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https://www.readbyqxmd.com/read/29223445/brucella-infection-following-total-joint-arthroplasty-a-systematic-review-of-the-literature
#1
Seung-Ju Kim, Hyun-Soo Park, Dong-Woo Lee, Jong Hun Kim
INTRODUCTION: The aim of this systematic review was to analyze the results of published treatment options in Brucella infection following total joint arthroplasty (TJA). METHODS: We performed a systematic review of the literature regarding outcomes of Brucella infection after TJA (hip and knee). We searched multiple databases for articles in the area published from 1950 to 2016. RESULTS: A total of 18 patients (12 male and 6 female; mean age 59 years) from 14 published studies were identified...
December 6, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29205552/the-role-of-the-cror-response-regulator-in-resistance-of-enterococcus-faecalis-to-d-cycloserine-is-defined-using-an-inducible-receiver-domain
#2
Cécile Muller, Sébastien Massier, Yoann Le Breton, Alain Rincé
Enterococcus faecalis is an opportunistic multidrug-resistant human pathogen causing severe nosocomial infections. Previous investigations revealed that the CroRS two-component regulatory pathway likely displays a pleiotropic role in E. faecalis, involved in virulence, macrophage survival, oxidative stress response as well as antibiotic resistance. Therefore, CroRS represents an attractive potential new target for antibiotherapy. In this report, we further explored CroRS cellular functions by characterizing the CroR regulon: the "domain swapping" method was applied and a CroR chimera protein was generated by fusing the receiver domain from NisR to the output domain from CroR...
December 4, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29201587/quinolone-resistant-clinical-strains-of-pseudomonas-aeruginosa-isolated-from-university-hospital-in-tunisia
#3
Mouna Ben Nejma, Olfa Sioud, Maha Mastouri
In this study, we examined mutations in the quinolone resistance-determining regions (QRDRs) of the gyrA and parC genes of Pseudomonas aeruginosa (P. aeruginosa) clinical isolates collected from patients hospitalized in University Hospital of Monastir, Tunisia. A total of 81 P. aeruginosa strains, obtained from clinical specimens, were included in the present study. Isolates were tested against 11 different antibiotics by a disk diffusion method. Minimum inhibitory concentrations (MICs) of ciprofloxacin were evaluated by E test method...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29162286/medical-management-of-a-subretinal-klebsiella-pneumoniae-abscess-with-excellent-visual-outcome-without-performing-vitrectomy
#4
A Martel, B Butet, J C Ramel, D Martiano, S Baillif
OBJECTIVE: To report the case of a Klebsiella pneumoniae endogenous endophthalmitis (KPEE) of hepatic and urinary origin that was successfully treated with systemic antibiotherapy and 13 intravitreal antibiotics injections without performing a vitrectomy. PATIENT AND METHOD: Case report of a 60-year-old man with a subretinal abscess in the left eye that developed 3 days after initial presentation for K. pneumoniae bacteremia, liver abscess and urinary tract infection...
November 18, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29113712/prior-antimicrobial-therapy-duration-influences-causative-pathogens-identification-in-ventilator-associated-pneumonia
#5
Jean-François Llitjos, Marlène Amara, Ahlem Benzarti, Guillaume Lacave, Jean-Pierre Bedos, Béatrice Pangon
OBJECTIVE: To determine whether prior antimicrobial therapy, divided in recent or current antibiotic treatment, influences the identification rate and/or the type of causative pathogens in patients with suspected episodes of ventilator-acquired pneumonia. DESIGN: Monocentric retrospective study. SETTING: Intensive car unit in a universitary hospital. PATIENTS: 230 episodes of ventilator-associated pneumonia with a Clinical Pulmonary Infection Score≥6 were retrospectively evaluated...
October 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29089118/primary-infectious-spondylodiscitis-in-51-patients-over-75-years-old-a-comparative-study
#6
Jean-Jacques Dubost, Julien Lopez, Bruno Pereira, Benjamin Castagne, Anne Tournadre, Martin Soubrier, Marion Couderc
BACKGROUND AND OBJETIVE: The incidence of infectious spondylodiscitis has been shown to rise with age; however, they had not been extensively investigated in the very elderly. MATERIAL AND METHODS: This retrospective, monocentric study included patients hospitalized in our department of rheumatology for primary infectious spondylodiscitis between 2000 and 2015, and compared over 75-year-olds with younger patients. RESULTS: Of the 152 patients, 51 (33...
October 28, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29055117/can-neutrophil-to-lymphocyte-ratio-predict-late-onset-sepsis-in-preterm-infants
#7
Senem Alkan Ozdemir, Esra Arun Ozer, Ozkan Ilhan, Sumer Sutcuoglu
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) is an easily accessible biomarker that has been reported to represent disease severity in adult trials. The aim of this study was to evaluate the relationship between culture positiveness and NLR in cases where the reason of sepsis was considered, and to foresight an idea about the active agents. METHODS: Preterm infants with birth weights ≤1500 g and/or ≤32 gestational weeks were eligible for this study...
