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https://www.readbyqxmd.com/read/29449941/cardiovascular-risk-factor-burden-in-africa-and-the-middle-east-across-country-income-categories-a-post-hoc-analysis-of-the-cross-sectional-africa-middle-east-cardiovascular-epidemiological-ace-study
#1
Frederick J Raal, Alawi A Alsheikh-Ali, Mohamed I Omar, Wafa Rashed, Omar Hamoui, Abdoul Kane, Mohamed Alami, Paula Abreu, Walid M Mashhoud
Background: A significant number of cardiovascular disease (CVD)-related deaths occur in developing countries. An increasing prevalence of CVD is associated with a change in the macro-economy of these countries. In this post hoc analysis, CVD risk factor (CVDRF) prevalence is evaluated across countries based on national income in the Africa and Middle East Region (AfME). Methods: Data from the Africa Middle East Cardiovascular Epidemiological (ACE) study were used; a cross-sectional study in 14 AfME countries (94 clinics) from July 2011-April 2012, which evaluated CVDRF prevalence in stable adult outpatients...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29438437/a-novel-lpl-intronic-variant-g-18704c-a-identified-by-re-sequencing-kuwaiti-arab-samples-is-associated-with-high-density-lipoprotein-very-low-density-lipoprotein-and-triglyceride-lipid-levels
#2
Suzanne A Al-Bustan, Ahmad Al-Serri, Babitha G Annice, Majed A Alnaqeeb, Wafa Y Al-Kandari, Mohammed Dashti
The role interethnic genetic differences play in plasma lipid level variation across populations is a global health concern. Several genes involved in lipid metabolism and transport are strong candidates for the genetic association with lipid level variation especially lipoprotein lipase (LPL). The objective of this study was to re-sequence the full LPL gene in Kuwaiti Arabs, analyse the sequence variation and identify variants that could attribute to variation in plasma lipid levels for further genetic association...
2018: PloS One
https://www.readbyqxmd.com/read/29428373/first-line-paclitaxel-and-cisplatin-used-sequentially-or-in-combination-in-metastatic-breast-cancer-a-phase-ii-randomized-study
#3
Mostafa M Elserafi, Ahmed A Zeeneldin, Ibrahim M Abdelsalam, Hanan R Nassar, Manar M Moneer, Wafa H Buhoush
INTRODUCTION: Breast cancer (BC) is the commonest cancer among females worldwide. Some patients present initially at advanced stages and more than 50% of them will develop metastasis (MBC) at some point. Compared to single agents, combination chemotherapy produces higher response rates (RR), longer progression-free survival (PFS) than single agents. This is associated with remarkably higher toxicities. At the same time, overall survival (OS) is comparable. This study aimed to compare safety and efficacy of combination and sequential chemotherapy...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29419428/ibrutinib-for-chronic-lymphocytic-leukemia-international-experience-from-a-named-patient-program
#4
Peter Hillmen, Joris Diels, Nollaig Healy, Wafae Iraqi, Johan Aschan, Mark Wildgust
No abstract text is available yet for this article.
February 1, 2018: Haematologica
https://www.readbyqxmd.com/read/29404767/shear-wave-elastography-can-evaluate-annulus-fibrosus-alteration-in-adolescent-scoliosis
#5
Tristan Langlais, Claudio Vergari, Raphael Pietton, Jean Dubousset, Wafa Skalli, Raphael Vialle
OBJECTIVES: In vitro studies showed that annulus fibrosus lose its integrity in idiopathic scoliosis. Shear-wave ultrasound elastography can be used for non-invasive measurement of shear-wave speed (SWS) in vivo in the annulus fibrosus, a parameter related to its mechanical properties. The main aim was to assess SWS in lumbar annulus fibrosus of scoliotic adolescents and compare it to healthy subjects. METHODS: SWS was measured in 180 lumbar IVDs (L3L4, L4L5, L5S1) of 30 healthy adolescents (13 ± 1...
