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biomarker and AKI META

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https://www.readbyqxmd.com/read/29056166/long-term-adverse-events-associated-with-acute-kidney-injury
#1
Manisha Singh, Nithin Karakala, Sudhir V Shah
Acute kidney injury (AKI) occurs in approximately 10% to 15% of hospital-admitted patients and is associated with in-hospital mortality of 50% in patients requiring renal replacement therapy. Recently, multiple observational studies have demonstrated that patients who survive AKI have significant long-term consequences including cardiovascular events, progression to advanced-stage chronic kidney disease (CKD), and mortality. A direct link between AKI and CKD is provided by studies that demonstrate that some patients with normal renal function who develop AKI requiring dialysis never recover...
November 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28992285/remote-ischaemic-preconditioning-for-renal-and-cardiac-protection-in-adult-patients-undergoing-cardiac-surgery-with-cardiopulmonary-bypass-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Giacomo Deferrari, Alice Bonanni, Maurizio Bruschi, Cristiano Alicino, Alessio Signori
Background: The main aim of this systematic review was to assess whether remote ischaemic preconditioning (RIPC) protects kidneys and the heart in cardiac surgery with cardiopulmonary bypass (CPB) and to investigate a possible role of anaesthetic agents. Methods: Randomized clinical trials (RCTs) on the effects of RIPC through limb ischaemia in adult patients undergoing cardiac surgery with CPB were searched (1965-October 2016) in PubMed, Cochrane Library and article reference lists...
July 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28682920/the-diagnostic-accuracy-of-urinary-timp-2-%C3%A2-igfbp7-for-acute-kidney-injury-in-adults-a-prisma-compliant-meta-analysis
#3
REVIEW
Chao Liu, Xiaochun Lu, Zhi Mao, Hongjun Kang, Hui Liu, Liang Pan, Jie Hu, Li Wang, Feihu Zhou
INTRODUCTION: Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed this meta-analysis to assess the diagnostic accuracy of urinary [TIMP-2]·[IGFBP7] for AKI in adult patients. METHODS: We searched the PubMed, Embase, and Cochrane Library databases from database inception to March 2017...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28682476/plasma-levels-of-hepatocyte-growth-factor-and-placental-growth-factor-predict-mortality-in-a-general-population-a-prospective-cohort-study
#4
K Santalahti, A Havulinna, M Maksimow, T Zeller, S Blankenberg, A Vehtari, H Joensuu, S Jalkanen, V Salomaa, M Salmi
BACKGROUND: Circulating levels of growth factors involved in leucocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all-cause cardiovascular disease (CVD) or cancer mortality. METHODS: Baseline plasma levels of a range of growth factors were measured in two cohorts of the population-based FINRISK study (1997 Discovery cohort, N = 8444, aged 25-74; 2002 Replication cohort, N = 2951, aged 51-74 years) using a multiplexed bead array methodology and ELISA...
October 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28646585/prognostic-value-of-cell-cycle-arrest-biomarkers-in-patients-at-high-risk-for-acute-kidney-injury-a-systematic-review-and-meta-analysis
#5
REVIEW
Hui-Miao Jia, Li-Feng Huang, Yue Zheng, Wen-Xiong Li
AIM: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are G1 cell cycle arrest biomarkers. This systematic review aimed to evaluate the prognostic value of urinary [TIMP-2]·[IGFBP7] in patients at high risk for AKI. METHODS: The MEDLINE (via PubMed), Ovid, EMBASE and Cochrane Library databases were systematically searched from inception to December 25, 2016. Original clinical studies which met the eligibility criteria were included in this study...
June 24, 2017: Nephrology
https://www.readbyqxmd.com/read/28629397/optimal-timing-of-renal-replacement-therapy-initiation-in-acute-kidney-injury-the-elephant-felt-by-the-blindmen
#6
Chih-Chung Shiao, Tao-Min Huang, Herbert D Spapen, Patrick M Honore, Vin-Cent Wu
Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome...
