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Exercise and Parkinson disease

Stefano Strano, Alessandra Fanciulli, Massimiliano Rizzo, Paolo Marinelli, Paolo Palange, Dorina Tiple, Giuseppe De Vincentis, Giovanni Calcagnini, Federica Censi, Giuseppe Meco, Carlo Colosimo
BACKGROUND: The clinical presentation of Parkinson's disease (PD) includes a wide spectrum of non-motor features, including cardiovascular autonomic failure. OBJECTIVE: To evaluate cardiovascular autonomic status and cardiac functional capacity in drug-naïve PD patients. METHODS: 18 newly-diagnosed PD patients underwent laboratory cardiovascular autonomic function tests using power spectral analysis of the R-R interval, blood pressure (BP) short-term variability and non-invasive baroreflex sensitivity (BRS)...
November 15, 2016: Journal of the Neurological Sciences
Mingming Zhao, Caiyou Hu, Zhixin Wu, Yu Chen, Zhengming Li, Mingsheng Zhang
PURPOSE: To determine the effects of a new exercise training regimen, i.e. coordination and manipulation therapy (CMT), on motor, balance, and cardiac functions in patients with Parkinson disease (PD). MATERIALS AND METHODS: We divided 36 PD patients into the CMT (n = 22) and control (n = 14) groups. The patients in the CMT group performed dry-land swimming (imitation of the breaststroke) and paraspinal muscle stretching for 30 min/workday for 1 year. The control subjects did not exercise regularly...
October 14, 2016: International Journal of Neuroscience
Catherine Sherrington, Zoe A Michaleff, Nicola Fairhall, Serene S Paul, Anne Tiedemann, Julie Whitney, Robert G Cumming, Robert D Herbert, Jacqueline C T Close, Stephen R Lord
OBJECTIVE: Previous meta-analyses have found that exercise prevents falls in older people. This study aimed to test whether this effect is still present when new trials are added, and it explores whether characteristics of the trial design, sample or intervention are associated with greater fall prevention effects. DESIGN: Update of a systematic review with random effects meta-analysis and meta-regression. DATA SOURCES: Cochrane Library, CINAHL, MEDLINE, EMBASE, PubMed, PEDro and SafetyLit were searched from January 2010 to January 2016...
October 4, 2016: British Journal of Sports Medicine
Chun-Lian Ma, Xiao-Tang Ma, Jin-Ju Wang, Hua Liu, Yan-Fang Chen, Yi Yang
Accumulating evidence from animal and human research indicate that adult hippocampal neurogenesis plays a key role in cognition. Meanwhile, cognitive decline is well known to associate with ageing-related neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Therefore, prevention of hippocampal neurogenesis reduction should be critical for these diseases. Physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential therapy or an adjunctive therapeutic strategy for cognitive decline...
October 1, 2016: Behavioural Brain Research
C Duchesne, F Gheysen, A Bore, G Albouy, A Nadeau, M E Robillard, F Bobeuf, A L Lafontaine, O Lungu, L Bherer, J Doyon
BACKGROUND: Aerobic exercise training (AET) has been shown to provide general health benefits, and to improve motor behaviours in particular, in individuals with Parkinson's disease (PD). However, the influence of AET on their motor learning capacities, as well as the change in neural substrates mediating this effect remains to be explored. OBJECTIVE: In the current study, we employed functional Magnetic Resonance Imaging (fMRI) to assess the effect of a 3-month AET program on the neural correlates of implicit motor sequence learning (MSL)...
2016: NeuroImage: Clinical
Laure Mathevon, Nicolas Leroux, Céline Piscicelli, Emmanuelle Clarac, Shenhao Dai, Patrice Davoine, Paul Krack, Dominic Perennou
OBJECTIVE: To take care of postural disorders is a major issue in Parkinson's disease (PD). We present a documented observation suggesting the existence of a biased representation of verticality in PD, resulting in a severe retropulsion and recurrent falls. A rehabilitation program aimed to modulate verticality perception dramatically improved the postural perception of the vertical, trunk posture and balance abilities, and reduced retropulsion as well as lastingly fall frequency. OBSERVATIONS: A 68 year-old patient with Parkinson's disease fall backward 3 times a day...
