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Exercise and Parkinson disease

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https://www.readbyqxmd.com/read/29449201/peer-coaching-through-mhealth-targeting-physical-activity-in-people-with-parkinson-disease-feasibility-study
#1
Cristina Colón-Semenza, Nancy K Latham, Lisa M Quintiliani, Terry D Ellis
BACKGROUND: Long-term engagement in exercise and physical activity mitigates the progression of disability and increases quality of life in people with Parkinson disease (PD). Despite this, the vast majority of individuals with PD are sedentary. There is a critical need for a feasible, safe, acceptable, and effective method to assist those with PD to engage in active lifestyles. Peer coaching through mobile health (mHealth) may be a viable approach. OBJECTIVE: The purpose of this study was to develop a PD-specific peer coach training program and a remote peer-mentored walking program using mHealth technology with the goal of increasing physical activity in persons with PD...
February 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29439360/aerobic-rehabilitation-program-for-improving-muscle-function-in-parkinson-s-disease
#2
Siria Di Martino, Caterina Tramonti, Elisa Unti, Claudia Del Gamba, Ubaldo Bonuccelli, Bruno Rossi, Roberto Ceravolo, Carmelo Chisari
BACKGROUND: Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle metabolic features are still available. OBJECTIVE: To evaluate the efficiency of skeletal muscle oxidative metabolism in PD patients in comparison with age-matched controls and test the role of an intensive aerobic treatment on muscle oxidative metabolism and its clinical effects...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29428927/dancing-for-healthy-aging-functional-and-metabolic-perspectives
#3
Josianne Rodrigues-Krause, Mauricio Krause, Alvaro Reischak-Oliveira
Context • Dancing has been used as a form of exercise to improve functional and metabolic outcomes during aging. The field lacks randomized, clinical trials (RCTs) evaluating metabolic outcomes related to dance interventions, but dancing may be a form of exercise that could induce positive effects on the metabolic health of older adults. However, primary studies seem very heterogonous regarding the trial designs, characteristics of the interventions, the methods for outcomes assessments, statistical powers, and methodological quality...
February 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29419747/voluntary-physical-exercise-improves-subsequent-motor-and-cognitive-impairments-in-a-rat-model-of-parkinson-s-disease
#4
Shih-Chang Hsueh, Kai-Yun Chen, Jing-Huei Lai, Chung-Che Wu, Yu-Wen Yu, Yu Luo, Tsung-Hsun Hsieh, Yung-Hsiao Chiang
BACKGROUND: Parkinson's disease (PD) is typically characterized by impairment of motor function. Gait disturbances similar to those observed in patients with PD can be observed in animals after injection of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. Exercise has been shown to be a promising non-pharmacological approach to reduce the risk of neurodegenerative disease. METHODS: In this study, we investigated the long-term effects of voluntary running wheel exercise on gait phenotypes, depression, cognitive, rotational behaviors as well as histology in a 6-OHDA-lesioned rat model of PD...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29413803/motor-learning-in-people-with-parkinson-s-disease-implications-for-fall-prevention-across-the-disease-spectrum
#5
REVIEW
Serene S Paul, Leland E Dibble, Daniel S Peterson
BACKGROUND: Falls are a significant burden for people with Parkinson's disease (PD), however, individuals across the spectrum of disease severity respond differently to fall prevention interventions. Despite the multifactorial causes of falls in people with PD, recent work has provided insight into interventions that hold promise for fall prevention. Further, studies have begun to identify patient characteristics that may predict responsiveness to such interventions. RESEARCH QUESTION: We discuss (i) the postural motor learning abilities of people with mild versus severe PD that could affect their ability to benefit from fall prevention interventions, (ii) how people with different severity of PD respond to such interventions, and (iii) the practical considerations of providing effective fall prevention interventions for people with PD across the spectrum of disease severity...
