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DGF AND NGAL META

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https://www.readbyqxmd.com/read/25643790/rherythropoietin-b-as-a-tissue-protective-agent-in-kidney-transplantation-a-pilot-randomized-controlled-trial
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RANDOMIZED CONTROLLED TRIAL
Beatrice Coupes, Declan G de Freitas, Stephen A Roberts, Ian Read, Hany Riad, Paul E C Brenchley, Michael L Picton
BACKGROUND: Extended criteria donor (ECD) and donation after circulatory death (DCD) kidneys are at increased risk of delayed graft function (DGF). Experimental evidence suggests that erythropoietin (EPO) attenuates renal damage in acute kidney injury. This study piloted the administration of high dose recombinant human EPO-beta at implantation of ECD and DCD kidneys, and evaluated biomarkers of kidney injury post-transplant. METHODS: Forty patients were randomly assigned to receive either rhEPO-b (100,000 iu) (n = 19 in the intervention group, as 1 patient was un-transplantable post randomisation), or placebo (n = 20) in this, double blind, placebo-controlled trial at Manchester Royal Infirmary from August 2007 to June 2009...
February 3, 2015: BMC Research Notes
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