February 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29402821/completeness-and-legibility-of-handwritten-prescriptions-at-sana-a-yemen
#6
Yaser Mohammed Al-Worafi, Rahul P Patel, Syed Tabish Razi Zaidi, Wafa Mohammed Alseragi, Masaad Saeed Almutairi, Ali Saleh Alkhoshaiban, Long Chiau Ming
OBJECTIVE: The aim of this study was to investigate the completeness and legibility of prescriptions dispensed in community pharmacies located at Sana'a, Yemen. MATERIALS AND METHODS: A cross-sectional study was conducted at 23 randomly selected community pharmacies throughout the capital city of Sana'a, Yemen from May 2015 to January 2016. A total of 2178 prescriptions were analyzed for the essential elements of a complete prescription using a validated checklist...
January 31, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29387328/sarcoidosis-and-spondyloarthritis-a-coincidence-or-common-etiopathogenesis
#7
Hamdi Wafa, Miladi Saoussen, Kaffel Dhia, Zouch Imen, Kchir Mohamed Montacer
Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Case Presentation: A 48-years-old woman presented with inflammatory back pain for 5 years and ankle swelling for 1 year. On physical examination, she had an exaggerated dorsal kyphosis and disappearance of lumbar lordosis with limitation in motion of the cervical and lumbar spine...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29374472/exploring-health-care-seeking-knowledge-perceptions-and-practices-for-childhood-diarrhea-and-pneumonia-and-their-context-in-a-rural-pakistani-community
#8
Wafa Aftab, Leah Shipton, Fauziah Rabbani, Kashif Sangrasi, Shagufta Perveen, Aysha Zahidie, Imran Naeem, Shamim Qazi
BACKGROUND: Where access to facilities for childhood diarrhea and pneumonia is inadequate, community case management (CCM) is an effective way of improving access to care. In Pakistan, utilization of CCM for these diseases through the Lady Health Worker Program remains low. Challenges of access to facilities persist leading to delayed care and poor outcomes. Estimating caregiver knowledge, understanding their perceptions and practices, and recognizing how these are related to care seeking decisions about childhood diarrhea and pneumonia is crucial to bring about coherence between supply and demand-side practices...
January 27, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29337393/provision-of-information-on-dental-implant-treatment-patients-thoughts-and-experiences
#9
Wafa Ahmed Kashbour, Nikki S Rousseau, James Mark Thomason, Janice Sarah Ellis
OBJECTIVES: To explore patients' thoughts and perceptions of information provision regarding dental implant treatment. METHODS: This generic qualitative study involved 38 semi-structured face-to-face and telephone interviews with 34 participants, who were at different stages of dental implant treatment. The interviews were transcribed verbatim. The data collection and coding process followed the principles of qualitative thematic analysis. RESULTS: Clinical sources of information were generally trusted by patients; however, patients clearly lacked information relative to their own specific situation, concerns and preferences, and this may lead to patients' reliance on other general sources of information...
January 16, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29335593/bacterial-iron-reduction-and-biogenic-mineral-formation-for-the-stabilisation-of-corroded-iron-objects
#10
Wafa M Kooli, Lucrezia Comensoli, Julien Maillard, Monica Albini, Arnaud Gelb, Pilar Junier, Edith Joseph
Exploiting bacterial metabolism for the stabilisation of corroded iron artefacts is a promising alternative to conventional conservation-restoration methods. Bacterial iron reduction coupled to biogenic mineral formation has been shown to promote the conversion of reactive into stable corrosion products that are integrated into the natural corrosion layer of the object. However, in order to stabilise iron corrosion, the formation of specific biogenic minerals is essential. In this study, we used the facultative anaerobe Shewanella loihica for the production of stable biogenic iron minerals under controlled chemical conditions...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334084/a-cyanine-based-fluorescent-cassette-with-aggregation-induced-emission-for-sensitive-detection-of-ph-changes-in-live-cells
#11
Mingxi Fang, Shuai Xia, Jianheng Bi, Travis P Wigstrom, Loredana Valenzano, Jianbo Wang, Wafa Mazi, Marina Tanasova, Fen-Tair Luo, Haiying Liu
An aggregation-induced emission (AIE) cyanine-based fluorescent cassette with a large pseudo-Stokes shift was designed and prepared to sensitively image pH changes in live cells via through-bond energy transfer (TBET) from a tetraphenylethene (TPE) donor to a cyanine acceptor.
