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https://www.readbyqxmd.com/read/28315066/failure-patterns-according-to-molecular-subtype-in-patients-with-invasive-breast-cancer-following-postoperative-adjuvant-radiotherapy-long-term-outcomes-in-contemporary-clinical-practice
#1
Yu Jin Lim, Sea-Won Lee, Noorie Choi, Jeanny Kwon, Keun-Yong Eom, Eunyoung Kang, Eun-Kyu Kim, Sung-Won Kim, Jee Hyun Kim, Yu Jung Kim, Se Hyun Kim, So Yeon Park, Jae-Sung Kim, In Ah Kim
PURPOSE: Although gene expression profiling provides critical information, knowledge remains limited regarding the differential effects of molecular subtype on clinical course. This study evaluated the impact of molecular status on long-term patterns of failure in patients with non-metastatic breast cancer. METHODS: We analyzed data from 1181 individuals with invasive breast cancer undergoing surgery plus PORT from 2003 to 2011. Molecular subtypes were defined as luminal A (LA), luminal B (LB)-HER2(-), LB-HER2(+), HER2, and triple-negative (TN) based on the 2013 St...
March 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28303950/effect-of-grain-structure-on-charpy-impact-behavior-of-copper
#2
Ningning Liang, Yonghao Zhao, Jingtao Wang, Yuntian Zhu
Nanostructured (NS) and ultrafine-grained (UFG) materials have high strength and relatively low ductility. Their toughness has not been comprehensively investigated. Here we report the Charpy impact behavior and the corresponding microstructural evolutions in UFG Cu with equi-axed and elongated grains which were prepared by equal channel angular pressing (ECAP) for 2 and 16 passes at room temperature. It is found that their impact toughness (48 J/cm(2)) is almost comparable to that of coarse grained (CG) Cu: 55 J/cm(2)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303802/rotation-excited-perfect-oscillation-of-a-tri-walled-nanotube-based-oscillator-at-ultralow-temperature
#3
Kun Cai, Xiaoni Zhang, Jiao Shi, Qing H Qin
In recent years, carbon-nanotube (CNT)-based gigahertz oscillators have been widely used in numerous areas of practical engineering such as high-speed digital, analog circuits, and memory cells. One of the major challenges to practical applications of the gigahertz oscillator is generating a stable oscillation process from the gigahertz oscillators and then maintaining the stable process for a specified period of time. To address this challenge, an oscillator from a triple-walled CNT-based rotary system is proposed and analyzed numerically in this paper, using a molecular dynamics approach...
April 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28302483/production-of-an-active-form-of-vitamin-d2-by-genetically-engineered-cyp105a1
#4
Kaori Yasuda, Yuya Yogo, Hiroshi Sugimoto, Hiroki Mano, Teisuke Takita, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro, Kiyoshi Yasukawa, Yoshitsugu Shiro, Toshiyuki Sakaki
Our previous studies revealed that CYP105A1 can convert vitamin D3 (VD3) to its active form, 1α,25-dihydroxyvitamin D3 (1,25D3). Site-directed mutagenesis of CYP105A1 based on its crystal structure dramatically enhanced its activity; the activity of double variants R73A/R84A and R73A/R84V was more than 100-fold higher than that of the wild type of CYP105A1. In contrast, these variants had a low ability to convert vitamin D2 (VD2) to 1α,25-dihydroxyvitamin D2 (1,25D2), whereas they catalyzed the sequential hydroxylation at positions C25 and C26 to produce 25,26D2...
