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Severe malnutrition children

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https://www.readbyqxmd.com/read/29165579/investigating-mediators-of-the-poor-pneumonia-outcomes-of-human-immunodeficiency-virus-exposed-but-uninfected-children
#1
Matthew S Kelly, Jiayin Zheng, Sefelani Boiditswe, Andrew P Steenhoff, Kristen A Feemster, Tonya Arscott-Mills, Boitshepe Seme, Bakgaki Ratshaa, Ikanyeng Rulaganyang, Mohamed Z Patel, Savarra Mantzor, Samir S Shah, Coleen K Cunningham
Background: Human immunodeficiency virus-exposed but uninfected (HIV-EU) children have a higher mortality rate than the children of HIV-negative mothers (HIV-unexposed). Causal mediators of the poor health outcomes of HIV-EU children remain poorly defined. Methods: We conducted a hospital-based prospective cohort study of children aged 1 to 23 months with clinically defined pneumonia. The children were recruited at a referral hospital in Gaborone, Botswana, between April 2012 and June 2016...
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29152260/improving-estimates-of-the-burden-of-severe-acute-malnutrition-and-predictions-of-caseload-for-programs-treating-severe-acute-malnutrition-experiences-from-nigeria
#2
Assaye Bulti, André Briend, Nancy M Dale, Arjan De Wagt, Faraja Chiwile, Stanley Chitekwe, Chris Isokpunwu, Mark Myatt
Background: The burden of severe acute malnutrition (SAM) is estimated using unadjusted prevalence estimates. SAM is an acute condition and many children with SAM will either recover or die within a few weeks. Estimating SAM burden using unadjusted prevalence estimates results in significant underestimation. This has a negative impact on allocation of resources for the prevention and treatment of SAM. A simple method for adjusting prevalence estimates intended to improve the accuracy of burden estimates and caseload predictions has been proposed...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29152220/preference-and-willingness-to-pay-for-nutritional-counseling-services-in-urban-hanoi
#3
Hai Viet Nguyen, Ngoc Bao Trinh, Huong Thi Le, Cuong Tat Nguyen, Hue Thi Mai, Tho Dinh Tran, Huong Thi Le, Bach Xuan Tran, Thuc Thi Minh Vu
Background: Despite substantial achievement in reducing malnutrition rates in Vietnam, there has been an increasing rate of overweight individuals in urban areas, which may result in a high burden of non-communicable diseases. Nutritional counseling clinics have been introduced in several settings; however, little is known about the preference for this service among urban clients. This study aimed to assess the preference and willingness to pay (WTP) for nutritional counseling services among urban clients.  Methods: We interviewed 429 clients who attended Hanoi Medical University Nutritional Counseling Clinic (Hanoi, Vietnam)...
2017: F1000Research
https://www.readbyqxmd.com/read/29149905/the-kusamala-program-for-primary-caregivers-of-children-6-59-months-of-age-hospitalized-with-severe-acute-malnutrition-in-malawi-study-protocol-for-a-cluster-randomized-controlled-trial
#4
Allison I Daniel, Meta van den Heuvel, Wieger P Voskuijl, Melissa Gladstone, Mike Bwanali, Isabel Potani, Celine Bourdon, Jenala Njirammadzi, Robert H J Bandsma
BACKGROUND: Severe acute malnutrition (SAM) is associated with high mortality rates and impairments in growth and development in children that do survive. There are complex nutritional, health, and behavioural risk factors involving severely malnourished children and their primary caregivers, requiring integrated intervention approaches. METHODS: A cluster-randomized controlled trial at the Queen Elizabeth Central Hospital in Blantyre, Malawi will be conducted to evaluate the effectiveness of a 4-day hospital-based intervention programme directed at primary caregivers...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29146679/undernutrition-and-severe-acute-malnutrition-in-children
#5
Suparna Ghosh-Jerath, Archna Singh, Nameet Jerath, Suruchi Gupta, Elizabeth F Racine
No abstract text is available yet for this article.
