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Thymus radioactive iodine

Tae Joo Jeon, Yong Sang Lee, Jae-Hoon Lee, Hang Seok Chang, Young Hoon Ryu
BACKGROUND: Rebound thymic hyperplasia (RTHP) is not an uncommon finding after radiation or chemotherapy in patients with various malignancies. However, there are limited case reports of this phenomenon after radioactive iodine ablation therapy (RIAT) in differentiated thyroid cancer (DTC). The goal of this study was to evaluate the incidence, patterns, and factors affecting RTHP after RIAT using (18)F-FDG PET/CT. METHODS: The study design was a retrospective review of 2550 patients (568 men, 1982 women; age 13-79 years) who underwent FDG PET/CT imaging after total thyroidectomy and RIAT from June 2009 through June 2012...
November 2014: Thyroid: Official Journal of the American Thyroid Association
Kenji Iwaku, Jaeduk Yoshimura Noh, Eiji Sasaki, Nami Suzuki, Tosiaki Kameda, Sakiko Kobayashi, Ai Yoshihara, Hidemi Ohye, Natsuko Watanabe, Miho Suzuki, Masako Matsumoto, Yo Kunii, Koji Mukasa, Kiminori Sugino, Koichi Ito
Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, screening of children with thyroid ultrasonography has been carried out, yielding numerous findings, suggesting a possible influence from the Accident. We report thyroid ultrasonographic findings, used by similar device at Fukushima Prefecture's study, at Ito-hospital...
2014: Endocrine Journal
Yue-Nan Liu, Sheng-Han Wang, Tao Li, Qin Wang, Wei Tu, Kun Cai, Xiao-Jun Hou, Ren-Mao Tian, Xiang Gao, Hao Liu, Le Xiao, Jing Shi, Yuan-Guo Cheng, Jian-Chun Li, Hui Wang
Shiga toxin type 2, a major virulence factor produced by the Shiga toxin-producing Escherichia coli, is a potential toxin agent of bioterrorism. In this study, iodine-125 (125I) was used as an indicator to describe the in vivo Stx2 biodistribution profile. The rats were injected intravenously (i.v.) with 125I-Stx2 at three doses of 5.1-127.5 μg/kg body weight. Stx2 had a short distribution half-life (t (1/2)α, less than 6 min) and a long elimination half-life in rat. The toxicokinetics of Stx2 in rats was dose dependent and nonlinear...
September 2011: Archives of Toxicology
Clodagh S O'Gorman, Jill Hamilton, Marianna Rachmiel, Abha Gupta, Bo Ye Ngan, Denis Daneman
BACKGROUND: Thyroid cancer (TC) is an uncommon childhood malignancy, but the incidence may be increasing. Recent American Thyroid Association guidelines focus primarily on adult data. Natural history studies of TC in childhood are important to determine outcomes. The objectives of this study were to describe the demographics and outcomes in children with TC treated at The Hospital for Sick Children, Toronto, from 1983 to 2006. We hypothesized that childhood TC was increasing at our institution...
April 2010: Thyroid: Official Journal of the American Thyroid Association
Maria Eduarda Mello, Rodrigo C Flamini, Rossana Corbo, Marcelo Mamede
The radioactive iodine has been used with great value as a diagnostic and therapeutic method in patients with differentiated thyroid carcinoma previously submitted to total thyroidectomy. False-positive whole-body scans may occur due to misinterpretation of the physiologic distribution of the radioisotope or lack of knowledge on the existence of other pathologies that could eventually present radioiodine uptake. Thymic uptake is an uncommon cause of false-positive whole-body scan, and the mechanism through which it occurs is not completely understood...
October 2009: Arquivos Brasileiros de Endocrinologia e Metabologia
Motoko Saito, Yasushi Yoshigae, Junichi Nakayama, Yukie Ogawa, Masahiko Ohtsuki, Atsushi Kurihara, Toshihiko Ikeda
R-125224 is a novel humanized anti-human Fas monoclonal antibody prepared from HFE7A, which is a monoclonal mouse IgG anti-Fas antibody, by grafting the mouse complementarity-determining regions to human IgG, presently being developed as a drug for treatment of rheumatoid arthritis. In the present study, we investigated the tissue distribution of radioactivity in cynomolgus monkeys with collagen-induced arthritis at the arm joint (CIA monkeys) after intravenous administration of (125)I-labeled R-125224 ((125)I-R-125224)...
