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Shabnam Saquib, Wafa Elhussein Mohammed Talha
Abdominal pregnancy is a rare, life-threatening condition defined as pregnancy in the peritoneal cavity exclusive of tubal, ovarian, or intraligamentary locations. It can be primarily located in the peritoneal cavity or secondary to a ruptured ectopic pregnancy or tubal abortion. We present two cases of abdominal pregnancy, one primary and another secondary, both diagnosed and successfully managed in our institution. The first patient, a para 2 at 14 weeks gestation, presented with abdominal pain, distension, and dizziness, which had started four days prior...
March 2018: Oman Medical Journal
Mayson H Alkhatib, Wafa S Alshehri, Faiza B Abdu
Context: Doxorubicin (DOX) and gemcitabine (GEM) are anticancer drugs that were combined in a nanoemulsion (NE) to reduce their adverse side effects. Aim: To detect the antitumor activity of the combination formulas of GEM and DOX, loaded either in water (GEM+DOX-Sol) or in NEs (GEM-DOX combination/loaded NE [GEM+DOX/LNE]), in female Swiss albino mice inoculated with Ehrlich ascites carcinoma (EAC). Settings and Design: The anticancer assessment of the NE formulas was implemented in 200 mice, which were divided into 10 groups...
January 2018: Journal of Pharmacy & Bioallied Sciences
Wafa Mnejja, Nabil Toumi, Nejla Fourati, Racem Bouzguenda, Abdelmonem Ghorbel, Mounir Frikha, Wicem Siala, Jamel Daoud
PURPOSE: A retrospective study to evaluate the efficacy and safety of the addition of neoadjuvant chemotherapy to concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma. PATIENTS AND METHODS: Data from 62 patients treated for non-metastatic nasopharyngeal carcinoma were analyzed by comparing two groups of patients: a first group of 32 patients treated with 3 cycles of neoadjuvant chemotherapy based on docetaxel, cisplatin and 5-fluoro-uracil every 21 days followed by concurrent chemoradiotherapy (weekly cisplatin 40mg/m2 with radiotherapy 70Gy, 2Gy per session, 5 sessions per week) and a second group of 30 patients treated with the same concurrent chemoradiotherapy...
April 9, 2018: Bulletin du Cancer
Mingxi Fang, Rashmi Adhikari, Jianheng Bi, Wafa Mazi, Nethaniah Dorh, Jianbo Wang, Nathan Conner, Jon Ainsley, Tatyana G Karabencheva-Christova, Fen-Tair Luo, Ashutosh Tiwari, Haiying Liu
We report five fluorescent probes based on coumarin-hybridized fluorescent dyes with spirolactam ring structures (A-E) to detect pH changes in live cell by monitoring visible and near-infrared fluorescence changes. Under physiological or basic conditions, the fluorescent probes A, B, C, D and E preserve their spirolactam ring-closed forms and only display fluorescent peaks in the visible region corresponding to coumarin moieties at 497, 483, 498, 497 and 482 nm, respectively. However, at acidic pH, the rings of the spirolactam forms of the fluorescent probes A, B, C, D and E open up, generating new near-infrared fluorescence peaks at 711, 696, 707, 715, and 697 nm, respectively, through significantly extended π-conjugation to coumarin moieties of the fluorophores...
December 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Asma'a A Al-Ekrish, Sara A Alfadda, Dania Tamimi, Wafa Alfaleh, Romed Hörmann, Wolfgang Puelacher, Gerlig Widmann
PURPOSE: To investigate whether ultra-low-dose multidetector computed tomography (MDCT) combined with the reconstruction techniques filtered backprojection (FBP), adaptive statistical iterative reconstruction (ASIR), or model-based iterative reconstruction (MBIR) alters the subjective classification of revised Lekholm and Zarb (LZ) bone types at prospective dental implant sites. MATERIALS AND METHODS: Three cadavers underwent a reference MDCT examination using a standard dose volume (CT dose index [CTDIvol ]: 29...
March 28, 2018: International Journal of Prosthodontics
Giuseppe Catanuto, Wafa Taher, Nicola Rocco, Francesca Catalano, Dario Allegra, Filippo Luigi Maria Milotta, Filippo Stanco, Giovanni Gallo, Maurizio Bruno Nava
Background: Breast shape is defined utilizing mainly qualitative assessment (full, flat, ptotic) or estimates, such as volume or distances between reference points, that cannot describe it reliably. Objectives: We will quantitatively describe breast shape with two parameters derived from a statistical methodology denominated principal component analysis (PCA). Methods: We created a heterogeneous dataset of breast shapes acquired with a commercial infrared 3-dimensional scanner on which PCA was performed...
March 20, 2018: Aesthetic Surgery Journal
S Michaud, K Dasgupta, L Bell, J-F Yale, N Anjachak, S Wafa, M Nakhla
AIMS: To assess adult diabetes care providers' current transition practices, knowledge about transition care, and perceived barriers to implementation of best practices in transition care for emerging adults with Type 1 diabetes mellitus. METHODS: We administered a 38-item web-based survey to adult diabetes care providers identified through the Québec Endocrinologist Medical Association and Diabetes Québec. RESULTS: Fifty-three physicians responded (35%)...
