Dun Li, Lihui Zhou, Zhi Cao, Jida Wang, Hongxi Yang, Mingqian Lyu, Yuan Zhang, Rongrong Yang, Ju Wang, Yuhong Bian, Weili Xu, Yaogang Wang
Neurodegenerative diseases (NDDs) remain a global health challenge. Previous studies have reported potential links between environmental factors and NDDs, however, findings remain controversial across studies and elusive to be interpreted as evidence of robust causal associations. In this study, we comprehensively explored the causal associations of the common environmental factors with major NDDs including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), based on updated large-scale genome-wide association study data through two-sample Mendelian randomization (MR) approach...
March 2024: Ageing Research Reviews