May 8, 2007: Life Sciences
Moon Suk Nam, Young Chae Chu, Won Sick Choe, Sei Joong Kim, Seong Bin Hong, Yoe Joo Kim, Yong Seong Kim
Clinically detectable metastatic follicular thyroid carcinoma to the thymus is very rare in the literature and sometimes confused with false positive uptake of Iodine(131) (I(131)) in the normal thymus or hilar lymph node. The authors report a 35-year-old woman with metastatic follicular carcinoma to the thymus. She underwent total thyroidectomy and I(131) ablation with 200 mCi. Six months later, a follow-up I(131) whole body scan showed continued radioactive iodine uptake in the retrosternal area and the serum thyroglobulin level remained continuously elevated with levothyroxine suppression therapy (22...
October 2002: Yonsei Medical Journal
Rohit Dwivedi, Paul Skierczynski, Hee-Myung Park
No abstract text is available yet for this article.
February 2002: Thyroid: Official Journal of the American Thyroid Association
M Centanni, G Canettieri, N Viceconti, R Sibilla, A Bei, M Andreoli
OBJECTIVE: We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes. MATERIALS AND METHODS: Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.6), in the presence or absence of 1mM tryptophan, was started by adding 25 pM [(125)I]T3. At the end of incubation, samples were cooled in ice, centrifuged over a 30% sucrose cushion and the cell-associated radioactivity was measured in the pellet...
July 2000: European Journal of Endocrinology
F Vermiglio, E Baudin, J P Travagli, B Caillou, P Fragu, M Ricard, M Schlumberger
A 14-yr-old boy underwent a total thyroidectomy with bilateral neck dissection for a papillary carcinoma with lymph node metastases. Total-body scanning with 3.7 GBq 131I revealed radioiodine accumulation in the anterior mediastinum. CT and MRI demonstrated a mediastinal mass which corresponded to the area of increased radioactivity. Five months later, another therapeutic dose of 131I was followed by a sternotomy and removal of the thymus because a hand-held radiodetecting surgical probe demonstrated that the thymus was the mediastinal structure which concentrated iodine...
November 1996: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
I Petkova, O Koparanova, Z Kemileva, S Milanov
The aim of the study was to label TAM with radioactive iodine and to follow its distribution in different organs of rats. T-actemodulin is a thymic hormone isolated from calf thymus by a new technology. TAM was labeled according to the method of Greenwood and Hunter. Two major peaks were observed on the gel chromatography: The first peak contained the labeled TAM; the second peak contained 125I which was not bound to the organic compound. Additional purification of the first peak was performed on a Sephadex G-75 column, and the eluate was designated as purified peak I...
1993: Acta Physiologica et Pharmacologica Bulgarica
Z M Tang, X W Liu, L P Xu, C W Shan, Q S Song
125I-labeled human recombinant interleukin-2 (125I-rIL-2) was prepared by iodogen method with rIL-2 and Na125I. Product was purified by Sephacryl S-200 gel filtration. Eluate fractions were identified by SDS-PAGE and compared with standard rIL-2. Radioactive 95% purified 125I-rIL-2 fractions were selected for pharmacokinetic study, with a specific activity of 56 PBq.mol-1. Concentration-time curves after iv 75, 530, 603, and 6767 ng of 125I-rIL-2/mouse were fitted to a 3-compartment model: with a fast distribution phase T1/2 of 2 min, a slow distribution phase T1/2 of 30-120 min, and a terminal elimination T1/2 of 6-15 h...
January 1994: Zhongguo Yao Li Xue Bao, Acta Pharmacologica Sinica
K I Fhölenhag, I M Sandström, K Malmlöf, A I Skottner, F J Nyberg
The purpose of this study was to investigate if human growth hormone (hGH) crosses the placenta to the fetus of the pregnant rat. Pregnant rats were injected i.v. with 125I-hGH alone or co-injected with unlabelled hormone on gestational day 20 or 21. The rats were sacrificed 10 min after injection, and the distribution of the radioactivity was determined by direct measurement in brain, thymus, liver, kidney, rectus femoris muscle, placenta and fetus. Free iodine was determined in samples from maternal liver, placental and fetal tissue homogenates after precipitation of proteins by trichloroacetic acid...
