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https://www.readbyqxmd.com/read/29694988/the-role-of-lung-ultrasound-in-viral-lower-respiratory-tract-infections
#1
Nadya Yousef, Daniele De Luca
Despite being a bedside technique under rapid development and diffusion, lung ultrasound has not been often used in the management of viral low respiratory tract infections, although these infections represent a significant burden of care in neonatology and pediatrics. The aim of this article is to review the lung ultrasound findings and the evidence-based data available on this topic. Guidance on bedside imaging interpretation and future research direction are also discussed in this article.
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29694956/multiples-of-median-transformed-normalized-reference-ranges-of-steroid-profiling-data-independent-of-age-sex-and-units
#2
Dominika Zalas, Thomas Reinehr, Marek Niedziela, Christoph Borzikowsky, Maciej Flader, Gunter Simic-Schleicher, Halit Ilker Akkurt, Sabine Heger, Nadine Hornig, Paul-Martin Holterhus, Alexandra E Kulle
BACKGROUND/AIMS: The high complexity of pediatric reference ranges across age, sex, and units impairs clinical application and comparability of steroid hormone data, e.g., in congenital adrenal hyperplasia (CAH). We developed a multiples-of-median (MoM) normalization tool to overcome this major drawback in pediatric endocrinology. METHODS: Liquid chromatography tandem mass spectrometry data comprising 10 steroid hormones representing 905 controls (555 males, 350 females, 0 to > 16 years) from 2 previous datasets were MoM transformed across age and sex...
April 25, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29694654/prevalence-and-risk-factors-of-pressure-ulcers-in-a-tunisian-hospital
#3
Fatma Ben Mbarka, Khouloud Ben Jeddou, Mehdi Khalfallah, Dorra Jarraya, Hichem Jarraya, Zeineb Ouahchi, Ramzi Nouira, Chadli Dziri
BACKGROUND: the aim of thisstudywas to investigate the prevalence of pressure ulcers in hospitalized patients at the Charles Nicolle Hospital in Tunis, measure the risk of their occurrence, analyzepreventive and curative measuresundertaken and evaluatefactorspredisposing to pressure ulcers. METHODS: A one-day survey was performed in all hospitalized patients. Emergency services, neonatology and pediatrics were excluded. The Braden scale was used to measure the patient's risk for the development of pressure ulcers...
July 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29694606/cardiovascular-abnormalities-in-patients-with-oral-cleft-a-clinical-electrocardiographic-echocardiographic-study
#4
Gisele C P Leite, Marcela A G Ururahy, João F Bezerra, Valéria M G D M Lima, Maria I F Costa, Sandra S C Freire, André D Luchessi, Jussara M C Maia, Maria E F Brito, Vera L Gil-da-Silva-Lopes, Adriana A Rezende
OBJECTIVES: The present study aims to describe the clinical, electrocardiographic, and echocardiographic cardiological findings in a group of patients with oral clefts. METHODS: This is a prospective cross-sectional study on 70 children (age range from 13 days to 19 years) with oral clefts who attended the multidisciplinary program of a university hospital from March 2013 to September 2014. The patients were evaluated by a pediatric cardiologist and underwent detailed anamnesis, physical examination, electrocardiogram, and echocardiogram...
2018: Clinics
https://www.readbyqxmd.com/read/29694460/development-of-hospitalization-resource-intensity-scores-for-kids-h-risk-and-comparison-across-pediatric-populations
#5
Troy Richardson, Jonathan Rodean, Mitch Harris, Jay Berry, James C Gay, Matt Hall
BACKGROUND: In the Medicare population, measures of relative severity of illness (SOI) for hospitalized patents have been used in prospective payment models. Similar measures for pediatric populations have not been fully developed. OBJECTIVE: To develop hospitalization resource intensity scores for kids (H-RISK) using pediatric relative weights (RWs) for SOI and to compare hospital types on case-mix index (CMI). DESIGN/METHODS: Using the 2012 Kids' Inpatient Database (KID), we developed RWs for each All Patient Refined Diagnosis Related Group (APR-DRG) and SOI level...
