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https://www.readbyqxmd.com/read/27862680/the-natural-history-of-gastro-esophageal-reflux-disease-a-comprehensive-review
#1
REVIEW
E Savarino, N de Bortoli, C De Cassan, M Della Coletta, O Bartolo, M Furnari, A Ottonello, E Marabotto, G Bodini, V Savarino
Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27853226/i-can-haz-more-science-emoji-host-of-nerd-icons-proposed
#2
Katherine Bourzac
No abstract text is available yet for this article.
November 8, 2016: Nature
https://www.readbyqxmd.com/read/27848027/different-effects-of-dietary-factors-on-reflux-esophagitis-and-non-erosive-reflux-disease-in-11-690-korean-subjects
#3
Su Youn Nam, Bum Joon Park, Yeong-Ah Cho, Kum Hei Ryu, Il Ju Choi, Sohee Park, Young-Woo Kim
BACKGROUND: Although dietary factors seem to be associated with gastroesophageal reflux symptoms, their effects on reflux esophagitis and non-erosive reflux disease (NERD) are unclear. We evaluate dietary effects on NERD and reflux esophagitis. METHODS: A total of 11,690 health check-up persons completed questionnaires for reflux symptoms and 3-day recordings for dietary intake and underwent esophagogastroduodenoscopy from 2004 to 2008. Multiple logistic regression with odds ratio (OR) and 95% confidence interval (CI) was used to evaluate the relationship of dietary components with NERD or reflux esophagitis...
November 15, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27805264/identification-of-phenotypic-clusters-of-nonsteroidal-anti-inflammatory-drugs-exacerbated-respiratory-disease
#4
H Y Lee, Y M Ye, S H Kim, G Y Ban, S C Kim, J H Kim, Y S Shin, H S Park
BACKGROUND: Clinical presentation of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters to determine NERD subtypes. METHODS: We performed two-step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a NERD cohort comprising 302 patients. Asthma exacerbation was defined as receiving at least one burst of intravenous steroid treatment and/or at least two bursts of oral steroid use (≥ 45 mg/3 days) per year...
November 2, 2016: Allergy
https://www.readbyqxmd.com/read/27779082/hypersensitivity-reactions-to-non-steroidal-anti-inflammatory-drugs
#5
Inmaculada Doña, María Salas, James R Perkins, Esther Barrionuevo, Francesco Gaeta, Jose A Cornejo-García, Paloma Campo, Maria José Torres
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions to drugs, and they are classified in two groups: those induced by non-specific immunological mechanisms (non-allergic or cross-intolerance (CI) reactions), or by specific immunological mechanisms (allergic or selective reactions (SR)). The pathogenesis of CI is associated with their pharmacological activity (COX-1 inhibition), with symptoms due to an imbalance in the arachidonic acid pathway, independently of their chemical structure...
September 28, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27770460/alcohol-hyper-responsiveness-in-chronic-rhinosinusitis-with-nasal-polyps
#6
Els De Schryver, Lara Derycke, Paloma Campo, Eline Gabriels, Guy F Joos, Thibaut Van Zele, Claus Bachert, Peter W Hellings, Philippe Gevaert
BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks has not been fully investigated yet. OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness...
October 22, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27712770/from-samter-s-triad-to-nerd-the-long-and-winding-road-to-understanding-aspirin-exacerbated-respiratory-disease
#7
Stephen A Tilles
No abstract text is available yet for this article.
November 2016: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27703114/sex-and-gender-differences-in-gastroesophageal-reflux-disease
#8
Young Sun Kim, Nayoung Kim, Gwang Ha Kim
It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects more women than men. GERD symptoms are more frequent in patients with NERD than in those with reflux esophagitis. However, men suffer pathologic diseases such as reflux esophagitis, Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) more frequently than women. The prevalence of reflux esophagitis is significantly increased with age in women, especially after their 50s...