June 20, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28616656/accuracy-of-neutrophil-gelatinase-associated-lipocalin-for-acute-kidney-injury-diagnosis-in-children-systematic-review-and-meta-analysis
#7
REVIEW
Luís Taddeo Filho, Antonio Jose Grande, Tamy Colonetti, Éverton Simon Possamai Della, Maria Inês da Rosa
OBJECTIVE: To estimate the accuracy of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a biomarker for acute kidney injury (AKI) in children. METHODS: A systematic review of the literature was performed. The review protocol was registered at PROSPERO (CRD 42015024153). We conducted searches in the following databases: Medline (PubMed), LILACS (BVS), SCOPUS (Elsevier), Embase (OVID), Cochrane Central Register of Controlled Trials (CENTRAL), Biomed Central, and ISI Web of Science, from January 1990 to October 2016...
June 14, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28602971/new-developments-in-hepatorenal-syndrome
#8
Ayse L Mindikoglu, Stephen C Pappas
Hepatorenal syndrome (HRS) continues to be one of the major complications of decompensated cirrhosis, leading to death in the absence of liver transplantation. Challenges in precisely evaluating renal function in the patient with cirrhosis remain because of the limitations of serum creatinine (Cr) alone in estimating glomerular filtration rate (GFR); current GFR estimating models appear to underestimate renal function. Newer models incorporating renal biomarkers, such as the Cr-Cystatin C GFR Equation for Cirrhosis appear to estimate true GFR more accurately...
June 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28389482/what-are-the-risks-and-benefits-of-temporarily-discontinuing-medications-to-prevent-acute-kidney-injury-a-systematic-review-and-meta-analysis
#9
Penny Whiting, Andrew Morden, Laurie A Tomlinson, Fergus Caskey, Thomas Blakeman, Charles Tomson, Tracey Stone, Alison Richards, Jelena Savović, Jeremy Horwood
OBJECTIVES: To summarise evidence on temporary discontinuation of medications to prevent acute kidney injury (AKI). DESIGN: Systematic review and meta-analysis of randomised and non-randomised studies. PARTICIPANTS: Adults taking diuretics, ACE inhibitors (ACEI), angiotensin receptor blockers (ARB), direct renin inhibitors, non-steroidal anti-inflammatories, metformin or sulfonylureas, experiencing intercurrent illnesses, radiological or surgical procedures...
April 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28372557/accuracy-of-cystatin-c-in-prediction-of-acute-kidney-injury-in-children-serum-or-urine-levels-which-one-works-better-a-systematic-review-and-meta-analysis
#10
Babak Nakhjavan-Shahraki, Mahmoud Yousefifard, Neamatollah Ataei, Masoud Baikpour, Fatemeh Ataei, Behnaz Bazargani, Arash Abbasi, Parisa Ghelichkhani, Faezeh Javidilarijani, Mostafa Hosseini
BACKGROUND: There is still an ongoing discussion on the prognostic value of cystatin C in assessment of kidney function. Accordingly, the present study aimed to conduct a meta-analysis to provide evidence for the prognostic value of this biomarker for acute kidney injury (AKI) in children. METHODS: An extensive search was performed in electronic databases of Medline, Embase, ISI Web of Science, Cochrane library and Scopus until the end of 2015. Standardized mean difference (SMD) with a 95% of confidence interval (95% CI) and the prognostic performance characteristics of cystatin C in prediction of AKI were assessed...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28340605/diagnostic-value-of-urinary-tissue-inhibitor-of-metalloproteinase-2-and-insulin-like-growth-factor-binding-protein-7-for-acute-kidney-injury-a-meta-analysis
#11
Hui-Miao Jia, Li-Feng Huang, Yue Zheng, Wen-Xiong Li
BACKGROUND: Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), inducers of G1 cell cycle arrest, are two recently discovered good biomarkers for early diagnosis of acute kidney injury (AKI). To obtain a more robust performance measurement, the present meta-analysis was performed, pooling existing studies. METHODS: Literature in the MEDLINE (via PubMed), Ovid, Embase, and Cochrane Library databases was systematically searched from inception to 12 October 2016...
