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https://www.readbyqxmd.com/read/28426813/correction-phenolic-extract-from-oleaster-olea-europaea-var-sylvestris-leaves-reduces-colon-cancer-growth-and-induces-caspase-dependent-apoptosis-in-colon-cancer-cells-via-the-mitochondrial-apoptotic-pathway
#1
Wafa Zeriouh, Abdelhafid Nani, Meriem Belarbi, Adélie Dumont, Charlotte de Rosny, Ikram Aboura, Fatima Zahra Ghanemi, Babar Murtaza, Danish Patoli, Charles Thomas, Lionel Apetoh, Cédric Rébé, Dominique Delmas, Naim Akhtar Khan, François Ghiringhelli, Mickael Rialland, Aziz Hichami
[This corrects the article DOI: 10.1371/journal.pone.0170823.].
2017: PloS One
https://www.readbyqxmd.com/read/28422707/factors-underlying-cognitive-decline-in-old-age-and-alzheimer-s-disease-the-role-of-the-hippocampus
#2
Wafa Jaroudi, Julia Garami, Sandra Garrido, Michael Hornberger, Szabolcs Keri, Ahmed A Moustafa
There are many factors that strongly influence the aetiology, development, and progression of cognitive decline in old age, mild cognitive impairment (MCI), and Alzheimer's disease (AD). These factors include not only different personality traits and moods but also lifestyle patterns (e.g. exercise and diet) and awareness levels that lead to cognitive decline in old age. In this review, we discuss how personality traits, mood states, and lifestyle impact brain and behaviour in older adults. Specifically, our review shows that these lifestyle and personality factors affect several brain regions, including the hippocampus, a region key for memory that is affected by cognitive decline in old age as well as AD...
April 19, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28418808/effects-of-maternal-supplementation-with-omega-3-precursors-on-human-milk-composition
#3
Evelyne Mazurier, Virginie Rigourd, Paul Perez, Rachel Buffin, Leslie Couedelo, Carole Vaysse, Wafae Belcadi, Rémi Sitta, Fabienne Nacka, Delphine Lamireau, Gilles Cambonie, Jean-Charles Picaud, Claude Billeaud
BACKGROUND: Long-chain polyunsaturated fatty acids (LC-PUFAs) are important for newborn neurosensory development. Supplementation of breastfeeding mothers' diets with omega-3 PUFAs, such as alpha-linolenic acid (ALA), may increase their concentration in human milk. Research aim: This study aimed to assess human milk composition after 15-day supplementation regimens containing either omega-3 PUFAs or olive oil, which does not provide ALA. METHODS: A multicenter factorial randomized trial was conducted with four groups of breastfeeding women, with each group containing 19 to 22 women...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28411136/augmentation-of-keratinized-gingiva-around-dental-implants
#4
Kissa Jamila, El Kholti Wafa, Laalou Younes, El Farouki Mohamed
To date, there is no general consensus with respect to the amount of soft-tissue volume needed for esthetic and functional purposes on the buccal aspect of dental implants. Numerous studies have investigated the relationship between the width of keratinized mucosa and the health of peri-implant tissues. Our purpose was to discuss about the necessity of keratinized tissue to maintain the peri-implant health and to report clinical efficacy of different technics used to increase the keratinized tissue around dental implants...
