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O C Francke
No abstract text is available yet for this article.
1978: Nordisk Medicinhistorisk årsbok
G Bunone, M Uggeri, P Mondellini, M A Pierotti, I Bongarzone
The RET proto-oncogene encodes a receptor tyrosine kinase for transforming growth factor-beta-related neurotrophic factors, which include GDNF and neurturin. The expression of RET proto-oncogene was detected in several tissues, such as spleen, thymus, lymph nodes, salivary gland, and spinal cord, and in several neural crest-derived cell lines. RET expression in the thyroid gland was reported to be restricted to neural crest-derived C cells. The presence of RET mRNA or protein has not yet been reported in thyroid follicular cells...
June 1, 2000: Cancer Research
G Bunone, P Vigneri, L Mariani, S Butó, P Collini, S Pilotti, M A Pierotti, I Bongarzone
Experimental evidence has shown, both in vitro and in animal models, that neoplastic growth and subsequent metastasis formation depend on the tumor's ability to induce an angiogenic switch. This requires a change in the balance of angiogenic stimulators and inhibitors. To assess the potential role of angiogenesis factors in human thyroid tumor growth and spread, we analyzed their expression by semiquantitative RT-PCR and immunohistochemistry in normal thyroid tissues, benign lesions, and different thyroid carcinomas...
December 1999: American Journal of Pathology
L Sard, P Accornero, S Tornielli, D Delia, G Bunone, M Campiglio, M P Colombo, M Gramegna, C M Croce, M A Pierotti, G Sozzi
Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. FHIT gene transfer into lung cancer cell line H460 lacking Fhit protein expression resulted in reversion of tumorigenicity. To gain insight into the biological function of FHIT, we compared the H460 cell line with its Fhit transfectants (H460/FHIT). A significant inhibition of cell growth was observed in H460/FHIT cells. The analysis of apoptosis by in situ terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling revealed a high rate of apoptosis-induced DNA strand breaks in stable clones...
July 20, 1999: Proceedings of the National Academy of Sciences of the United States of America
J P Lièvremont, C Sciorati, E Morandi, C Paolucci, G Bunone, G Della Valle, J Meldolesi, E Clementi
SK-N-BE neuroblastoma cell clones transfected with p75(NTR) and lacking Trk neurotrophin receptors, previously reported to undergo extensive spontaneous apoptosis and to be protected by nerve growth factor (NGF) (Bunone, G., Mariotti, A., Compagni, A., Morandi, E., and Della Valle, G. (1997) Oncogene 14, 1463-1470), are shown to exhibit (i) increased levels of the pro-apoptotic lipid metabolite ceramide and (ii) high activity of caspases, the proteases of the cell death cascade. In the p75(NTR)-expressing cells, these parameters were partially normalized by prolonged NGF treatment, which, in addition, decreased apoptosis, similar to caspase blockers...
May 28, 1999: Journal of Biological Chemistry
D Picard, G Bunone, J W Liu, O Donzé
No abstract text is available yet for this article.
May 1997: Biochemical Society Transactions
G Bunone, A Mariotti, A Compagni, E Morandi, G Della Valle
The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell line that lacks expression of both p75NTR and TrkA. Cell clones expressing elevated levels of p75NTR showed a high degree of cell death by apoptosis, even in serum-supplemented medium. Moreover, the level of apoptosis correlated directly with the expression level of the receptor, indicating that p75NTR could activate the cell death program by itself...
March 27, 1997: Oncogene
G Bunone, P A Briand, R J Miksicek, D Picard
The estrogen receptor (ER) can be activated as a transcription factor either by binding of cognate estrogenic ligand or, indirectly, by a variety of other extracellular signals. As a first step towards elucidating the mechanism of 'steroid-independent activation' of the ER by the epidermal growth factor (EGF), we have mapped the ER target domain and determined the signaling pathway. We show that the N-terminal transcriptional activation function AF-1, but not the C-terminal AF-2, is necessary for the EGF response...
May 1, 1996: EMBO Journal
F A Peverali, D Orioli, L Tonon, P Ciana, G Bunone, M Negri, G Della-Valle
N-myc expression is negatively regulated by retinoic acid (RA) which induces the growth arrest and differentiation of neuroblastoma (NB) cells. However, it has not been completely defined whether N-Myc promotes growth and/or antagonises neuronal differentiation of NB cells or whether the down regulation of N-myc occurs as a consequence of the onset of differentiation. By transfecting an N-myc gene construct into these cells, we found that the constitutive overexpression of N-myc stimulated proliferation in RA containing medium and, although these cells were still responsive to RA, they were no longer able to differentiate...
