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Chd epidemiology

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https://www.readbyqxmd.com/read/27872105/multiethnic-exome-wide-association-study-of-subclinical-atherosclerosis
#1
Pradeep Natarajan, Joshua C Bis, Lawrence F Bielak, Amanda J Cox, Marcus Dörr, Mary F Feitosa, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Aaron Isaacs, Min A Jhun, Maryam Kavousi, Ruifang Li-Gao, Leo-Pekka Lyytikäinen, Riccardo E Marioni, Ulf Schminke, Nathan O Stitziel, Hayato Tada, Jessica van Setten, Albert V Smith, Dina Vojinovic, Lisa R Yanek, Jie Yao, Laura M Yerges-Armstrong, Najaf Amin, Usman Baber, Ingrid B Borecki, J Jeffrey Carr, Yii-Der Ida Chen, L Adrienne Cupples, Pim A de Jong, Harry de Koning, Bob D de Vos, Ayse Demirkan, Valentin Fuster, Oscar H Franco, Mark O Goodarzi, Tamara B Harris, Susan R Heckbert, Gerardo Heiss, Udo Hoffmann, Albert Hofman, Ivana Išgum, J Wouter Jukema, Mika Kähönen, Sharon L R Kardia, Brian G Kral, Lenore J Launer, Joseph Massaro, Roxana Mehran, Braxton D Mitchell, Thomas H Mosley, Renée de Mutsert, Anne B Newman, Khanh-Dung Nguyen, Kari E North, Jeffrey R O'Connell, Matthijs Oudkerk, James S Pankow, Gina M Peloso, Wendy Post, Michael A Province, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Fernando Rivadeneira, Frits Rosendaal, Samantha Sartori, Kent D Taylor, Alexander Teumer, Stella Trompet, Stephen T Turner, André G Uitterlinden, Dhananjay Vaidya, Aad van der Lugt, Uwe Völker, Joanna M Wardlaw, Christina L Wassel, Stefan Weiss, Mary K Wojczynski, Diane M Becker, Lewis C Becker, Eric Boerwinkle, Donald W Bowden, Ian J Deary, Abbas Dehghan, Stephan B Felix, Vilmundur Gudnason, Terho Lehtimäki, Rasika Mathias, Dennis O Mook-Kanamori, Bruce M Psaty, Daniel J Rader, Jerome I Rotter, James G Wilson, Cornelia M van Duijn, Henry Völzke, Sekar Kathiresan, Patricia A Peyser, Christopher J O'Donnell
BACKGROUND: -The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease (CHD). We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent CHD. METHODS AND RESULTS: -We studied a total of 25,109 European ancestry and African-American participants with coronary artery calcification (CAC) measured by cardiac computed tomography and 52,869 with common carotid intima media thickness (CIMT) measured by ultrasonography within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27821413/lipoprotein-a-a-historical-appraisal
#2
Karam M Kostner, Gert M Kostner
Initially, Lp(a) was believed to be a genetic variant of lipoprotein-B. Since its lipid moiety is almost identical to LDL, Lp(a) has been deliberately considered to be highly atherogenic. Lp(a) was detected in 1963 by Kare Berg, and individuals who were positive for this factor were called Lpa+. Lpa+ individuals were found more frequently in patients with coronary heart disease (CHD) than in controls. After the introduction of quantitative methods for measuring Lp(a), it became apparent that Lp(a) in fact is present in all individuals, yet to a greatly variable extent...
November 7, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27815926/hypertension-is-a-risk-factor-for-several-types-of-heart-disease-review-of-prospective-studies
#3
Yoshihiro Kokubo, Chisa Matsumoto
Many prospective cohort studies have demonstrated that hypertension is a strong risk factor for total mortality and cardiovascular disease (CVD). Heart disease includes coronary heart disease (CHD), heart failure, atrial fibrillation, valvular disease, sudden cardiac death (SCD), sick sinus syndrome (SSS), cardiomyopathy, and aortic aneurysms. Most of the epidemiologic prospective studies of heart disease focused on coronary/ischemic heart disease. Here we comprehensively reviewed the association between hypertension and the above-mentioned heart diseases...
