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https://www.readbyqxmd.com/read/29776891/chronic-recurrent-multifocal-osteomyelitis-in-pediatrics-a-diagnostic-challenge
#1
N Roig-Abraham, M Méndez-Hernández, M Martínez-Morillo
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disease that presents with aseptic bone inflammation and can be accompanied by multisystemic symptoms. We present the case of a 14-year-old male with a 2-week history of pain located at the tibial metaphysis and fever. X-ray revealed a lytic lesion in the tibial metaphysis. MRI revealed an intramedullary bone lesion with perilesional bone oedema. CT-guided biopsy discounted malignancy and microbiological cultures were negative. The patient's symptoms and fever worsened after the biopsy; therefore antibiotherapy was commenced for a suspected superinfection...
May 15, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29776758/using-preference-learning-for-detecting-inconsistencies-in-clinical-practice-guidelines-methods-and-application-to-antibiotherapy
#2
Rosy Tsopra, Jean-Baptiste Lamy, Karima Sedki
Clinical practice guidelines provide evidence-based recommendations. However, many problems are reported, such as contradictions and inconsistencies. For example, guidelines recommend sulfamethoxazole/trimethoprim in child sinusitis, but they also state that there is a high bacteria resistance in this context. In this paper, we propose a method for the semi-automatic detection of inconsistencies in guidelines using preference learning, and we apply this method to antibiotherapy in primary care. The preference model was learned from the recommendations and from a knowledge base describing the domain...
May 15, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29721386/in-situ-delivery-of-allogeneic-natural-killer-cell-nk-combined-with-cetuximab-in-liver-metastases-of-gastrointestinal-carcinoma-a-phase-i-clinical-trial
#3
O Adotevi, Y Godet, J Galaine, Z Lakkis, I Idirene, J M Certoux, M Jary, R Loyon, C Laheurte, S Kim, A Dormoy, F Pouthier, C Barisien, F Fein, P Tiberghien, X Pivot, S Valmary-Degano, C Ferrand, P Morel, E Delabrousse, C Borg
Despite successful introduction of NK-based cellular therapy in the treatment of myeloid leukemia, the potential use of NK alloreactivity in solid malignancies is still elusive. We performed a phase I clinical trial to assess the safety and efficacy of in situ delivery of allogeneic NK cells combined with cetuximab in liver metastasis of gastrointestinal origin. The conditioning chemotherapy was administrated before the allogeneic NK cells injection via hepatic artery. Three escalating doses were tested (3...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29708869/delayed-cholecystectomy-for-acute-cholecystitis-in-elderly-patients-treated-primarily-with-antibiotics-or-percutaneous-drainage-of-the-gallbladder
#4
Gaëtan-Romain Joliat, Grégoire Longchamp, Céline Du Pasquier, Alban Denys, Nicolas Demartines, Emmanuel Melloul
BACKGROUND: In high-risk patients with acute cholecystitis, antibiotics with or without percutaneous drainage of the gallbladder followed by delayed cholecystectomy (DC) can be performed. This study aimed to review our current management of elderly patients with acute cholecystitis treated with DC. METHODS: All consecutive patients older than 70 with acute cholecystitis treated primarily with antibiotics with or without percutaneous drainage followed by DC between 2006 and 2015 were retrospectively reviewed...
April 30, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29706238/-a-fatal-septic-shock-due-to-capnocytophaga-canimorsus-and-review-of-literature
#5
G Vignon, P Combeau, J Violette, A-S Cognée, S Méglio, F Carrère, P Aucher, F Lellouche
INTRODUCTION: Capnocytophaga canimorsus is a Gram-negative bacterium present in normal dogs and cats mouths. It can be responsible for septic shocks after dog or cat bite, especially in asplenic patients. CASE REPORT: We report here a case of C. canimorsus infection rapidly presenting as a multiple organ dysfonction syndrome in an immunocompetent 54 years old patient, who lives near a dog, without any sign of bite. The evolution was a rapidly fatal fulminant septic shock...
April 26, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29701398/trauma-an-unusual-cause-of-endocarditis
#6
Ana Braga, Marta Marques, Miguel Abecacis, José Pedro Neves
INTRODUCTION: Infective endocarditis (IE) remains a dangerous condition with considerable associated mortality. Usual risk factors for IE include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a recent history of invasive procedures. METHODS: The authors describe the case report of a patient with IE having trauma as an unusual risk factor. RESULTS: A 33-year old male patient was referred to our department due to infective endocarditis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29692244/inhibition-of-chlamydia-trachomatis-growth-during-the-last-decade-a-mini-review
#7
Nawal Serradji, V U Thi Huyen, Hyunjoon Kim, Jayanth Panyam, Philippe Verbeke
Chlamydia trachomatis is responsible for the most frequent sexually transmitted bacterial infection in the world and for trachoma, the world's leading infectious cause of blindness. Genital chlamydial infection is very common among sexually active young people, and when untreated, leads to serious complications. No vaccine is available. Although Chlamydia resistance to antibiotics is rarely observed in vivo, studies showed that 10-20% of patients remain infected at the end of antibiotherapy, without being reinfected...
