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https://www.readbyqxmd.com/read/28343905/the-dana-farber-consortium-protocol-for-the-treatment-of-adolescents-and-young-adults-with-acute-lymphoblastic-leukemia-a-single-institution-experience-in-saudi-arabia
#1
Amal S Alabdulwahab, Hussein G Elsayed, Mohamed A Sherisher, Wafa M Elbjeirami, Nelly Alieldin
BACKGROUND: Recent retrospective analyses and phase II trials have shown differential outcomes in adolescents and young adults when treated with pediatric compared with adult protocols. The aim of this study was to evaluate the efficacy and toxicity of the Dana Farber Consortium Protocol (DFCP) in Saudi young adults diagnosed with de novo acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: In this retrospective study we included 38 patients with de novo ALL who presented to King Abdulla Medical City in the period from June 2010 to March 2015 and received the DFCP (Princess Margret modified version)...
February 16, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28327262/clinical-performance-of-pedo-jacket-crowns-in-maxillary-anterior-primary-teeth
#2
Aimee Castro, Sherine B Y Badr, Wafa El-Badrawy, Gajanan Kulkarni
PURPOSES: To assess the clinical performance of Pedo Jacket crowns for restoration of carious primary anterior teeth. METHODS: A total of 129 carious primary incisors and canines of 48 children younger than 71 months of age- were restored with Pedo Jacket crowns and resin-modified glass ionomer cementation. They were assessed for: ease of use; presence of recurrent decay; wear; partial or complete loss of the crown; color stability; gingival health; and overall clinical success over a 12-month follow-up...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28321939/examining-the-sociocultural-sensitivity-of-subjective-drunkenness-comparing-arab-and-jewish-israeli-pub-patrons
#3
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
INTRODUCTION AND AIMS: Subjective drunkenness measures may be useful screening tools for alcohol-related problems. However, if self-reported drunkenness is influenced by social and cultural understandings, the measure may not predict drinking patterns equally across different sociocultural groups. The current study aims to determine whether the two main sociocultural groups in Israel (Arabs and Jews) are equally likely to report drunkenness at comparable levels of breath alcohol content (BrAC)...
March 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28318648/rates-of-central-line-associated-bloodstream-infection-in-tertiary-care-hospitals-in-3-arabian-gulf-countries-6-year-surveillance-study
#4
Hanan H Balkhy, Aiman El-Saed, Seif S Al-Abri, Jameela Alsalman, Huda Alansari, Zaina Al Maskari, Ayman El Gammal, Wafa Al Nasser, Amina AlJardani, Abdulhakeem Althaqafi
The objective of this study was to compare central line-associated bloodstream infection (CLABSI) rates in Gulf Cooperation Council (GCC) states with those of the U.S. National Healthcare Safety Network (NHSN) and International Nosocomial Infection Control Consortium (INICC) using pooled data from 6 hospitals in 3 GCC countries. The overall CLABSI rate was 3.1 per 1,000 central line days. After adjusting for differences in intensive care unit types, the risk of CLABSI in GCC hospitals was 146% higher than NHSN hospitals but 33% lower than INICC hospitals...
March 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28297677/recombinant-bcg-expressing-esx-1-of-mycobacterium-marinum-combines-low-virulence-with-cytosolic-immune-signaling-and-improved-tb-protection
#5
Matthias I Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis vaccine, Mycobacterium bovis BCG, provides limited protection. A feature of BCG is the partial deletion of the ESX-1 type VII secretion system, which governs phagosomal rupture and cytosolic pattern recognition, key intracellular phenotypes linked to increased immune signaling...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28287451/sensor-based-assistive-devices-for-visually-impaired-people-current-status-challenges-and-future-directions
#6
Wafa Elmannai, Khaled Elleithy
The World Health Organization (WHO) reported that there are 285 million visuallyimpaired people worldwide. Among these individuals, there are 39 million who are totally blind. There have been several systems designed to support visually-impaired people and to improve the quality of their lives. Unfortunately, most of these systems are limited in their capabilities. In this paper, we present a comparative survey of the wearable and portable assistive devices for visuallyimpaired people in order to show the progress in assistive technology for this group of people...
March 10, 2017: Sensors
https://www.readbyqxmd.com/read/28285930/exploiting-the-cancer-niche-tumor-associated-macrophages-and-hypoxia-as-promising-synergistic-targets-for-nano-based-therapy
#7
REVIEW
Vera L Silva, Wafa' T Al-Jamal
The tumor microenvironment has been widely exploited as an active participant in tumor progression. Extensive reports have defined the dual role of tumor-associated macrophages (TAMs) in tumor development. The protumoral effect exerted by the M2 phenotype has been correlated with a negative outcome in most solid tumors. The high infiltration of immune cells in the hypoxic cores of advanced solid tumors leads to a chain reaction of stimuli that enhances the expression of protumoral genes, thrives tumor malignancy, and leads to the emergence of drug resistance...