April 11, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28407949/direct-technique-for-monitoring-lipid-oxidation-in-water-in-oil-emulsions-based-on-micro-calorimetry
#5
Wafa Dridi, Jean Toutain, Alain Sommier, Wafa Essafi, Fernando Leal-Calderon, Maud Cansell
An experimental device based on the measurement of the heat flux dissipated during chemical reactions, previously validated for monitoring lipid oxidation in plant oils, was extended to follow lipid oxidation in water-in-oil emulsions. Firstly, validation of the approach was performed by correlating conjugated diene concentrations measured by spectrophotometry and the heat flux dissipated by oxidation reactions and measured directly in water-in-oil emulsions, in isothermal conditions at 60°C. Secondly, several emulsions based on plant oils differing in their n-3 fatty acid content were compared...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28399450/synthesis-of-new-n3-substituted-dihydropyrimidine-derivatives-as-l-t-type-calcium-channel-blockers
#6
Mohamed Teleb, Fang-Xiong Zhang, Ahmed M Farghaly, Omaima M Aboul Wafa, Frank R Fronczek, Gerald W Zamponi, Hesham Fahmy
Cardiovascular diseases (CVDs) are the main cause of deaths worldwide. Up-to-date, hypertension is the most significant contributing factor to CVDs. Recent clinical studies recommend calcium channel blockers (CCBs) as effective treatment alone or in combination with other medications. Being the most clinically useful CCBs, 1,4-dihydropyridines (DHPs) attracted great interest in improving potency and selectivity. However, the short plasma half-life which may be attributed to the metabolic oxidation to the pyridine-counterparts is considered as a major limitation for this class...
April 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28390942/fluorinated-tranylcypromine-analogues-as-inhibitors-of-lysine-specific-demethylase-1-lsd1-kdm1a
#7
Maria Teresa Borrello, Benjamin Schinor, Katharina Bartels, Hanae Benelkebir, Sara Pereira, Wafa T Al-Jamal, Leon Douglas, Patrick J Duriez, Graham Packham, Günter Haufe, A Ganesan
We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring. A number of compounds with additional m- or p-substitution of the aryl ring were micromolar inhibitors of the LSD1 enzyme. In cellular assays, the compounds inhibited the proliferation of acute myeloid leukemia cell lines. Increased levels of the biomarkers H3K4me2 and CD86 were consistent with LSD1 target engagement.
March 29, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28385156/childhood-pre-b-cell-acute-lymphoblastic-leukemia-with-translocation-t-1-19-q21-1-p13-3-and-two-additional-chromosomal-aberrations-involving-chromosomes-1-6-and-13-a-case-report
#8
Abdulsamad Wafa, Manar As'sad, Thomas Liehr, Abdulmunim Aljapawe, Walid Al Achkar
BACKGROUND: The translocation t(1;19)(q23;p13), which results in the TCF3-PBX1 chimeric gene, is one of the most frequent rearrangements observed in B cell acute lymphoblastic leukemia. It appears in both adult and pediatric patients with B cell acute lymphoblastic leukemia at an overall frequency of 3 to 5%. Most cases of pre-B cell acute lymphoblastic leukemia carrying the translocation t(1;19) have a typical immunophenotype with homogeneous expression of CD19, CD10, CD9, complete absence of CD34, and at least diminished CD20...
April 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28381037/temperature-dependence-of-ti-sapphire-fluorescence-spectra-for-the-design-of-cryogenic-cooled-ti-sapphire-cpa-laser
#9
Harry Burton, Christopher Debardelaben, Wafa Amir, Thomas A Planchon
The fluorescence spectra of titanium doped sapphire (Ti:Sapphire) crystals were measured for temperature ranging from 300K to 77K. The resulting gain cross-section line shapes were calculated and used in a three-dimensional amplification model to illustrate the importance of the precise knowledge of these fluorescence spectra for the design of cryogenic cooled Ti:Sapphire based chirped-pulse laser amplifiers.
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28374932/genotyping-of-commensal-neisseria-spp-strains-by-pulsed-field-gel-electrophoresis-and-16s-rrna-gene-sequencing
#10
Arij Mechergui, Wafa Achour, Assia Ben Hassen
BACKGROUND: We investigated the diversity of the primary sequences of the 16S rRNA genes among 46 commensal Neisseria strains and evaluated the use of this approach as a molecular typing tool in comparison with PFGE analysis. METHODS: Identification to the genus was done using conventional methods and API NH (bio-Mérieux(®) ). Identification to species level was based on 16S rRNA gene sequencing. PFGE analysis was done using SpeI. RESULTS: Fourteen, two, three and fourteen 16S rRNA sequence types were found among twenty Neisseria flavescens, two Neisseria sicca, five Neisseria macacae and nineteen Neisseria mucosa clinical isolates...
