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Ken storey

Gordon K Wilcock, Serge Gauthier, Giovanni B Frisoni, Jianping Jia, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Bjoern O Schelter, Damon J Wischik, Charles S Davis, Roger T Staff, Vesna Vuksanovic, Trevor Ahearn, Luc Bracoud, Kohkan Shamsi, Ken Marek, John Seibyl, Gernot Riedel, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: LMTM is being developed as a treatment for AD based on inhibition of tau aggregation. OBJECTIVES: To examine the efficacy of LMTM as monotherapy in non-randomized cohort analyses as modified primary outcomes in an 18-month Phase III trial in mild AD. METHODS: Mild AD patients (n = 800) were randomly assigned to 100 mg twice a day or 4 mg twice a day. Prior to unblinding, the Statistical Analysis Plan was revised to compare the 100 mg twice a day as monotherapy subgroup (n = 79) versus 4 mg twice a day as randomized (n = 396), and 4 mg twice a day as monotherapy (n = 76) versus 4 mg twice a day as add-on therapy (n = 297), with strong control of family-wise type I error...
2018: Journal of Alzheimer's Disease: JAD
David E Newby, Pier M Mannucci, Grethe S Tell, Andrea A Baccarelli, Robert D Brook, Ken Donaldson, Francesco Forastiere, Massimo Franchini, Oscar H Franco, Ian Graham, Gerard Hoek, Barbara Hoffmann, Marc F Hoylaerts, Nino Künzli, Nicholas Mills, Juha Pekkanen, Annette Peters, Massimo F Piepoli, Sanjay Rajagopalan, Robert F Storey
No abstract text is available yet for this article.
January 7, 2015: European Heart Journal
Rob S James, Jason A Tallis, Frank Seebacher, Ken Storey
Djungarian hamsters (Phodopus sungorus) undergo bouts of daily torpor in response to reduced photoperiod. Metabolic rate, body temperature and energy cost are reduced during torpor. The present study exposed Djungarian hamsters to two different photoperiod regimes at a room temperature of 19-21°C: long photoperiod (control, 16 h:8 h light:dark, N=8) and short photoperiod (torpor, 8 h:16 h light:dark, N=8). After 14 weeks, muscle mechanics were analyzed in each group, examining both extensor digitorum longus (EDL) muscle and soleus muscle from each individual...
September 1, 2011: Journal of Experimental Biology
Sabrina Leverrier, Daniele Bergamaschi, Lucy Ghali, Ayodele Ola, Gary Warnes, Baki Akgül, Ken Blight, Ramón García-Escudero, Aubin Penna, Ayad Eddaoudi, Alan Storey
Apoptotic elimination of UV-damaged cells from the epidermis is an important step in preventing both the emergence and expansion of cells with carcinogenic potential. A pivotal event in apoptosis is the release of apoptogenic factors from the mitochondria, although the mechanisms by which the different proteins are released are not fully understood. Here we demonstrate that UV radiation induced the mitochondrial to nuclear translocation of apoptosis inducing factor (AIF) in normal skin. The human papillomavirus (HPV) E6 protein prevented release of AIF and other apoptotic factors such as cytochrome c and Omi from mitochondria of UV-damaged primary epidermal keratinocytes and preserved mitochondrial integrity...
March 2007: Apoptosis: An International Journal on Programmed Cell Death
Jean M Cox-Ganser, Sandra K White, Rebecca Jones, Ken Hilsbos, Eileen Storey, Paul L Enright, Carol Y Rao, Kathleen Kreiss
We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, lifetime asthma, and current asthma, 3.3 for adult-onset asthma, and 3.4 for symptoms improving away from work (p < 0.05). Two-thirds (66/103) of the adult-onset asthma arose after occupancy, with an incidence rate of 1...
April 2005: Environmental Health Perspectives
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