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Brigitte Barrois, Brigitte Perrouin-Verbe, Xavier De-Boissezon, Djamel Ben Smail, Dominique Casanova, Anthony Gelis, Denis Colin
Surgical indication is recommended for specific locations (pelvic stage 3 and 4 pressure ulcers) and if medical treatment is impossible: - global patient assessment is recommended before surgical indication with benefits and risks analysis; - analysis is conducted on several stages; - risk factors analysis and control level; - efficiency analysis about medical and preventive coverage; - pressure ulcer origin analysis; - compliance patient assessment (care contract); - systematic pre operative procedure is recommended: - multi-disciplinary et pluriprofessionnal consultation; - psychological assessment and follow up; - radiological assessment (systematical, no systematical IRM except if osteitis, no TDM, no scintigraphy); - biological assessment (inflammatory nutritional, micro biological); - no pre-operative antibiotherapy; - specify definition of surgical type - realize pre-operative micro biological taking is recommended:(according to bone aspect): - enforce systematic post operative procedures is recommended: - plan patient installation: every patient must have a preventive mattress and book curative mattress for multiple scrap; - plan total immediate post operative dumped according to patient compliance in PRM ward (during at least 3 weeks, often 4); - organize seated station progressive recharging in PRM ward (during at least 3 weeks); - extend patient supervision and allow seated station; - plan further supervision...
September 2016: Annals of Physical and Rehabilitation Medicine
Simona Gurzu, Calin Molnar, Anca Otilia Contac, Annamaria Fetyko, Ioan Jung
Intestinal tuberculosis (TB) is an uncommon lesion for which differential diagnosis can be difficult. We present a case of a 53-year-old male and a systematic review of the literature, from clinical symptoms to differential diagnosis, unusual complications and therapy. The patient was admitted to the hospital with signs of acute abdomen as a result of a perforated terminal ileitis. Based on the skip lesions of the terminal ileum and cecum, Crohn's disease (CD) was clinically suspected. An emergency laparotomy and right colectomy with terminal ileum resection was performed and systematic antibiotherapy was prescribed...
September 16, 2016: World Journal of Clinical Cases
Rolf Nyah-Tuku Nzalie, Hortense Kamga Gonsu, Sinata Koulla-Shiro
Introduction. Community-acquired urinary tract infections (CAUTIs) are usually treated empirically. Geographical variations in etiologic agents and their antibiotic sensitivity patterns are common. Knowledge of antibiotic resistance trends is important for improving evidence-based recommendations for empirical treatment of UTIs. Our aim was to determine the major bacterial etiologies of CAUTIs and their antibiotic resistance patterns in a cosmopolitan area of Cameroon for comparison with prescription practices of local physicians...
2016: International Journal of Microbiology
Mevlut Karatas, Sedat Saylan, Ugur Kostakoglu, Gurdal Yilmaz
OBJECTIVES: Ventilator-associated pneumonia (VAP) is a significant cause of hospital-related infections, one that must be prevented due to its high morbidity and mortality. The purpose of this study was to evaluate the incidence and risk factors in patients developing VAP in our intensive care units (ICUs). METHODS: This retrospective cohort study involved in mechanically ventilated patients hospitalized for more than 48 hours. VAP diagnosed patients were divided into two groups, those developing pneumonia (VAP(+)) and those not (VAP(-))...
July 2016: Pakistan Journal of Medical Sciences Quarterly
María Luisa Martínez, Ricard Ferrer, Eva Torrents, Raquel Guillamat-Prats, Gemma Gomà, David Suárez, Luis Álvarez-Rocha, Juan Carlos Pozo Laderas, Ignacio Martín-Loeches, Mitchell M Levy, Antonio Artigas
OBJECTIVES: Time to clearance of pathogens is probably critical to outcome in septic shock. Current guidelines recommend intervention for source control within 12 hours after diagnosis. We aimed to determine the epidemiology of source control in the management of sepsis and to analyze the impact of timing to source control on mortality. DESIGN: Prospective observational analysis of the Antibiotic Intervention in Severe Sepsis study, a Spanish national multicenter educational intervention to improve antibiotherapy in sepsis...
September 8, 2016: Critical Care Medicine
Tufan Nayir, Ramazan Azim Okyay, Hakki Yesilyurt, Muhsin Akbaba, Ersin Nazlıcan, Yasemin Acık, Halil Ibrahim Akkus
The concepts of "essential drugs" and "national drug policy" described by the World Health Assembly in 1975 were the first steps taken towards the rational use of drugs (RUD). According to WHO, more than half of all medicines worldwide are prescribed, dispensed or sold inappropriately and half of the patients fail to take them appropriately. The aim of this study has been to evaluate the habits of patients related to RUD with a specific aim to investigate the factors associated with self-medication. This descriptive survey study was carried out in Elazıg, located at the Southeastern region of Turkey...
