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https://www.readbyqxmd.com/read/27894678/a-simple-orthosis-solves-a-problem-in-a-patient-with-a-dystonic-finger-after-stroke
#1
Stefano Vercelli, Giorgio Ferriero, Elisabetta Bravini, Wafa Al Yazeedi, Ludovit Salgovic, Marco Caligari, Francesco Sartorio
These authors use a custom-fabricated orthotic device to improve hand motion and function for a client with hand dystonia after stroke. Clinical observation and reasoning resulted in an effective solution to control the dystonia that was acceptable to the client. - Kristin Valdes, OTD, OT, CHT, Practice Forum Editor.
November 25, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#2
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27892691/a-new-sulfonylated-flavonoid-and-other-bioactive-compounds-isolated-from-the-aerial-parts-of-cotula-anthemoides-l
#3
Wafa Tadrent, Abdulmagid Alabdul Magid, Ahmed Kabouche, Dominique Harakat, Laurence Voutquenne-Nazabadioko, Zahia Kabouche
A new sulfonyl flavonol glucoside, 5,7,4',5'-tetrahydoxyflavonol 2'-[propanoic acid-(2″'-acetoxy-1″'-sulfonyl)]-5'-O-β-d-glucopyranoside (1) was isolated from the aerial parts of Cotula anthemoides L. in addition to 15 known compounds (2-16). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D-, 2D-NMR and HR-ESI-MS techniques and by comparing their NMR data with those reported in the literature. These compounds were evaluated for their DPPH radical scavenging and tyrosinase inhibitory activity...
November 28, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27878773/ramadan-fasting-in-patients-with-adrenal-insufficiency
#4
Mélika Chihaoui, Fatma Chaker, Meriem Yazidi, Wafa Grira, Zohra Ben Amor, Ons Rejeb, Hedia Slimane
AIM: The risks of fasting during Ramadan in patients with adrenal insufficiency are unknown. The aims of this study were to evaluate these risks in such patients, to determine the risk factors and finally to set some recommendations. METHODS: It is a cross-sectional study about 180 patients with known and treated adrenal insufficiency. The patients responded to a 14-item questionnaire concerning their knowledge about the disease and fasting during the last month of Ramadan...
November 23, 2016: Endocrine
https://www.readbyqxmd.com/read/27863659/docetaxel-loaded-liposomes-the-effect-of-lipid-composition-and-purification-on-drug-encapsulation-and-in-vitro-toxicity
#5
Sara Pereira, Raphael Egbu, Gemma Jannati, Wafa' T Al-Jamal
Docetaxel (DTX)-loaded liposomes have been formulated to overcome DTX solubility issue, improve its efficacy and reduce its toxicity. This study investigated the effect of steric stabilisation, varying liposome composition, and lipid:drug molar ratio on drug loading and on the physicochemical properties of the DTX-loaded liposomes. Size exclusion chromatography (SEC) was used to remove free DTX from the liposomal formulation, and its impact on drug loading and in vitro cytotoxicity was also evaluated. Liposomes composed of fluid, unsaturated lipid (DOPC:Chol:DSPE-PEG2000) showed the highest DTX loading compared to rigid, saturated lipids (DPPC:Chol:DSPE-PEG2000 and DSPC:Chol:DSPE-PEG2000)...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27863656/engineering-thermosensitive-liposome-nanoparticle-hybrids-loaded-with-doxorubicin-for-heat-triggered-drug-release
#6
Zahraa Al-Ahmady, Neus Lozano, Kuo-Ching Mei, Wafa' T Al-Jamal, Kostas Kostarelos
The engineering of responsive multifunctional delivery systems that combine therapeutic and diagnostic (theranostic) capabilities holds great promise and interest. We describe the design of thermosensitive liposome-nanoparticle (NP) hybrids that can modulate drug release in response to external heating stimulus. These hybrid systems were successfully engineered by the incorporation of gold, silver, and iron oxide NPs into the lipid bilayer of lysolipid-containing thermosensitive liposomes (LTSL). Structural characterization of LTSL-NP hybrids using cryo-EM and AFM revealed the incorporation of metallic NPs into the lipid membranes without compromising doxorubicin loading and retention capability...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27848393/comparison-of-rat-and-rabbit-embryo-fetal-developmental-toxicity-data-for-379-pharmaceuticals-on-the-nature-and-severity-of-developmental-effects
#7
Peter T Theunissen, Sonja Beken, Bruce K Beyer, William J Breslin, Gregg D Cappon, Connie L Chen, Gary Chmielewski, Luc De Schaepdrijver, Brian Enright, Jennifer E Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M Hoberman, Julia Y Hui, Thomas B Knudsen, Susan B Laffan, Susan L Makris, Matt Martin, Mary Ellen McNerney, Christine L Siezen, Dinesh J Stanislaus, Jane Stewart, Kary E Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F Weinbauer, Sandra Wood, Aldert H Piersma
Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo-fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT testing could be limited to one species, or whether the testing in a second species could be decided on a case-by-case basis. As part of a consortium initiative, we built and queried a database of 379 compounds with EFDT studies (in both rat and rabbit animal models) conducted for marketed and non-marketed pharmaceuticals for their potential for adverse developmental and maternal outcomes, including EFDT incidence and the nature and severity of adverse findings...