September 2016: Annals of Physical and Rehabilitation Medicine
Anke C Winter, Pamela M Rist, Julie E Buring, Tobias Kurth
BACKGROUND: Individuals with Parkinson's disease (PD) may have an increased risk of overall mortality compared to the general population. Women may have lower mortality rates from PD than men; however, studies among women on the effect of PD on mortality have been limited and may not have adequately controlled for confounding by comorbidities. METHODS: We conducted a matched cohort study among participants in the Women's Health Study. 396 incident PD cases were identified through self-report...
2016: BMJ Open
Parijat Kabiraj, Jose Eduardo Marin, Armando Varela-Ramirez, Mahesh Narayan
Amyloid beta (Aβ) aggregation is generally associated with Alzheimer's onset. Here, we demonstrate that incubation of dopaminergic SH-SY5Y cells with an Aβ peptide fragment (an 11-mer composed of residues 25-35; Aβ (25-35)) results in elevated intracellular nitrosative stress and induces chemical mutation of protein disulfide isomerase (PDI), an endoplasmic reticulum-resident oxidoreductase chaperone. Furthermore, Aβ (25-35) provokes aggregation of both the minor and major biomarkers of Parkinson's disease, namely, synphilin-1 and α-synuclein, respectively...
October 3, 2016: ACS Chemical Neuroscience
Fang-Yu Cheng, Yea-Ru Yang, Li-Mei Chen, Yih-Ru Wu, Shih-Jung Cheng, Ray-Yau Wang
Two different training strategies to improve turning performance in individuals with Parkinson's disease (PD) were designed and investigated in this study. Subjects were randomly assigned to a specific exercise group, turning-based training group, or control group to receive training that emphasized balance and strengthening, turning-based treadmill training, and general exercise training, respectively. A total of 12 30-min training sessions followed by 10 min of turning training on a level surface were administered over 4 to 6 weeks...
2016: Scientific Reports
Hanan Khalil, Mohammad Nazzal, Nihaya Al-Sheyab
BACKGROUND: Perceived barriers to engaging in exercise in people with Parkinson's disease (PD) are becoming more defined in countries such as the UK and the US. This, however, may vary by culture and environment. This study aimed to explore the perceptions of exercise and barriers that may affect participation in people with PD from Jordan. METHODS: Two focus groups and seven individual interviews were conducted with people with PD. Additionally, individual interviews were conducted with two neurologists...
October 2016: Physiotherapy Theory and Practice
Veronica Southard, Joanne DiFrancisco-Donoghue, James Mackay, Stephanie Idjadi, Neil Wright
BACKGROUND: Symptoms of Parkinson's disease (PD) include bradykinesia, gait abnormalities, balance deficits, restless leg syndrome, and muscular fatigue. Compression garments (CG) have been shown to improve performance in athletes by increasing venous return and reduce lactic acid. OBJECTIVE: Assess the effect of compression garments on the performance of 3 standardized functional tests in persons with PD. METHODOLOGY: The functional tests selected represented strength, endurance, and mobility measures in individuals with PD...
July 2016: International Journal of Health Sciences
Levent Özgönenel, Sultan Çağırıcı, Murat Çabalar, Gülis Durmuşoğlu
BACKGROUND: Parkinson's disease (PD) predisposes to falls due to postural instability and decreased coordination. Postural and coordination exercises could ameliorate the incoordination and decrease falls. AIMS: In this study, we explored the efficiency of a game console as an adjunct to an exercise program in treating incoordination in patients with PD. STUDY DESIGN: Case-control study. METHODS: In this single-blind, prospective clinical trial, rehabilitation with the Xbox (Microsoft; Washington, USA) game console was used as an adjunct to a standard rehabilitation program...
July 2016: Balkan Medical Journal
John G Geisler, Krisztina Marosi, Joshua Halpern, Mark P Mattson
Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as a treatment for obesity, stimulates several adaptive cellular stress-response signaling pathways in neurons including those involving the brain-derived neurotrophic factor (BDNF), the transcription factor cyclic AMP response element-binding protein (CREB), and autophagy...
September 4, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Marie Demonceau, Didier Maquet, Boris Jidovtseff, Anne F Donneau, Thierry Bury, Jean L Croisier, Jean M Crielaard, Carlos Rodriguez DE LA Cruz, Valérie Delvaux, Gaëtan Garraux
BACKGROUND: Physical exercises in addition to standard care (SC) in patients with Parkinson's disease (PD) are now common practice in many care units. However, exercises can cover a wide range of interventions, and the specific effects of different interventions still deserve to be further investigated. AIM: To compare the effects of 12 weeks of two different types of physical exercises with SC in patients suffering from PD. DESIGN: Pseudo-randomized controlled trial...
