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Delayed graft function meta

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https://www.readbyqxmd.com/read/28129389/limited-clinical-utility-of-remote-ischemic-conditioning-in-renal-transplantation-a-meta-analysis-of-randomized-controlled-trials
#1
Chang-Cheng Zhou, Yu-Zheng Ge, Wen-Tao Yao, Ran Wu, Hui Xin, Tian-Ze Lu, Ming-Hao Li, Kai-Wei Song, Min Wang, Yun-Peng Zhu, Meng Zhu, Li-Guo Geng, Xiao-Fei Gao, Liu-Hua Zhou, Sheng-Li Zhang, Jia-Geng Zhu, Rui-Peng Jia
OBJECTIVE: We conducted this meta-analysis of randomized controlled trials (RCTs) to investigate whether remote ischemic conditioning (RIC) could improve graft functions in kidney transplantation. METHODS: PubMed, Web of Science, and Cochrane Library were comprehensively searched to identify all eligible studies by October 5, 2016. The treatment effects were examined with risk ratio (RR) and weighted mean difference with the corresponding 95% confidence intervals (CI)...
2017: PloS One
https://www.readbyqxmd.com/read/28077085/erythropoiesis-stimulating-agents-and-reno-protection-a-meta-analysis
#2
Steve Elliott, Dianne Tomita, Zoltan Endre
BACKGROUND: Erythropoiesis stimulating agents (ESAs) were proposed to enhance survival of renal tissues through direct effects via activation of EPO receptors on renal cells resulting in reduced cell apoptosis, or indirect effects via increased oxygen delivery due to increased numbers of Hb containing red blood cells. Thus through several mechanisms there may be benefit of ESA administration on kidney disease progression and kidney function in renal patients. However conflicting ESA reno-protection outcomes have been reported in both pre-clinical animal studies and human clinical trials...
January 11, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28009142/robotic-kidney-transplantation-current-status-and-future-perspectives
#3
Angelo Territo, Alex Mottrie, Ronney Abaza, Craig Rogers, Mani Menon, Mahendra Bhandari, Rajesh Ahlawat, Alberto Breda
INTRODUCTION: For the treatment of patients with end-stage renal disease, kidney transplantation is preferred to renal replacement modalities such as hemodialysis and peritoneal dialysis. Although open surgery remains the gold standard, minimally invasive approaches have recently been applied in transplant kidney surgery. Despite growing enthusiasm and potential benefits of robotic kidney transplant, many aspects of this novel technique remain controversial. Aim of this study was to analyze the current status and future developments in robotic-assisted surgery for kidney transplantation...
2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28007762/association-of-pre-transplant-dialysis-modality-and-post-transplant-outcomes-a-meta-analysis
#4
Emily Joachim, Ali I Gardezi, Micah R Chan, Jung I Shin, Brad C Astor, Sana Waheed
♦ Background: It remains unclear whether post-transplant outcomes differ according to the pre-transplant dialysis modality (peritoneal dialysis [PD] versus hemodialysis [HD]). We performed a meta-analysis of studies that assessed either post-transplant mortality, graft survival, or delayed graft function (DGF) in both PD and HD patients. ♦ Methods: Two independent authors searched English-language literature from January 1, 1980, through August 31, 2014, national conference proceedings, and reference lists...
December 22, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27901336/robotic-kidney-transplantation-current-status-and-future-perspectives
#5
Angelo Territo, Alex Mottrie, Ronney Abaza, Craig Rogers, Mani Menon, Mahendra Bhandari, Rajesh Ahlawat, Alberto Breda
INTRODUCTION: For the treatment of patients with end-stage renal disease, kidney transplantation is preferred to renal replacement modalities such as hemodialysis and peritoneal dialysis. Although open surgery remains the gold standard, minimally invasive approaches have recently been applied in transplant kidney surgery. Despite growing enthusiasm and potential benefits of robotic kidney transplant, many aspects of this novel technique remain controversial. Aim of this study was to analyze the current status and future developments in robotic-assisted surgery for kidney transplantation...