November 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27847022/an-exceptional-location-of-tuberculous-arthritis-the-metatarsal-phalangeal-joint
#8
Mohamed Ali Sbai, Sofien Benzarti, Wafa Gharbi, Wadia Khoffi, Riadh Maalla, Adel Khorbi
Osteoarticular tuberculosis is a rare type of tuberculosis. The spine is the most frequent location, while peripheral locations in the limbs are rare. We report a case of tuberculous osteoarthritis of the metatarsophalangeal joint of the first ray of the foot in a 48-year-old woman. The patient presented with painful swelling of the dorsum of the big toe, insidiously evolving for 6months. Diagnosis was obtained with histological study after surgical biopsy. Antitubercular chemotherapy for 12months promoted healing...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27837547/stable-discoidal-bicelles-a-platform-of-lipid-nanocarriers-for-cellular-delivery
#9
Ying Liu, Yan Xia, Armin Tahmasbi Rad, Wafa Aresh, Mu-Ping Nieh
Bicellar mixtures have been used as alignable membrane substrates for the structural characterization of membrane-associated proteins. Most recently, it has been shown that bicelles can serve as nanocarriers to effectively deliver hydrophobic molecules to cancer cells with a 3- to 10-fold enhancement compared to that of chemically identical liposomes. In this chapter, a detailed preparation protocol, common structural characterization methods, the structural stability and the cellular uptake of bicellar nanodisks are discussed...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27817139/three-dimensional-reconstruction-using-stereoradiography-for-evaluating-adult-spinal-deformity-a-reproducibility-study
#10
Emmanuelle Ferrero, Renaud Lafage, Shaleen Vira, Pierre-Yves Rohan, Jonathan Oren, Edward Delsole, Pierre Guigui, Frank Schwab, Virginie Lafage, Wafa Skalli
PURPOSE: In addition to the sagittal alignment, impact of transverse plane parameters (TPP) and rotatory subluxation on patients reported outcomes were highlighted. One of the hypotheses for genesis of degenerative scoliosis is disc degeneration with increased axial vertebral (AVR) and intervertebral rotation (AIR). Therefore, TPP analysis at early stage of the scoliosis seems of particular interest. This study aims at assessing reliability of tridimensional (3D) reconstructions of adult spinal deformity (ASD) patients...
November 5, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27816983/a-micro-computed-tomography-study-of-the-root-canal-morphology-of-mandibular-first-premolars-in-an-emirati-population
#11
Wafa Alkaabi, Emad AlShwaimi, Imran Farooq, Harold E Goodis, Sami M A Chogle
No abstract text is available yet for this article.
November 3, 2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/27816344/-a-psychiatric-disorder-reveals-a-neurobrucellosis
#12
Inès Feki, Wafa Abbes, Salma Sakka, Imen Bouchhima, Chokri Mhiri, Jaweher Masmoudi
No abstract text is available yet for this article.
November 2, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27807772/invariance-of-head-pelvis-alignment-and-compensatory-mechanisms-for-asymptomatic-adults-older-than-49%C3%A2-years
#13
Celia Amabile, Jean-Charles Le Huec, Wafa Skalli
PURPOSE: The aim was to quantify the postural alignment of asymptomatic elderly, in comparison to a reference population, searching for possible invariants and compensatory mechanisms. METHODS: 41 volunteers (49-76 years old) underwent bi-planar X-rays with 3D reconstructions of the spine and pelvis. Alignment parameters were compared with those of a reference group of asymptomatic subjects younger than 40 years old, with a particular focus on center of acoustic meati (CAM) and odontoid (OD) with regard to hip axis (HA)...