November 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29140236/impact-of-childhood-nutritional-status-on-pathogen-prevalence-and-severity-of-acute-diarrhea
#6
Kirkby D Tickell, Patricia B Pavlinac, Grace C John-Stewart, Donna M Denno, Barbra A Richardson, Jaqueline M Naulikha, Ronald K Kirera, Brett E Swierczewski, Benson O Singa, Judd L Walson
Children with acute and chronic malnutrition are at increased risk of morbidity and mortality following a diarrheal episode. To compare diarrheal disease severity and pathogen prevalence among children with and without acute and chronic malnutrition, we conducted a cross-sectional study of human immunodeficiency virus-uninfected Kenyan children aged 6-59 months, who presented with acute diarrhea. Children underwent clinical and anthropometric assessments and provided stool for bacterial and protozoal pathogen detection...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29138201/effect-of-iron-and-zinc-biofortified-pearl-millet-consumption-on-growth-and-immune-competence-in-children-aged-12-18-months-in-india-study-protocol-for-a-randomised-controlled-trial
#7
Saurabh Mehta, Julia L Finkelstein, Sudha Venkatramanan, Samantha L Huey, Shobha A Udipi, Padmini Ghugre, Caleb Ruth, Richard L Canfield, Anura V Kurpad, Ramesh D Potdar, Jere D Haas
INTRODUCTION: Biofortified crops represent a sustainable agricultural solution for the widespread micronutrient malnutrition in India and other resource-limited settings. This study aims to investigate the effect of the consumption of foods prepared with iron- and zinc-biofortified pearl millet (FeZn-PM) by children on biomarkers of iron and zinc status, growth, and immune function. METHODS AND ANALYSIS: We will conduct a randomised controlled feeding trial in identified slums of Mumbai, India among 200 children aged between 12 and 18 months...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132283/predictors-of-survival-among-hiv-positive-children-on-art-in-swaziland
#8
Patrick Shabangu, Andy Beke, Samuel Manda, Nobuhle Mthethwa
The objective of the study was to determine predictors of survival among HIV-positive children (<15 years) in Swaziland. A retrospective cohort analysis of medical records for 4 167 children living with HIV who were initiated on antiretroviral therapy (ART) between 2004 and 2008, and followed up until 2014 was conducted in clinical settings at 36 health facilities. The Kaplan Meier Estimator, signed-ranks test, and the Cox proportional hazards regression model were applied to determine survival probabilities, significant difference among stratified survival functions and adjusted hazard ratios respectively...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29130701/patient-generated-subjective-global-assessment-of-nutritional-status-in-pediatric-patients-with-recent-cancer-diagnosis
#9
Mayra Jezabel Vázquez de la Torre, Katja Stein, Edgar Manuel Vásquez Garibay, Miguel Roberto Kumazawa Ichikawa, Rogelio Troyo Sanromán, Alicia Guadalupe Salcedo Flores, Fernando Antonio Sánchez Zubieta
BACKGROUND: The subjective global assessment (SGA) is a simple, sensitive tool used to identify nutritional risk. It is widely used in the adult population, but there is little evidence on its effectiveness in children with cancer. OBJECTIVE: This cross-sectional study was undertaken to demonstrate significant correlation between a simplified version of the Patient-Generated SGA (PG-SGA) and anthropometric assessment to identify nutritional status in children recently diagnosed with cancer...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29120331/management-of-children-with-severe-acute-malnutrition-in-india-we-know-enough-to-act-and-we-should-act-now
#10
Pavitra Mohan, Sanjana Brahmawar Mohan
No abstract text is available yet for this article.
October 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29117103/development-and-physico-chemical-characterization-of-a-shea-butter-containing-lipid-nutrition-supplement-for-sub-saharan-africa
#11
Elizabeth M Sloffer, Shashank Gaur, Nicki J Engeseth, Juan E Andrade
Lipid-based nutrient supplements (LNS) are used to prevent and treat moderate and severe acute malnutrition, a leading cause of mortality in children-under-five. The physical and chemical changes of two new LNS products were evaluated before and after accelerated shelf life testing (ASLT) according to protocols suggested by the U.S. Agency for International Development (USAID) and Doctors without Borders and compared against USAID's A-20 paste as a control. LNS formulas containing Shea butter from the Shea nut tree (Vitellaria paradoxa), a common fat source in parts of Sub-Saharan Africa, with and without flax-seed oil, as a source of omega-3 fatty acids, were developed...
November 8, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29116252/leptin-regulates-granzyme-a-pd-1-and-ctla-4-expression-in-t-cell-to-control-visceral-leishmaniasis-in-balb-c-mice
#12
Alti Dayakar, Sambamurthy Chandrasekaran, Jalaja Veronica, Vadloori Bharadwaja, Radheshyam Maurya
Visceral leishmaniasis (VL) is responsible for several deaths in malnourished children accompanied by diminished circulating leptin and impaired cell-mediated immunity. Typically, leptin deficiency is associated with the Th2 polarization that markedly coincides with the pathogenesis of VL. The aim of the present study was to unravel the prophylactic role of leptin in malnutrition-coupled VL mice. Interestingly, we observed that L. donovani infection itself reduces the serum leptin levels in malnutrition. Exogenous leptin restored severe body weight loss and parasite load in the spleen and liver of malnourished infected mice compared to controls...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115985/use-of-tuberculin-skin-test-for-assessment-of-immune-recovery-among-previously-malnourished-children-in-ethiopia
#13
Paluku Bahwere, Philip James, Alemseged Abdissa, Yesufe Getu, Yilak Getnet, Kate Sadler, Tsinuel Girma
OBJECTIVE: To compare levels of immunity in children recovering from severe acute malnutrition (cases) against those of community controls (controls). RESULTS: At baseline children recovering from severe acute malnutrition had lower, mid upper arm circumference (122 mm for cases and 135 mm for controls; p < 0.001), weight-for-height Z-score (- 1.0 for cases and - 0.5 for controls; p < 0.001), weight-for-age Z-score (- 2.8 for cases and - 1.1 for controls; p < 0...