January 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29408547/acute-effects-of-aerobic-exercise-on-cognitive-function-in-individuals-with-parkinson-s-disease
#6
Carolina R A Silveira, Eric A Roy, Quincy J Almeida
BACKGROUND: Deficits in executive functions are highly prevalent in Parkinson's disease (PD). Although chronic physical exercise has been shown to improve executive functions in PD, evidence of acute exercise effects is limited. This study aimed to evaluate the effects of an acute bout of exercise on cognitive processes underlying executive functions in PD. METHODS: Twenty individuals with PD were assessed in both a Control and an Exercise conditions. In each condition, individuals started performing a simple and a choice reaction time (RT) task...
February 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29406917/lack-of-an-association-between-attention-deficit-hyperactivity-disorder-adhd-and-amyotrophic-lateral-sclerosis-als
#7
Leonie Ebel, Susanne Petri, Joachim K Krauss, Reinhard Dengler, Martina de Zwaan
BACKGROUND: Lulé, Ludolph, and Ludolph (2008) hypothesized that there may be a pathophysiological link between attention-deficit/hyperactivity disorder (ADHD) and amyotrophic lateral sclerosis (ALS). They summarized common clinical features, specifically enhanced physical and psychological activity, which have been described typically for ADHD patients and also as common personality traits before disease onset in patients with ALS. METHODS: We assessed the lifetime prevalence rate of ADHD in 104 patients with ALS using valid self-report instruments for ADHD symptoms in childhood (WURS-k) and adulthood (ADHD-SB)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29402651/progressive-resistance-and-balance-training-for-falls-prevention-in-long-term-residential-aged-care-a-cluster-randomized-trial-of-the-sunbeam-program
#8
Jennifer Hewitt, Stephen Goodall, Lindy Clemson, Timothy Henwood, Kathryn Refshauge
BACKGROUND: Falls prevention is an international priority, and residents of long-term aged care fall approximately 3 times more often than community dwellers. There is a relative scarcity of published trials in this setting. OBJECTIVES: Our objective was to undertake a randomized controlled trial to test the effect of published best practice exercise in long-term residential aged care. The trial was designed to determine if combined high level balance and moderate intensity progressive resistance training (the Sunbeam Program) is effective in reducing the rate of falls in residents of aged care facilities...
February 2, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29394208/caring-interactions-in-secondary-prevention-programs-a-qualitative-inquiry-of-individuals-with-parkinson-s-disease
#9
Lindsey E Greviskes, Leslie Podlog, Maria Newton, Leland E Dibble, Ryan D Burns, Wanda Pillow, Morgan S Hall, Christopher Hammer
BACKGROUND AND PURPOSE: With Parkinson's disease (PD) prevalence rates steadily increasing and long-term adherence to regular physical activity and exercise often difficult to achieve, it is imperative to investigate factors promoting adherence to secondary prevention programs (SPP) that help limit the progression of motor and nonmotor signs and symptoms of the disease. Caring interactions between patients and their rehabilitation team may be particularly germane to individuals with PD, given the physical and psychosocial issues that often accompany this disease (eg, loss of physical function, depression, apathy, and cognitive impairments)...
February 1, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29375679/the-efficacy-of-homemade-tolcapone-in-the-treatment-of-patients-with-parkinsons-disease
#10
Pei-Lan Zhang, Yu-Xin Wang, Yan Chen, Chen-Hao Zhang, Chen-Hua Li
The aim of the study was to investigate the efficacy of homemade tolcapone in treatment of patients with Parkinson's disease (PD). Eighty patients with PD were subjected to randomized, double-blind, placebo-controlled and parallel-group study. PD patients were randomly divided into the tolcapone treatment group (41 cases) and placebo group (39 cases). Each patient received 1 pill of tolcapone or placebo, 3 times per day for 26 weeks. Efficacy was evaluated using the internationally used unified Parkinson's disease rating scale (UPDRS) scoring system for PD symptoms...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29366918/the-role-of-the-rehabilitation-in-subjects-with-progressive-supranuclear-palsy-a-narrative-review
#11
REVIEW
Domenico Intiso, Michelangelo Bartolo, Andrea Santamato, Filomena Di Rienzo
Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder due to the deposition of abnormal proteins in neurons of the basal ganglia that limit motor ability producing disability and reduced quality of life. So far, no pharmacologic therapy has been developed and the treatment remains symptomatic. The aim of the present study was to investigate systematically literature, and to determine the types and effects of rehabilitative interventions. A search of all studies was conducted in MEDLINE/PubMed, the Cochrane Central Register of Controlled Trials, CINAHL and EMBASE...