July 2016: Pakistan Journal of Pharmaceutical Sciences
Mohamed Ben Moussa, Mehdi Khalfallah, Ilhem Boutiba Ben Boubaker, Ramzi Nouira, Amine Slim, Hichem Jerraya, Chadli Dziri
BACKGROUND: Identifying the infecting bacterial flora is one of the main rules to be followed to ensure the success of antibiotherapy in the treatment of the infected diabetic foot. The aim of the work was to define the bacteriological profile of the bacteria causing the infection of the diabetic foot at the surgery unit B of Charles Nicolle's hospital in Tunis and determine the prognostic factors of this condition. METHODS: It was an open prospective study. It concerned 100 diabetic patients operated on for diabetic foot infection...
February 2016: La Tunisie Médicale
A C Ray, J M Foletti, N Graillon, L Guyot, C Chossegros
INTRODUCTION: Primary intraosseous carcinoma (PIOC) of the jaws is a rare epidermoid carcinoma from epithelial origin and initially strictly localized within the bone. Histologically, type 3 PIOC (PIOC3) is a de novo primary intraosseous carcinoma. Because of the rarity of this illness, we propose an analysis of a personal case and a revue of the literature. MATERIAL AND METHODS: Two search engines (Pubmed(®), Sciencedirect(®)) were questioned over the period 1976-February 2016 by using following keywords carcinoma, intraosseous, jaws, squamous cell carcinoma...
August 13, 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
Frédéric Raymond, Maxime Déraspe, Maurice Boissinot, Michel G Bergeron, Jacques Corbeil
Antibiotics profoundly affect the gut microbiome and modulate microbial communities. We recently observed that antimicrobial drugs also impact the abundance and distribution of antibiotic resistance genes. In this addendum, we reanalyze our ∼1 trillion nucleotide shotgun metagenomic dataset to quantify comprehensive genomic differences at the sequence level before and after antibiotic treatment. We show that 7 day exposure to cefprozil leads to a statistically significant loss of metagenome sequences. Recovery of gut microbiomes 3 months after antibiotherapy was characterized by the emergence of new genome sequences not observed prior to antibiotic exposure...
September 2, 2016: Gut Microbes
Ghada Asmar, Dominique Cochelard, Jacques Mokhbat, Mohamed Lemdani, Ahmed Haddadi, Fouad Ayoubz
INTRODUCTION: General dentists issue approximately 10% of antibiotic prescriptions across the global medical community consummation. The use of antibiotics for the management of dentoalveolar infections should be considered only in the presence of an increased risk of a systemic involvement or to prevent metastatic infections. This study aimed to investigate the prophylactic and therapeutic antibiotic prescription patterns of Lebanese dentists for the management of dentoalveolar abscesses...
2016: Journal of Contemporary Dental Practice
Richard Garceau, Christine Bourque, Louise Thibault, Jean-Charles Côté, Jean Longtin, Marc-Christian Domingo
An 88-year-old man was admitted to the hospital with worsening malaise, fever, and weakness. Anaerobic blood culture bottles revealed the presence of an anaerobic, Gram-positive sporulated bacillus. Empirical antibiotherapy with intravenous piperacillin-tazobactam was initiated. The patient defervesced after four days and was switched to oral amoxicillin on his 6th day of antibiotic therapy and later discharged from the hospital. Four months later, he had recovered. The bacterium was initially identified as Clostridium butyricum using anaerobic manual identification panel...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
Claire Goumard, David Fuks, François Cauchy, Jacques Belghiti, Catherine Paugam-Burtz, Yves Castier, Olivier Soubrane
BACKGROUND: Postoperative pleural empyema following liver resection has not been thoroughly described in the literature yet. Hence, we aimed to describe characteristics of patients experiencing this complication. METHODS: Characteristics and outcomes of 21 patients who developed pleural empyema after hepatectomy, defined as a bacteriologically proven pleural infection with clinical and biological inflammatory signs requiring antibiotherapy and thoracic drainage, from 2001 to 2014, were retrospectively analyzed...
July 27, 2016: World Journal of Surgery
Altay Atalay, Ayse Nedret Koc, Gulsah Akyol, Nuri Cakir, Leylagul Kaynar, Aysegul Ulu-Kilic
A 66-year-old female patient with multiple myeloma (MM) was admitted to the emergency service on 29.09.2014 with an inability to walk, and urinary and faecal incontinence. She had previously undergone autologous bone marrow transplantation (ABMT) twice. The patient was hospitalized at the Department of Haematology. Further investigations showed findings suggestive of a spinal mass at the T5-T6-T7 level, and a mass lesion in the iliac fossa. The mass lesion was resected and needle biopsy was performed during a colonoscopy...
