Read by QxMD icon Read


Ben Ajmia Wafa, Mohamed Makni, Sonda Ammar, Lamia Khannous, Amal Ben Hassana, Mohamed Bouaziz, Nour Eddine Es-Safi, Radhouane Gdoura
Punica granatum L. is widely recognized for its potency against a broad spectrum of bacterial pathogens. The purpose of this study was to explore the inhibitory and the bactericidal activities of Punica granatum against Salmonella strains. The effect of extracts obtained from different parts (peels, seeds, juice and flowers) of pomegranate and using different solvents against Salmonella enterica serovars Kentucky and Enteritidis isolated from chicken meat was thus investigated. Salmonella strains were identified with the standard API-20E system and confirmed by real time PCR...
October 11, 2016: International Journal of Food Microbiology
Peter T Theunissen, Sonia Beken, Bruce Beyer, William J Breslin, Gregg D Cappon, Connie L Chen, Gary Chmielewski, Luc de Schaepdrijver, Brian Enright, Jennifer E Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M Hoberman, Julia Y Hui, Thomas B Knudsen, Susan B Laffan, Susan L Makris, Matthew Martin, Mary Ellen McNerney, Christine L Siezen, Dinesh J Stanislaus, Jane Stewart, Kary E Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F Weinbauer, Sandra Wood, Aldert H Piersma
A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental lowest adverse effect level (dLOAEL). For the vast majority of cases (83% based on AUC of n = 283), dLOAELs in rats and rabbits were within the same order of magnitude (less than 10-fold different) when compared based on available data on AUC and Cmax exposures...
October 21, 2016: Critical Reviews in Toxicology
Farah Ben Tanfous, Carla Andrea Alonso, Wafa Achour, Laura Ruiz-Ripa, Carmen Torres, Assia Ben Hassen
The aim of this study was to investigate the molecular features among Klebsiella pneumoniae and Escherichia coli strains showing a resistant/intermediate-resistant phenotype to ertapenem (R/IR-ERT), implicated in colonization/infection in patients of the Hematology and Graft Units of the National Bone Marrow Transplant Center of Tunisia (3-year period, 2011-2014). The major carbapenemase, extended-spectrum beta-lactamase, and plasmidic AmpC beta-lactamase genes were analyzed and characterized by PCR and sequencing...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Wafa Khaali, Khalid Moumad, El Khalil Ben Driss, Abdellatif Benider, Wided Ben Ayoub, Mokhtar Hamdi-Cherif, Kada Boualga, Elham Hassen, Marilys Corbex, Meriem Khyatti
BACKGROUND: Genetic susceptibility plays a key role in the development of nasopharyngeal carcinoma (NPC) and in fact the disease presents with an unusually high incidence in certain regions of the world like North Africa. We investigated the association between polymorphism of the Transforming growth factor-β1 (TGF-β1) and risk of NPC in North Africa. TGF-β1 is a multifunctional cytokine that acts as both a tumor suppressor and a stimulator of cancer development; it has been shown to influence risk of numerous other carcinomas including lung, breast and prostate cancer...
October 12, 2016: BMC Medical Genetics
Daniel S Schechter, Dominik A Moser, Virginie C Pointet, Tatjana Aue, Ludwig Stenz, Ariane Paoloni-Giacobino, Wafae Adouan, Aurélia Manini, Francesca Suardi, Marylene Vital, Ana Sancho Rossignol, Maria I Cordero, Molly Rothenberg, François Ansermet, Sandra Rusconi Serpa, Alexandre G Dayer
BACKGROUND: Methylation of the serotonin 3A receptor gene (HTR3A) has been linked to child maltreatment and adult psychopathology. The present study examined whether HTR3A methylation might be associated with mothers' lifetime exposure to interpersonal violence (IPV), IPV-related psychopathology, child disturbance of attachment, and maternal neural activity. METHODS: Number of maternal lifetime IPV exposures and measures of maternal psychopathology including posttraumatic stress disorder (PTSD), major depression and aggressive behavior (AgB), and a measure of child attachment disturbance known as "secure base distortion" (SBD) were assessed in a sample of 35 mothers and children aged 12-42 months...
October 5, 2016: Behavioural Brain Research
Cristina Maria de Barros, Emad Ibrahim Wafa, Khanidtha Chitphet, Kawther Ahmed, Sean M Geary, Aliasger K Salem
Immune adjuvants, such as ligands for pathogen-associated molecular patterns (PAMPs), have been showing promise in boosting immune responses to tumor associated antigens, and delivering these adjuvants as discrete packages is considered advantageous over delivery in soluble form. Here we describe in detail, methods for independently loading a range of adjuvants into polymer-based biodegradable particles. We also describe the means by which to characterize these particles with respect to adjuvant loading and release kinetics as well as in terms of particle size, shape, and zeta-potential...