April 4, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28366400/ostreopsis-cf-ovata-in-the-gulf-of-gab%C3%A3-s-south-eastern-mediterranean-sea-morphological-molecular-and-ecological-characterization
#11
Moufida Abdennadher, Amel Bellaaj Zouari, Wafa Feki Sahnoun, Elsa Alverca, Antonella Penna, Asma Hamza
In the last few decades, the frequency of the toxic benthic dinoflagellate Ostreopsis cf. ovata proliferation has increased in the Mediterranean Sea. These blooms are associated with harmful effects on human health and the environment. The present work provides the first long term study on the spatio-temporal distribution of O. cf. ovata in relation to physical parameters in the Gulf of Gabès coastal waters (south-eastern Mediterranean Sea), as well as its morphological, molecular and physiological features...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28366386/a-bayesian-network-approach-to-determine-environmental-factors-controlling-karenia-selliformis-occurrences-and-blooms-in-the-gulf-of-gab%C3%A3-s-tunisia
#12
Wafa Feki-Sahnoun, Asma Hamza, Hasna Njah, Nouha Barraj, Mabrouka Mahfoudi, Ahmed Rebai, Malika Bel Hassen
A Bayesian Network modeling framework is introduced to explore the effect of physical and meteorological factors on the dinoflagellate red tide forming Karenia selliformis in various sampling sites of the national phytoplankton monitoring program. The proposed models took into account the physical environment effects (salinity, temperature and tide amplitude), meteorological constraints (evaporation, air temperature, insolation, rainfall, atmospheric pressure and humidity), sampling months and sites on both Karenia selliformis occurrences and blooms...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28363639/increased-expression-of-ctla4-by-t-cells-induced-by-b7-in-sera-reduces-adaptive-immunity-in-patients-with-acute-liver-failure
#13
Wafa Khamri, Robin D Abeles, Tie Zheng Hou, Amy E Anderson, Ahmed El-Masry, Evangelos Triantafyllou, Christine Bernsmeier, Fin S Larsen, Arjuna Singanayagam, Nobuaki Kudo, Lucia A Possamai, Fanny Lebosse, Georg Auzinger, William Bernal, Christopher Willars, Christopher J Weston, Giovanna Lombardi, Julia Wendon, Mark Thursz, Charalambos G Antoniades
BACKGROUND & AIMS: Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immuneparesis) and are susceptible to sepsis. Cytotoxic T-lymphocyte associated protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called CD80 and CD86), is a negative regulator of T-cell activation. We collected T cells from patients with ALF and investigated whether inhibitory signals downregulate adaptive immune responses in patients with ALF. METHODS: We collected peripheral blood mononuclear cells from patients with ALF and controls from September 2013 through September 2015 (45 patients with ALF, 20 patients with acute-on-chronic liver failure, 15 patients with cirrhosis with no evidence of acute decompensation, 20 patients with septic shock but no cirrhosis or liver disease, and 20 healthy individuals)...
March 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28348158/ges-14-producing-acinetobacter-baumannii-in-a-neonatal-intensive-care-unit-in-tunisia-are-associated-with-a-typical-middle-east-clone-and-a-transferable-plasmid
#14
Aymen Mabrouk, Filipa Grosso, João Botelho, Wafa Achour, Assia Ben Hassen, Luisa Peixe
The occurrence of carbapenem-resistant Acinetobacter baumannii (CRAB) is mainly due to the production of class D β-lactamases (CHDL).….