January 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29305958/description-of-a-novel-mutation-in-the-atpc-gene-in-optochin-resistant-streptococcus-pneumoniae-strains-isolates-from-tunisia
#12
Anis Raddaoui, Farah Ben Tanfous, Wafa Achour, Rekaya Baaboura, Assia Benhassen
The identification of Streptocooccus pneumoniae among other α-hemolytic streptococci is based on phenotypic or genotypic characteristics as colony morphology, bile solubility and optochin susceptibility. We report in this study three optochin-resistant S. pneumoniae isolated from immunocompromised patients in Tunisia. The three isolates were positive for bile solubility test. The biochemical identification with API® 20 Strep was not discriminatory for two strains. The three strains had different serotypes (6C, 19F and 23F) and three different sequence types (ST386, ST320, and ST326)...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29305079/combinatorial-effect-of-photorhabdus-luminescens-tt01-and-bacillus-thuringiensis-vip3aa16-toxin-against-agrotis-segetum
#13
Wafa Jallouli, Hanen Boukadi, Sameh Sellami, Fakher Frikha, Lobna Abdelkefi-Mesrati, Slim Tounsi
The entomopathogenic Photorhabdus luminescens TT01 is a promoting bacterium that controls effectively many insect pests. Indeed, it exhibited a mortality rate of 32.36% against the first instar larvae of the turnip moth Agrotis segetum, when it was used at a concentration of 5 × 107 cells/ml but no toxicity against the second instar larvae in the same condition. P. luminescens TT01 oral toxicity is associated to septicaemia since cells fraction exhibited the highest mortality rate of 34%. In order to enhance P...
January 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29298777/prevalence-of-keratoconus-in-paediatric-patients-in-riyadh-saudi-arabia
#14
Emilio Almeida Torres Netto, Wafa Majed Al-Otaibi, Nikki L Hafezi, Sabine Kling, Haya M Al-Farhan, J Bradley Randleman, Farhad Hafezi
BACKGROUND/AIM: Keratoconus (KC) is a ectatic corneal disorder with marked progression during childhood and puberty that may lead to severe visual loss. In addition to KC prevalence, estimate shows major geographical variations; recent studies using Scheimpflug technology are in contrast to the 1980s and 1990s literature. The present study aims to determine the prevalence of KC in paediatric patients in Riyadh, Saudi Arabia (KSA). METHODS: This prospective, cross-sectional, observational, multicentre study collected data from paediatric patients from 6 years and 21 years of age who were seen at multiple non-ophthalmic emergency departments within KSA...
January 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29296066/multimodality-imaging-assessment-of-a-caseous-calcification-of-the-mitral-valve-annulus
#15
Imen Hamdi, Chadia Chourabi, Younes Arous, Mehdi Ghommidh, Khalil Houissa, Abdeddayem Haggui, Nadhem Hajlaoui, Dhaker Lahidheb, Nejmeddine Ben Abdallah, Wafa Fehri, Habib Haouala
Caseous calcification of the mitral annulus (CCMA) is a rare echocardiographic finding. It is commonly misdiagnosed as an abscess, tumor or infective vegetation on the mitral valve. Since it is a benign process, differentiating it from malignant intra-cardiac mass is primordial to avoid unnecessary surgery. Various imaging modalities can be complimentary for definitive diagnosis. We present a case of CCMA in a 71-year-old female patient. Her medical history revealed hypertension, diabetes mellitus, hyperlipidaemia and coronary artery disease...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29288806/transparent-predictive-modelling-of-the-twin-screw-granulation-process-using-a-compensated-interval-type-2-fuzzy-system
#16
Wafa' H AlAlaween, Bilal Khorsheed, Mahdi Mahfouf, Ian Gabbott, Gavin K Reynolds, Agba D Salman
In this research, a new systematic modelling framework which uses machine learning for describing the granulation process is presented. First, an interval type-2 fuzzy model is elicited in order to predict the properties of the granules produced by twin screw granulation (TSG) in the pharmaceutical industry. Second, a Gaussian mixture model (GMM) is integrated in the framework in order to characterize the error residuals emanating from the fuzzy model. This is done to refine the model by taking into account uncertainties and/or any other unmodelled behaviour, stochastic or otherwise...