November 5, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27812514/association-between-genetic-variations-affecting-mean-telomere-length-and-the-prevalence-of-hypertension-and-coronary-heart-disease-in-koreans
#4
Jean Kyung Paik, Ryungwoo Kang, Yoonsu Cho, Min-Jeong Shin
In this study, we investigated whether the single nucleotide polymorphisms (SNPs) associated with telomere length (TL) were associated with the incidence of hypertension (HTN)/coronary heart disease (CHD) and cardiovascular risk factors in the Korean population. Data from 5,705 (ages 39-70) participants in the Korean Genome Epidemiology Study (rural Ansung and urban Ansan cohorts) were studied. Twelve SNPs known to be associated with telomere biology were tested for an association with HTN/CHD. As results, no significant associations were found between the selected TL-related SNPs and prevalence of HTN and CHD...
October 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/27773540/secondary-cv-prevention-in-south-america-in-a-community-setting-the-pure-study
#5
Alvaro Avezum, Gustavo B F Oliveira, Fernando Lanas, Patricio Lopez-Jaramillo, Rafael Diaz, J Jaime Miranda, Pamela Seron, Paul A Camacho-Lopez, Andres Orlandini, Antonio Bernabe-Ortiz, Antônio Cordeiro Mattos, Shofiqul Islam, Sumathy Rangarajan, Koon Teo, Salim Yusuf
BACKGROUND: Despite the availability of evidence-based therapies, there is no information on the use of medications for the secondary prevention of cardiovascular disease in urban and rural community settings in South America. OBJECTIVES: This study sought to assess the use, and its predictors, of effective secondary prevention therapies in individuals with a history of coronary heart disease (CHD) or stroke. METHODS: In the PURE (Prospective Urban Rural Epidemiological) study, we enrolled 24,713 individuals from South America ages 35 to 70 years from 97 rural and urban communities in Argentina, Brazil, Chile, and Colombia...
October 20, 2016: Global Heart
https://www.readbyqxmd.com/read/27758973/evolution-of-chagas-disease-in-brazil-epidemiological-perspective-and-challenges-for-the-future-a-critical-review
#6
Rafael Bello Corassa, Carmen Aceijas, Paula Aryane Brito Alves, Hemda Garelick
AIMS: This article aimed to provide a critical review of the evolution of Chagas' disease (ChD) in Brazil, its magnitude, historical development and management, and challenges for the future. METHODS: A literature search was performed using PubMed, SciELO and Google Scholar and throughout collected articles' references. Narrative analysis was structured around five main themes identified: vector transmission, control programme, transfusion, oral and congenital transmission...
October 10, 2016: Perspectives in Public Health
https://www.readbyqxmd.com/read/27754269/sy-16-3-healthy-alcohol-consumption-myth-or-reality
#7
J Michael Gaziano
The health effects of alcohol have been studied for decades. While it is clear that excessive alcohol consumption is harmful, hundreds of studies have demonstrated that light to moderate alcohol consumption may reduce the risk of certain cardiovascular conditions. Light to moderate alcohol consumption has been consistently associated with lower risk of coronary heart disease (CHD) among a wide variety of population groups including men and women, those with hypertension, diabetes and heart disease. Alcohol has been associated with increases in HDL cholesterol and lower risks of diabetes...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754018/js-ksh-jsh-chl-01-1-cardio-metabolic-risks-in-hypertension-are-we-different-from-western-societies
#8
Hiroshi Itoh
Many hypertension guidelines have been published mainly from Western countries to standardize the management of hypertension all over the world, however, the significance of hypertension, along with other cardio-metabolic risks, such as obesity, diabetes or dyslipidemia should differ among different races. This paper compares the relevance of hypertension, one of the most important cardio-metabolic risk factors, in Asian and Western societies.1) Low target level of blood pressure control for diabetic hypertensives in JapanIn the Japanese Society of Hypertension Guidelines for the management of Hypertension (JSH2014), the target of blood pressure (BP) control in hypertensive patients with diabetes was set as < 130/80 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744207/prevalence-and-incidence-of-q-wave-unrecognized-myocardial-infarction-in-general-population-diagnostic-value-of-the-electrocardiogram-the-regicor-study
#9
Rafel Ramos, Xavier Albert, Joan Sala, Maria Garcia-Gil, Roberto Elosua, Jaume Marrugat, Anna Ponjoan, María Grau, Manel Morales, Antoni Rubió, Pedro Ortuño, Lia Alves-Cabratosa, Ruth Martí-Lluch
BACKGROUND: Diagnosis of unrecognized myocardial infarction (UMI) remains an open question in epidemiological and clinical studies, inhibiting effective secondary prevention of myocardial infarction. We aimed to determine the prevalence and incidence of Q-wave UMI in asymptomatic individuals aged 35 to 74years, and to ascertain the positive predictive value (PPV) of asymptomatic Q-wave to diagnose UMI. METHODS: Two population-based cross-sectional studies were conducted, in 2000 (with 10-year follow-up) and in 2005...