January 18, 1996: Oncogene
A Marozzi, R Meneveri, G Bunone, C De Santis, L Lopalco, A Beretta, A Agresti, A G Siccardi, G Della Valle, E Ginelli
Flow cytometry with the specific monoclonal antibody (MoAb) L31 was used to analyse the expression of HLA class I heavy chains not bound with beta 2-microglobulin (beta 2m) by neuroblastoma (NB) cell lines IMR-32 and LA-N-1. The cells, which express barely detectable amounts of beta 2m-free (L31-positive molecules) and beta 2m-complexed HLA class I antigens (W6.32- and BBM.1-reactive molecules), expressed MHC class I molecules not bound to light chains upon differentiation with either retinoic acid or serum starvation...
June 1993: Scandinavian Journal of Immunology
A Mariotti, E Marcora, G Bunone, A Costa, U Veronesi, M A Pierotti, G Della Valle
No abstract text is available yet for this article.
August 17, 1994: Journal of the National Cancer Institute
G Bunone, M G Borrello, R Picetti, I Bongarzone, F A Peverali, V de Franciscis, G Della Valle, M A Pierotti
RET proto-oncogene products are involved in neural crest development, and constitutional RET mutations are associated with syndromes characterized by tumors of neural crest origin. To study the regulation of RET transcription during neuronal differentiation we analyzed RET expression in neuroblastoma cell lines treated with various differentiating agents. A marked increase in RET mRNA levels was observed in all the cell lines examined shortly after retinoic acid (RA) treatment and before the onset of detectable morphological changes...
March 1995: Experimental Cell Research
R Pellegrini, A Mariotti, E Tagliabue, R Bressan, G Bunone, D Coradini, G Della Valle, F Formelli, L Cleris, P Radice
The retinoid N-(hydroxyphenyl) retinamide (4-HPR) appears to be a promising tool for chemoprevention of breast carcinoma, and clinical trials to evaluate its effect are in progress. However, its action on tumor cells has remained largely undefined. We report here that 4-HPR induced apoptosis and/or differentiation in breast cancer cell lines, independent of hormone receptor status and retinoic acid receptor expression, although it was slightly more efficient in inhibiting proliferation of estrogen receptor-positive cells...
July 1995: Cell Growth & Differentiation: the Molecular Biology Journal of the American Association for Cancer Research
W Hoffmann-Axthelm
No abstract text is available yet for this article.
November 16, 1967: Zahnärztliche Mitteilungen
D Granier
No abstract text is available yet for this article.
November 17, 1988: Le Chirurgien-dentiste de France
F A Peverali, M D'Esposito, D Acampora, G Bunone, M Negri, A Faiella, A Stornaiuolo, M Pannese, E Migliaccio, A Simeone
Mammalian genes containing a class-I homeobox (HOX genes) are highly expressed in the embryonic nervous system. As a first step towards the molecular analysis of the role these genes play in neural cells, we studied the expression of four human HOX genes in five neuroblastoma (NB) cell lines - SK-N-BE, CHP-134, IMR-32, SK-N-SH and LAN-1 - during the process of differentiation induced by treatment with retinoic acid (RA). The four genes, HOX1D, 2F, 3E and 4B, located at corresponding positions in the four HOX loci, share a high degree of sequence similarity with the Drosophila Deformed homeotic gene and constitute a homology group, group 10...
October 1990: Differentiation; Research in Biological Diversity
S Saccone, G Biamonti, S Maugeri, M T Bassi, G Bunone, S Riva, G Della Valle
Heterogeneous nuclear ribonucleoprotein (HNRP) core protein A1 is a major component of mammalian HNRP particles. The human HNRP A1 protein was shown to be encoded by a 4.6-kb gene, split into 10 exons, belonging to a multigene family of about 30 A1-specific sequences per haploid genome, many of which correspond to pseudogenes of the processed type. Here we report the mapping of the human HNRPA1 gene to band 12q13.1. Localization was performed by nonisotopic in situ hybridization using a phage genomic clone that contains the active HNRPA1 gene as well as 13...
January 1992: Genomics
A Verri, S Verzeletti, P Mazzarello, S Spadari, M Negri, G Bunone, G Della Valle, U Hübscher, F Focher
The activity of nuclear DNA polymerases alpha, beta and delta/epsilon, uracil-DNA glycosylase, thymidine kinase and the presence of Proliferating Cell Nuclear Antigen (PCNA) have been examined in developing rat glial cells, in rat and human glioma, in human neuroblastoma and in differentiated neuroblastoma cell lines in vitro. During glial development the activity of all enzymes tested, except DNA polymerase beta, markedly decreased, suggesting their coordinate regulation in respect to the proliferative state of the cells...
July 1992: Anticancer Research
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No abstract text is available yet for this article.
April 1975: Tic
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