April 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29675007/mechanistic-and-structural-insights-into-the-unique-tetr-dependent-regulation-of-a-drug-efflux-pump-in-mycobacterium-abscessus
#8
Matthias Richard, Ana Victoria Gutiérrez, Albertus J Viljoen, Eric Ghigo, Mickael Blaise, Laurent Kremer
Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were linked to increased resistance to thiacetazone derivatives. Herein, the DNA-binding activity of MAB_4384 was investigated by electrophoretic mobility shift assays using the palindromic sequence IRS5/L5 located upstream of mmpS5/mmpL5 ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29671364/infectious-complications-in-morbidly-adherent-placenta-treated-with-leaving-placenta-in-situ-a-cohort-series-and-suggested-approach
#9
Mehmet Kutuk, Aysegul Kilic, Mehmet Ak, Mahmut Ozgun
BACKGROUND: The aim of this study is to assess the clinical and microbiological features of infections in patients with morbidly adherent placenta (MAP) treated by leaving placenta in situ (LPIS). MATERIAL AND METHODS: Retrospective analysis of MAP cases who were treated by LPIS between 2 May, 2010 and 15 March 2017. The inclusion criteria's were: gestational age at or above 24 weeks, prenatal diagnosis elective operation, and complete data. RESULTS: Nineteen MAP cases were treated by LPIS during the study period...
April 19, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29598881/-prevent-bacteria-from-communicating-divide-and-cure
#10
REVIEW
S Mion, B Rémy, L Plener, E Chabrière, D Daudé
Quorum Sensing (QS) is a communication system used by numerous bacteria to synchronize their behavior according to the cell density. In this way, bacteria secrete and sense small mediating molecules, called autoinducers (AI), which concentration increases in the environment proportionally to bacterial cell number. QS induces major physiological and phenotypic changes such as virulence induction and biofilm formation. Biofilm represents a physical barrier which shelters bacteria poorly sensitive to antimicrobial treatments and favors the apparition of resistance mechanisms...
March 26, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29568806/antibiotic-resistance-patterns-of-urinary-tract-pathogens-in-turkish-children
#11
Suzan Gunduz, Hatice Uludağ Altun
Background: Knowledge of local antimicrobial resistance patterns is essential for evidence- based empirical antibiotic prescribing. We aimed to investigate the distribution and changes in causative agents of urinary tract infections in children and the resistance rates, and to recommend the most appropriate antibiotics. Methods: In this retrospective study, we evaluated causative agents and antimicrobial resistance in urine isolates from the positive community from September 2014 to April 2016 in a single hospital in Ankara, Turkey...
2018: Global health research and policy
https://www.readbyqxmd.com/read/29548256/-prophylactic-antibiotherapy-in-hip-arthroplasty-cohort-study
#12
M Garrote-Garrote, J A Del-Moral-Luque, A Checa-García, J F Valverde-Cánovas, C Campelo-Gutiérrez, J Martínez-Martín, A Gil-de-Miguel, G Rodríguez-Caravaca
OBJECTIVE: The surgical site infection is the main cause of nosocomial infection in surgical patients, being antibiotic prophylaxis one of the most important factors for preventing it. This study evaluates adequacy of antibiotic prophylaxis in hip arthroplasty surgery as well as its effect on preventing surgical site infection. METHODS: A prospective cohort study was carried out from January 2011 to December 2016. We assessed the degree of adequacy of antibiotic prophylaxis in hip arthroplasty...
April 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29513244/clostridium-difficile-infection-in-patients-hospitalized-in-the-gastroenterology-ward-retrospective-analysis
#13
Kinga Podlaszewska, Ewa Małecka-Panas, Anita Gąsiorowska
INTRODUCTION: Clostridium difficile associated colitis became over last years a worldwide medical issue. It involves patients of the Polish hospitals too. The aim of the study was the analysis of CDAD incidence and the course of infection in Gastroenterology Ward of Regional Specialist Hospital of Zgierz, 2012-2015. MATERIAL AND METHODS: Retrospective analysis of the medical documentation of 79 patients with CDAD was performed. Demographic and epidemiological data and the clinical course of infection were analyzed...
February 28, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29498325/aerococcus-urinae-an-underestimated-cause-of-spine-infection-case-report-and-review-of-the-literature
#14
Elodie Degroote, Halil Yildiz, Frederic Lecouvet, Alexia Verroken, Leila Belkhir
OBJECTIVE AND IMPORTANCE: New methods of microbiology identification as MALDI-TOF MS increased the rate of Aerococci detection in microbiological samples making this germ an emerging pathogen. The purpose of this case report and literature review is to highlight the role of A. urinae in spine infection and discuss the management of this type of infection. CLINICAL PRESENTATION AND INTERVENTION: A 32-year-old man, with a medical history of paraplegia secondary to a relapsing form of multiple sclerosis, was admitted because of lower back-pain following complaints suggestive of urinary tract infection...