November 30, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27749583/maximizing-kidneys-for-transplantation-using-machine-perfusion-from-the-past-to-the-future-a-comprehensive-systematic-review-and-meta-analysis
#6
REVIEW
Ahmer M Hameed, Henry C Pleass, Germaine Wong, Wayne J Hawthorne
BACKGROUND: The two main options for renal allograft preservation are static cold storage (CS) and machine perfusion (MP). There has been considerably increased interest in MP preservation of kidneys, however conflicting evidence regarding its efficacy and associated costs have impacted its scale of clinical uptake. Additionally, there is no clear consensus regarding oxygenation, and hypo- or normothermia, in conjunction with MP, and its mechanisms of action are also debated. The primary aims of this article were to elucidate the benefits of MP preservation with and without oxygenation, and/or under normothermic conditions, when compared with CS prior to deceased donor kidney transplantation...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27569938/meta-analysis-on-the-safety-and-efficacy-of-the-reperfusion-use-of-a-single-high-dose-of-anti-t-lymphocyte-globulin-fresenius-in-kidney-transplantation
#7
X Du, W Wang, Z-J Sun, L L Su, X-D Zhang
BACKGROUND: The aim of this study was to evaluate the effects of a single high dose of the anti-T-lymphocyte globulin Fresenius (ATG-F), given before kidney transplantation, on the prevention of acute rejection response and infections and on the survival rate of the renal graft and patient. METHODS: Databases including PubMed, Embase, and the Cochrane Library were searched to identify randomized controlled trials relevant to studying the presurgical use of a single high dose of ATG-F...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27470979/multiple-renal-arteries-in-kidney-transplantation-a-systematic-review-and-meta-analysis
#8
REVIEW
Marcel Zorgdrager, Christina Krikke, Sybrand H Hofker, Henri G D Leuvenink, Robert A Pol
BACKGROUND: The use of grafts with multiple renal arteries (MRA) in renal transplantation has not been clearly established. MATERIAL/METHODS: A systematic literature review used predefined terms to search PubMed, EMBASE, and the Cochrane Library for all studies since 1985 that included more than 50 MRA grafts. A total of 23 studies, comprising a total of 18,289 patients, were eligible to be included in the meta-analysis. RESULTS: Patients who received an MRA graft compared to single renal artery (SRA) grafts showed significantly higher complication rates (13...
July 29, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27296631/a-comparison-of-transplant-outcomes-in-peritoneal-and-hemodialysis-patients-a-meta-analysis
#9
Maozhi Tang, Tianyi Li, Hong Liu
BACKGROUND: Peritoneal dialysis (PD) and hemodialysis (HD) have been considered the 2 standard pre-transplant dialysis modalities in patients awaiting kidney transplantation. However, the impact of pretransplant dialysis on the short- and long-term post-transplant outcomes remains controversial. METHODS: We searched PubMed, EMBASE and the Cochrane central register of controlled trials for this review. Twelve studies were identified by strict screening for the meta-analysis...
2016: Blood Purification
https://www.readbyqxmd.com/read/27126975/effect-of-fty720-fingolimod-on-graft-survival-in-renal-transplant-recipients-a-systematic-review-protocol
#10
REVIEW
Reza Gholamnezhadjafari, Reza Falak, Nader Tajik, Reza Aflatoonian, Abbas Ali Keshtkar, Abbas Rezaei
INTRODUCTION: Studies have shown that FTY720 has inconsistent effects in kidney transplant recipients. Several review articles on FTY720 have been published, but most have focused on the mechanism of action of FTY720. Therefore, this review aims to evaluate and determine the beneficial and harmful effects of FTY720 therapy in kidney transplant recipients. METHODS AND ANALYSIS: We electronically searched the following databases: PubMed, Scopus, the Web of Sciences, EMBASE, Cochrane databases and the Cochrane Central Registry of Controlled Trials...
April 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/27015530/determining-the-superior-technique-for-living-donor-nephrectomy-the-laparoscopic-intraperitoneal-versus-the-retroperitoneoscopic-approach
#11
REVIEW
Bulang He, Alexandra Bremner, Ying Han, Jeffrey M Hamdorf
OBJECTIVES: Laparoscopic living-donor nephrectomy is now widely used because of its many beneficial features. Currently, there are 2 major techniques: the laparoscopic intraperitoneal approach and the retroperitoneoscopic approach. There is no evidence to support one particular approach over another. Therefore, in this study, we conducted a systematic literature review with the aim of defining which technique is superior. MATERIALS AND METHODS: The Embase, PubMed, and Cochrane literature databases were searched for English language articles published between January 1994 and January 2013 using the terms "laparoscopic donor nephrectomy," "retroperitoneoscopic donor nephrectomy," and "live donor nephrectomy...
