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https://www.readbyqxmd.com/read/29666962/activity-of-indatuximab-ravtansine-against-triple-negative-breast-cancer-in-preclinical-tumor-models
#1
Kurt Schönfeld, Peter Herbener, Chantal Zuber, Thomas Häder, Katrin Bernöster, Christoph Uherek, Jörg Schüttrumpf
PURPOSE: Triple-negative breast cancer (TNBC) is related with a poor prognosis as patients do hardly benefit from approved therapies. CD138 (Syndecan-1) is upregulated on human breast cancers. Indatuximab ravtansine (BT062) is an antibody-drug-conjugate that specifically targets CD138-expressing cells and has previously shown clinical activity in multiple myeloma. Here we show indatuximab ravtansine as a potential mono- and combination therapy for TNBC. METHODS: The effects of indatuximab ravtansine were assessed in vitro in SK-BR-3 and T47D breast cancer cell lines...
April 17, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29664605/ultra-stable-and-high-ion-conducting-polyelectrolyte-based-on-six-membered-n-spirocyclic-ammonium-for-hydroxide-exchange-membrane-fuel-cell-applications
#2
Nanjun Chen, Chuan Long, Yunxi Li, Chuanrui Lu, Hong Zhu
In response to prepare high stable and ion-conducting polyelectrolyte for hydroxide exchange membrane (HEM) applications, we present an ultra-stable polyelectrolyte based on six-membered heterocyclic 6-azonia-spiro [5.5] undecane (ASU) and polyphenyl ether (PPO). A series of ASU-functionalized PPO polyelectrolytes (ASU-PPO), which can be easily dissolved in low-boiling pointing solvent, have been successfully synthesized by a remote-grafting method. The ASU precursor is stable in 1 M NaOH/D2 O at 80 °C for 2500 h as well as in 5 M NaOH/D2 O at 80 °C for 2000 h, and the predicted half-life of the ASU precursor would exceed 10000 h, even higher in the future...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29663626/treatment-of-auricular-keloids-by-triple-combination-therapy-surgical-excision-platelet-rich-plasma-and-cryosurgery
#3
Ehab Zaki Azzam, Salma Samir Omar
BACKGROUND: Surgical excision alone for auricular keloids is frequently followed by recurrence making combining treatment options necessary. OBJECTIVE: We aimed to assess the long-term efficacy of combining surgical excision, cryosurgery, and platelet-rich plasma (PRP) in treatment of auricular keloids. METHODS: This interventional study was carried out on fifty auricular keloids in 50 patients. Patients were subjected to a combination therapy of surgical excision of the keloids, intraoperative cryosurgery, and PRP injections...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29658179/vav1-down-modulates-akt-in-different-breast-cancer-subtypes-a-new-promising-chance-to-improve-breast-cancer-outcome
#4
Silvia Grassilli, Federica Brugnoli, Rossano Lattanzio, Marco Marchisio, Letizia Perracchio, Mauro Piantelli, Alberto Bavelloni, Silvano Capitani, Valeria Bertagnolo
Targeting different members of the Akt pathways is a promising therapeutic chance in solid tumors including breast cancer. The variable expression levels of Akt isoforms with opposite effects on tumor growth and metastasis, however, makes it difficult to select the inhibitors to be used for specific breast tumor subtypes. By using in vitro and in vivo models, we demonstrated here that Vav1, ectopically expressed in invasive breast tumors derived cells, down-modulates Akt acting at expression and/or activation levels depending on tumor subtype...
April 15, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29656222/prolactin-induced-protein-pip-is-a-potential-biomarker-for-early-stage-and-malignant-breast-cancer
#5
Anju Gangadharan, Themba Nyirenda, Kishan Patel, Nydia Jaimes-Delgadillo, Dominique Coletta, Takemi Tanaka, Ayal C Walland, Zena Jameel, Srinivasa Vedantam, Sittinon Tang, Ciaran Mannion, Grace Y Lee, Andre Goy, Andrew Pecora, K Stephen Suh
OBJECTIVES: Breast cancer (BC) is the second leading cause of cancer-related mortality in women. Bioinformatic analysis and expression screening showed that Prolactin Induced Protein (PIP) was differentially expressed in BC. The objective of this investigation was to characterize the expression pattern of PIP, an aspartyl proteinase, in malignant and non-malignant breast tissues. MATERIALS AND METHODS: Real time quantitative PCR was employed to analyze PIP and androgen receptor (AR) mRNA levels in BC cell lines and 190 normal tissues and tumor samples...