January 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29357501/effects-of-aging-and-parkinson-s-disease-on-motor-unit-remodeling-influence-of-resistance-exercise-training
#12
Neil A Kelly, Kelley G Hammond, C Scott Bickel, Samuel T Windham, S Craig Tuggle, Marcas M Bamman
Aging muscle atrophy is in part a neurodegenerative process revealed by denervation-reinnervation events leading to motor unit remodeling (i.e. myofiber type grouping). However, this process and its physiologic relevance are poorly understood, as is the wide-ranging heterogeneity among aging humans. Here, we attempted to address the: (i) relation between myofiber type grouping and molecular regulators of neuromuscular junction (NMJ) stability; (ii) impact of motor unit remodeling on recruitment during submaximal contractions; (iii) prevalence and impact of motor unit remodeling in Parkinson's disease (PD), an age-related neurodegenerative disease; and (iv) influence of resistance exercise training (RT) on regulators of motor unit remodeling...
December 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29345633/impacts-of-an-exercise-program-and-motivational-telephone-counseling-on-health-related-quality-of-life-in-people-with-parkinson-s-disease
#13
JuHee Lee, MoonKi Choi, Yonju Yoo, Sangwoo Ahn, Justin Y Jeon, Ji Young Kim, Ji Yong Byun
PURPOSE: The purpose of this study was to test the effects of group exercise and telephone counseling on physical and psychosocial health in people with Parkinson's disease (PD). DESIGN: This was a quasiexperimental study with a nonequivalent control group. METHODS: This study took place in Seoul, South Korea. Twenty-two and 20 subjects participated in the intervention and comparison groups, respectively. The intervention group performed group exercises twice a week and received motivational telephone counseling every 2 weeks for 12 weeks...
November 14, 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29337023/the-effects-of-functional-training-bicycle-exercise-and-exergaming-on-walking-capacity-of-elderly-with-parkinson-s-disease-a-pilot-randomized-controlled-single-blinded-trial
#14
Daniel Dominguez Ferraz, Karen Valadares Trippo, Gabriel Pereira Duarte, Mansueto Gomes Neto, Kionna Oliveira Bernardes Santos, Jamary Oliveira Filho
OBJECTIVES: To compare the effects of functional training, bicycle exercise and exergaming on walking capacity of elderly with Parkinson disease (PD). DESIGN: A pilot randomized controlled single-blinded trial. SETTING: A State Reference Health Care Centre for Elderly, a public reference outpatient clinic for the elderly. PARTICIPANTS: Sixty-two elderly individuals (≥60 years-old) with idiopathic PD (stage 2 to 3 of modified Hoehn and Yahr) according to the London Brain Bank...
January 11, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29331916/aerobic-exercise-is-more-effective-than-goal-based-exercise-for-the-treatment-of-cognition-in-parkinson-s-disease
#15
Carolina R A Silveira, Eric A Roy, Brittany N Intzandt, Quincy J Almeida
BACKGROUND: Little is known about how different exercise modalities influence cognition in Parkinson's disease (PD). Moreover, the focus of previous investigations on examining the effects of exercise mainly on executive functions and the exclusion of individuals with cognitive impairment may limit the potential to define exercise as a treatment for cognitive decline in PD. OBJECTIVE: The aim of this study was to compare the effects of aerobic and goal-based exercise on five cognitive domains in cognitively normal and impaired individuals with PD...