December 27, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29283332/diverse-signaling-pathways-and-current-status-of-molecular-targeted-treatments-for-hepatocellular-carcinoma
#17
Bushra Akhtar, Faqir Muhammad, Ali Sharif, Muhammad Furqan Akhtar, Wafa Majeed
Hepatocellular carcinoma (HCC) is one of the leading causes of death associated with cancer. Various molecular mechanisms are involved in HCC development. Alterations in these molecular mechanisms include chromosomal instability, gene mutations, and variations in protein expressions. A number of cell signaling pathways that are associated with the occurrence of apoptosis, cell proliferation, and angiogenesis provide new prospects for the development of HCC treatments. Newly designed, potential therapeutic regimens target specific receptors, kinases, and vital proteins...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29250295/early-pulmonary-vein-conduction-recovery-after-catheter-ablation-of-atrial-fibrillation
#18
Ayman Mortada, Saeed Khaled, Samir Wafa, Hayam Eldamanhoury, Ahmed Nabil
Background: Pulmonary vein electrical isolation (PVI) is an effective treatment for atrial fibrillation (AF). However, recurrence of pulmonary vein (PV) conduction after ablation may limit long-term success. Early identification and treatment of acute PV conduction recovery during initial ablation may have an impact on subsequent clinical results. Objective: To assess the prevalence of acute PV conduction recovery during the observation time after PV isolation for paroxysmal AF, and to evaluate the impact of re-isolation treatment on long-term clinical results...
April 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29229831/clinical-genetic-and-structural-basis-of-apparent-mineralocorticoid-excess-due-to-11%C3%AE-hydroxysteroid-dehydrogenase-type-2-deficiency
#19
Mabel Yau, Shozeb Haider, Ahmed Khattab, Chen Ling, Mehr Mathew, Samir Zaidi, Madison Bloch, Monica Patel, Sinead Ewert, Wafa Abdullah, Aysenur Toygar, Vitalii Mudryi, Maryam Al Badi, Mouch Alzubdi, Robert C Wilson, Hanan Said Al Azkawi, Hatice Nur Ozdemir, Wahid Abu-Amer, Jozef Hertecant, Maryam Razzaghy-Azar, John W Funder, Aisha Al Senani, Li Sun, Se-Min Kim, Tony Yuen, Mone Zaidi, Maria I New
Mutations in 11β-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) cause an extraordinarily rare autosomal recessive disorder, apparent mineralocorticoid excess (AME). AME is a form of low renin hypertension that is potentially fatal if untreated. Mutations in the HSD11B2 gene result either in severe AME or a milder phenotype (type 2 AME). To date, ∼40 causative mutations have been identified. As part of the International Consortium for Rare Steroid Disorders, we have diagnosed and followed the largest single worldwide cohort of 36 AME patients...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29227919/a-subject-specific-biomechanical-control-model-for-the-prediction-of-cervical-spine-muscle-forces
#20
Maxim Van den Abbeele, Fan Li, Vincent Pomero, Dominique Bonneau, Baptiste Sandoz, Sébastien Laporte, Wafa Skalli
BACKGROUND: The aim of the present study is to propose a subject-specific biomechanical control model for the estimation of active cervical spine muscle forces. METHODS: The proprioception-based regulation model developed by Pomero et al. (2004) for the lumbar spine was adapted to the cervical spine. The model assumption is that the control strategy drives muscular activation to maintain the spinal joint load below the physiological threshold, thus avoiding excessive intervertebral displacements...
December 6, 2017: Clinical Biomechanics
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