June 1, 2016: Le Infezioni in Medicina
T L Palama, I Canard, G J P Rautureau, C Mirande, S Chatellier, B Elena-Herrmann
Identification of bacterial species is a crucial bottleneck for clinical diagnosis of infectious diseases. Quick and reliable identification is a key factor to provide suitable antibiotherapies and avoid the development of multiple-drug resistance. We propose a novel nuclear magnetic resonance (NMR)-based metabolomics strategy for rapid discrimination and identification of several bacterial species that relies on untargeted metabolic profiling of supernatants from bacterial culture media. We show that six bacterial species (Gram negative: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis; Gram positive: Enterococcus faecalis, Staphylococcus aureus, and Staphylococcus saprophyticus) can be well discriminated from multivariate statistical analysis, opening new prospects for NMR applications to microbial clinical diagnosis...
August 7, 2016: Analyst
Romain Saljoghi, Allan Lipsker, Kévin Caillet, Josselin Malaterre, Fabien Le Roux, Géraldine Pignot, Fabien Saint
Encrusted uretero-pyelitis is a rare and serious disease, related to the presence of calcifications in the pelvicalyceal system and ureter, associated with chronic urinary tract infection. In most cases, the causal agent of this infection lithiasis is corynebacterium urealyticum. The specific aspect of calcifications on CT scan can help to suggest diagnosis. To avoid a delay in diagnosis (which is frequent), an accurate exploration by the bacteriologist is crucial. The combination of a glycopeptides antibiotherapy and urine acidification has proved its effectiveness, as described in the medical literature...
July 2016: Urology Case Reports
Pınar Tarkun, Abdullah Hacıhanefioğlu, Emine Demirbağ, Tuğba Turgut
Drug induced autoimmune hemolytic anemia is a well-known complication of drug therapy but it is often misdiagnosed. Drug induced autoimmune hemolytic anemia is difficult to differantiate from classical autoimmune hemolytic anemia. Here, we have reported a case with autoimmune hemolytic anemia might be caused by drugs such as teicoplanin, imipenem and amphotericin B. In our case, on the fifteenth postadmission day was occur autoimmune hemolytic anemia. At this while, chemotherapy of patient had been completed and the patient have been taking antibiotherapy which include teicoplanin, imipenem and amphotericin B...
June 5, 2005: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Harry Etienne, Joseph Touma, Jean-Pierre Becquemin
Propionibacterium acnes, an anaerobic gram-positive bacillus that inhabits the skin, has rarely been incriminated in abdominal aortic endograft infection. It is usually responsible for typical delayed and low-grade postoperative infections. We report the case of a 66-year-old patient who developed acute P. acnes aortic stent-graft infection 9 days after percutaneous embolization for type II endoleak. The stent graft had been implanted 2 years before. Because of persistent signs of sepsis and discovery of a posterior periaortic abscess formation on the computed tomography scan, removal of the stent graft was necessary...
August 2016: Annals of Vascular Surgery
Ana Silva, Ana Margarida Sousa, Diana Alves, Anália Lourenço, Maria Olívia Pereira
The emergence of Klebsiella pneumoniae multidrug-resistant strains paves the way to the re-introduction of colistin as a salvage therapy. However, recent planktonic studies have reported several cases of heteroresistance to this antimicrobial agent. The aim of this present work was to gain better understanding about the response of K. pneumoniae biofilms to colistin antibiotherapy and inspect the occurrence of heteroresistance in biofilm-derived cells. Biofilm formation and its susceptibility to colistin were evaluated through the determination of biofilm-cells viability...
July 2016: Pathogens and Disease
Adnan Kara, Haluk Celik, Ali Seker, Ozgur Karakoyun, Raffi Armagan, Ersin Kuyucu, Mehmet Erdil
BACKGROUND: Developed for the treatment of deformity correction, computer-assisted circular external fixators in recent years have also been used for fracture fixation. In this study, we aimed to present the efficacy of computer-assisted circular external fixator use in open long bone fractures with our new technique. METHODS: Between February 2013 and June 2014, 14 patients (mean age 24.5 (range 20-32)) with open tibial or femoral open fractures were treated with the computer-assisted fixation system (Spider Frame-Tasarım Medikal, Istanbul, Turkey)...
2016: Journal of Orthopaedic Surgery and Research
Bertrand Volard, Loïc Mignot, Emmanuel Piednoir, Christophe de Champs, Anne Limelette, Thomas Guillard
Erysipelothrix rhusiopathiae is mostly isolated in swine causing erysipelas. Human invasive infections due to E. rhusiopathiae remain poorly described and interestingly bacteraemia associated with endocarditis are a source of ineffective empirical antibiotherapy. We report a case of sepsis without endocarditis due to E. rhusiopathiae and a review of the literature.
June 1, 2016: Annales de Biologie Clinique
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