October 30, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27698970/association-between-pattern-of-gastritis-and-gastroesophageal-reflux-disease-in-patients-with-helicobacter-pylori-infection
#9
Hossein Nobakht, Amirhossein Boghratian, Masoudreza Sohrabi, Mohammad Panahian, Naser Rakhshani, Mehdi Nikkhah, Hossein Ajdarkosh, Gholamreza Hemmasi, Mahmoodreza Khonsari, Ali Gholami, Neda Rabiei, Farhad Zamani
: BACKGROUND Reflux disease is a common gastrointestinal problem. The association between reflux disease and gastritis pattern is controversial. AIM: To determine the association between reflux disease and gastritis pattern in patients with Helicobacter pylori (H. pylori) infection. METHODS 470 patients with dyspepsia and reflux disease were enrolled in this study. The inclusion criteria were willing to participate in the study, age over 40 years, and having the criteria of ROME III for at least 3 months...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27620303/the-added-diagnostic-value-of-postreflux-swallow-induced-peristaltic-wave-index-and-nocturnal-baseline-impedance-in-refractory-reflux-disease-studied-with-on-therapy-impedance-ph-monitoring
#10
M Frazzoni, N de Bortoli, L Frazzoni, S Tolone, M Furnari, I Martinucci, V G Mirante, S Marchi, V Savarino, E Savarino
BACKGROUND: On-therapy impedance-pH monitoring in proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) yielded conflicting results. We aimed to assess the diagnostic value of postreflux swallow-induced peristaltic wave (PSPW) index and mean nocturnal baseline impedance (MNBI) in PPI-refractory heartburn. METHODS: On-therapy impedance-pH tracings from 189 consecutive patients with PPI-refractory heartburn were blindly reviewed. Patients were subdivided into refractory reflux esophagitis (RRE), healed reflux esophagitis (HRE), non-erosive reflux disease (NERD), and functional heartburn (FH) according to endoscopic and conventional impedance-pH findings...
September 12, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27581096/the-efficacy-and-safety-of-proton-pump-inhibitors-in-treating-patients-with-non-erosive-reflux-disease-a-network-meta-analysis
#11
Lingxiao Chen, Yujie Chen, Bo Li
Proton-pump inhibitors (PPIs) have been proved as safe and effective ways to treat patients with non-erosive reflux disease (NERD). However, less is known about the comparisons among different PPIs and their best dosage. We aimed to synthesize the available evidence through network meta-analysis to investigate the efficacy and safety of different PPIs in treating patients with NERD. Fifteen studies with 6309 patients were included in the meta-analyses. For the rate of symptomatic relief, compared with control groups, all interventions except rabeprazole 5 mg significantly increased rate of symptomatic relief...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27578463/nonsteroidal-anti-inflammatory-drug-nsaid-exacerbated-respiratory-disease-phenotype-topical-nsaid-and-asthma-control-a-possible-oversight-link
#12
Jessica Han Ying Tan, Anne Ann Ling Hsu
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) also recently known as nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease (NERD) must avoid aspirin and all other oral NSAIDs. The effect of topical NSAID (tNSAID), especially salicylates which are commonly present in topical medicated preparations, on asthma control of this phenotype is studied. METHODS: The study inclusion criteria were adults with: 1) NSAID hypersensitivity; 2) nasal polyposis/chronic rhinosinusitis; 3) not well-/poorly controlled asthma and 4) exposure to tNSAID...
September 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27576498/motility-characteristics-in-the-transition-zone-in-gastroesophageal-reflux-disease-gord-patients
#13
Yu-Wen Li, Chen-Xi Xie, Kai-Ming Wu, Min-Hu Chen, Ying-Lian Xiao
BACKGROUND: Defects in distal oesophageal peristalsis was thought to be an indication of incomplete bolus transit (BT). However, the role of transition zone (TZ) defects in the BT in gastroesophageal reflux disease (GORD) patients needs clarification. The aim of this study was to assess the TZ defects in GORD patients and to explore the relationship between TZ defects and BT. METHODS: One hundred and two patients with reflux symptoms and 20 healthy adults were included in the study...
August 30, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27571846/associations-among-gastroesophageal-reflux-disease-psychological-stress-and-sleep-disturbances-in-japanese-adults
#14
Masatsugu Okuyama, Osamu Takaishi, Kenichi Nakahara, Narika Iwakura, Tomoki Hasegawa, Maizumi Oyama, Ayumi Inoue, Hirotaka Ishizu, Hiroshi Satoh, Yasuhiro Fujiwara
BACKGROUND AND AIM: Gastroesophageal reflux disease (GERD) and psychological stress are associated with sleep disturbances. The aim of the present study was to examine the prevalence of sleep disturbances, anxiety, and depression by GERD subtypes and to identify factors associated with sleep disturbances in general population. METHODS: A total of 2002 Japanese subjects, who underwent annual health checkups, were enrolled and asked to fill out a questionnaire, including the frequency scale for the symptoms of GERD (FSSG), Athens Insomnia Scale (AIS), Rome III questionnaire, and Hospital Anxiety and Depression Scale (HADS)...