April 25, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29694375/prevalence-of-burnout-in-paediatric-nurses-a-systematic-review-and-meta-analysis
#6
Laura Pradas-Hernández, Tania Ariza, José Luis Gómez-Urquiza, Luis Albendín-García, Emilia I De la Fuente, Guillermo A Cañadas-De la Fuente
INTRODUCTION: Although burnout in paediatric nurses has been addressed in previous research, the heterogeneous nature of the results obtained and of the variables studied highlights the need for a detailed analysis of the literature. OBJECTIVE: The aim of this study was to analyse the literature on burnout characteristics, reported prevalence, severity and risk factors, to achieve a better understanding of the risk of emotional exhaustion, depersonalisation and feelings of low personal accomplishment...
2018: PloS One
https://www.readbyqxmd.com/read/29694232/loss-of-myogenic-potential-and-fusion-capacity-of-muscle-stem-cells-isolated-from-contractured-muscle-in-children-with-cerebral-palsy
#7
Andrea A Domenighetti, Margie A Mathewson, Rajeswari Pichika, Lydia A Sibley, Leyna Zhao, Henry G Chambers, Richard L Lieber
Cerebral palsy (CP) is the most common cause of pediatric neurodevelopmental and physical disability in the United States. It is defined as a group of motor disorders caused by a non-progressive perinatal insult to the brain. While the brain lesion is non-progressive, there is a progressive, lifelong impact on skeletal muscles, which are shorter, spastic, and may develop debilitating contractures. Satellite cells are resident muscle stem cells that are indispensable for postnatal growth and regeneration of skeletal muscles...
April 25, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29693574/liver-transplantation-and-gut-microbiota-profiling-in-a-child-colonized-by-a-multi-drug-resistant-klebsiella-pneumoniae-a-new-approach-to-move-from-antibiotic-to-eubiotic-control-of-microbial-resistance
#8
Federica Del Chierico, Sabrina Cardile, Andrea Pietrobattista, Daniela Liccardo, Alessandra Russo, Manila Candusso, Maria Sole Basso, Chiara Grimaldi, Laura Pansani, Paola Bernaschi, Giuliano Torre, Lorenza Putignani
The increase of microorganisms multi-drug resistant (MDR) to antibiotics (ATBs) is becoming a global emergency, especially in frail subjects. In chronic liver disease (LD) with indications for liver transplantation (LT), MDR colonization can significantly affect the LT outcome. However, no clear guidelines for microbial management are available. A novel approach toward MDR-colonized patients undergoing LT was developed at our Center refraining from ATBs use during the transplant waiting list, and use of an intensive perioperative prophylaxis cycle...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29693572/sialidosis-a-review-of-morphology-and-molecular-biology-of-a-rare-pediatric-disorder
#9
REVIEW
Aiza Khan, Consolato Sergi
Sialidosis (MIM 256550) is a rare, autosomal recessive inherited disorder, caused by α- N -acetyl neuraminidase deficiency resulting from a mutation in the neuraminidase gene ( NEU1 ), located on 6p21.33. This genetic alteration leads to abnormal intracellular accumulation as well as urinary excretion of sialyloligosaccharides. A definitive diagnosis is made after the identification of a mutation in the NEU1 gene. So far, 40 mutations of NEU1 have been reported. An association exists between the impact of the individual mutations and the severity of clinical presentation of sialidosis...
April 25, 2018: Diagnostics
https://www.readbyqxmd.com/read/29693570/pharmacists-attitudes-and-practices-regarding-tetanus-diphtheria-and-pertussis-tdap-vaccination-in-pregnancy-and-surrounding-newborns
#10
Christine A Echtenkamp, Stacie J Lampkin, Amany K Hassan
BACKGROUND: Bordetella pertussis or whooping cough is a serious and vaccine-preventable illness. Despite widespread vaccination in the pediatric population, pertussis still infects approximately 100,000 infants each year in the United States. The purpose of this study was to determine gaps in pharmacists’ understanding, attitudes, practices, and barriers surrounding the tetanus, diphtheria, and pertussis (Tdap) vaccination recommendation for patients who are pregnant or planning to come in close contact with infants...