October 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29054948/gentamicin-vancomycin-colistin-local-antibiotherapy-in-a-cement-spacer-in-a-54-year-old-haemophilic-patient-with-relapsing-plurimicrobial-severe-prosthetic-joint-infection
#8
Tristan Ferry, Romain Desmarchelier, Sophie Magréault, Florent Valour
No abstract text is available yet for this article.
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29046368/enhancement-of-lung-gene-delivery-after-aerosol-a-new-strategy-using-non-viral-complexes-with-antibacterial-properties
#9
REVIEW
Angélique Mottais, Tony Le Gall, Yann Sibiril, Julian Ravel, Véronique Laurent, Frédérique d'Arbonneau, Tristan Montier
The pathophysiology of obstructive pulmonary diseases, such as cystic fibrosis (CF), leads to the development of chronic infections in the respiratory tract. Thus, the symptomatic management of the disease requires, in particular, repetitive antibiotherapy. Besides these antibacterial treatments, certain pathologies, such as CF or chronic obstructive pulmonary disease (COPD), require the intake of many drugs. This simultaneous absorption may lead to undesirable drug interactions. For example, Orkambi® (lumacaftor/Ivacaftor, Vertex), a pharmacological drug employed to treat F508del patients, cannot be used with antibiotics such as rifampicin or rifabutin (rifamycin family) which are necessary to treat Mycobacteriaceae...
December 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29033313/developing-a-model-for-cystic-fibrosis-sociomicrobiology-based-on-antibiotic-and-environmental-stress
#10
Susana Patrícia Lopes, Nuno Filipe Azevedo, Maria Olívia Pereira
Cystic fibrosis (CF) infections are invariably biofilm-mediated and polymicrobial, being safe to assume that a myriad of factors affects the sociomicrobiology within the CF infection site and modulate the CF community dynamics, by shaping their social activities, overall functions, virulence, ultimately affecting disease outcome. This work aimed to assess changes in the dynamics (particularly on the microbial composition) of dual-/three-species biofilms involving CF-classical (Pseudomonas aeruginosa) and unusual species (Inquilinus limosus and Dolosigranulum pigrum), according to variable oxygen conditions and antibiotic exposure...
September 28, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29030135/staphylococcus-saprophyticus-which-beta-lactam
#11
Hélène Pailhoriès, Viviane Cassisa, Rachel Chenouard, Marie Kempf, Matthieu Eveillard, Carole Lemarié
BACKGROUND: Staphylococcus saprophyticus is resistant to the drugs most often used for the empirical treatment of urinary tract infections (UTI). The adequacy of antimicrobial treatments prescribed for UTI due to S. saprophyticus is not usually questioned. This study described the epidemiology of such infections and assessed the susceptibility of S. saprophyticus to ceftriaxone and amoxicillin-clavulanic acid. METHODS: Methicillin-susceptible S. saprophyticus (MSSS) isolated from clinical samples between November 2014 and July 2016 were included...
October 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29022657/-shortening-the-antibiotherapy-is-in-progress-get-up-to-date
#12
Isaline Bonnemain, Heidi Sarrasin, Florie Sierro, Daniel Genné
In a world where the emergence of resistant bacteria threatens the future use of many antibiotics, it is now critical to prescribe antibiotics carefully in order to minimize selective pressure. Limiting treatment duration would be one of the strategies to achieve this goal. Recent studies state that a reduction of the course of treatment is showing great benefit with no outcome difference.
October 11, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28994886/is-there-a-real-benefit-of-hyperbaric-oxygenotherapy-in-the-treatment-of-necrotizing-otitis-externa
#13
Ali Mardassi, Senda Turki, Rim Lahiani, Hajer Mbarek, Sonia Benzarti, Hédi Gharsallah
INTRODUCTION: Necrotizing otitis externa remains a severe and sometimes life-threatening disease in diabetic patient. Many therapeutic approaches have been described but what about the real benefit of hyperbaric oxygenotherapy in the management of this disease? METHODS: The authors reported a retrospective study about 42 patients treated for necrotizing external otitis over a period of 9 years (2006 to 2014). The patients were treated either by only antibiotherapy (23 cases) or with both antibiotherapy and hyperbaric oxygenotherapy (19 cases)...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28990681/limb-shortening-as-a-strategy-for-limb-sparing-treatment-of-appendicular-osteosarcoma-of-the-distal-radius-in-a-dog
#14
Sarah E Boston, Owen T Skinner
OBJECTIVE: To develop and report a novel limb sparing technique for the distal radius in a dog. STUDY DESIGN: Case report. ANIMAL: A 14-year-old, female spayed Labrador Retriever with an osteosarcoma of the right distal radius and a pathological fracture. A previous mast cell tumor had been treated 5 years prior to presentation with marginal excision and a full-course radiation over the right metacarpal bones. The dog had received 2 doses of palliative radiation just prior to presentation...