September 1, 2016: European Journal of Physical and Rehabilitation Medicine
Tim Stuckenschneider, Ingo Helmich, Anke Raabe-Oetker, Boris Feodoroff, Ingo Froböse, Stefan Schneider
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Renata Terra de Oliveira, Lilian Assunção Felippe, Lilian Teresa Bucken Gobbi, Fabio Augusto Barbieri, Gustavo Christofoletti
OBJECTIVE: We have made a 3-arm trial (group vs. individual exercise vs. no treatment) to test the effects of a 6-month exercise program upon the executive functions in participants with Parkinson disease. METHODS: Twenty-four subjects were randomly allocated in 3 groups and undertook individualized exercises (G1, n = 8), group exercises (G2, n = 8), or monitoring (G3, n = 8). Executive functions were evaluated by means of the Wisconsin card sorting test and the Raven colored matrices, both assessed at the beginning of the program and after 6 months...
August 31, 2016: American Journal of Physical Medicine & Rehabilitation
Melanie E Cusso, Kenneth J Donald, Tien K Khoo
Parkinson's disease (PD) is a neurological disorder that is associated with both motor and non-motor symptoms (NMS). The management of PD is primarily via pharmaceutical treatment; however, non-pharmaceutical interventions have become increasingly recognized in the management of motor and NMS. In this review, the efficacy of physical activity, including physiotherapy and occupational therapy, as an intervention in NMS will be assessed. The papers were extracted between the 20th and 22nd of June 2016 from PubMed, Web of Science, Medline, Ovid, SportsDiscuss, and Scopus using the MeSH search terms "Parkinson's," "Parkinson," and "Parkinsonism" in conjunction with "exercise," "physical activity," "physiotherapy," "occupational therapy," "physical therapy," "rehabilitation," "dance," and "martial arts...
2016: Frontiers in Medicine
Fabian Jude David, Julie A Robichaud, David E Vaillancourt, Cynthia Poon, Wendy M Kohrt, Cynthia L Comella, Daniel M Corcos
In Parkinson's disease (PD), the characteristic triphasic agonist and antagonist muscle activation pattern during ballistic movement is impaired: the number of agonist muscle bursts is increased and the amplitudes of the agonist and antagonist bursts are reduced. The breakdown of the triphasic EMG pattern has been hypothesized to underlie bradykinesia in PD. Progressive resistance exercise has been shown to improve clinical measures of bradykinesia, but it is not clear if the benefits for bradykinesia are accompanied by changes in agonist and antagonist muscle activity...
August 31, 2016: Journal of Neurophysiology
Ellen L McGough, Cynthia A Robinson, Mark D Nelson, Raymond Houle, Gabriell Fraser, Leslie Handley, Emilie R Jones, Dagmar Amtmann, Valerie E Kelly
BACKGROUND AND PURPOSE: Individuals with Parkinson disease (PD) have motor and nonmotor impairments that interfere with exercise participation. The purpose of this study was to examine the feasibility and physical performance outcomes of a community-based indoor tandem cycling program that was designed to facilitate a higher cadence, consistency, and intensity of training. METHODS: Forty-one participants with mild to moderate PD were enrolled. A high-cadence cycling protocol using mechanically augmented (or forced) exercise on a tandem bicycle was adapted for our program...
October 2016: Journal of Neurologic Physical Therapy: JNPT
Gaia Bonassi, Elisa Pelosin, Carla Ogliastro, Cecilia Cerulli, Giovanni Abbruzzese, Laura Avanzino
Mirror visual feedback (MVF) therapy has been applied to improve upper limb function in stroke. When combined with motor training, MVF improves the performance of the trained and untrained hand by enhancing the excitability of both primary motor cortices (M1s). Bradykinesia is a typical feature of Parkinson's disease (PD), characterized by slowness in the execution of movement. This condition is often asymmetrical and possibly supported by a volitional hypoactivation of M1. MVF therapy could tentatively treat bradykinesia since the untrained hand, which benefits from the exercise, is generally more severely impaired in undertaking sequential movements...
2016: Neural Plasticity
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