March 2, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29450387/orbital-cellulitis-and-brain-abscess-rare-complications-of-maxillo-spheno-ethmoidal-rhinosinusitis
#15
Farah Constantin, Patricia-Alexandra Niculescu, Oana Petre, Daniel Balasa, Alexandru Tunas, Ioana Rusu, Mihai Lupascu, Cristiana Orodel
Sinus infections can be complicated by ocular infections and, in late phases, by brain parenchyma infection. The article debates the case of a 12-year-old patient suffering from paucisymptomatic maxillo-spheno-ethmoidal rhinosinusitis, which was later complicated by orbital cellulitis, ending with the development of a brain abscess. The treatment is complex, initially targeting the source of the infection through draining the collection by middle maxillary antrostomy and anterior posterior ethmoidectomy, then the ablation of the brain abscess and postoperatively with prolonged massive antibiotherapy...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436423/evaluation-of-the-diagnostic-accuracy-of-two-immunochromatographic-tests-detecting-campylobacter-in-stools-and-their-role-in-campylobacter-infection-diagnosis
#16
Emilie Bessède, Julien Asselineau, Paul Perez, Guillaume Valdenaire, Olivier Richer, Philippe Lehours, Francis Mégraud
The detection of campylobacters in stools is performed essentially by culture, but this technique has a low sensitivity. New detection methods are now available. Among them, immunochromatography tests (ICTs) are very attractive in that they offer a result within 15 min. However, previous studies suggest that these tests have a relatively low specificity. The objective of this study was to evaluate the performance of these tests. During the study period, all patients who consulted the emergency units and had a stool culture were included...
April 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29435712/antimicrobial-therapy-in-palliative-care-an-overview
#17
REVIEW
Filipa Macedo, Catarina Nunes, Katia Ladeira, Filipa Pinho, Nadine Saraiva, Nuno Bonito, Luísa Pinto, Francisco Gonçalves
In the advanced stages of illness, patients often face challenging decisions regarding their treatment and overall medical care. Terminal ill patients are commonly affected by infections. However, in palliative care, the use of antimicrobials can be an ethical dilemma. Deciding whether to treat, withhold, or withdraw the antimicrobial treatment for an infection can be difficult. Antimicrobial administration can lead to adverse outcomes but the two main benefits, longer survival and symptom relief, are the main reasons why physicians prescribe antimicrobial when treating terminally ill patients...
May 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29433694/antibioth%C3%A3-rapie-des-infections-n%C3%A3-onatales-bact%C3%A3-riennes-pr%C3%A3-coces-chez-les-nouveau-n%C3%A3-s-n%C3%A3-s-%C3%A3-partir-de-34-semaines-d%C3%A2-am%C3%A3-norrh%C3%A3-e
#18
O Romain
All newborns superior to 34 weeks of gestationnal age (GA) are concerned by these guidelines of the French Society of Neonatology and the French Society of Pediatrics. Only newborns at risk of Early-Onset Neonatal Bacterial Infection who are clinically symptomatic have to be treated with probabilistic antibiotherapy treatment. The antibiotic combination of choice is amoxicillin + gentamicin. The two exceptions that justify dual therapy with Cefotaxime and Gentamicin are the bacteriological documentation of Escherichia coli and/or the presence of clinical signs of severity...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29425755/streptococcus-anginosus-dental-implant-related-osteomyelitis-of-the-jaws-an-insidious-and-calamitous-entity
#19
Sybille Chatelain, Tommaso Lombardi, Paolo Scolozzi
PURPOSE: We analyzed the data from a series of patients with dental implant-related suppurative osteomyelitis of the jaws (DIOMJ) due to Streptococcus anginosus. PATIENTS AND METHODS: The medical records of all patients seen for osteomyelitis of the jaws from 2011 to 2016 were reviewed. The primary outcome variable was Streptococcus anginosus DIOMJ. Other variables included age, gender, smoking habits, associated comorbidities, dental implant localization, type of osteomyelitis, delay between dental implant placement and DIOMJ, microbiologic examination and antibiogram, antibiotherapy, type of surgery, and final outcome...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29421969/management-and-outcome-of-prosthetic-vascular-graft-infections-a-single-center-experience
#20
Maxime Elens, Muzhakkir Dusoruth, Parla Astarci, Stefano Mastrobuoni, Michel J Bosiers, Jane Nardella, Valérie Lacroix, Julien Possoz, Robert Verhelst
BACKGROUND: Prosthetic vascular graft infection (PVGI) remains a severe and challenging complication in vascular surgery with high morbidity and mortality rates. Incidence has been reported between 1% and 6%. The aim of this study was to report our experience in terms of general and surgical management as well as outcome, over 15 years. METHODS: A retrospective consecutive study was conducted of all patients treated in our department for PVGI between January 2000 and December 2015...
April 2018: Vascular and Endovascular Surgery
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