April 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27015529/consequences-of-recipient-obesity-on-postoperative-outcomes-in-a-renal-transplant-a-systematic-review-and-meta-analysis
#12
REVIEW
Anshuman Sood, David N Hakim, Nadey S Hakim
OBJECTIVES: The prevalence of obesity is increasing rapidly and globally, yet systemic reviews on this topic are scarce. Our meta-analysis and systemic review aimed to assess how obesity affects 5 postoperative outcomes: biopsy-proven acute rejection, patient death, allograft loss, type 2 diabetes mellitus after transplant, and delayed graft function. MATERIALS AND METHODS: We evaluated peer-reviewed literature from 22 medical databases. Studies were included if they were conducted in accordance with the Meta-analysis of Observational Studies in Epidemiology criteria, only examined postoperative outcomes in adult patients, only examined the relation between recipient obesity at time of transplant and our 5 postoperative outcomes, and had a minimum score of > 5 stars on the Newcastle-Ottawa scale for nonrandomized studies...
April 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/26387917/validation-in-a-single-center-cohort-of-existing-predictive-models-for-delayed-graft-function-after-kidney-transplantation
#13
Alexander Decruyenaere, Philippe Decruyenaere, Patrick Peeters, Frank Vermassen
BACKGROUND Kidney transplantation is the preferred treatment for patients with end-stage renal disease. Delayed graft function (DGF) is a common complication and is associated with short- and long-term outcomes. Several predictive models for DGF have been developed. MATERIAL AND METHODS 497 kidney transplantations from deceased donors at our center between 2005-2011 are included. Firstly, the predictive accuracy of the existing models proposed by Irish et al. (M1), Jeldres et al. (M2), Chapal et al. (M3), and Zaza et al...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/26086831/right-versus-left-laparoscopic-living-donor-nephrectomy-a-meta-analysis
#14
REVIEW
Kun Wang, Peijin Zhang, Xianlin Xu, Min Fan
OBJECTIVES: We assessed the safety and efficacy of right versus left laparoscopic living-donor nephrectomy. Few clinical controlled studies have compared the right and left side, and most trials have a small sample number and varied results. A meta-analysis of published trials was performed to determine the effects of the 2 different approaches. MATERIALS AND METHODS: Major databases including Medline (PubMed), Embase, Ovid, and Cochrane were searched to identify studies comparing right and left laparoscopic living-donor nephrectomy (January 2000 to January 2014)...
June 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/26044837/recipient-obesity-and-outcomes-after-kidney-transplantation-a-systematic-review-and-meta-analysis
#15
REVIEW
Christopher J Hill, Aisling E Courtney, Christopher R Cardwell, Alexander P Maxwell, Giuseppe Lucarelli, Massimiliano Veroux, Frederico Furriel, Robert M Cannon, Ellen K Hoogeveen, Mona Doshi, Jennifer A McCaughan
BACKGROUND: The prevalence of obesity is increasing globally and is associated with chronic kidney disease and premature mortality. However, the impact of recipient obesity on kidney transplant outcomes remains unclear. This study aimed to investigate the association between recipient obesity and mortality, death-censored graft loss and delayed graft function (DGF) following kidney transplantation. METHODS: A systematic review and meta-analysis was conducted using Medline, Embase and the Cochrane Library...
August 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25963131/body-mass-index-and-outcome-in-renal-transplant-recipients-a-systematic-review-and-meta-analysis
#16
REVIEW
Jeffrey A Lafranca, Jan N M IJermans, Michiel G H Betjes, Frank J M F Dor
BACKGROUND: Whether overweight or obese end stage renal disease (ESRD) patients are suitable for renal transplantation (RT) is often debated. The objective of this review and meta-analysis was to systematically investigate the outcome of low versus high BMI recipients after RT. METHODS: Comprehensive searches were conducted in MEDLINE OvidSP, Web of Science, Google Scholar, Embase, and CENTRAL (the Cochrane Library 2014, issue 8). We reviewed four major guidelines that are available regarding (potential) RT recipients...
