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https://www.readbyqxmd.com/read/28724165/cytogenotoxicity-of-inclusion-complexes-of-diazepam-with-2-hydroxypropyl-%C3%AE-cyclodextrin
#1
Jasmina Hadžiabdić, Nevenka Kopjar, Davor Želježić, Selma Špirtović-Halilović, Davorka Završnik
Background Diazepam, as one of the most frequent prescribed drug from 1,4-benzodiazepine group, has certain limitations in pharmaceutical technology due to its poor solubility in water. By forming inclusion complexes with 2-hydroxypropyl-β-cyclodextrin, diazepam's biopharmaceutical properties can be greatly improved. Aim Aim of this research was to in vitro evaluate genotoxicity of prepared novel complexes of diazepam and their influence on proliferation of human peripheral blood lymphocytes. Methods For identification of possible genotoxicity of diazepam inclusion complexes, cytokinesis-block micronucleus assay has been chosen...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28723986/the-contributions-of-digital-technologies-in-the-teaching-of-nursing-skills-an-integrative-review
#2
Maurício de Souza Silveira, Ana Luísa Petersen Cogo
Objective: To analyze the contributions of digital educational technologies used in teaching nursing skills. Method: Integrative literature review, search in five databases, from 2006 to 2015 combining the descriptors 'education, nursing', 'educational technology', 'computer-assisted instruction' or related terms in English. Results: Sample of 30 articles grouped in the thematic categories 'technology in the simulation with manikin', 'incentive to learning' and 'teaching of nursing skills'...
July 13, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28723674/nanoparticles-and-female-reproductive-system-how-do-nanoparticles-affect-oogenesis-and-embryonic-development
#3
REVIEW
Cong-Cong Hou, Jun-Quan Zhu
Along with the increasing application of nanoparticles (NPs) in many walks of life, environmental exposure to NPs has raised considerable health concerns. When NPs enter a pregnant woman's body through inhalation, venous injection, ingestion or skin permeation, maternal toxic stress reactions such as reactive oxygen species (ROS), inflammation, apoptosis and endocrine dyscrasia are induced in different organs, particularly in the reproductive organs. Recent studies have shown that NPs disturb the developing oocyte by invading the protective barrier of theca cells, granulosa cell layers and zona pellucida...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723342/molecular-analysis-of-circulating-free-dna-from-lung-cancer-patients-in-routine-laboratory-practice-a-cross-platform-comparison-of-three-different-molecular-methods-for-mutation-detection
#4
Stephan Bartels, Sascha Persing, Britta Hasemeier, Elisa Schipper, Hans Kreipe, Ulrich Lehmann
Cell-free DNA (cfDNA), which is isolated from blood plasma, represents a noninvasive source for the detection of mutations conferring resistance against epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small-cell lung cancer patients. In advanced disease stages, performing regular biopsies is often not possible because of the general health condition of the patients. Furthermore, a biopsy of a single tumor lesion or metastasis may not reflect the heterogeneous genotype of the tumor and its metastases...
July 16, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28723088/development-of-a-transferable-reactive-force-field-of-p-h-systems-application-to-the-chemical-and-mechanical-properties-of-phosphorene
#5
Hang Xiao, Xiaoyang Shi, Feng Hao, Xiangbiao Liao, Yayun Zhang, Xi Chen
We developed ReaxFF parameters for phosphorus and hydrogen to give a good description of the chemical and mechanical properties of pristine and defected black phosphorene. ReaxFF for P/H is transferable to a wide range of phosphorus and hydrogen containing systems including bulk black phosphorus, blue phosphorene, edge-hydrogenated phosphorene, phosphorus clusters and phosphorus hydride molecules. The potential parameters were obtained by conducting global optimization with respect to a set of reference data generated by extensive ab initio calculations...
July 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28722297/assessing-guest-molecule-diffusion-in-heterogeneous-powder-samples-of-metal-organic-frameworks-through-pfg-nmr
#6
Roland Thoma, Jörg Kärger, Nader de Sousa Amadeu, Sandra Nießing, Christoph Janiak
Investigation of guest diffusion in porous metal-organic frameworks (MOFs) is of major importance since many porosity-related properties of MOFs are influenced by diffusion effects. The diffusion of dimethylsulfoxide (DMSO) in the metal-organic framework (MOF) MIL-53-NH2(Al) was investigated through pulsed-field-gradient (PFG) NMR spectroscopy. The microporous material was synthesized in small crystallites (under 500 nm), which agglomerated in a large range of particle sizes, giving a morphologically very heterogeneous sample...