March 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28285813/-an-unusual-cutaneous-tumor
#8
Sarra Ben Rejeb, Dorra Ben Ghachem, Amen Dhaoui, Wafa Bayoudh, Asmahane Souissi, Khadija Bellil
No abstract text is available yet for this article.
March 9, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28279202/systemic-administration-of-mesenchymal-stem-cells-combined-with-parathyroid-hormone-therapy-synergistically-regenerates-multiple-rib-fractures
#9
Doron Cohn Yakubovich, Dmitriy Sheyn, Maxim Bez, Yeshai Schary, Eran Yalon, Afeef Sirhan, May Amira, Alin Yaya, Sandra De Mel, Xiaoyu Da, Shiran Ben-David, Wafa Tawackoli, Eric J Ley, Dan Gazit, Zulma Gazit, Gadi Pelled
BACKGROUND: A devastating condition that leads to trauma-related morbidity, multiple rib fractures, remain a serious unmet clinical need. Systemic administration of mesenchymal stem cells (MSCs) has been shown to regenerate various tissues. We hypothesized that parathyroid hormone (PTH) therapy would enhance MSC homing and differentiation, ultimately leading to bone formation that would bridge rib fractures. METHODS: The combination of human MSCs (hMSCs) and a clinically relevant PTH dose was studied using immunosuppressed rats...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28268221/cross-cultural-validity-in-self-reported-alcohol-use
#10
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
BACKGROUND AND AIM: Little evidence is available on whether respondents from divergent sociocultural populations report alcohol consumption in systematically similar ways. Therefore, this study examined whether the validity of self-reported alcohol use differed between Arab and Jewish Israeli pub patrons. METHODS: The analytical sample consisted of 227 Arab and 900 Jewish Israeli pub patrons who were approached as they left pubs and asked to record their Breath Alcohol Content (BrAC) value and complete a questionnaire that probed into their alcohol use...
March 8, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28261517/formulation-and-evaluation-of-new-glimepiride-sublingual-tablets
#11
Wafa Al-Madhagi, Ahmed Abdulbari Albarakani, Abobakr Khaled Alhag, Zakaria Ahmed Saeed, Nahlah Mansour Noman, Khaldon Mohamed
Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation...
2017: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28260451/descemet-stripping-automated-endothelial-keratoplasty-our-experience-at-king-hussein-medical-center
#12
Amal Al-Thawabi, Wafa Asfour, Mousa Al-Madani
OBJECTIVES: In this study, we report our experience at King Hussein Medical Center with Descemet stripping automated endothelial keratoplasty. MATERIALS AND METHODS: This study was conducted at King Hussein Medical Center of the Royal Medical Services during the period between January 2015 and January 2016. Patients who underwent Descemet stripping automated endothelial keratoplasty were enrolled in the study. We performed a comprehensive overview of the advantages of the surgery and analyzed the donor tissue selection criteria, indications, detailed surgical techniques of the procedure, and surgical outcomes...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28255604/detection-of-a-new-jcv-strain-of-genotype-a-in-a-subpopulation-of-colorectal-adenocarcinomas-in-tunisia
#13
Wafa Toumi, Alessandro Ripalti, Luigi Ricciardiello, Abderraouf Cherif, Dalila Gargouri, Ahmed Bouhafa, Jamel Kharrat, Slim Jarboui, Hichem Benrhouma, Mohamed Zili, Ridha Khelifa
The etiology of colorectal cancer (CRC) remains elusive in spite of major advances in knowledge of this disease and related risk factors. Several studies report the detection of human polyomavirus JC (JCV) in colorectal tumors and some suggest its association with CRC. Since many known human virus associations with cancer are linked to factors such as ethnic and geographical origin, it is interesting to search for the postulated association of JCV with CRC in different populations and regions. In this perspective, the present work was undertaken to assess the presence of JCV in CRC tumors in Tunisia...
March 3, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28254365/macrotopographic-closure-promotes-tissue-growth-and-osteogenesis-in-vitro
#14
Laura Juignet, Baptiste Charbonnier, Virginie Dumas, Wafa Bouleftour, Mireille Thomas, Coralie Laurent, Laurence Vico, Nathalie Douard, David Marchat, Luc Malaval
While the impact of substrate topographies at nano- and microscale on bone cell behavior has been particularly well documented, very few studies have analyzed the role of substrate closure at a tissular level. Moreover, these have focused on matrix deposition rather than on osteoblastic differentiation. In the present work, mouse calvaria cells were grown for 15days on hydroxyapatite (HA) ceramics textured with three different macrogrooves shapes ((**)100µm): 1 sine and 2 triangle waveforms. We found that macrotopography favors cell attachment, and that bone-like tissue growth and organization are promoted by a tight "closure angle" of the substrate geometry...
