Daniëlle D B Holthuijsen, Eline H van Roekel, Martijn J L Bours, Per M Ueland, Stéphanie O Breukink, Maryska L G Janssen-Heijnen, Eric T P Keulen, Biljana Gigic, Andrea Gsur, Klaus Meyer, Jennifer Ose, Arve Ulvik, Matty P Weijenberg, Simone J P M Eussen
INTRODUCTION: Colorectal cancer (CRC) survivors often experience neuropsychological symptoms, including anxiety and depression. Mounting evidence suggests a role for the kynurenine pathway in these symptoms due to potential neuroprotective and neurotoxic roles of involved metabolites. However, evidence remains inconclusive and insufficient in cancer survivors. Thus, we aimed to explore longitudinal associations of plasma tryptophan, kynurenines, and their established ratios with anxiety and depression in CRC survivors up to 12 months post-treatment...
January 26, 2024: Psychoneuroendocrinology