March 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28301433/a-comparison-of-bilateral-muscular-imbalance-ratio-calculations-using-functional-tests
#5
Theodoros M Bampouras, Susan Dewhurst
Bilateral muscular imbalance can increase the risk of injury and negatively impact sporting performance. Bilateral muscular imbalances are typically calculated as ((side 1-side 2)/reference value) x 100, to provide a percentage value of the difference between limbs. Using different numerator (right-left or strong-weak) or reference values (left, right, strong, weak, average of the two) could mask or inflate the true difference value. The present study aimed to compare the bilateral muscular imbalance ratio calculations, using the absolute difference between limbs as the numerator and the five different options as reference values...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28300970/falls-cuts-and-burns-in-children-0-4-years-of-age-2004-pelotas-brazil-birth-cohort
#6
Raquel Siqueira Barcelos, Iná S Santos, Alicia Matijasevich, Aluísio J D Barros, Fernando C Barros, Giovanny Vinicius Araújo França, Vera Lúcia Schmidt da Silva
Knowledge on the incidence of childhood accidents according to the child's stage of development is important for designing preventive programs targeting each age bracket. The aim of this study was to describe the incidence of falls, cuts, and burns in children up to four years of age according to family economic status and maternal age and schooling, in children from the 2004 Pelotas (Brazil) birth cohort. We calculated the incidence rates and incidence rates ratios for the 0-12, 12-24, and 24-48- months of age...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28299888/the-relationship-of-race-oncotype-dx-and-ki67-in-a-population-highly-screened-for-breast-cancer
#7
Amber A Guth, Jennifer Chun Kim, Shira Schwartz, Jennifer Montes, Rebecca Akiko Snyder, Deborah Axelrod, Freya Schnabel
Oncotype DX recurrence score (ODX) can predict risk of invasive breast cancer recurrence and benefit of chemotherapy. Literature is limited on the relationship of ODX and race in women with hormone receptor positive and node negative/positive disease. Our study examines the relationship between race and clinical characteristics within a population of highly screened women with newly diagnosed breast cancer. The institutional Breast Cancer Database was queried for patients with newly diagnosed breast cancer between January2010 and March2015...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28298074/evaluation-of-growth-inhibitory-response-of-resveratrol-and-salinomycin-combinations-against-triple-negative-breast-cancer-cells
#8
Girish Rai, Shankar Suman, Sanjay Mishra, Yogeshwer Shukla
Resveratrol (RSVL) a dietary phytochemical showed to enhance the efficacy of chemotherapeutic drugs. Recently, Salinomycin (SAL) has gained importance as cancer therapeutic value for breast cancer (BC), however, its superfluxious toxicity delimits the utility. Taking the advantage of RSVL, the therapeutic efficacy of RSVL and SAL combination was studied in vitro and in vivo system. Firstly, the synergistic combination dose of RSVL and SAL was calculated and further, the efficacy was examined by wound healing, and Western blots analysis...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28295213/using-the-national-cancer-data-base-for-quality-evaluation-to-assess-adherence-to-treatment-guidelines-for-nonmetastatic-inflammatory-breast-cancer
#9
Heather Y Lin, Isabelle Bedrosian, Gildy V Babiera, Simona F Shaitelman, Henry M Kuerer, Wendy A Woodward, Naoto T Ueno, Yu Shen
BACKGROUND: Guidelines for the treatment of nonmetastatic inflammatory breast cancer (IBC) using trimodality therapy (TT) (chemotherapy, surgery, and radiotherapy) have remained largely unchanged since 2000. However, many patients with nonmetastatic IBC do not receive TT. It is unknown how patient-level (PL) and facility-level (FL) factors contribute to TT use. METHODS: Using the National Cancer Data Base, patients with nonmetastatic IBC who underwent locoregional treatment from 2003 through 2011 were identified...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28293912/breast-cancer-subtype-distribution-is-different-in-normal-weight-overweight-and-obese-women
#10
Victoria Gershuni, Yun R Li, Austin D Williams, Alycia So, Laura Steel, Elena Carrigan, Julia Tchou
PURPOSE: Obesity is associated with tumor promoting pathways related to insulin resistance and chronic low-grade inflammation which have been linked to various disease states, including cancer. Many studies have focused on the relationship between obesity and increased estrogen production, which contributes to the pathogenesis of estrogen receptor-positive breast cancers. The link between obesity and other breast cancer subtypes, such as triple-negative breast cancer (TNBC) and Her2/neu+ (Her2+) breast cancer, is less clear...