April 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29656196/a-fast-and-robust-hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-method-for-determining-methylpentose-hexose-hexosamine-and-hexonic-acid-in-pneumococcal-polysaccharide-vaccine-hydrolysates
#6
Zhen Long, Jia Li, Zhimou Guo, Zhaoqi Zhan, Yueqi Li, Yutian Wang, Changkun Li, Feng Ji, Lixiao Li, Taohong Huang
The conventional UV/Vis spectroscopy methods recommended by the European Pharmacopoeia (EP) for determining hexosamine, hexonic acid and methylpentose in pneumococcal polysaccharide vaccine (PPSV) hydrolates are time-consuming due to derivatization process (typically, an analysis cycle is more than 4 h) and improvements of selectivity and precision of the methods are in demand. In this study, a new approach based on hydrophilic interaction liquid chromatography and triple quadrupole mass spectrometry (HILIC-MS/MS) was optimized to overcome the drawbacks of the EP methods for simultaneous determination of methylpentose, hexose, hexosamine and hexonic acid in PPSV hydrolysates...
April 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29655318/simulations-of-submonolayer-xe-on-pt-111-the-case-for-a-chaotic-low-temperature-phase
#7
Anthony D Novaco, Jessica Bavaresco
Molecular dynamics simulations are reported for the structural and thermodynamic properties of submonolayer xenon adsorbed on the (111) surface of platinum for temperatures up to the (apparently incipient) triple point and beyond. While the motion of the atoms in the surface plane is treated with a standard two-dimensional molecular dynamics simulation, the model takes into consideration the thermal excitation of quantum states associated with surface-normal dynamics in an attempt to describe the apparent smoothing of the corrugation with increasing temperature...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29651845/accurate-measurement-of-formaldehyde-induced-dna-protein-crosslinks-by-high-resolution-orbitrap-mass-spectrometry
#8
Chih-Wei Liu, Xu Tian, Hadley J Hartwell, Jiapeng Leng, Liang Chi, Kun Lu, James A Swenberg
Genomic instability caused by DNA-protein crosslink (DPCs)-induced DNA damage is implicated in disease pathogenesis, aging and cancer development. The covalent linkages between DNA and protein are induced by chemical reactions catalyzed by the endogenous metabolic intermediates and exogenous agents such as aldehydes, chemotherapeutic agents, and ionizing radiation. Formaldehyde has been classified as a genotoxic carcinogen. In addition, endogenous formaldehyde-induced DPCs may increase the risks of bone marrow toxicity and leukemia...
April 13, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29651273/are-there-differences-in-androgen-receptor-expression-in-invasive-breast-cancer-in-african-tanzanian-population-in-comparison-with-the-caucasian-italian-population
#9
Sara Bravaccini, Sara Ravaioli, Dino Amadori, Emanuela Scarpi, Maurizio Puccetti, Andrea Rocca, Maria Maddalena Tumedei, Nestory Masalu, Jackson Kahima, Akwilina Pangan, Lucas Faustine, Alberto Farolfi, Roberta Maltoni, Massimiliano Bonafè, Patrizia Serra, Giuseppe Bronte
Purpose: Androgen receptor (AR) has been shown to have prognostic implication on breast cancer (BC). Data on the biological features of African BCs are poor. We decided for the first time to compare AR expression of Tanzanian and Italian BC patients. Patients and methods: Of the 69 consecutive patients seen at the Bugando Medical Center (Mwanza, Tanzania) from 2003 to 2010, who underwent resection of primary BC evaluable for estrogen receptor, progesterone receptor (PgR), and HER2 only 65 were evaluable for AR by immunohistochemistry...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29650699/update-of-an-occupational-asthma-specific-job-exposure-matrix-to-assess-exposure-to-30-specific-agents
#10
Nicole Le Moual, Jan-Paul Zock, Orianne Dumas, Theodore Lytras, Eva Andersson, Linnéa Lillienberg, Vivi Schlünssen, Geza Benke, Hans Kromhout
OBJECTIVES: We aimed to update an asthmagen job exposure matrix (JEM) developed in the late 1990s. Main reasons were: the number of suspected and recognised asthmagens has since tripled; understanding of the aetiological role of irritants in asthma and methodological insights in application of JEMs have emerged in the period. METHODS: For each agent of the new occupational asthma-specific JEM (OAsJEM), a working group of three experts out of eight evaluated exposure for each International Standard Classification of Occupations, 1988 (ISCO-88) job code into three categories: 'high' (high probability of exposure and moderate-to-high intensity), 'medium' (low-to-moderate probability or low intensity) and 'unexposed'...