April 25, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29693554/increase-in-random-component-of-heart-rate-variability-coinciding-with-developmental-and-degenerative-stages-of-life
#11
Junichiro Hayano, Kei Ohashi, Yutaka Yoshida, Emi Yuda, Tooru Nakamura, Ken Kiyono, Yoshiharu Yamamoto
For adapting to a new environment or situation, the biological systems explore the most convenient state while moving between attractors by the force of random fluctuation. From this concept, the random component in physiological signals is assumed to increase during developmental and degenerative stages of life. To examine this hypothesis, we measured the age-dependent changes in the random component of heart rate variability (HRV) in 24-h electrocardiography (ECG) big data and in patients with developmental disorder (DD)...
April 25, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29693445/qualitative-development-and-content-validation-of-the-promis-pediatric-sleep-health-items
#12
Katherine B Bevans, Lisa J Meltzer, Anna De La Motte, Amy Kratchman, Dominique Viél, Christopher B Forrest
OBJECTIVE: To develop the Patient Reported Outcome Measurement Information System (PROMIS) Pediatric Sleep Health item pool and evaluate its content validity. PARTICIPANTS: Participants included 8 expert sleep clinician-researchers, 64 children ages 8-17 years, and 54 parents of children ages 5-17 years. METHODS: We started with item concepts and expressions from the PROMIS Sleep Disturbance and Sleep Related Impairment adult measures. Additional pediatric sleep health concepts were generated by expert (n = 8), child (n = 28), and parent (n = 33) concept elicitation interviews and a systematic review of existing pediatric sleep health questionnaires...
April 25, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29692593/complement-deficiency-in-pediatric-onset-systemic-lupus-erythematosus
#13
Parisa Afzali, Anna Isaeian, Peyman Sadeghi, Bobak Moazzami, Nima Parvaneh, Masoumeh Robatjazi, Vahid Ziaee
BACKGROUND: Pediatric-onset systemic lupus erythematosus (pSLE) accounts for about 10%-20% of all patients with SLE. Deficiencies in early complement components of the classical pathway are the strong genetic risk factor for the development of SLE. In this study, clinical and laboratory manifestations of both complement-deficient and normal complement pSLE patients were compared. MATERIALS AND METHODS: To investigate clinical and immunological manifestations of pSLE in Iran, 36 consecutive pSLE patients (onset before 18 years) who were followed up over a period of 2 years, were studied...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29692591/earlier-and-higher-rates-of-cytomegalovirus-infection-in-pediatric-liver-transplant-recipients-as-compared-to-adults-an-observational-study
#14
Yogita Verma, Ekta Gupta, Niteen Kumar, Nadeem Hasnain, Ajeet Singh Bhadoria, Viniyendra Pamecha, Rajeev Khanna
AIM: To study and compare the incidence and time of occurrence of cytomegalovirus (CMV) infection in the posttransplant period in adult and pediatric liver transplant recipients. MATERIALS AND METHODS: Consecutive live donor liver transplant recipients not on CMV prophylaxis, were prospectively enrolled from March 2012 to September 2015 and followed up for 1 year post transplant to look for CMV infection. For analysis, patients were divided into pediatric (up to 18 years) and adult (>18 years) age groups...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29691919/impact-of-different-assumptions-on-estimates-of-childhood-diseases-obtained-from-health-care-data-a-retrospective-cohort-study
#15
Osemeke U Osokogu, Alexandra Pacurariu, Mees Mosseveld, Peter Rijnbeek, Daniel Weibel, Katia Verhamme, Miriam C J M Sturkenboom
PURPOSE: Accurate estimates of disease incidence in children are required to support pediatric drug development. Analysis of electronic health care records (EHR) may yield such estimates but pediatric-specific methods are lacking. We aimed to understand the impact of assumptions regarding duration of disease episode and length of run-in period on incidence estimates from EHRs. METHODS: Children aged 0 to 17 years (5-17 years for asthma) registered in the Integrated Primary Care Information database between 2002 and 2014 were studied...
