Jeremy Puthumana, Isaac E Hall, Peter P Reese, Bernd Schröppel, Francis L Weng, Heather Thiessen-Philbrook, Mona D Doshi, Veena Rao, Chun Geun Lee, Jack A Elias, Lloyd G Cantley, Chirag R Parikh
Deceased donor kidneys with AKI are often discarded for fear of poor transplant outcomes. Donor biomarkers that predict post-transplant renal recovery could improve organ selection and reduce discard. We tested whether higher levels of donor urinary YKL-40, a repair phase protein, associate with improved recipient outcomes in a prospective cohort study involving deceased kidney donors from five organ procurement organizations. We measured urinary YKL-40 concentration in 1301 donors (111 had AKI, defined as doubling of serum creatinine) and ascertained outcomes in the corresponding 2435 recipients, 756 of whom experienced delayed graft function (DGF)...
February 2017: Journal of the American Society of Nephrology: JASN