March 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28292011/jatamanvaltrate-p-induces-cell-cycle-arrest-apoptosis-and-autophagy-in-human-breast-cancer-cells-in-vitro-and-in-vivo
#11
Bo Yang, Rui Zhu, Shasha Tian, Yiqi Wang, Siyue Lou, Huajun Zhao
Jatamanvaltrate P is a novel iridoid ester isolated from Valeriana jatamansi Jones, a traditional medicine used to treat nervous disorders. In this study, we found that Jatamanvaltrate P possessed notable antitumor properties and therefore evaluated its anticancer effects against human breast cancer cells in vitro and in vivo. Jatamanvaltrate P inhibited the growth and proliferation of MCF-7 and triple-negative breast cancer (TNBC) cell lines (MDA-MB-231, MDA-MB-453 and MDA-MB-468) in a concentration-dependent manner, while displayed relatively low cytotoxicity to human breast epithelial cells (MCF-10A)...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28288011/using-activity-monitors-to-measure-sit-to-stand-transitions-in-overweight-obese-youth
#12
Tarrah Mitchell, Kelsey Borner, Jonathan Finch, Jacqueline Kerr, Jordan Carlson
INTRODUCTION: Reducing sedentary behavior has emerged as an important health intervention strategy. Although hip-worn, and more recently wrist-worn, accelerometers are commonly used for measuring physical activity and sedentary behavior, they may not provide accurate measures of postural changes. The current study examined the validity of commonly used hip- and wrist-worn accelerometer cut points and the thigh-worn activPAL activity monitor for measuring sit-to-stand transitions as compared to direct observation in youth with overweight and obesity...
March 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28287747/assessment-of-gold-nano-particle-mediated-enhanced-hyperthermia-using-mr-guided-high-intensity-focused-ultrasound-ablation-procedure
#13
Surendra Balaji Devarakonda, Matthew R Myers, Matthew Lanier, Charles Dumoulin, Rupak Kumar Banerjee
High-intensity focused ultrasound (HIFU) has gained increasing popularity as a non-invasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nano-particles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28285154/the-pharmacokinetics-of-12-week-continuous-contraceptive-patch-use
#14
Antonella F Lavelanet, Denis Rybin, Katharine O White
OBJECTIVES: We sought to assess the change in serum ethinyl estradiol (EE2) and norelgestromin (NGMN) levels over 12 weeks of continuous contraceptive patch use. STUDY DESIGN: We asked participants (n=30) to apply consecutive patches to be worn continuously (without a patch-free interval) for 12 weeks. We collected blood samples at the end of each patch week and two times during weeks 4, 8, and 12 (with the additional blood draw occurring mid-week). Liquid chromatography-tandem triple quadrupole mass spectrometry (LC-MS/MS) was utilized to assess EE2 and NGMN levels...
March 8, 2017: Contraception
https://www.readbyqxmd.com/read/28278370/exploring-the-influence-of-the-aromaticity-on-the-anti-cancer-and-anti-vascular-activities-of-organoplatinum-ii-complexes
#15
Ana Zamora, Sergio A Pérez, Matthias Rothemund, Venancio Rodríguez, Rainer Schobert, Christoph Janiak, José Ruiz
A series of new organometallic Pt(II) complexes of the type [Pt(C^N)Cl(DMSO)] (C^N = N,N-dimethyl-1-(2-aryl)methanamine-K2C2,N; aryl = phenyl 2a, biphenyl 2b, p-terphenyl 2c, naphthyl 2d, anthracenyl 2e, pyrenyl 2f) have been synthesized to explore the influence of the aromaticity on their anticancer activity. The best performers 2b and 2d are more active than CDDP in epithelial ovarian carcinoma cells A2780, with 2d having a higher selectivity factor than CDDP in all the tested cell lines. In addition, all the new compounds overcome the acquired resistance in A2780cisR cells and interestingly, show low micromolar IC50 values towards the triple negative breast tumour cell line MDA-MB-231 and the highly metastatic 518A2 melanoma cells...