April 12, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29650479/core-shell-indium-iii-sulfide-metal-organic-framework-nanocomposite-as-an-adsorbent-for-the-dispersive-solid-phase-extraction-of-nitro-polycyclic-aromatic-hydrocarbons
#11
Yuqian Jia, Yanfang Zhao, Mei Zhao, Zhenhua Wang, Xiangfeng Chen, Minglin Wang
A core-shell discoid shaped indium (III) sulfide@metal-organic framework (MIL-125(Ti)) nanocomposite was synthesized by a solvothermal method and explored as an adsorbent material for dispersive solid-phase extraction (d-SPE). The as-synthesized sorbent was characterized by scanning electron microscopy, energy-dispersive spectroscopy, transmission electron microscopy, powder X-ray diffraction, N2 adsorption-desorption analysis, and Fourier transform infrared spectroscopy. The extraction performance was evaluated by the d-SPE of 16 nitro-polycyclic aromatic hydrocarbons (NPAHs) from water samples...
April 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29649805/comparing-the-efficacy-of-cbasp-with-two-versions-of-cbt-for-depression-in-a-routine-care-center-a-randomized-clinical-trial
#12
Winfried Rief, Gabi Bleichhardt, Katharina Dannehl, Frank Euteneuer, Katrin Wambach
BACKGROUND: The cognitive-behavioral analysis system of psychotherapy (CBASP) was developed for the treatment of chronic, early-onset depression. However, it is unclear whether this approach can be recommended for depression in general (episodic and chronic), and no direct comparisons between CBASP with different versions of cognitive-behavioral therapy (CBT) exist. METHODS: A randomized controlled trial compared 3 treatment conditions (all lasting 16 sessions) with a waiting list group (WL): CBASP, CBT with a focus on physical exercise (CBT-E), and CBT with a focus on pleasurable, low-energy and mindful activities (CBT-M)...
April 12, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29643987/proteomic-analysis-defines-kinase-taxonomies-specific-for-subtypes-of-breast-cancer
#13
Kyla A L Collins, Timothy J Stuhlmiller, Jon S Zawistowski, Michael P East, Trang T Pham, Claire R Hall, Daniel R Goulet, Samantha M Bevill, Steven P Angus, Sara H Velarde, Noah Sciaky, Tudor I Oprea, Lee M Graves, Gary L Johnson, Shawn M Gomez
Multiplexed small molecule inhibitors covalently bound to Sepharose beads (MIBs) were used to capture functional kinases in luminal, HER2-enriched and triple negative (basal-like and claudin-low) breast cancer cell lines and tumors. Kinase MIB-binding profiles at baseline without perturbation proteomically distinguished the four breast cancer subtypes. Understudied kinases, whose disease associations and pharmacology are generally unexplored, were highly represented in MIB-binding taxonomies and are integrated into signaling subnetworks with kinases that have been previously well characterized in breast cancer...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29627648/questioning-triple-rice-intensification-on-the-vietnamese-mekong-delta-floodplains-an-environmental-and-economic-analysis-of-current-land-use-trends-and-alternatives
#14
Dung Duc Tran, Gerardo van Halsema, Petra J G J Hellegers, Fulco Ludwig, Andrew Wyatt
Large areas of the Vietnamese Mekong Delta floodplains (VMDF) are protected by high dikes to facilitate three rice crops per year. While this has increased rice production, there is evidence that triple rice systems have negative long-term effects, both environmental and economic. Double rice cropping, or other alternatives, may be more advantageous. We analyzed the costs and benefits of intensive rice systems over time and compared these with alternatives farming systems, based on data collected via field surveys and interviews with farmers in two provinces in the VMDF...
April 5, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29623473/copper-complex-derived-from-s-benzyldithiocarbazate-and-3-acetylcoumarin-induced-apoptosis-in-breast-cancer-cell
#15
Jhi Biau Foo, May Lee Low, Ji Hui Lim, Yan Zhi Lor, Rusyidah Zainol Abidin, Vilasini Eh Dam, Napsiah Abdul Rahman, Chaw Yee Beh, Lee Chin Chan, Chee Wun How, Yin Sim Tor, Latifah Saiful Yazan
Copper complexes have been widely studied for the anti-tumour application as cancer cells are reported to take up greater amounts of copper than normal cells. Preliminary study revealed that the newly synthesised copper complex [Cu(SBCM)2 ] displayed marked anti-proliferative towards triple-negative MDA-MB-231 breast cancer cells. Therefore, Cu(SBCM)2 has great potential to be developed as an agent for the management of breast cancer. The present study was carried out to investigate the mode of cell death induced by Cu(SBCM)2 towards MDA-MB-231 breast cancer cells...
