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tim3 and polymorphism

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https://www.readbyqxmd.com/read/27034168/genetic-polymorphisms-of-immune-checkpoint-proteins-pd-1-and-tim-3-are-associated-with-survival-of-patients-with-hepatitis-b-virus-related-hepatocellular-carcinoma
#1
Zhu Li, Na Li, Fang Li, Zhihua Zhou, Jiao Sang, Zhao Jin, Huihui Liu, Qunying Han, Yi Lv, Zhengwen Liu
Programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain containing molecule 3 (TIM-3) are involved in hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study examined the associations of PD1 and TIM3 polymorphisms with the overall survival (OS) of a prospective cohort of 258 HBV-related HCC patients. Results showed that PD1 +8669 G allele-containing genotypes or TIM3 -1516 genotype GG were significantly associated with longer OS (P < 0.001 and P = 0...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/23291409/genetic-variations-of-pd1-and-tim3-are-differentially-and-interactively-associated-with-the-development-of-cirrhosis-and-hcc-in-patients-with-chronic-hbv-infection
#2
Zhu Li, Na Li, Qianqian Zhu, Guoyu Zhang, Qunying Han, Pingping Zhang, Meng Xun, Yawen Wang, Xiaoyan Zeng, Cuiling Yang, Zhengwen Liu
Cooperation or interaction of programmed cell death-1 (PD-1) and T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) molecules is more relevant than either molecule alone to immune dysfunction in chronic viral infection and cancers. This study simultaneously investigated polymorphisms at PD1 +8669 and TIM3 -1516 loci in 845 hepatitis B virus (HBV) chronically infected patients [151 asymptomatic carriers, 202 chronic hepatitis, 221 cirrhosis and 271 hepatocellular carcinoma (HCC)], 141 HBV infection resolvers and 318 healthy controls...
March 2013: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/22587604/tim3-gene-polymorphisms-in-patients-with-chronic-hepatitis-b-virus-infection-impact-on-disease-susceptibility-and-hepatocellular-carcinoma-traits
#3
Z Li, Z Liu, G Zhang, Q Han, N Li, Q Zhu, Y Lv, J Chen, F Xing, Y Wang, F Li
Hepatitis B virus (HBV) infection is associated with the development of acute and chronic liver diseases including hepatocellular carcinoma (HCC). T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3), which negatively regulates T-cell response and mediates phagocytosis of apoptotic cells, has been implicated in HBV infection and cancers. This study explored the polymorphisms of TIM3 gene in 535 patients with HBV-related liver diseases including 213 chronic hepatitis, 178 cirrhosis and 144 HCC, 72 HBV infection resolvers and 182 healthy controls and analyzed the effects of these polymorphisms on the disease susceptibility and HCC traits...
August 2012: Tissue Antigens
https://www.readbyqxmd.com/read/22048452/tim-polymorphisms-genetics-and-function
#4
REVIEW
J Lee, B Phong, A M Egloff, L P Kane
The transmembrane immunoglobulin and mucin domain (TIM) family was identified more than a decade ago. Although the founding member of the family was first described in a rat model of ischemia-reperfusion injury, much of the recent interest in the TIM family members has focused on their potential roles in immunity. There are now a large number of genetic studies that have investigated the possible association of various TIM1 and TIM3 polymorphisms with different diseases. Here, we review this body of literature, and highlight some of the most interesting studies...
December 2011: Genes and Immunity
https://www.readbyqxmd.com/read/21565238/t-cell-immunoglobulin-and-mucin-domain-3-genetic-polymorphisms-are-associated-with-rheumatoid-arthritis-independent-of-a-shared-epitope-status
#5
Yeong Wook Song, Churl Hyun Im, Jae Hee Park, Yun Jong Lee, Eun Young Lee, Eun Bong Lee, Kyungsook Park
The aim of this study was to investigate T-cell immunoglobulin and mucin domain 3 (TIM3) genetic polymorphisms and rheumatoid arthritis (RA) according to the shared epitope (SE) status. Six single nucleotide polymorphisms (SNPs: rs11742259 [C/T], rs10515746 [C/A], rs35960726 [A/G], rs1036199 [A/C], rs4704846 [A/G], and rs11134551 [A/G]) in the TIM3 gene from 366 RA patients and 389 healthy controls were investigated using the real-time polymerase chain reaction method. Associations between these SNPs and clinical manifestations (including SE status) were investigated using the SPSS program and Haploview...