2017: Methods in Molecular Biology
Lamia Ysmail-Dahlouk, Wafa Nouari, Mourad Aribi
BACKGROUND: Type 1 diabetes (T1D) is associated with an imbalance between inflammation and repair. Recently, the biologically active form of vitamin D3, i.e. 1,25(OH)2D3, has been reported to have potent immunomodulatory effects on both innate and adaptive immune cells, as well as on the production of their specific cytokines. METHODS: We examined the effect of 1,25(OH)2D3 on the production of proinflammatory Th1/Th17 and anti-inflammatory Th2/Treg related cytokines, as well as on the phosphorylation of monocyte-expressed STAT4 and STAT6 at the recent-onset human T1D...
October 4, 2016: Immunology Letters
Hélène Pillet, Elena Bergamini, Goulven Rochcongar, Valentina Camomilla, Patricia Thoreux, Philippe Rouch, Aurelio Cappozzo, Wafa Skalli
In-vivo estimates of the positions of knee ligament attachment sites are crucial for subject-specific knee modelling. The present study provides template digital models of femur, tibia and fibula that embed the positions of centroids of the origins and insertions of cruciate and collateral ligaments, along with information on their dispersion related to inter-individual variability. By using a shape transformation procedure of choice, these templates can be made to match anatomical information measured on a subject under analysis...
October 3, 2016: Journal of Biomechanics
Mohnad Abdalla, Ya Nan Dai, Chang Biao Chi, Wang Cheng, Dong Dong Cao, Kang Zhou, Wafa Ali, Yuxing Chen, Cong Zhao Zhou
Glutaredoxins (Grxs) constitute a superfamily of proteins that perform diverse biological functions. The Saccharomyces cerevisiae glutaredoxin Grx6 not only serves as a glutathione (GSH)-dependent oxidoreductase and as a GSH transferase, but also as an essential [2Fe-2S]-binding protein. Here, the dimeric structure of the C-terminal domain of Grx6 (holo Grx6C), bridged by one [2Fe-2S] cluster coordinated by the active-site Cys136 and two external GSH molecules, is reported. Structural comparison combined with multiple-sequence alignment demonstrated that holo Grx6C is similar to the [2Fe-2S] cluster-incorporated dithiol Grxs, which share a highly conserved [2Fe-2S] cluster-binding pattern and dimeric conformation that is distinct from the previously identified [2Fe-2S] cluster-ligated monothiol Grxs...
October 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
Wafa Bouleftour, Renata Neves Granito, Arnaud Vanden-Bossche, Odile Sabido, Bernard Roche, Mireille Thomas, Marie Thérèse Linossier, Jane E Aubin, Marie-Hélène Lafage-Proust, Laurence Vico, Luc Malaval
The bone organ integrates the activity of bone tissue, bone marrow and blood vessels and the factors ensuring this coordination remain ill defined. Bone sialoprotein (BSP) is with osteopontin (OPN) a member of the Small Integrin Binding Ligand N-Linked Glycoprotein (SIBLING) family, involved in bone formation, hematopoiesis and angiogenesis. In rodents, bone marrow ablation induces a rapid formation of medullary bone which peaks by ∼8 days (d8) and is blunted in BSP-/- mice. We investigated the coordinate hematopoietic and vascular recolonization of the bone shaft after marrow ablation of 2 month old BSP + /+ and BSP-/- mice...
October 5, 2016: Journal of Cellular Physiology
Olfa El Amine, Malek Ayadi, Aida Goucha, Aida Khadhar, Wafa Rekik, M Rezgani, Tarek Dhiab, Khaled Rahal, Ahmed El May, Amor Gamoudi
No abstract text is available yet for this article.
April 2016: La Tunisie Médicale
Amene Hermi, Wafa Achour
Introduction Item analysis is the process of collecting, summarizing and using information from students' responses to assess test items' quality. This study used this approach to evaluate the quality of items and examinations given in the Faculty of Medicine of Tunis (FMT).    Methods This study concerned the examinations of 2012-2013 (principal session). It analyzed 3138 items from 66 examinations, of which, 46 were multidisciplinary (187 disciplines). A total of 2515 students took the examinations. "AnItem...
April 2016: La Tunisie Médicale
Nathan Chejanovsky, Mohammad Rezai, Federico Paolucci, Youngwook Kim, Torsten Rendler, Wafa Rouabeh, Felipe Fávaro de Oliveira, Patrick Herlinger, Andrej Denisenko, Sen Yang, Ilja Gerhardt, Amit Finkler, Jurgen H Smet, Jörg Wrachtrup
Newly discovered van der Waals materials like MoS2, WSe2, Hexagonal boron nitride (h-BN) and recently C2N have sparked intensive research to unveil the quantum behavior associated with their 2D structure. Of great interest are 2D materials that host single quantum emitters. h-BN, with a band-gap of 5.95 eV, has been shown to host single quantum emitters which are stable at room temperature in the UV and visible spectrum. In this paper we investigate correlations between h-BN structural features and emitter location from bulk down to the mono-layer at room temperature...
