella Gobbi, Flavia Valtorta, Lotfi Gaha, Stefano Comai
OBJECTIVES: Patients affected by major depression (MDD) are at high risk of suicide. The metabolism of tryptophan (Trp) along the serotonin (5-HT) and kynurenine (Kyn) pathways was found dysfunctional in MDD and in suicide. However, a clear biological framework linking dysfunctions in Trp metabolism via 5-HT and Kyn, cortisol, and the activities of tryptophan and indoleamino 2,3-dioxygenase (TDO, IDO) enzymes has not been yet clarified in MDD with or without suicidal behaviors. METHODS: We analyzed peripheral markers of Trp via 5-HT and Kyn pathways, Kyn/Trp ratio as a measure of TDO/IDO activities, cortisol, and psychopathology in 73 non-suicidal and 56 suicidal MDD patients, and in 40 healthy controls...
April 23, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29683364/inflammatory-biomarkers-in-saliva-and-serum-of-patients-with-rheumatoid-arthritis-with-respect-to-periodontal-status
#15
Leena Äyräväinen, Anna Maria Heikkinen, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Leena Laasonen, Eeva Moilanen, Mari Hämäläinen, Taina Tervahartiala, Jukka H Meurman, Marjatta Leirisalo-Repo, Timo Sorsa
OBJECTIVE: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation. METHODS: 53 early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug...
April 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29683319/multiply-intercalator-substituted-cu-ii-cyclen-complexes-as-dna-condensers-and-dna-rna-synthesis-inhibitors
#16
Jan Hormann, Jaroslav Malina, Oliver Lemke, Max J Hülsey, Stefanie Wedepohl, Jan Potthoff, Claudia Schmidt, Ingo Ott, Bettina G Keller, Viktor Brabec, Nora Kulak
Many drugs that are applied in anticancer therapy such as the anthracycline doxorubicin contain DNA-intercalating 9,10-anthraquinone (AQ) moieties. When Cu(II) cyclen complexes were functionalized with up to three (2-anthraquinonyl)methyl substituents, they efficiently inhibited DNA and RNA synthesis resulting in high cytotoxicity (selective for cancer cells) accompanied by DNA condensation/aggregation phenomena. Molecular modeling suggests an unusual bisintercalation mode with only one base pair between the two AQ moieties and the metal complex as a linker...
April 23, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29683082/regulatory-forum-opinion-paper-considerations-for-toxicologic-pathologists-evaluating-the-safety-of-biomaterials-and-finished-medical-devices
#17
Shayne C Gad, JoAnn C L Schuh
Safety ("biocompatibility") assessment of medical devices has evolved along a different path than that of drugs, being historically governed more by the considerations and needs of engineers rather than chemists and biologists. As a result, the involvement of veterinary pathologists has been much more limited-almost entirely to evaluating tissue responses in tissues in direct contact with implanted devices. As devices have become more complex in composition, structure, placement, and use, concerns as to adverse systemic responses in patients have called for more comprehensive and thoughtful evaluations of effects throughout the body...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29683004/metabolomics-assisted-metabolic-network-modeling-and-network-wide-analysis-of-metabolites-in-microbiology
#18
Junhua Wang, Cheng Wang, Huanhuan Liu, Haishan Qi, Hong Chen, Jianping Wen
Metabolomics is the science of qualitatively and quantitatively analyzing low molecular weight metabolites occur in a given biological system. It provides valuable information to elucidate the functional roles and relations of different metabolites in a metabolic pathway. In recent years, a large amount of research on microbial metabolomics has been conducted. It has become a useful tool for achieving highly efficient synthesis of target metabolites. At the same time, many studies have been conducted over the years in order to integrate metabolomics data into metabolic network modeling, which has yielded many exciting results...
April 22, 2018: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29682858/natural-biological-variation-of-white-matter-microstructure-is-accentuated-in-huntington-s-disease
#19
Sarah Gregory, Helen Crawford, Kiran Seunarine, Blair Leavitt, Alexandra Durr, Raymund A C Roos, Rachael I Scahill, Sarah J Tabrizi, Geraint Rees, Douglas Langbehn, Michael Orth
Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by a CAG-repeat expansion in the Huntingtin gene. Presence of this expansion signifies certainty of disease onset, but only partly explains age at which onset occurs. Genome-wide association studies have shown that naturally occurring genetic variability influences HD pathogenesis and disease onset. Investigating the influence of biological traits in the normal population, such as variability in white matter properties, on HD pathogenesis could provide a complementary approach to understanding disease modification...
April 22, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29682838/red-and-near-infrared-light-cleavable-polymers
#20
REVIEW
Xiaolong Zeng, Xuechang Zhou, Si Wu
Photocleavable polymers have attracted much attention in drug delivery, photopatterning, and controlling cell behavior. Photolysis is usually induced by UV light. However, UV light cannot penetrate deeply into biological tissue and may damage biological components. Therefore, conventional UV-light-cleavable polymers are problematic for deep-tissue biomedical applications. In this feature article, red and near-infrared light-cleavable polymers are reviewed, and their potential applications are highlighted. The remaining challenges in the field of photocleavable polymers are discussed...
April 23, 2018: Macromolecular Rapid Communications
keyword
keyword
112828
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"