May 12, 2015: BMC Medicine
https://www.readbyqxmd.com/read/25899552/tympanoplasty-for-chronic-tympanic-membrane-perforation-in-children-systematic-review-and-meta-analysis
#17
REVIEW
John Hardman, Jameel Muzaffar, Paul Nankivell, Chris Coulson
OBJECTIVE: To study the effectiveness of Type 1 tympanoplasty for chronic tympanic membrane perforations in the pediatric age group and to investigate factors influencing its success. DATA SOURCES: Searches were conducted of the MEDLINE database and the Cochrane Database of Systematic Reviews using terms focused around tympanoplasty and children. Searches were performed on June 23, 2014 and limited to English language entries since January 1, 1997. STUDY SELECTION: Studies reporting tympanoplasty closure rates in children 18 years and younger, with a minimum follow-up of 6 months, were included...
June 2015: Otology & Neurotology
https://www.readbyqxmd.com/read/25661334/effect-of-high-dose-erythropoietin-on-graft-function-after-kidney-transplantation-a-meta-analysis-of-randomized-controlled-trials
#18
Hui Xin, Yu-Zheng Ge, Ran Wu, Qian Yin, Liu-Hua Zhou, Jiang-Wei Shen, Tian-Ze Lu, Zhi-Kai Hu, Min Wang, Chang-Cheng Zhou, Jian-Ping Wu, Wen-Cheng Li, Jia-Geng Zhu, Rui-Peng Jia
PURPOSE: Current evidence suggests that preconditioning with erythropoietin (EPO) can protect against ischemia reperfusion injury in rodents. However, randomized controlled trials (RCTs) assessing the efficacy and safety of high-dose EPO in kidney transplantation have yielded inconclusive results. Herein, we performed a meta-analysis of RCTs to assess whether the administration of high-dose EPO can improve graft function and the potential adverse events. METHODS: Relevant RCT studies that investigated high-dose EPO on graft function after kidney transplantation were comprehensively searched in Pubmed, Embase, and Cochrane Library until July 10, 2014...
February 2015: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/25643790/rherythropoietin-b-as-a-tissue-protective-agent-in-kidney-transplantation-a-pilot-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Beatrice Coupes, Declan G de Freitas, Stephen A Roberts, Ian Read, Hany Riad, Paul E C Brenchley, Michael L Picton
BACKGROUND: Extended criteria donor (ECD) and donation after circulatory death (DCD) kidneys are at increased risk of delayed graft function (DGF). Experimental evidence suggests that erythropoietin (EPO) attenuates renal damage in acute kidney injury. This study piloted the administration of high dose recombinant human EPO-beta at implantation of ECD and DCD kidneys, and evaluated biomarkers of kidney injury post-transplant. METHODS: Forty patients were randomly assigned to receive either rhEPO-b (100,000 iu) (n = 19 in the intervention group, as 1 patient was un-transplantable post randomisation), or placebo (n = 20) in this, double blind, placebo-controlled trial at Manchester Royal Infirmary from August 2007 to June 2009...
February 3, 2015: BMC Research Notes
https://www.readbyqxmd.com/read/25516244/perioperative-administration-of-high-dose-recombinant-human-erythropoietin-for-delayed-graft-function-prevention-in-kidney-transplantation-a-meta-analysis
#20
REVIEW
Georgios Vlachopanos, Theodoros I Kassimatis, Athanasios Agrafiotis
Delayed graft function (DGF) due to ischemia-reperfusion injury is a major early complication of kidney transplantation (KT). Recombinant human erythropoietin (rHuEPO) has been shown to exert nephroprotective action in animal models. We conducted a meta-analysis to explore the impact of rHuEPO on DGF in KT. Eligible studies comparing perioperative high-dose rHuEPO with placebo or no therapy for prevention of DGF were identified through MEDLINE, CENTRAL, and Transplant Library. Their design and data were assessed by two independent reviewers...
March 2015: Transplant International: Official Journal of the European Society for Organ Transplantation
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