October 5, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27710205/meta-analysis-of-egg-consumption-and-risk-of-coronary-heart-disease-and-stroke
#10
Dominik D Alexander, Paula E Miller, Ashley J Vargas, Douglas L Weed, Sarah S Cohen
The possible relationship between dietary cholesterol and cardiac outcomes has been scrutinized for decades. However, recent reviews of the literature have suggested that dietary cholesterol is not a nutrient of concern. Thus, we conducted a meta-analysis of egg intake (a significant contributor to dietary cholesterol) and risk of coronary heart disease (CHD) and stroke. A comprehensive literature search was conducted through August 2015 to identify prospective cohort studies that reported risk estimates for egg consumption in association with CHD or stroke...
November 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27697938/evidence-from-prospective-cohort-studies-does-not-support-current-dietary-fat-guidelines-a-systematic-review-and-meta-analysis
#11
Zoë Harcombe, Julien S Baker, Bruce Davies
OBJECTIVES: National dietary guidelines were introduced in 1977 and 1983, by the US and UK governments to reduce coronary heart disease (CHD) mortality by reducing dietary fat intake. Our 2016 systematic review examined the epidemiological evidence available to the dietary committees at the time; we found no support for the recommendations to restrict dietary fat. The present investigation extends our work by re-examining the totality of epidemiological evidence currently available relating to dietary fat guidelines...
October 3, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27663421/serum-uric-acid-as-prognostic-marker-of-coronary-heart-disease-chd
#12
Samudrala Purnima, Bahiga Galal Abd El-Aal
BACKGROUND: A substantial body of epidemiological and experimental evidence suggests the significance of serum uric acid as an important and independent risk factor of cardio vascular and renal diseases especially in patients with diabetes mellitus, hypertension. Hyperuricemia is a risk factor of coronary heart disease. Several studies showed positive association between hyperuricemia and CHD risk factors. OBJECTIVE: To analyze the serum uric acid levels in patients with diabetes and hypertension, which helps in understanding its role as prognostic marker of coronary heart disease...
September 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27650262/how-to-compare-cardiovascular-disease-and-risk-factors-in-elderly-patients-with-haemophilia-with-the-general-population
#13
K Berger, D Schopohl, G Lowe, P A Holme, R C Tait, C Combescure, S Rauchensteiner, R Klamroth
INTRODUCTION: Studies on the prevalence of cardiovascular disease (CVD) and risk factors in patients with haemophilia (PWH) in comparison to the general population have generated inconsistent results. The ADVANCE Working Group collected data on CV comorbidities in PWH aged ≥40 years (H(3) Study). AIM: Identification of German epidemiological data on CVD for the general population, evaluation for appropriateness, and execution of comparisons with PWH. METHODS: Identification of data sources by structured literature (EMBASE, MEDLINE) searches...
September 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27648593/theoretical-effects-of-substituting-butter-with-margarine-on-risk-of-cardiovascular-disease
#14
Qing Liu, Jacques E Rossouw, Mary B Roberts, Simin Liu, Karen C Johnson, James M Shikany, JoAnn E Manson, Lesley F Tinker, Charles B Eaton
BACKGROUND: Several recent articles have called into question the deleterious effects of high animal fat diets due to mixed results from epidemiologic studies and the lack of clinical trial evidence in meta-analyses of dietary intervention trials. We were interested in examining the theoretical effects of substituting plant-based fats from different types of margarine for animal-based fat from butter on the risk of atherosclerosis-related cardiovascular disease (CVD). METHODS: We prospectively studied 71,410 women, aged 50-79 years, and evaluated their risk for clinical myocardial infarction (MI), total coronary heart disease (CHD), ischemic stroke, and atherosclerosis-related CVD with an average of 13...
