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ceacam1 and polymorphism

Rona Ortenberg, Gilli Galore-Haskel, Ilanit Greenberg, Bella Zamlin, Sivan Sapoznik, Eyal Greenberg, Iris Barshack, Camila Avivi, Yulia Feiler, Israel Zan-Bar, Michal J Besser, Ester Azizi, Friedman Eitan, Jacob Schachter, Gal Markel
The prognostic value of the carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) in melanoma was demonstrated more than a decade ago as superior to Breslow score. We have previously shown that intercellular homophilic CEACAM1 interactions protect melanoma cells from lymphocyte-mediated elimination. Here, we study the direct effects of CEACAM1 on melanoma cell biology. By employing tissue microarrays and low-passage primary cultures of metastatic melanoma, we show that CEACAM1 expression gradually increases from nevi to metastatic specimens, with a strong dominance of the CEACAM1-Long tail splice variant...
May 2014: Neoplasia: An International Journal for Oncology Research
Jae Hwi Song, Zhang Cao, Jung Hwan Yoon, Suk Woo Nam, Su Young Kim, Jung Young Lee, Won Sang Park
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed on epithelial cells throughout the intestinal tract and is a negative regulator of tumor cell growth, suggesting that it may function as a tumor suppressor. In this study, to determine whether the CEACAM1 is involved in colorectal tumorigenesis, we have investigated the genetic alterations, including mutations and allelic loss, of the CEACAM1 gene in 17 colonic adenomas and 123 sporadic colorectal cancers. In addition, the expression pattern of the CEACAM1 protein was examined in 60 colonic adenomas and 123 sporadic colorectal adenocarcinomas...
March 2011: Pathology Oncology Research: POR
M J Callaghan, K Rockett, C Banner, E Haralambous, H Betts, S Faust, M C J Maiden, J S Kroll, M Levin, D P Kwiatkowski, A J Pollard
Adhesion between the opacity-associated adhesin (Opa) proteins of Neisseria meningitidis and human carcino-embryonic antigen cell adhesion molecule (CEACAM) proteins is an important stage in the pathogenesis of meningococcal disease, a globally important bacterial infection. Most disease is caused by a small number of meningococcal genotypes known as hyperinvasive lineages. As these are also carried asymptomatically, acquisition of them alone cannot explain why only some hosts develop meningococcal disease...
January 2008: Genes and Immunity
Silvia Villullas, Darryl J Hill, Richard B Sessions, Jon Rea, Mumtaz Virji
A common overlapping site on the N-terminal IgV-like domain of human carcinoembryonic antigen (CEA)-related cell adhesion molecules (CEACAMs) is targeted by several important human respiratory pathogens. These include Neisseria meningitidis (Nm) and Haemophilus influenzae (Hi) that can cause disseminated or persistent localized infections. To define the precise structural features that determine the binding of distinct pathogens with CEACAMs, we have undertaken molecular modelling and mutation of the receptor molecules at previously implicated key target residues required for bacterial binding...
February 2007: Cellular Microbiology
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