November 2, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27795792/aseptic-necrosis-of-the-femoral-head-after-pregnancy-a-case-report
#14
Kawtar Nassar, Wafae Rachidi, Saadia Janani, Ouafa Mkinsi
A documented case of beginning aseptic necrosis of the femoral head associated with pregnancy together with a review of the literature about this rare complication of pregnancy is presented. The known risk factors of osteonecrosis are; steroid use, alcoholism, organ transplantation, especially after kidney transplant or bone marrow transplantation bone, systemic lupus erythematosus, dyslipidemia especially hypertriglyceridemia, dysbaric decompression sickness, drepanocytosis and Gaucher's disease. Among the less established factors, we mention procoagulations abnormalities, HIV infection, chemotherapy...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27795763/-the-possum-a-good-scoring-system-for-predicting-mortality-in-elderly-patients-undergoing-emergency-surgery
#15
Zeineb Mzoughi, Rached Bayar, Achref Djebbi, Ghofrane Talbi, Hayfa Romdhane, Wafa Aloui, Gharbi Lassaad, Mohamed Taher Khalfallah
INTRODUCTION: POSSUM (Physiologic and Operative Severity Score for the enumeration of Mortality and morbidity) is a scoring system for predicting mortality which is largely used in elective aortic and abdominal surgery. The aim of our study was to validate POSSUM with regards to elderly patients (> 70 years) undergoing digestive emergency surgery. We wanted to determine the optimal threshold for POSSUM, consisting of a physiological score and of an operative score for predicting mortality in this population...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27789465/systemic-inhibition-of-il-6-stat3-signalling-protects-against-experimental-osteoarthritis
#16
Augustin Latourte, Chahrazad Cherifi, Jérémy Maillet, Hang-Korng Ea, Wafa Bouaziz, Thomas Funck-Brentano, Martine Cohen-Solal, Eric Hay, Pascal Richette
OBJECTIVE: To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis (OA). METHODS: Expression of major catabolic and anabolic factors of cartilage was determined in IL-6-treated mouse chondrocytes and cartilage explants. The anti-IL-6-receptor neutralising antibody MR16-1 was used in the destabilisation of the medial meniscus (DMM) mouse model of OA...
October 27, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27784252/core-shell-semiconductor-nanocrystals-%C3%A2-effect-of-composition-size-surface-coatings-on-their-optical-properties-toxicity-and-pharmacokinetics
#17
Wafa T Al-Jamal
Quantum dots are semiconducting nanocrystals that exhibit extraordinary optical properties. QD have shown higher photostability compared to standard organic dye type probes. Therefore, they have been heavily explored in the biomedical field. This review will discuss the different approaches to synthesis, solubilise and functionalise QD. Their main biomedical applications in imaging and photodynamic therapy will be highlighted. Finally, QD biodistribution profile and in vivo toxicity will be discussed.
October 26, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27779608/early-detection-of-progressive-adolescent-idiopathic-scoliosis-a-severity-index
#18
Wafa Skalli, Claudio Vergari, Eric Ebermeyer, Isabelle Courtois, Xavier Drevelle, Remi Kohler, Kariman Abelin-Genevois, Jean Dubousset
STUDY DESIGN: Early detection of progressive adolescent idiopathic scoliosis (AIS) was assessed based on 3D quantification of the deformity. OBJECTIVE: Based on 3D quantitative description of scoliosis curves, the aim is to assess a specific phenotype that could be an early detectable severity index for progressive AIS. SUMMARY OF BACKGROUND DATA: Early detection of progressive scoliosis is important for adapted treatment to limit progression...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27776287/antimicrobial-effect-of-the-tunisian-nana-variety-punica-granatum-l-extracts-against-salmonella-enterica-serovars-kentucky-and-enteritidis-isolated-from-chicken-meat-and-phenolic-composition-of-its-peel-extract
#19
Ben Ajmia Wafa, Mohamed Makni, Sonda Ammar, Lamia Khannous, Amal Ben Hassana, Mohamed Bouaziz, Nour Eddine Es-Safi, Radhouane Gdoura
Punica granatum L. is widely recognized for its potency against a broad spectrum of bacterial pathogens. The purpose of this study was to explore the inhibitory and the bactericidal activities of Punica granatum against Salmonella strains. The effect of extracts obtained from different parts (peels, seeds, juice and flowers) of pomegranate and using different solvents against Salmonella enterica serovars Kentucky and Enteritidis isolated from chicken meat was thus investigated. Salmonella strains were identified with the standard API-20E system and confirmed by real time PCR...
October 11, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27766926/comparing-rat-and-rabbit-embryo-fetal-developmental-toxicity-data-for-379-pharmaceuticals-on-systemic-dose-and-developmental-effects
#20
Peter T Theunissen, Sonia Beken, Bruce Beyer, William J Breslin, Gregg D Cappon, Connie L Chen, Gary Chmielewski, Luc de Schaepdrijver, Brian Enright, Jennifer E Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M Hoberman, Julia Y Hui, Thomas B Knudsen, Susan B Laffan, Susan L Makris, Matthew Martin, Mary Ellen McNerney, Christine L Siezen, Dinesh J Stanislaus, Jane Stewart, Kary E Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F Weinbauer, Sandra Wood, Aldert H Piersma
A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental lowest adverse effect level (dLOAEL). For the vast majority of cases (83% based on AUC of n = 283), dLOAELs in rats and rabbits were within the same order of magnitude (less than 10-fold different) when compared based on available data on AUC and Cmax exposures...
October 21, 2016: Critical Reviews in Toxicology
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