January 2017: Epidemiology
https://www.readbyqxmd.com/read/27643266/sy-16-3-healthy-alcohol-consumption-myth-or-reality
#15
J Michael Gaziano
The health effects of alcohol have been studied for decades. While it is clear that excessive alcohol consumption is harmful, hundreds of studies have demonstrated that light to moderate alcohol consumption may reduce the risk of certain cardiovascular conditions. Light to moderate alcohol consumption has been consistently associated with lower risk of coronary heart disease (CHD) among a wide variety of population groups including men and women, those with hypertension, diabetes and heart disease. Alcohol has been associated with increases in HDL cholesterol and lower risks of diabetes...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642936/js-ksh-jsh-chl-01-1-cardio-metabolic-risks-in-hypertension-are-we-different-from-western-societies
#16
Hiroshi Itoh
Many hypertension guidelines have been published mainly from Western countries to standardize the management of hypertension all over the world, however, the significance of hypertension, along with other cardio-metabolic risks, such as obesity, diabetes or dyslipidemia should differ among different races. This paper compares the relevance of hypertension, one of the most important cardio-metabolic risk factors, in Asian and Western societies.1) Low target level of blood pressure control for diabetic hypertensives in JapanIn the Japanese Society of Hypertension Guidelines for the management of Hypertension (JSH2014), the target of blood pressure (BP) control in hypertensive patients with diabetes was set as < 130/80 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633455/application-of-dual-source-ct-coronary-angiography-in-type-2-diabetic-patients-with-symptomatic-coronary-heart-disease
#17
Ci He, Peng Wang, Fei-Zhou Du, Jian-Wen Gu, Zhi-Gang Yang
OBJECTIVE: To evaluate the epidemiological and morphological characteristics of coronary plaque in diabetic patients with symptomatic coronary heart disease (CHD) by dual-source computed tomography (DSCT). MATERIALS AND METHODS: From June 2013 to December 2014, 267 consecutive patients with type 2 diabetes mellitus were examined by DSCT. Plaque type, distribution, as well as extent and obstructive characteristics were determined for each segment. RESULTS: A total of 225 patients were included in the final study...
September 14, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27602082/epidemiological-aspects-of-heart-diseases
#18
Aimin Shi, Ziqi Tao, Peng Wei, Jing Zhao
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Coronary heart disease (CHD) is the main cause of mortality in heart patients following stroke, rheumatic heart disease and myocardial infarctions. Approximately 80% of individuals succumb to CVDs, due to poor living conditions in low and middle income families and malnutrition. Infectious diseases, human immunodeficiency, tuberculosis, malaria, high blood pressure or hypertension, obesity and overweight, and nutritional disorders including smoking, excessive alcohol consumption, high salt and sugar intake, as well as other factors are responsible for CVDs and CHDs in young as well as elderly individuals...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27594907/complications-from-carcinoid-syndrome-review-of-the-current-evidence
#19
REVIEW
José Mauricio Mota, Luana Guimarães Sousa, Rachel P Riechelmann
Patients with well-differentiated neuroendocrine tumours may develop carcinoid syndrome (CS), which is characterised by flushing, abdominal cramps, diarrhoea, and bronchospasms. In this scenario, long-term secretion of vasoactive substances-serotonin, tachynins, and others, may induce fibrogenic responses in local or distant tissues, leading to complications such as carcinoid heart disease (CHD), mesenteric and/or retroperitoneal fibrosis. Rare cases of lung/pleural fibrosis and scleroderma have also been described...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27584973/renal-function-and-attributable-risk-of-death-and-cardiovascular-hospitalization-in-patients-with-cardiovascular-risk-factors-from-a-registry-based-cohort-the-estudio-cardiovascular-valencia-risk-study
#20
Maria Tellez-Plaza, Domingo Orozco-Beltran, Vicente Gil-Guillen, Salvador Pita-Fernandez, Jorge Navarro-Pérez, Vicente Pallares, Francisco Valls, Antonio Fernandez, Ana María Perez-Navarro, Carlos Sanchis, Alejandro Dominguez-Lucas, Jose M Martin-Moreno, Josep Redon
BACKGROUND: Information about the attributable risk associated with renal dysfunction in patients with cardiovascular risk factors is lacking. OBJECTIVE: We aimed to estimate the attributable risk associated with chronic kidney disease Epidemiology Collaboration-estimated glomerular filtration rate (eGFR), for all-cause mortality, and cardiovascular hospitalization. DESIGN, SETTING, AND PARTICIPANTS: Prospective study of study participants with cardiovascular risk factors in 2008-2012...
November 2016: Journal of Hypertension
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