March 25, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28107490/diagnostic-value-of-urine-tissue-inhibitor-of-metalloproteinase-2-and-insulin-like-growth-factor-binding-protein-7-for-acute-kidney-injury-a-meta-analysis
#12
Yuanyuan Su, Zhiyan Gong, Yan Wu, Yuan Tian, Xiaohui Liao
BACKGROUND: Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein-7 (IGFBP7) are both involved in renal tubular epithelial cell cycle arrest in acute kidney injury (AKI). Several recent studies showed that urine TIMP-2 times IGFBP7 ([TIMP-2]*[IGFBP7]) is a promising biomarker to predict AKI. METHODS: The aim of this meta-analysis was to assess the diagnostic value of urine [TIMP-2]*[IGFBP7] for early diagnosis of AKI. Relevant studies were retrieved from the PubMed, EMBASE, and Cochrane Library databases...
2017: PloS One
https://www.readbyqxmd.com/read/28013112/urine-interleukin-18-and-lipocalin-2-are-biomarkers-of-acute-tubular-necrosis-in-patients-with-cirrhosis-a-systematic-review-and-meta-analysis
#13
Jeremy Puthumana, Xavier Ariza, Justin M Belcher, Isabel Graupera, Pere Ginès, Chirag R Parikh
BACKGROUND & AIMS: Acute kidney injury (AKI) is a common complication in patients with cirrhosis that increases mortality. The most common causes of AKI in these patients are prerenal azotemia, acute tubular necrosis (ATN), and hepatorenal syndrome; it is important to determine the etiology of AKI to select the proper treatment and predict patient outcome. Urine biomarkers could be used to differentiate between patients with ATN and functional causes of AKI. We performed a systematic review and meta-analysis of published studies to determine whether urine levels of interleukin (IL)18 and lipocalin 2 or neutrophil gelatinase-associated lipocalin (NGAL) are associated with the development of ATN in patients with cirrhosis...
July 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27225716/the-role-of-scoring-systems-and-urine-dipstick-in-prediction-of-rhabdomyolysis-induced-acute-kidney-injury-a-systematic-review
#14
REVIEW
Saeed Safari, Mahmoud Yousefifard, Behrooz Hashemi, Alireza Baratloo, Mohammad Mehdi Forouzanfar, Farhad Rahmati, Maryam Motamedi, Iraj Najafi
INTRODUCTION: During the past decade, using serum biomarkers and clinical decision rules for early prediction of rhabdomyolysis-induced acute kidney injury (AKI) has received much attention from researchers. This study aimed to broadly review the value of scoring systems and urine dipstick in prediction of rhabdomyolysis-induced AKI. MATERIALS AND METHODS: The study was designed based on the guidelines of the Meta-analysis of Observational Studies in Epidemiology statement...
May 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/27091767/effect-of-remote-ischemic-preconditioning-on-postoperative-acute-kidney-injury-among-patients-undergoing-cardiac-and-vascular-interventions-a-meta-analysis
#15
REVIEW
Bingjue Li, Xiabing Lang, Luxi Cao, Yuchen Wang, Yingying Lu, Shi Feng, Yi Yang, Jianghua Chen, Hong Jiang
It is currently controversial whether remote ischemic preconditioning (RIPC) reduces the incidence of acute kidney injury (AKI) in patients undergoing cardiovascular interventions. The main objective of this meta-analysis was to investigate whether RIPC provides renal protection for patients undergoing cardiac or vascular surgery. We searched the PubMed database (1966-Oct 2015), Embase database (1966-Oct 2015), Google Scholar, Cochrane Library, ClinicalTrials Database and Open Grey. Then we conducted a meta-analysis of the randomized controlled trials that met the inclusion criteria of our study...