August 30, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27537561/role-of-altered-esophageal-intraluminal-baseline-impedance-levels-in-patients-with-gatroesophageal-reflux-disease-refractory-to-proton-pump-inhibitors
#15
Liuqin Jiang, Bixing Ye, Lin Lin, Ying Wang, Meifeng Wang
Numerous studies have investigated utility of esophageal intraluminal baseline impedance levels (BILs) in gastroesophageal reflux disease (GERD). However, effect of BILs in refractory GERD (RGERD) has not been well investigated. The aim of this study is to evaluate role of BILs in RGERD patients. Total 62 subjects with refractory gastroesophageal reflux symptoms underwent 24-hour impedance-pH monitoring and gastroendoscopy. Distal BILs in acid reflux type were significantly lower than those in nonacid reflux type and functional heartburn (FH) group...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27521389/nonsteroidal-anti-inflammatory-drug-administration-in-children-with-history-of-wheeze
#16
Kendra Sih, Ran D Goldman
QUESTION: A child in my clinic who recently sprained his ankle is experiencing pain and having trouble bearing weight on the affected leg. His mother has been giving him acetaminophen, as she was told never to use nonsteroidal anti-inflammatory drugs (NSAIDs) because of his pharmacologically controlled asthma. Is asthma in children a contraindication to giving NSAIDs? Is NSAID-exacerbated respiratory disease (NERD) a real entity? ANSWER: Nonsteroidal anti-inflammatory drugs are effective analgesic and antipyretic medications...
August 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27512850/increased-trpv1-and-par2-mrna-expression-levels-are-associated-only-with-the-esophageal-reflux-symptoms-but-not-with-the-extraesophageal-reflux-symptoms
#17
Jin Joo Kim, Nayoung Kim, Yoon Jin Choi, Joo Sung Kim, Hyun Chae Jung
Transient receptor potential vanilloid-1 (TRPV1) receptor and proteinase-activated receptor 2 (PAR2) have been implicated in the mechanism of acid-induced inflammation in gastroesophageal reflux disease (GERD). We aimed to evaluate TRPV1 and PAR2 mRNA expression levels in the GERD patients and their relationship with endoscopic findings and reflux symptoms.Sixteen healthy controls, 45 patients with erosive reflux disease (ERD), and 14 nonerosive reflux disease (NERD) patients received endoscopy and completed questionnaires...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27489545/asthma-and-rhinitis-induced-by-selective-immediate-reactions-to-paracetamol-and-non-steroidal-anti-inflammatory-drugs-in-aspirin-tolerant-subjects
#18
Diana Pérez-Alzate, Natalia Blanca-López, Inmaculada Doña, José A Agúndez, Elena García-Martín, José A Cornejo-García, James R Perkins, Miguel Blanca, Gabriela Canto
In subjects with non-steroidal anti-inflammatory drugs (NSAIDs)- exacerbated respiratory disease (NERD) symptoms are triggered by acetyl salicylic acid (ASA) and other strong COX-1 inhibitors, and in some cases by weak COX-1 or by selective COX-2 inhibitors. The mechanism involved is related to prostaglandin pathway inhibition and leukotriene release. Subjects who react to a single NSAID and tolerate others are considered selective responders, and often present urticaria and/or angioedema and anaphylaxis (SNIUAA)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27472432/between-gerd-and-nerd-the-relevance-of-weakly-acidic-reflux
#19
Nicola de Bortoli, Andrea Ottonello, Frank Zerbib, Daniel Sifrim, C Prakash Gyawali, Edoardo Savarino
Nonerosive reflux disease (NERD) is a common condition and the most frequent phenotype of gastroesophageal reflux disease (GERD). NERD is extremely heterogeneous and includes patients with negative endoscopy but abnormal esophageal acid exposure and/or positive reflux-symptom association analysis (hypersensitive esophagus). This segregation is only possible owing to the use of impedance-pH monitoring. Indeed, weakly acidic reflux represents one of the most common causes of refractory symptoms in patients evaluated off antisecretory therapy and, more importantly, during antisecretory drug treatment...
September 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27443619/the-prevalence-and-clinical-features-of-non-responsive-gastroesophageal-reflux-disease-to-practical-proton-pump-inhibitor-dose-in-korea-a-multicenter-study
#20
Hong Jun Park, Soo Heon Park, Ki Nam Shim, Yong Sung Kim, Hyun Jin Kim, Jae Pil Han, Yong Sik Kim, Byoung Wook Bang, Gwang Ha Kim, Gwang Ho Baik, Hyung Hun Kim, Seon Young Park, Sung Soo Kim
BACKGROUND/AIMS: In Korea, there are no available multicenter data concerning the prevalence of or diagnostic approaches for non-responsive gastroesophageal reflux disease (GERD) which does not respond to practical dose of proton pump inhibitor (PPI) in Korea. The purpose of this study is to evaluate the prevalence and the symptom pattern of non-responsive GERD. METHODS: A total of 12 hospitals who were members of a Korean GERD research group joined this study. We used the composite score (CS) as a reflux symptom scale which is a standardized questionnaire based on the frequency and severity of typical symptoms of GERD...
July 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
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