April 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29623316/high-crystallization-of-a-multiple-cation-perovskite-absorber-for-low-temperature-stable-zno-solar-cells-with-high-efficiency-of-over-20
#16
Xuemei Dong, Dong Chen, Junshuai Zhou, Yan-Zhen Zheng, Xia Tao
ZnO as a promising electron transport layer (ETL) to TiO2 for perovskite solar cells (PSCs) has achieved a power conversion efficiency (PCE) of 18.9%; however, this is still lower than that obtained for TiO2-based PSCs (higher than 20%). Herein, we report the fabrication of high-efficiency methylammonium (MA) and Cs co-alloyed formamidinium (FA) triple cation perovskite based ZnO PSCs via delicate control of the cation compositions and annealing temperatures. By virtue of structural, morphological, spectral and electrochemical characterizations and analysis, we found that the incorporation of MA and Cs into FA perovskite enables the formation of a highly crystalline black phase perovskite with reduced surface roughness, which inhibits charge recombination and promotes electron transfer at the ZnO/perovskite/spiro-OMeTAD interfaces and hence improves Jsc and FF values of the cell...
April 6, 2018: Nanoscale
https://www.readbyqxmd.com/read/29623068/nuclear-insulin-like-growth-factor-binding-protein-3-as-a-biomarker-in-triple-negative-breast-cancer-xenograft-tumors-effect-of-targeted-therapy-and-comparison-with-chemotherapy
#17
Sohel M Julovi, Janet L Martin, Robert C Baxter
Triple-negative breast cancer (TNBC) typically has a worse outcome than other breast cancer subtypes, in part owing to a lack of approved therapeutic targets or prognostic markers. We have previously described an oncogenic pathway in basal-like TNBC cells, initiated by insulin-like growth factor binding protein-3 (IGFBP-3), in which the epidermal growth factor receptor (EGFR) is transactivated by sphingosine-1-phosphate (S1P) resulting from sphingosine kinase (SphK)-1 activation. Oncogenic IGFBP-3 signaling can be targeted by combination treatment with the S1P receptor modulator and SphK inhibitor, fingolimod, and the EGFR kinase inhibitor, gefitinib (F + G)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29622901/the-triple-challenges-of-low-and-middle-income-countries
#18
EDITORIAL
Abraham Haileamlak
No abstract text is available yet for this article.
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29622545/pam50-and-risk-of-recurrence-scores-for-interval-breast-cancers
#19
Samantha Puvanesarajah, Sarah J Nyante, Cherie M Kuzmiak, Mengjie Chen, Chiu-Kit Tse, Xuezheng Sun, Emma H Allott, Erin L Kirk, Lisa A Carey, Charles M Perou, Andrew F Olshan, Louise M Henderson, Melissa A Troester
Breast cancers detected after a negative breast screening examination and prior to the next screening are referred to as interval cancers. These cancers generally have poor clinical characteristics compared to screen-detected cancers, but associations between interval cancer and genomic cancer characteristics are not well understood. Mammographically-screened women diagnosed with primary invasive breast cancer from 1993-2013 (n=370) were identified by linking the Carolina Breast Cancer Study and the Carolina Mammography Registry...
April 5, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29620436/probabilistic-risk-model-to-assess-the-potential-for-resistance-selection-following-the-use-of-antimicrobial-medicated-feed-in-pigs
#20
Maria Eleni Filippitzi, Ilias Chantziaras, Mathias Devreese, Jeroen Dewulf
The cross-contamination of non-medicated feed with residues of antimicrobials (AM) causes a public and animal health concern associated with the potential for selection and dissemination of resistance. To analyze the associated risks, a probabilistic model was built using @Risk® (Palisade Corporation®) to show the potential extent of the effect of cross-contaminated pig feed on resistance selection. The results of the model include estimations of the proportion of pigs per production stage with residues of doxycycline, chlortetracycline, sulfadiazine and trimethoprim in their intestinal contents, as a result of exposure to cross-contaminated feed with different carry-over levels, in Belgium...
April 5, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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