November 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29113618/milk-products-in-the-dietary-management-of-childhood-undernutrition-a-historical-review
#14
Veronika Scherbaum, M Leila Srour
The present narrative review outlines the use of milk products in infant and young child feeding from early history until today and illustrates how research findings and technical innovations contributed to the evolution of milk-based strategies to combat undernutrition in children below the age of 5 years. From the onset of social welfare initiatives, dairy products were provided by maternal and child health services to improve nutrition. During the last century, a number of aetiological theories on oedematous forms of undernutrition were developed and until the 1970s the dogma of protein deficiency was dominant...
November 8, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29113439/nurses-knowledge-and-attitudes-regarding-malnutrition-in-children-and-its-management-in-ghana
#15
Victor Mogre, Alaru Yakubu, Musah Fuseini, Anthony Amalba, Sixtus Aguree
BACKGROUND: Malnutrition contributes significantly to child morbidity and mortality. Nurses require appropriate knowledge, skills and attitudes to prevent and treat malnutrition in children using appropriate guidelines or protocols. OBJECTIVES: The aim of this article was to assess nurses' knowledge, attitudes towards malnutrition and its management using the World Health Organization (WHO) or United Nations International Children's Fund guidelines for the treatment of severely malnourished children and to evaluate factors associated with their knowledge and attitudes...
October 31, 2017: Curationis
https://www.readbyqxmd.com/read/29101654/inflammatory-bowel-disease-effects-on-bone-and-mechanisms
#16
Francisco A Sylvester
Inflammatory bowel disease (IBD) is associated with decreased bone mass and alterations in bone geometry from the time of diagnosis, before anti-inflammatory therapy is instituted. Deficits in bone mass can persist despite absence of symptoms of active IBD. The effects of IBD on the skeleton are complex. Protein-calorie malnutrition, inactivity, hypogonadism, deficits in calcium intake and vitamin D consumption and synthesis, stunted growth in children, decreased skeletal muscle mass, and inflammation all likely play a role...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29092084/hormonal-correlates-and-predictors-of-nutritional-recovery-in-malnourished-african-children
#17
Helen M Nabwera, Robin M Bernstein, Schadrac C Agbla, Sophie E Moore, Momodou K Darboe, Mariama Colley, Amadou T Jallow, Richard Bradbury, Jennifer Karafin, Anthony J Fulford, Andrew M Prentice
Background: Malnourished children show variable growth responses to nutritional rehabilitation. We aimed to investigate whether these differences could be explained by variations in growth and energy-regulating hormones. Methods: Quasi-experimental study: Children aged 6-24 months in rural Gambia were recruited to controls if weight-for-height z-score (WHZ) > -2 (n = 22), moderate acute malnutrition if WHZ < -2 and > -3 (n = 18) or severe acute malnutrition if WHZ < -3 (n = 20)...
October 30, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29090271/oral-rehydration-of-malnourished-children-with-diarrhoea-and-dehydration-a-systematic-review
#18
Kirsty A Houston, Jack G Gibb, Kathryn Maitland
Background: Diarrhoea complicates over half of admissions to hospital with severe acute malnutrition (SAM). World Health Organization (WHO) guidelines for the management of dehydration recommend the use of oral rehydration with ReSoMal (an oral rehydration solution (ORS) for SAM), which has lower sodium (45mmols/l) and higher potassium (40mmols/l) content than old WHO ORS. The composition of ReSoMal was designed specifically to address theoretical risks of sodium overload and potential under-treatment of severe hypokalaemia with rehydration using standard ORS...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29080380/nutritional-risk-factors-predict-severe-acute-graft-versus-host-disease-and-early-mortality-in-pediatric-allogeneic-hematopoietic-stem-cell-transplantation
#19
Eva H Kerby, Yimei Li, Kelly D Getz, Elizabeth C Smith, Laura T Smith, Nancy J Bunin, Alix E Seif
BACKGROUND: Malnutrition is a pro-inflammatory state, yet data on nutritional risk factors and development of acute graft-versus-host disease (aGVHD) are extremely limited. PROCEDURE: We conducted a retrospective cohort analysis of pediatric patients up to age 21 years who underwent allogeneic hematopoietic stem cell transplantation (HSCT) at the Children's Hospital of Philadelphia from January 2011 to September 2014 to determine whether malnutrition was associated with development of aGVHD and early mortality...
October 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29076801/quality-of-care-of-treatment-for-uncomplicated-severe-acute-malnutrition-provided-by-lady-health-workers-in-pakistan
#20
Eleanor Rogers, Muhammad Ali, Shahid Fazal, Deepak Kumar, Saul Guerrero, Imtiaz Hussain, Sajid Soofi, Jose Luis Alvarez Morán
OBJECTIVE: To assess the quality of care provided by lady health workers (LHW) managing cases of uncomplicated severe acute malnutrition (SAM) in the community. DESIGN: Cross-sectional quality-of-care study. SETTING: The feasibility of the implementation of screening and treatment for uncomplicated SAM in the community by LHW was tested in Sindh Province, Pakistan. An observational, clinical prospective multicentre cohort study compared the LHW-delivered care with the existing outpatient health facility model...
October 27, 2017: Public Health Nutrition
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