April 24, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29691808/total-body-irradiation-for-hematopoietic-stem-cell-transplantation-during-early-childhood-is-associated-with-the-risk-for-diabetes-mellitus
#16
Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies and related diseases. Recently, the long-term prognosis of HSCT during childhood has greatly improved; however, the late adverse effects of HSCT have been found to cause substantial morbidity among long-term survivors. Although metabolic complications, such as diabetes mellitus (DM) and hyperlipidemia (HL), are the major late effects of pediatric HSCT, the clinical details are not clarified sufficiently...
April 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29691724/neuroimmunologic-and-neurotrophic-interactions-in-autism-spectrum-disorders-relationship-to-neuroinflammation
#17
REVIEW
Kshama Ohja, Evelyne Gozal, Margaret Fahnestock, Lu Cai, Jun Cai, Jonathan H Freedman, Andy Switala, Ayman El-Baz, Gregory Neal Barnes
Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental components including possible dysfunction of the immune system. The relationship of the immune system to aberrant neural circuitry output in the form of altered behaviors and communication characterized by ASD is unknown. Dysregulation of neurotrophins such as BDNF and their signaling pathways have been implicated in ASD. While abnormal cortical formation and autistic behaviors in mouse models of immune activation have been described, no one theory has been described to link activation of the immune system to specific brain signaling pathways aberrant in ASD...
April 24, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29691341/epigenetic-regulation-of-tumor-suppressors-by-helicobacter-pylori-enhances-ebv-induced-proliferation-of-gastric-epithelial-cells
#18
Saurabh Pandey, Hem Chandra Jha, Sanket Kumar Shukla, Meghan K Shirley, Erle S Robertson
Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can establish lifelong persistent infection in the host. This leads to chronic inflammation, which also contributes to development of cancer. Association with H. pylori increases the risk of gastric carcinoma, and coexistence with EBV enhances proliferation of infected cells. Further, H. pylori -EBV coinfection causes chronic inflammation in pediatric patients. We have established an H. pylori -EBV coinfection model system using human gastric epithelial cells...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29690631/pediatric-integrative-medicine-in-residency-program-relationship-between-lifestyle-behaviors-and-burnout-and-wellbeing-measures-in-first-year-residents
#19
Hilary McClafferty, Audrey J Brooks, Mei-Kuang Chen, Michelle Brenner, Melanie Brown, Anna Esparham, Dana Gerstbacher, Brenda Golianu, John Mark, Joy Weydert, Ann Ming Yeh, Victoria Maizes
It is widely recognized that burnout is prevalent in medical culture and begins early in training. Studies show pediatricians and pediatric trainees experience burnout rates comparable to other specialties. Newly developed Accreditation Council for Graduate Medical Education (ACGME) core competencies in professionalism and personal development recognize the unacceptably high resident burnout rates and present an important opportunity for programs to improve residents experience throughout training. These competencies encourage healthy lifestyle practices and cultivation of self-awareness, self-regulation, empathy, mindfulness, and compassion—a paradigm shift from traditional medical training underpinned by a culture of unrealistic endurance and self-sacrifice...
April 23, 2018: Children
https://www.readbyqxmd.com/read/29689748/probiotic-lactococcus-lactis-decreases-incidence-and-severity-of-necrotizing-enterocolitis-in-a-preterm-animal-model
#20
L A Gurien, K Stallings-Archer, S D Smith
BACKGROUND: Necrotizing enterocolitis (NEC) persists as the most common and serious gastrointestinal disorder among premature infants. Lactococcus lactis (LL), a lactic acid producing bacteria commonly found in buttermilk and cheese products, has several unique properties making it an ideal probiotic for neonates. We evaluated if the probiotic LL prevents development of NEC in a preterm rabbit model with Cronobacter sakazakii (CS). METHODS: Two-day preterm New Zealand white rabbit pups were randomly assigned to three diets: control (no additives), CS, and CS+LL...
2018: Journal of Neonatal-perinatal Medicine
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