March 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28270211/syndecan-1-is-a-novel-molecular-marker-for-triple-negative-inflammatory-breast-cancer-and-modulates-the-cancer-stem-cell-phenotype-via-the-il-6-stat3-notch-and-egfr-signaling-pathways
#16
Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte
BACKGROUND: Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular markers of IBC is of major importance. The heparan sulfate proteoglycan Syndecan-1 acts as a coreceptor for growth factors and chemokines, modulating inflammation, tumor progression, and cancer stemness, thus it may emerge as a molecular marker for IBC. METHODS: We characterized expression of Syndecan-1 and the CSC marker CD44, Notch-1 & -3 and EGFR in carcinoma tissues of triple negative IBC (n = 13) and non-IBC (n = 17) patients using qPCR and immunohistochemistry...
March 7, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28268680/fully-implantable-multi-channel-microstimulator-with-tracking-supply-ribbon-and-energy-recovery
#17
Amin Rashidi, Niloofar Yazdani, Amir M Sodagar
This paper proposes a novel energy-efficient approach dedicated to high-density implantable stimulators such as visual prostheses. Energy efficiency of the approach proposed in this work is achieved through two ideas: the `tracking supply ribbon' technique, and `reverse charge pumping'. The proposed approach is implemented, in the multichannel case, in such a way that power efficiency of each stimulation channel is enhanced according to its specific voltage/current condition and independently from other channels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264427/sensing-properties-of-a-novel-temperature-sensor-based-on-field-assisted-thermal-emission
#18
Zhigang Pan, Yong Zhang, Zhenzhen Cheng, Jiaming Tong, Qiyu Chen, Jianpeng Zhang, Jiaxiang Zhang, Xin Li, Yunjia Li
The existing temperature sensors using carbon nanotubes (CNTs) are limited by low sensitivity, complicated processes, or dependence on microscopy to observe the experimental results. Here we report the fabrication and successful testing of an ionization temperature sensor featuring non-self-sustaining discharge. The sharp tips of nanotubes generate high electric fields at relatively low voltages, lowering the work function of electrons emitted by CNTs, and thereby enabling the safe operation of such sensors...
February 27, 2017: Sensors
https://www.readbyqxmd.com/read/28263609/usefulness-of-caco-2-ht29-mtx-and-caco-2-ht29-mtx-raji-b-coculture-models-to-predict-intestinal-and-colonic-permeability-compared-to-caco-2-monoculture
#19
Isabel Lozoya-Agullo, Francisca Araújo, Isabel González-Álvarez, Matilde Merino-Sanjuán, Marta González-Álvarez, Marival Bermejo, Bruno Sarmento
The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human permeability but suffering from several and critical limitations. Therefore, some alternative cell cultures to mimic the human intestinal epithelium, as closely as possible, have been developed to achieve more physiological conditions, as the Caco-2/HT29-MTX coculture and the triple Caco-2/HT29-MTX/Raji B models. In this work the permeability of 12 model drugs of different Biopharmaceutical Classification System (BCS) characteristics, in the coculture and triple coculture models was assessed...
March 10, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28260874/copd-symptom-burden-impact-on-health-care-resource-utilization-and-work-and-activity-impairment
#20
Bo Ding, Mark Small, Gina Bergström, Ulf Holmgren
BACKGROUND: Chronic obstructive pulmonary disease (COPD) can greatly impact the quality of life by limiting patients' activities. However, data on impact of symptomatic burden on the health care resource utilization (HCRU) and employment in COPD are lacking. We examined the association between COPD Assessment Test (CAT) score and direct/indirect costs associated with HCRU and work productivity. METHODS: Data from >2,100 patients with COPD consulting for routine care were derived from respiratory disease-specific programs in Europe, the USA and China...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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