Jana Krystofova Mike, Yasmine White, Rachel S Hutchings, Christian Vento, Janica Ha, Hadiya Manzoor, Donald Lee, Courtney Losser, Kimberly Arellano, Oona Vanhatalo, Elena Seifert, Anya Gunewardena, Bo Wen, Lu Wang, Aijun Wang, Brian D Goudy, Payam Vali, Satyan Lakshminrusimha, Jogarao V S Gobburu, Janel Long-Boyle, Yvonne W Wu, Jeffrey R Fineman, Donna M Ferriero, Emin Maltepe
BACKGROUND: Hypoxic-ischemic brain injury/encephalopathy affects about 1.15 million neonates per year, 96% of whom are born in low- and middle-income countries. Therapeutic hypothermia is not effective in this setting, possibly because injury occurs significantly before birth. Here, we studied the pharmacokinetics, safety, and efficacy of perinatal azithromycin administration in near-term lambs following global ischemic injury to support earlier treatment approaches. METHODS: Ewes and their lambs of both sexes (n=34, 141-143 days) were randomly assigned to receive azithromycin or placebo before delivery as well as postnatally...
November 2023: Stroke; a Journal of Cerebral Circulation