July 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28722003/severe-unintentional-extrusion-of-mineral-trioxide-aggregate-during-apexification
#7
Levent Demiriz, Ebru Hazar Bodrumlu
The aim of this report was to present the long-term clinical and radiographic outcomes of a case including severe unintentional extrusion of mineral trioxide aggregate (MTA). An 11-year-old boy was referred with a previously traumatized permanent central incisor which was temporarily treated by using calcium hydroxide root canal filling material. Since having an open apex and a large periapical lesion, root canal treatment with MTA apexification was planned. During the apexification process, a huge amount of MTA was unintentionally extruded into periapical tissues...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28721203/evaluation-of-mineral-oil-saturated-hydrocarbons-mosh-and-mineral-oil-aromatic-hydrocarbons-moah-in-pure-mineral-hydrocarbon-based-cosmetics-and-cosmetic-raw-materials-using-1-h-nmr-spectroscopy
#8
Dirk W Lachenmeier, Gerd Mildau, Anke Krause, Gerhard Marx, Stephan G Walch, Andrea Hartwig, Thomas Kuballa
Mineral hydrocarbons consist of two fractions, mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). MOAH is a potential public health hazard because it may include carcinogenic polycyclic compounds. In the present study, 400 MHz nuclear magnetic resonance (NMR) spectroscopy was introduced, in the context of official controls, to measure MOSH and MOAH in raw materials or pure mineral hydrocarbon final products (cosmetics and medicinal products). Quantitative determination (qNMR) has been established using the ERETIC methodology (electronic reference to access in vivo concentrations) based on the PULCON principle (pulse length based concentration determination)...
2017: F1000Research
https://www.readbyqxmd.com/read/28720979/first-report-of-phyllosticta-citricarpa-and-description-of-two-new-species-p-%C3%A2-paracapitalensis-and-p-%C3%A2-paracitricarpa-from-citrus-in-europe
#9
V Guarnaccia, J Z Groenewald, H Li, C Glienke, E Carstens, V Hattingh, P H Fourie, P W Crous
The genus Phyllosticta occurs worldwide, and contains numerous plant pathogenic, endophytic and saprobic species. Phyllosticta citricarpa is the causal agent of Citrus Black Spot disease (CBS), affecting fruits and leaves of several citrus hosts (Rutaceae), and can also be isolated from asymptomatic citrus tissues. Citrus Black Spot occurs in citrus-growing regions with warm summer rainfall climates, but is absent in countries of the European Union (EU). Phyllosticta capitalensis is morphologically similar to P...
June 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28720109/cancer-related-fatigue-implementing-guidelines-for-optimal-management
#10
Elizabeth J M Pearson, Meg E Morris, Carol E McKinstry
BACKGROUND: Cancer-related fatigue (CRF) is a key concern for people living with cancer and can impair physical functioning and activities of daily living. Evidence-based guidelines for CRF are available, yet inconsistently implemented globally. This study aimed to identify barriers and enablers to applying a cancer fatigue guideline and to derive implementation strategies. METHODS: A mixed-method study explored the feasibility of implementing the CRF guideline developed by the Canadian Association for Psychosocial Oncology (CAPO)...
July 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28718399/certified-reference-material-for-use-in-1-h-31-p-and-19-f-quantitative-nmr-ensuring-traceability-to-the-international-system-of-units
#11
Romana Rigger, Alexander Rück, Christine Hellriegel, Robert Sauermoser, Fabienne Morf, Kathrin Breitruck, Markus Obkircher
In recent years, quantitative NMR (qNMR) spectroscopy has become one of the most important tools for content determination of organic substances and quantitative evaluation of impurities. Using Certified Reference Materials (CRMs) as internal or external standards, the extensively used qNMR method can be applied for purity determination, including unbroken traceability to the International System of Units (SI). The implementation of qNMR toward new application fields, e.g., metabolomics, environmental analysis, and physiological pathway studies, brings along more complex molecules and systems, thus making use of (1)H qNMR challenging...
July 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28718398/comparative-study-of-nmr-spectral-profiling-for-the-characterization-and-authentication-of-cannabis
#12
Xinyi Wang, Peter de Harrington, Steven Baugh
For the authentication of botanical materials, it is difficult to obtain representative reference materials because botanicals vary significantly with respect to cultivation conditions. Chemical profiling of plant extracts or spectral fingerprinting can differentiate botanicals and group them by their chemical profiles. NMR spectroscopy yields a powerful and useful method for profiling plant extracts. Both 500 MHz (1)H and (1)H-(1)H correlation NMR spectroscopy coupled with pattern recognition were used to discriminate among Cannabis samples...
July 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28718397/the-vitamin-d-standardization-program-vdsp-manual-for-retrospective-laboratory-standardization-of-serum-25-hydroxyvitamin-d-data
#13
Ramon Durazo-Arvizu, Lu Tian, Stephen Brooks, Kurtis Sarafin, Kevin Cashman, Mairead Kiely, Joyce Merkel, Gary Myers, Paul Coates, Christopher Sempos
Low concentrations of total 25-hydroxyvitamin D [25(OH)D], the principal biological measure of vitamin D status, have been associated with clinical and public health outcomes. The determination of levels under which there is an increase in the risk of disease, as well as comparisons across populations, have been difficult to establish due the large assay variability in measuring 25(OH)D. Accordingly, the Vitamin D Standardization Program (VDSP) includes the retrospective standardization of existing 25(OH)D values collected by epidemiological and clinical studies, as well as clinical trials, as one of its main objectives...