March 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Khalid Al-Rasadi, Ibrahim Al-Zakwani, Alawi A Alsheikh-Ali, Wael Almahmeed, Wafa Rashed, Mustafa Ridha, Raul D Santos, Mohammad Zubaid
BACKGROUND: Information on the epidemiology of familial hypercholesterolemia (FH) in the Arabian Gulf region, which has an elevated rate of consanguinity and type II diabetes, is scarce. OBJECTIVES: To assess the prevalence of FH, its management, and impact on atherosclerotic cardiovascular disease (ASCVD) outcomes in a multicenter cohort of Arabian Gulf patients with acute coronary syndrome (ACS). METHODS: Patients (N = 3224) hospitalized with ACS were studied...
February 14, 2018: Journal of Clinical Lipidology
Faten Moassass, Abdulsamad Wafa, Thomas Liehr, Ayman Al-Ablog, Walid Al Achkar
Background: Children with constitutional trisomy 21, i.e. Down syndrome (DS, OMIM #190685) have a 10 to 20-fold increased risk for a hematopoietic malignancy. They may suffer from acute lymphoblastic leukemia or acute myeloid leukemia (AML). AML referred to as myeloid leukemia of Down syndrome (ML-DS) is observed especially after birth at an early gestational age and characterized by enhanced white blood cell count, failure of spontaneous remission, liver fibrosis or liver dysfunction, and is significantly associated with early death...
2018: Molecular Cytogenetics
Raghad Mubarak Aljuhaysh, Nagah Mohamed Abo El-Fetoh, Malak Ibrahim Alanazi, Afaf Shuaib Albaqawi, Wafa Mohammed Alanazi, Najah Salah Alanazi, Reham Muqbil Alanazi, Atheer Mutab Alanazi, Eiman Mohammad Alnemer, Rahma Abdulhadi Alenezi, Tasleem Khoudier Alabdullatif, Rehab Abdallah Alanazi, Samiyah Sarhan Alanazi, Kawthar Saeed Alsultan, Ibtisam Matan Alanazi, Duaa Sami Alsunayni
Background and aim: Rh isoimmunization still contributes to the neonatal morbidity and mortality due to non-immunization, under-immunization, and in rare cases, false Rh typing. The main objective of this study was to determine the prevalence of Rh incompatibility, mothers' knowledge about Rh incompatibility, mothers' knowledge about anti-D immunoglobulin and to show the pregnancy outcome of Rh negative mothers. Methods: A cross-sectional study was carried out at the Maternity and Children Hospital in Arar city from November 2016 to May 2017...
December 2017: Electronic Physician
Muhammad Fuad Hilmi Yusof, Wafa' Zahari, Siti Nurnasihah Md Hashim, Zul Faizuddin Osman, Hamshawagini Chandra, Thirumulu Ponnuraj Kannan, Khairul Bariah Ahmad Amin Noordin, Ahmad Azlina
Manipulation of dental stem cells (DSCs) using current technologies in tissue engineering unveil promising prospect in regenerative medicine. DSCs have shown to possess angiogenic and osteogenic potential in both in vivo and in vitro. Neural crest derived DSCs can successfully be isolated from various dental tissues, exploiting their intrinsic great differentiation potential. In this article, researcher team intent to review the characteristics of DSCs, with focus on their angiogenic and osteogenic differentiation lineage...
January 2018: Journal of Oral Biology and Craniofacial Research
Samia Hadj Ahmed, Wafa Kharroubi, Nadia Kaoubaa, Amira Zarrouk, Fathi Batbout, Habib Gamra, Mohamed Fadhel Najjar, Gérard Lizard, Isabelle Hininger-Favier, Mohamed Hammami
BACKGROUND: Nutritional choices, which include the source of dietary fatty acids (FA), have an important significant impact on coronary artery disease (CAD). We aimed to determine on patients with CAD the relationships between Trans fatty acids (Trans FA) and different CAD associated parameters such as inflammatory and oxidative stress parameters in addition to Gensini score as a vascular severity index. METHODS: Fatty acid profiles were established by gas chromatography from 111 CAD patients compared to 120 age-matched control group...
March 15, 2018: Lipids in Health and Disease
Haitham Elleuch, Wafa Mihoubi, Mohamed Mihoubi, Emna Ketata, Ali Gargouri, Farhat Rezgui
The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates...