February 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/27017333/is-plasma-neutrophil-gelatinase-associated-lipocalin-a-predictive-biomarker-for-acute-kidney-injury-in-sepsis-patients-a-systematic-review-and-meta-analysis
#16
REVIEW
Sollip Kim, Hyun-Jung Kim, Hyeong-Sik Ahn, Ji Yang Song, Tae-Hyun Um, Chong-Rae Cho, Hoon Jung, Hyeon-Kyoung Koo, Joo Hyun Park, Sung-Soon Lee, Hye Kyeong Park
PURPOSE: Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for early diagnosis of acute kidney injury (AKI). However, the diagnostic value of NGAL for predicting AKI in sepsis patients is unclear. METHODS: MEDLINE, EMBASE, and Cochrane Library databases were searched to identify research publications. RESULTS: Twelve studies from 9 countries including a total of 1582 patients, of whom 315 (19.9%) developed AKI, were included in the study; plasma NGAL levels were significantly higher in adult sepsis patients with AKI than in those without AKI (mean difference, 274...
June 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/26882802/could-blood-neutrophil-gelatinase-associated-lipocalin-ngal-be-a-diagnostic-marker-for-acute-kidney-injury-in-neonates-a-systemic-review-and-meta-analysis
#17
REVIEW
Lina Jiang, Hong Cui
BACKGROUND: Blood neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be helpful for acute kidney injury (AKI) in pediatric patients and adults. Whether this is true in neonates remains unclear. METHODS: A systemic review and diagnostic meta-analysis was performed. Keywords included blood NGAL/serum NGAL, neonate/newborn, and AKI/acute kidney failure. Eligible studies measured blood or serum NGAL levels in neonates with AKI (first 30 days of life)...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26880194/diagnosis-and-prognosis-of-neutrophil-gelatinase-associated-lipocalin-for-acute-kidney-injury-with-sepsis-a-systematic-review-and-meta-analysis
#18
An Zhang, Ying Cai, Peng-Fei Wang, Jian-Ning Qu, Zhen-Chun Luo, Xiao-Dong Chen, Bin Huang, Yi Liu, Wen-Qi Huang, Jing Wu, Yue-Hui Yin
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early biomarker for prediction of acute kidney injury (AKI). However, the utility of NGAL to predict the occurrence of AKI in septic patients remains controversial. We performed a systematic review and meta-analysis to evaluate the evidence on diagnosis of sepsis AKI and the prediction of other clinical outcomes. METHOD: The MEDLINE, EMBASE, Cochrane Library, Wanfang, and CNKI databases were systematically searched up to August 19, 2015...
February 16, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26860774/predictive-value-of-neutrophil-gelatinase-associated-lipocalin-for-contrast-induced-acute-kidney-injury-after-cardiac-catheterization-a-meta-analysis
#19
REVIEW
Kun Wang, Chong-Yang Duan, Jun Wu, Yong Liu, Wei-Jie Bei, Ji-Yan Chen, Peng Cheng He, Yuan-Hui Liu, Ning Tan
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) accumulates in cortical tubules in acute kidney injury (AKI) patients, with its levels associated with serum creatinine. However, the predictive value of NGAL level for contrast-induced acute kidney injury (CI-AKI) remains unclear. METHODS: A total of 1520 patients from 14 relevant studies retrieved from PUBMED, MEDLINE, EMBASE, Web of Science, ClinicalTrials.gov, Cochrane Library, and Google Scholar from the inception to November 2014 and 15 data sets were included...
August 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26639967/biomarkers-differentiating-dementia-with%C3%A2-lewy-bodies-from-other-dementias-a%C3%A2-meta-analysis
#20
Aki Mishima, Takashi Nihashi, Yoshio Ando, Hisashi Kawai, Takashi Kato, Kengo Ito, Teruhiko Terasawa
BACKGROUND: Several nuclear imaging and cerebrospinal fluid (CSF) biomarkers are under investigation, aimed at facilitating the differential diagnosis of dementias. OBJECTIVE: To quantitatively synthesize data on test performance in differentiating dementia with Lewy bodies (DLB) from other dementias. METHODS: We searched PubMed (January 2000- March 2015) for English-language publications that assessed a selected set of five imaging and three CSF biomarkers for this purpose...
2016: Journal of Alzheimer's Disease: JAD
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