March 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28343905/the-dana-farber-consortium-protocol-for-the-treatment-of-adolescents-and-young-adults-with-acute-lymphoblastic-leukemia-a-single-institution-experience-in-saudi-arabia
#15
Amal S Alabdulwahab, Hussein G Elsayed, Mohamed A Sherisher, Wafa M Elbjeirami, Nelly Alieldin
BACKGROUND: Recent retrospective analyses and phase II trials have shown differential outcomes in adolescents and young adults when treated with pediatric compared with adult protocols. The aim of this study was to evaluate the efficacy and toxicity of the Dana Farber Consortium Protocol (DFCP) in Saudi young adults diagnosed with de novo acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: In this retrospective study we included 38 patients with de novo ALL who presented to King Abdulla Medical City in the period from June 2010 to March 2015 and received the DFCP (Princess Margret modified version)...
February 16, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28327262/clinical-performance-of-pedo-jacket-crowns-in-maxillary-anterior-primary-teeth
#16
Aimee Castro, Sherine B Y Badr, Wafa El-Badrawy, Gajanan Kulkarni
PURPOSES: To assess the clinical performance of Pedo Jacket crowns for restoration of carious primary anterior teeth. METHODS: A total of 129 carious primary incisors and canines of 48 children younger than 71 months of age- were restored with Pedo Jacket crowns and resin-modified glass ionomer cementation. They were assessed for: ease of use; presence of recurrent decay; wear; partial or complete loss of the crown; color stability; gingival health; and overall clinical success over a 12-month follow-up...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28321939/examining-the-sociocultural-sensitivity-of-subjective-drunkenness-comparing-arab-and-jewish-israeli-pub-patrons
#17
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
INTRODUCTION AND AIMS: Subjective drunkenness measures may be useful screening tools for alcohol-related problems. However, if self-reported drunkenness is influenced by social and cultural understandings, the measure may not predict drinking patterns equally across different sociocultural groups. The current study aims to determine whether the two main sociocultural groups in Israel (Arabs and Jews) are equally likely to report drunkenness at comparable levels of breath alcohol content (BrAC)...
March 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28318648/rates-of-central-line-associated-bloodstream-infection-in-tertiary-care-hospitals-in-3-arabian-gulf-countries-6-year-surveillance-study
#18
Hanan H Balkhy, Aiman El-Saed, Seif S Al-Abri, Jameela Alsalman, Huda Alansari, Zaina Al Maskari, Ayman El Gammal, Wafa Al Nasser, Amina AlJardani, Abdulhakeem Althaqafi
The objective of this study was to compare central line-associated bloodstream infection (CLABSI) rates in Gulf Cooperation Council (GCC) states with those of the U.S. National Healthcare Safety Network (NHSN) and International Nosocomial Infection Control Consortium (INICC) using pooled data from 6 hospitals in 3 GCC countries. The overall CLABSI rate was 3.1 per 1,000 central line days. After adjusting for differences in intensive care unit types, the risk of CLABSI in GCC hospitals was 146% higher than NHSN hospitals but 33% lower than INICC hospitals...
March 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28297677/recombinant-bcg-expressing-esx-1-of-mycobacterium-marinum-combines-low-virulence-with-cytosolic-immune-signaling-and-improved-tb-protection
#19
Matthias I Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis vaccine, Mycobacterium bovis BCG, provides limited protection. A feature of BCG is the partial deletion of the ESX-1 type VII secretion system, which governs phagosomal rupture and cytosolic pattern recognition, key intracellular phenotypes linked to increased immune signaling...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28287451/sensor-based-assistive-devices-for-visually-impaired-people-current-status-challenges-and-future-directions
#20
Wafa Elmannai, Khaled Elleithy
The World Health Organization (WHO) reported that there are 285 million visuallyimpaired people worldwide. Among these individuals, there are 39 million who are totally blind. There have been several systems designed to support visually-impaired people and to improve the quality of their lives. Unfortunately, most of these systems are limited in their capabilities. In this paper, we present a comparative survey of the wearable and portable assistive devices for visuallyimpaired people in order to show the progress in assistive technology for this group of people...
March 10, 2017: Sensors
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