March 3, 2018: Bioorganic Chemistry
Wafa Hassen, Mohamed Neifar, Hanene Cherif, Afef Najjari, Habib Chouchane, Rim C Driouich, Asma Salah, Fatma Naili, Amor Mosbah, Yasmine Souissi, Noura Raddadi, Hadda I Ouzari, Fabio Fava, Ameur Cherif
A number of Pseudomonas strains function as inoculants for biocontrol, biofertilization, and phytostimulation, avoiding the use of pesticides and chemical fertilizers. Here, we present a new metabolically versatile plant growth-promoting rhizobacterium, Pseudomonas rhizophila S211, isolated from a pesticide contaminated artichoke field that shows biofertilization, biocontrol and bioremediation potentialities. The S211 genome was sequenced, annotated and key genomic elements related to plant growth promotion and biosurfactant (BS) synthesis were elucidated...
2018: Frontiers in Microbiology
Andrea Borrego, Wafa Hanna Koury Cabrera, José Ricardo Jensen, Mara Correa, Orlando Garcia Ribeiro, Nancy Starobinas, Marcelo De Franco, Angela Pettinicchio, Tommaso A Dragani, Olga Célia Martinez Ibañez, Giacomo Manenti
Somatic KRAS mutations are common in human lung adenocarcinomas and are associated with worse prognosis. In mice, Kras is frequently mutated in both spontaneous and experimentally induced lung tumors, although the pattern of mutation varies among strains, suggesting that such mutations are not random events. We tested if the occurrence of Kras mutations is under genetic control in two mouse intercrosses. Codon 61 mutations were prevalent, but the patterns of nucleotide changes differed between the intercrosses...
March 3, 2018: Molecular Carcinogenesis
Wafa Babay, Hamza Ben Yahia, Nadia Boujelbene, Nour Zidi, Ahmed Baligh Laaribi, Dhikra Kacem, Radhia Ben Ghorbel, Abdellatif Boudabous, Hadda-Imene Ouzari, Roberta Rizzo, Vera Rebmann, Karima Mrad, Inès Zidi
BACKGROUND: The human leukocyte antigen (HLA)-G and HLA-E, non classical HLA class I molecules, have been highly implicated in immune tolerance. HLA-G and HLA-E molecules were proposed as putative markers of several advanced cancers. As a step towards a better understanding of ovarian carcinoma, we evaluated the expression of both HLA-G and HLA-E molecules and explored their prognostic implication. METHODS: HLA-G and HLA-E expression were studied by immunohistochemistry on ovarian carcinoma tissues...
February 27, 2018: Human Immunology
Wafa Al-Dhaheri, Imam Hassouna, Sherif M Karam
Breast cancer is the most common type of cancer and the leading cause of cancer-related deaths among women in the United Arab Emirates and worldwide. Although many factors contribute to the high incidence of breast cancer, a considerable number of cases are related to environmental factors. In the present study, breast cancer was induced in female rats using a single dose, 80 mg/kg body wt, of the environmental carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). The aim of the present study, was to characterize some of the molecular changes that occur during breast cancer development in the DMBA-treated rat model...
February 28, 2018: Oncology Reports
Wafa Redjdal, Nada Ibrahim, Belkacem Benmerad, Mouad Alami, Samir Messaoudi
Buchwald-Hartwig-Migita cross-coupling of 1-thiosugars with α- or β-3-iodo-N-glycosylquinolin-2-ones has been accomplished under mild and operationally simple reaction conditions through the use of a Pd-G3 XantPhos palladacycle precatalyst. This new methodology has been successfully applied to a variety of α- or β-mono-, di-, and poly-thiosugar derivatives to efficiently synthesize a series of α- or β-N,S-bis-glycosyl quinolin-2-ones, which are difficult to synthesize by classical methods.
February 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Haiying Liu, Jianbo Wang, Shuai Xia, Jianheng Bi, Mingxi Fang, Wafa Mazi, Yibin Zhang, Nathan Conner, Fen-Tair Luo, H Peter Lu
In the paper, we present three ratiometric near-infrared fluorescent probes (A-C) for accurate ratiometric detection of intracellular pH changes in live cells. Probe A consists of tetraphenylethene (TPE) donor and near-infrared hemicyanine acceptor in a through-bond energy transfer (TBET) strategy while probes B and C are composed of TPE and hemicyanine moieties through a single and double sp2 carbon-carbon bond connections in a π-conjugation modulation strategy. The specific targeting of the probes to lysosomes in live cells was achieved by introducing morpholine residues to the hemicyanine moieties to form closed spirolactam ring structures...
March 1, 2018: Bioconjugate Chemistry
Jesse Russell-Williams, Wafa Jaroudi, Tania Perich, Siobhan Hoscheidt, Mohamad El Haj, Ahmed A Moustafa
This study investigates the relationship between mindfulness, meditation, cognition and stress in people with Alzheimer's disease (AD), dementia, mild cognitive impairment and subjective cognitive decline. Accordingly, we explore how the use of meditation as a behavioural intervention can reduce stress and enhance cognition, which in turn ameliorates some dementia symptoms. A narrative review of the literature was conducted with any studies using meditation as an intervention for dementia or dementia-related memory conditions meeting inclusion criteria...
February 21, 2018: Reviews in the Neurosciences
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