August 2011: Human Immunology
https://www.readbyqxmd.com/read/21470319/tim1-and-tim3-are-not-essential-for-experimental-allergic-asthma
#6
J L Barlow, S H Wong, S J Ballantyne, H E Jolin, A N J McKenzie
BACKGROUND: Initial studies suggested that polymorphisms in Tim1 and Tim3 contribute to the development of airway hyperreactivity (AHR) in an acute mouse model of asthma. This was also mirrored in human genetic studies where polymorphisms in Tim1 and Tim3 have been associated with atopic populations. OBJECTIVE: Further studies using anti-Tim1 or -Tim3 antibodies, or Tim fusion proteins, have also suggested that these molecules may function as regulators of type-1 and type-2 immunity...
July 2011: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/19566956/lack-of-association-of-tim3-polymorphisms-and-allergic-phenotypes
#7
Jian Zhang, Denise Daley, Loubna Akhabir, Dorota Stefanowicz, Moira Chan-Yeung, Allan B Becker, Catherine Laprise, Peter D Paré, Andrew J Sandford
BACKGROUND: T-cell immunoglobulin mucin-3 (TIM3) is a TH1-specific type 1 membrane protein that regulates TH1 proliferation and the development of immunological tolerance. TIM3 and its genetic variants have been suggested to play a role in regulating allergic diseases. Polymorphisms in the TIM3 promoter region have been reported to be associated with allergic phenotypes in several populations. The aims of this study were to examine whether genetic variation in the promoter region of TIM3 influenced transcription of the gene and risk for allergic phenotypes...
2009: BMC Medical Genetics
https://www.readbyqxmd.com/read/18294362/significant-association-between-tim1-promoter-polymorphisms-and-protection-against-cerebral-malaria-in-thailand
#8
P Nuchnoi, J Ohashi, R Kimura, H Hananantachai, I Naka, S Krudsood, S Looareesuwan, K Tokunaga, J Patarapotikul
Although cerebral malaria is a major life-threatening complication of Plasmodium falciparum infection, its pathophysiology is not well understood. Prolonged activation of the T helper type 1 (Th1) response characterized by the production of pro-inflammatory cytokines such as IFN-gamma and TNF-alpha has been suggested to be responsible for immunopathological process leading to cerebral malaria unless they are downregulated by the anti-inflamatory cytokines produced by the Th2 response. The T cell immunoglobulin and mucin domain (TIM) family of proteins are cell surface proteins involved in regulating Th1 and Th2 immune responses...
May 2008: Annals of Human Genetics
https://www.readbyqxmd.com/read/12618867/insertion-deletion-coding-polymorphisms-in-hhavcr-1-are-not-associated-with-atopic-asthma-in-the-japanese-population
#9
E Noguchi, J Nakayama, M Kamioka, K Ichikawa, M Shibasaki, T Arinami
Hepatitis A virus receptor (HAVcr-1) and T-cell immunoglobulin- and mucin-domain-containing molecule (TIM)-3 were recently implicated as asthma susceptibility genes in the study of congenic mice. In a genome-wide screen, we found strong evidence for linkage of atopic asthma with marker D5S820, located approximately 0.5 Mb from hHAVcr-1 and human TIM3. We screened for mutations in human HAVcr-1 (hHAVcr-1) and in TIM3 and found seven, including two insertion/deletion polymorphisms, in hHAVcr-1 and two in TIM3...
March 2003: Genes and Immunity
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