January 10, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29282259/exercise-response-in-parkinson-s-disease-insights-from-a-cross-sectional-comparison-with-sedentary-controls-and-a-per-protocol-analysis-of-a-randomised-controlled-trial
#16
Foteini Mavrommati, Johnny Collett, Marloes Franssen, Andy Meaney, Claire Sexton, Andrea Dennis-West, Jill F Betts, Hooshang Izadi, Marko Bogdanovic, Martin Tims, Andrew Farmer, Helen Dawes
OBJECTIVES: To investigate the acute and adaptation cardiovascular and metabolic training responses in people with Parkinson's disease (pwP). DESIGN: (1) A cross-sectional study of exercise response of pwP compared with sedentary controls and (2) an interventional study of exercise training in pwP. SETTING: Community leisure facilities. PARTICIPANTS: pwP (n=83) and sedentary controls (n=55). INTERVENTIONS: Study 1 included participants from a two-arm-parallel single-blind phase II randomised controlled trial (RCT), that undertook a baseline maximal incremental exercise test and study 2 included those randomised to the exercise group in the RCT, who completed a 6-month weekly exercise programme (n=37)...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29273705/high-intensity-exercise-acutely-increases-substantia-nigra-and-prefrontal-brain-activity-in-parkinson-s-disease
#17
Neil A Kelly, Kimberly H Wood, Jane B Allendorfer, Matthew P Ford, C Scott Bickel, Jon Marstrander, Amy W Amara, Thomas Anthony, Marcas M Bamman, Frank M Skidmore
BACKGROUND Pathologic alterations in resting-state brain activity patterns exist among individuals with Parkinson's disease (PD). Since physical exercise alters resting-state brain activity in non-PD populations and improves PD symptoms, we assessed the acute effect of exercise on resting-state brain activity in exercise-trained individuals with PD. MATERIAL AND METHODS Resting-state functional magnetic resonance imaging (fMRI) was collected twice for 17 PD participants at the conclusion of an exercise intervention...
December 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29260454/neuroprotective-effect-of-treadmill-exercise-possibly-via-regulation-of-lysosomal-degradation-molecules-in-mice-with-pharmacologically-induced-parkinson-s-disease
#18
Dong-Joo Hwang, Jung-Hoon Koo, Ki-Cheon Kwon, Dong-Hoon Choi, Sung-Deuk Shin, Jae-Hoon Jeong, Hyun-Seob Um, Joon-Yong Cho
Dysfunction of mitophagy, which is a selective degradation of defective mitochondria for quality control, is known to be implicated in the pathogenesis of Parkinson's disease (PD). However, how treadmill exercise (TE) regulates mitophagy-related molecules in PD remains to be elucidated. Therefore, we aimed to investigate how TE regulates α-synuclein (α-syn)-induced neurotoxicity and mitophagy-related molecules in the nigro-striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mice. Our data showed that TE exhibited a significant restoration of tyrosine hydroxylase and motor coordination with suppression of α-syn expression, hallmarks of PD, possibly via up-regulation of lysosomal degradation molecules, LAMP-2 and cathepsin L, with down-regulation of p62, LC3-II/LC3-I ratio, PINK1 and parkin in the substantia nigra of MPTP mice...
December 19, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29228079/effect-of-high-intensity-treadmill-exercise-on-motor-symptoms-in-patients-with-de-novo-parkinson-disease-a-phase-2-randomized-clinical-trial
#19
Margaret Schenkman, Charity G Moore, Wendy M Kohrt, Deborah A Hall, Anthony Delitto, Cynthia L Comella, Deborah A Josbeno, Cory L Christiansen, Brian D Berman, Benzi M Kluger, Edward L Melanson, Samay Jain, Julie A Robichaud, Cynthia Poon, Daniel M Corcos
Importance: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. Objectives: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. Design, Setting, and Participants: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29227709/a-review-study-on-the-beneficial-effects-of-baduanjin
#20
Liye Zou, Zhujun Pan, Albert Yeung, Saira Talwar, Chaoyi Wang, Yang Liu, Yankai Shu, Xiaoan Chen, Garrett Anthony Thomas
AIM: Baduanjin, a Chinese traditional Qigong exercise that focuses on a mind-body integration, is considered to be an effective exercise in promoting health. Thus, we systematically and critically evaluated the emerging literature relating to the effects of Baduanjin on health outcomes. METHODS: We used seven English-language electronic databases for the literature search. At least one health-related parameter was reported in retrievable full-text Baduanjin intervention studies...
December 11, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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