February 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28245079/hemorrhagic-metalloproteinase-cc-hsm-iii-isolated-from-cerastes-cerastes-venom-purification-and-biochemical-characterization
#15
Wafa Tachoua, Hinda Boukhalfa-Abib, Fatima Laraba-Djebari
Snake venom metalloproteinases are the most abundant toxins in Viperidae venoms. In this study, a new hemorrhagin, Cc HSM-III (66 kDa), was purified from Cerastes cerastes venom by gel filtration, ion exchange, and reversed-phase high-performance liquid chromatographies. The analysis of Cc HSM-III by liquid chromatography with a tandem mass spectrometry revealed 32 peptides sharing a homology with P-III metalloproteinases from Echis ocellatus snake venom. Cc HSM-III displays hemorrhagic activity with a minimal hemorrhagic dose of 5 μg, which is abolished by ethylene diamine tetracetic acid but not by phenylmethylsulfonyl fluoride...
February 28, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28242570/roussouly-s-sagittal-spino-pelvic-morphotypes-as-determinants-of-gait-in-asymptomatic-adult-subjects
#16
Ziad Bakouny, Ayman Assi, Abir Massaad, Elie Saghbini, Virginie Lafage, Wafa Skalli, Ismat Ghanem, Gaby Kreichati
Sagittal alignment is known to greatly vary between asymptomatic adult subjects; however, there are no studies on the possible effect of these differences on gait. The aim of this study is to investigate whether asymptomatic adults with different Roussouly sagittal alignment morphotypes walk differently. Ninety-one asymptomatic young adults (46M & 45W), aged 21.6±2.2years underwent 3D gait analysis and full body biplanar X-rays with three-dimensional (3D) reconstructions of their spines and pelvises and generation of sagittal alignment parameters...
February 22, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28229452/expression-levels-of-transcription-factor-pu-1-and-interleukin-9-in-atopic-dermatitis-and-their-relation-to-disease-severity-and-eruption-types
#17
Ashraf M Hamza, Salma S Omar, Reham A H Abo El-Wafa, Marwa J Elatrash
BACKGROUND: The role of immunological factors in atopic dermatitis (AD) pathogenesis is well established. T-helper (TH) cells are central in AD pathogenesis. A relatively new subset of T cells, Th9 cells, was shown to be involved in the development of allergic asthma and allergic rhinitis, while its role in AD is still to be investigated. This study aimed to measure gene expression levels of interleukin-9 (IL-9) and PU.1, and to examine relationships with disease severity, serum IgE, and eruption types in AD patients...
February 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28213066/inguinal-lymph-node-presenting-as-the-delayed-site-of-metastasis-in-early-stage-endometrial-carcinoma-case-report
#18
Shomaila Amir M Akbar, Mutahir A Tunio, Wafa AlShakweer, AbdulAziz AlObaid, Mushabbab AlAsiri
INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked. CASE PRESENTATION: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma...
January 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28212423/phenolic-extract-from-oleaster-olea-europaea-var-sylvestris-leaves-reduces-colon-cancer-growth-and-induces-caspase-dependent-apoptosis-in-colon-cancer-cells-via-the-mitochondrial-apoptotic-pathway
#19
Wafa Zeriouh, Abdelhafid Nani, Meriem Belarbi, Adélie Dumont, Charlotte de Rosny, Ikram Aboura, Fatima Zahra Ghanemi, Babar Murtaza, Danish Patoli, Charles Thomas, Lionel Apetoh, Cédric Rébé, Dominique Delmas, Naim Akhtar Khan, François Ghiringhelli, Mickael Rialland, Aziz Hichami
Dietary polyphenols, derived from natural products, have received a great interest for their chemopreventive properties against cancer. In this study, we investigated the effects of phenolic extract of the oleaster leaves (PEOL) on tumor growth in mouse model and on cell death in colon cancer cell lines. We assessed the effect of oleaster leaf infusion on HCT116 (human colon cancer cell line) xenograft growth in athymic nude mice. We observed that oleaster leaf polyphenol-rich infusion limited HCT116 tumor growth in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28183263/aryl-butenes-active-against-k562-cells-and-lacking-tyrosinase-inhibitory-activity-as-new-leads-in-the-treatment-of-leukemia
#20
Mehdi El Arbi, Emna Ketata, Aref Neifar, Wafa Mihoubi, Girish K Gupta, Pascal Pigeon, Siden Top, Ali Gargouri, Gérard Jaouen
The inhibitory effects of four series of aryl butene derivatives, active against breast cancer, on the monophenolase activity of tyrosinase, in melanin-free ink from Sepia officinalis, have been studied. Hydroxytamoxifen 1, ferrociphenol 17 and several aryl butene analogs have shown strong antiproliferative activity on hormone-dependent and hormone-independent breast cancer cells and were evaluated in leukemia K562 cell proliferation. Their potential to induce skin depigmentation by evaluating their anti-tyrosinase activity was also estimated...
February 8, 2017: Mini Reviews in Medicinal Chemistry
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