July 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28716643/reduced-risk-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-after-bariatric-surgery-a-self-controlled-case-series-study
#14
Tadahiro Goto, Yusuke Tsugawa, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
BACKGROUND: Obesity is common among individuals with chronic obstructive pulmonary disease (COPD) and associated with increased COPD morbidities. However, little is known about the impact of weight reduction on COPD-related outcomes in obese patients. METHODS: Using the population-based emergency department (ED) and inpatient sample in three U.S. states (California, Florida, and Nebraska), we performed a self-controlled case series study of 481 obese adults (aged 40-65 years) with COPD who underwent bariatric surgery...
July 14, 2017: Chest
https://www.readbyqxmd.com/read/28715393/generation-and-long-term-maintenance-of-nerve-free-hydra
#15
Cassidy M Tran, Sharon Fu, Trevor Rowe, Eva-Maria S Collins
The interstitial cell lineage of Hydra includes multipotent stem cells, and their derivatives: gland cells, nematocytes, germ cells, and nerve cells. The interstitial cells can be eliminated through two consecutive treatments with colchicine, a plant-derived toxin that kills dividing cells, thus erasing the potential for renewal of the differentiated cells that are derived from the interstitial stem cells. This allows for the generation of Hydra that lack nerve cells. A nerve-free polyp cannot open its mouth to feed, egest, or regulate osmotic pressure...
July 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714196/impact-of-an-electronic-health-record-alert-in-primary-care-on-increasing-hepatitis-c-screening-and-curative-treatment-for-baby-boomers
#16
Monica A Konerman, Mary Thomson, Kristen Gray, Meghan Moore, Hetal Choxi, Elizabeth Seif, Anna Sf Lok
Despite effective treatment for chronic hepatitis C (CHC), deficiencies in diagnosis and access preclude disease elimination. Screening of baby boomers remains low. The aims of this study were to assess the impact of an electronic health record (EHR) based prompt on HCV screening rates in baby boomers in primary care, and access to specialty care and treatment among those newly diagnosed. We implemented an EHR based "Best Practice Advisory" (BPA) that prompted primary care providers (PCPs) to perform HCV screening for patients seen in primary care clinic: 1) born between 1945-1965; 2) lacked a prior diagnosis of HCV infection; and 3) lacked prior documented anti-HCV testing...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28714141/intrinsic-3d-prestressing-a-new-route-for-increasing-strength-and-improving-toughness-of-hybrid-inorganic-biocements
#17
Martha Schamel, Jake E Barralet, Michael Gelinsky, Jürgen Groll, Uwe Gbureck
Cement is the most consumed resource and is the most widely used material globally. The ability to extrinsically prestress cementitious materials with tendons usually made from steel allows the creation of high-strength bridges and floors from this otherwise brittle material. Here, a dual setting cement system based on the combination of hydraulic cement powder with an aqueous silk fibroin solution that intrinsically generates a 3D prestressing during setting, dramatically toughening the cement to the point it can be cut with scissors, is reported...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28713031/an-lc-ms-ms-based-candidate-reference-method-for-the-quantification-of-carbamazepine-in-human-serum
#18
Judith Taibon, Rupert Schmid, Stephanie Lucha, Stephan Pongratz, Kirill Tarasov, Christoph Seger, Christian Timm, Roland Thiele, Joachim Mark Herlan, Uwe Kobold
A validated LC-MS/MS-based candidate reference measurement procedure for the quantification of carbamazepine is presented in order to be used for standardization and harmonization of routine assays applied for therapeutic drug monitoring. Sample preparation was based on protein precipitation using acetonitrile followed by sample dilution. Since the previously listed certified reference material (CRM) SRM 1599 (anticonvulsant drug level assay standard) is no longer available, an ISO certified calibration material was used in this assay...
July 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28712550/towards-an-automatic-lab-on-valve-ion-mobility-spectrometric-system-for-detection-of-cocaine-abuse
#19
David J Cocovi-Solberg, Francesc A Esteve-Turrillas, Sergio Armenta, Miguel de la Guardia, Manuel Miró
A lab-on-valve miniaturized system integrating on-line disposable micro-solid phase extraction has been interfaced with ion mobility spectrometry for the accurate and sensitive determination of cocaine and ecgonine methyl ester in oral fluids. The method is based on the automatic loading of 500μL of oral fluid along with the retention of target analytes and matrix clean-up by mixed-mode cationic/reversed-phase solid phase beads, followed by elution with 100μL of 2-propanol containing (3% v/v) ammonia, which are online injected into the IMS...
June 30, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28712471/early-pliocene-anuran-fossils-from-kanapoi-kenya-and-the-first-fossil%C3%A2-record-for-the-african-burrowing-frog-hemisus-neobatrachia-hemisotidae
#20
Massimo Delfino
Isolated amphibian bones from the early Pliocene of Kanapoi (West Turkana, Kenya) help to improve the scarce fossil record of the late Neogene and Quaternary amphibians from East Africa. All currently available 579 bones are referable exclusively to the Anura (frogs and toads). More than half of the remains (366) are identified as Hemisus cf. Hemisus marmoratus, an extant species that still inhabits Kenya, but apparently not the northwest of the country and the Turkana area in particular. The rest of the remains are identified simply as Anura indet...
July 13, 2017: Journal of Human Evolution
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