October 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28980143/nmr-assignments-of-the-n-terminal-domain-of-staphylococcus-aureus-hibernation-promoting-factor-sahpf
#15
Konstantin S Usachev, Rustam Kh Ayupov, Shamil Z Validov, Iskander Sh Khusainov, Marat M Yusupov
Staphylococcus aureus: hibernation-promoting factor (SaHPF) is a 22.2 kDa stationary-phase protein that binds to the ribosome and turns it to the inactive form favoring survival under stress. Sequence analysis has shown that this protein is combination of two homolog proteins obtained in Escherichia coli-ribosome hibernation promoting factor (HPF) (11,000 Da) and ribosome modulation factor RMF (6500 Da). Binding site of E. coli HPF on the ribosome have been shown by X-ray study of Thermus thermophilus ribosome complex...
October 4, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28954408/history-and-outcome-of-febrile-neutropenia-outside-the-oncology-setting-a-retrospective-study-of-76-cases-related-to-non-chemotherapy-drugs
#16
Emmanuel Andrès, Rachel Mourot-Cottet, Frédéric Maloisel, Olivier Keller, Thomas Vogel, François Séverac, Martine Tebacher, Jacques-Eric Gottenberg, Jean-Christophe Weber, Georges Kaltenbach, Bernard Goichot, Jean Sibilia, Anne-Sophie Korganow, Raoul Herbrecht
BACKGROUND: Despite major advances in its prevention and treatment, febrile neutropenia remains a most concerning complication of cancer chemotherapy. Outside the oncology setting, however, only few data are currently available on febrile neutropenia related to non-chemotherapy drugs. We report here data on 76 patients with febrile neutropenia related to non-chemotherapy drugs, followed up in a referral center within a university hospital. PATIENTS AND METHODS: Data from 76 patients with idiosyncratic drug-induced febrile neutropenia were retrospectively reviewed...
September 26, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28918465/congenital-lumbar-kyphosis-with-skin-ulceration-and-osteomyelitis-in-a-myelomeningocele-child-a-case-report
#17
Benoit Vibert, Marco Turati, Pierre-Yves Rabattu, Marco Bigoni, Ahmad Eid, Aurélien Courvoisier
INTRODUCTION: Kyphosis is a frequent problem in children with spina bifida, and this deformity may cause different complications as respiratory insufficiency, bowel dysfunction, and skin ulcers. CASE REPORT: We report on a 13-year-old myelomeningocele male with a lumbar kyphoscoliosis associated to a septic skin ulceration that resulted in an acute sepsis. An X-ray revealed a kyphosis of 110° and a scoliosis of 25° between T9 and L5. The wound and blood cultures showed Staphylococcus aureus colonization, and an appropriate antibiotic therapy was started...
September 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28882940/varicella-complicated-by-cellulitis-and-deep-vein-thrombosis
#18
Gracinda Nogueira Oliveira, Susana Basso, Teresa Sevivas, Nelson Neves
We report a 16-month-old girl with varicella complicated by cellulitis, invasive Group A Streptococcus (GAS) infection and deep vein thrombosis. She presented with varicella lesions, fever and a painful firm tumefaction on the right lower leg (RLL). Ultrasound showed a local subcutaneous tissue thickening suggestive of cellulitis and antibiotics were initiated. Further swelling of the RLL motivated a second ultrasound that showed an obstructive thrombus for which she was started on enoxaparin. The blood culture confirmed GAS infection leading to directed antibiotherapy...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28818287/application-of-flexible-endoscopy-based-biopsy-in-the-diagnosis-of-tumour-pathologies-in-otorhinolaryngology
#19
Carlos Saga, Manuel Olalde, Ekhiñe Larruskain, Leire Álvarez, Xabier Altuna
INTRODUCTION AND OBJECTIVES: Interventional endoscopy allows us to act on the pathology of the patient with minimal discomfort, low costs and high efficiency. We assessed the validity of flexible endoscopic biopsies in our hospital, in lesions suspected of malignancy in the rhino-pharyngo-laryngeal space. SUBJECTS AND METHODS: Retrospective study of patients with a pathology suspected of malignancy assessed between 2006-2016 in our centre. We evaluated the effectiveness, the tolerance and the number of complications...
August 14, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28795550/-management-of-chronic-osteomyelitis-by-long-term-antibiotic-suppression
#20
C Kabore, A Wouters, F Frippiat, P Gillet
Chronic osteomyelitis is a chronic inflammatory disease induced by bone infection. It may be limited to a single portion of bone or involve several areas such as marrow, cortical, periosteum and adjacent soft tissues. Being able to persist for weeks, months or even years, it remains a therapeutic challenge in spite of the important medical and surgical advances, with a prolonged and complex management given the nature of the surgical interventions and the antibiotherapies required. We report a case of chronic osteomyelitis treated by long-term suppressive antibiotic therapy, which may be a reasonable alternative to surgery in inoperable clinical situations, but taking into account the risks associated with it in terms of side effects and selection of resistant organisms, as well as the cost of treatment and the quality of life of the patient...
July 2017: Revue Médicale de Liège
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