December 1994: Growth Regulation
A Takaori-Kondo, M Hosono, K Imada, Z S Yao, H Sakahara, H Yamabe, J Konishi, M Okuma, T Uchiyama
To clarify the mechanism of in vivo proliferation of adult T cell leukemia (ATL) cells, we examined the organ distribution of ATL-43T cell line cells derived from original leukemic cells in severe combined immunodeficiency (SCID) mice using radiometric techniques. First, we injected 111In-oxine-labeled ATL-43T cells into SCID and CB17 mice. On day 6, significant accumulation of radioactivity was found in the spleen and thymus of SCID mice (33.3 +/- 9.4 and 10.0 +/- 3.6% injected dose/g of tissue [%ID/g], respectively) in comparison with that in CB17 mice (19...
March 1995: Japanese Journal of Cancer Research: Gann
I L Gordon
Standard Scatchard analysis of ligand binding to cell receptors requires the use of isotopes and is imprecise at low ligand concentrations. To evaluate the feasibility of Scatchard analysis via fluorescence flow cytometry, the binding of fluorescein isothiocyanate-derivatized concanavalin A (FITC-ConA) to murine lymphocytes at 4 degrees C was compared to 125I-ConA binding. A FACS IV flow cytometer (Becton-Dickinson, Mountain View, CA) was used for analysis of cells after fluorescent ligand binding. A simple spectrophotometric technique was used to calibrate the relation between cytometer-determined fluorescence and ligand binding per cell...
July 1, 1995: Cytometry
K Yayama, M Yoshiya, K Takahashi, T Matsui, M Takano, H Okamoto
We studied the tissue distribution and plasma clearance of angiotensinogen (AGN) in rats following an i.v. injection of 125I-labeled AGN. The plasma clearance rate of [125I]AGN fits a two-compartment model with half-lives of 10.2 +/- 1.5 min and 4.1 +/- 0.5 h in non-treated rats, and the half-life of slower phase significantly increased to 10.2 +/- 1.1 h following bilateral nephrectomy. Radioactivity was predominantly distributed in the kidneys (4.9%), and to a lesser extent in the liver (1.8%), testis (1.2%), spleen (0...
1995: Life Sciences
C Goridis, M Hirsch, M Dossetto, E Baechler
Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glycoprotein species detected in cerebellar cell cultures after labelling with various radioactive sugars. The freshly iodinated molecules were firmly bound to the cells, but they were released into the medium upon prolonged incubation on the cultures...
January 27, 1980: Brain Research
M Shimada, S Abe, T Imahayashi
In order to visualize regional blood flow in various tissues of the mouse at the same time, the distribution of radioactive carbon from 14C-iodoantipyrine was studied by whole-body autoradiography. The mice were frozen with Dry-Ice-hexane at 1, 10, 30 min, and 1 h and 3 h after intravenous injection of 14C-iodoantipyrine. Whole-sagittal sections of the frozen mouse, obtained by using a cryostat microtome, were dried in a cryostat and subjected to autoradiograhy. The resulting dry autoradiographs are called untreated autoradiographs in the present work...
1982: Histochemistry
W Jilg, K Hannig, K O'Zeiller
Rat thymocytes and lymph node cells were separated into three T and one B subpopulation by means of free flow electrophoresis. The surface proteins of the separated cells were labeled by lactoperoxidase catalysed radioiodination. Most of the label was demonstrated to be at the cell surface. The labelled cells were either lysed in sodium dodecyl sulphate or treated with Nonidet P-40 to extract cell proteins. The radioiodinated proteins were analysed on sodium dodecyl sulphate polyacrylamide gel electrophoresis followed by autoradiography...
1980: Hoppe-Seyler's Zeitschrift Für Physiologische Chemie
S S Chen, J S Tung, S Gillis, R A Good, J W Hadden
Peanut agglutinin-positive thymocytes, peanut agglutinin-negative thymocytes, cortisone-resistant thymocytes, and unfractionated thymocytes were prepared from congeneic C57BL/6 Tla mice. By using surface iodination and immunoprecipitation of solubilized antigen with specific antisera (e.g., anti-H-2D, anti-TL, anti-Qa2/3, and anti-gp70), the released specific antigens were electrophoresed on polyacrylamide gels, and their radioactivity was measured. The relative percentages of surface antigens H-2D, TL, Qa2/3, and gp70 were 3...
October 1983: Proceedings of the National Academy of Sciences of the United States of America
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