October 4, 2016: Nano Letters
Wafa Al Nasser, Aiman El-Saed, Amina Al-Jardani, Abdulhakeem Althaqafi, Huda Alansari, Jameela Alsalman, Zaina Al Maskari, Ayman El Gammal, Seif S Al-Abri, Hanan H Balkhy
BACKGROUND: The true burden of catheter-associated urinary tract infections (CAUTIs) remains largely unknown because of a lack of national and regional surveillance reports in Gulf Cooperation Council (GCC) countries. The purpose of this study was to estimate location-specific CAUTI rates in the GCC region and to compare them with published reports from the U.S. National Healthcare Safety Network (NHSN) and the International Nosocomial Infection Control Consortium (INICC). METHODS: CAUTI rates and urinary catheter utilization between 2008 and 2013 were calculated using NHSN methodology pooled from 6 hospitals in 3 GCC countries: Saudi Arabia, Oman, and Bahrain...
September 28, 2016: American Journal of Infection Control
Wafa Omer, Abdul K Naveed, Omer J Khan, Dilshad A Khan
AIMS: Pro- and anti-inflammatory cytokines play a significant role in early atherosclerosis. Linkage disequilibrium patterns differ between ethnic groups pointing toward the need to develop population-specific gene risk scores. Our objective was to investigate the role of a cytokine gene score in the risk prediction of premature coronary artery disease (PCAD). METHODS: A case-control study was performed at the National University of Sciences and Technology (NUST) in collaboration with the Cardiovascular Genetics Institute, University College London, United Kingdom...
September 30, 2016: Genetic Testing and Molecular Biomarkers
Angélique Vétillard, Wafa Bouzid
Animal venoms are complex mixtures containing simple organic molecules, proteins, peptides, and other bioactive elements with extraordinary biological properties associated with their ability to act on a number of molecular receptors in the process of incapacitating their target organisms. In such a context, arthropod venoms are invaluable sources of bioactive substances, with therapeutic interest but the limited availability of some venom such as those from ants, has restricted the potential that these biomolecules could represent...
2016: Biologie Aujourd'hui
Ahmed R El-Nahas, Mohamed M Elsaadany, Diaa-Eldin Taha, Ahmed M Elshal, Mohamed Abo El-Ghar, Amani M Ismail, Essam A Elsawy, Hazem H Saleh, Ehab W Wafa, Amira Awadalla, Tamer S Barakat, Khaled Z Sheir
OBJECTIVE: To evaluate the protective effects of selenium with vitamins A, C and E (selenium ACE, i.e. antioxidants), verapamil (calcium channel blocker), and losartan (angiotensin receptor blocker) against extracorporeal shockwave lithotripsy (ESWL)-induced renal injury. PATIENTS AND METHODS: A randomised controlled trial was conducted between August 2012 and February 2015. Inclusion criteria were adult patients with a single renal stone (<2 cm) suitable for ESWL...
September 30, 2016: BJU International
Wafa Haj Hamad, Marwa Maraoui, Mouna Sghir, Mohamed Guedria, Wafa Said, Saida Jerbi, Wassia Kessomtini
OBJECTIVE: The aim of our study was firstly to determine the frequency and the characteristics of metabolic syndrome in patients with knee osteoarthritis and secondly to assess the functional consequences of this combination. MATERIAL/PATIENTS AND METHODS: This is a prospective study including patients with knee OA referred to the department of physical medicine of Mahdia. In all patients, we sought the clinical and biological criteria for metabolic syndrome (according to NCEP - ATP III) and determined the radiological grade of knee OA according to Kellgren and Lawrence (KL)...
September 2016: Annals of Physical and Rehabilitation Medicine
Wafa Haj Hamad, Mouna Sghir, Mohamed Guedria, Marwa Maraoui, Wafa Said, Saida Jerbi, Wassia Kessomtini
OBJECTIVE: Therapeutic education is an integral part of the management of knee osteoarthritis to acquire or to maintain skills allowing patients to manage their lives better. The aim of our study is to assess the contribution of therapeutic education in the management of knee osteoarthritis. MATERIAL/PATIENTS AND METHODS: This is a randomized prospective study on patients with knee OA referred to the department of Physical Therapy of Mahdia since January 2016. Patients were divided into 3 groups...
September 2016: Annals of Physical and Rehabilitation Medicine
Mouna Sghir, Mohamed Guedria, Marwa Maraoui, Wafa Haj Hamad, Wafa Said, Saida Jerbi, Wassia Kessomtini
OBJECTIVE: The femur aplasia is a congenital developmental defect of the femur often associated with malformations of the pelvis and lower limb. There are all intermediaries between the short femur and vestigial femoral. The total femur absence (agenesis) is rare. We report a case of a child followed in our Physical Medicine Department for proximal bilateral femoral agenesis. OBSERVATIONS: This is M.S., a 5 years old child, addressed for a waddling gait and a deformation of the trunk...
September 2016: Annals of Physical and Rehabilitation Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"