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Thomas A Masterson, Himanshu Arora, Shathiyah Kulandavelu, Rona S Carroll, Ursula B Kaiser, Sakir H Gultekin, Joshua M Hare, Ranjith Ramasamy
BACKGROUND: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis. AIM: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor-/- ) mouse model. METHODS: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor-/- mice were compared with those of age-matched wild-type (WT) mice...
March 29, 2018: Journal of Sexual Medicine
Sophorn Chip, David Fernández-López, Fan Li, Joel Faustino, Nikita Derugin, Zinaida S Vexler
The pathophysiology of neonatal stroke and adult stroke are distinct in many aspects, including the inflammatory response. We previously showed endogenously protective functions of microglial cells in acute neonatal stroke. We asked if galectin-3 (Gal3), a pleotropic molecule that mediates interactions between microglia/macrophages and the extracellular matrix (ECM), plays a role in early injury after transient middle cerebral occlusion (tMCAO) in postnatal day 9-10 mice. Compared to wild type (WT) pups, in Gal3 knockout pups injury was worse and cytokine/chemokine production altered, including further increase of MIP1α and MIP1β levels and reduced IL6 levels 72h after tMCAO...
February 2017: Brain, Behavior, and Immunity
Nikolaos P Daskalakis, Melly S Oitzl, Hartmut Schächinger, Danielle L Champagne, E Ronald de Kloet
BACKGROUND: In the present study, we tested both the cumulative stress and the mismatch hypothesis of psychopathology. For this purpose the combined effects of early-life adversity and later-life stress exposure on behavioral markers of psychosis susceptibility were studied in male Wistar rats. METHOD: Experiment I: rat pups divided on the basis of the levels of their maternal care experience in low, medium or high maternal care groups, were reared post-weaning in groups (Exp...
July 16, 2012: Physiology & Behavior
Philippe Pichat, Olivier E Bergis, Jean-Paul Terranova, Alexandre Urani, Christine Duarte, Vincent Santucci, Christiane Gueudet, Carole Voltz, Régis Steinberg, Jeanne Stemmelin, Florence Oury-Donat, Patrick Avenet, Guy Griebel, Bernard Scatton
SSR180711 (4-bromophenyl 1,4diazabicyclo(3.2.2) nonane-4-carboxylate, monohydrochloride) is a selective alpha7 nicotinic receptor (n-AChR) partial agonist. Based on the purported implication of this receptor in cognitive deficits associated with schizophrenia, the present study assessed efficacy of SSR180711 (i.p. and p.o.) in different types of learning and memory involved in this pathology. SSR180711 enhanced episodic memory in the object recognition task in rats and mice (MED: 0.3 mg/kg), an effect mediated by the alpha7 n-AChR, as it was no longer seen in mice lacking this receptor...
January 2007: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
K Fujita, K Yokouchi, T Fukuyama, N Fukushima, K Kawagishi, T Moriizumi
Functional roles of the perioral anatomical structures involved in breastfeeding were examined in newborn rat pups in which the hypoglossal (XII) and facial (VII) nerves had been resected at the neonatal stage. The XII nerve controls tongue movement and is comprised of two functionally distinct branches: the medial branch related to protrusion of the tongue and the lateral branch related to its retraction. Newborn rat pups with bilateral resection of either of the XII nerve components (main trunk: XII-trunk; medial branch: XII-med; lateral branch: XII-lat) failed to suckle milk and did not survive...
February 2006: International Journal of Developmental Neuroscience
Ronan Depoortère, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Annick Coste, Christophe Lanneau, Christophe Desvignes, Martine Poncelet, Michel Heaulme, Vincent Santucci, Michel Decobert, Annie Cudennec, Carolle Voltz, Denis Boulay, Jean Paul Terranova, Jeanne Stemmelin, Pierre Roger, Benoit Marabout, Mireille Sevrin, Xavier Vigé, Bruno Biton, Régis Steinberg, Dominique Françon, Richard Alonso, Patrick Avenet, Florence Oury-Donat, Ghislaine Perrault, Guy Griebel, Pascal George, Philippe Soubrié, Bernard Scatton
Noncompetitive N-methyl-D-aspartate (NMDA) blockers induce schizophrenic-like symptoms in humans, presumably by impairing glutamatergic transmission. Therefore, a compound potentiating this neurotransmission, by increasing extracellular levels of glycine (a requisite co-agonist of glutamate), could possess antipsychotic activity. Blocking the glycine transporter-1 (GlyT1) should, by increasing extracellular glycine levels, potentiate glutamatergic neurotransmission. SSR504734, a selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38 nM, respectively), blocked reversibly the ex vivo uptake of glycine (mouse cortical homogenates: ID50: 5 mg/kg i...
November 2005: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Stacy M Plum, Hong A Vu, Bobby Mercer, William E Fogler, Anne H Fortier
Angiogenesis, the process of new capillary formation from pre-existing vessels, has been established as an important mechanism involved in pathologic processes, such as cancer, as well as in normal physiology (Ribatti, D.; Vacca, A.; Roncali, L.; Dammacco, F. Angiogenesis under normal and pathological conditions. Haematologica 1991, 76 (4), 311-320). Basic fibroblast growth factor (FGF-2) is a critical mediator of angiogenesis that is important for normal reproduction and wound healing. FGF-2 mediates its pro-angiogenic effects by binding to heparin sulfate proteoglycan in addition to a tyrosine kinase receptor (Baird, A...
February 2004: Immunopharmacology and Immunotoxicology
Ronan Depoortere, Denis Boulay, Ghislaine Perrault, Olivier Bergis, Michel Decobert, Dominique Françon, Mireille Jung, Jacques Simiand, Philippe Soubrié, Bernard Scatton
SSR181507 ((3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride) is a novel tropanemethanamine benzodioxane that displays antagonist activity at dopamine D(2) receptors and agonist activity at 5-HT(1A) receptors. SSR181507 antagonized apomorphine-induced climbing in mice and stereotypies in rats (ED(50) of 2 and 3.4 mg/kg i.p., respectively) and blocked D-amphetamine-induced hyperlocomotion in rats at lower doses (0.3-1 mg/kg i...
November 2003: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
James L Smart, Malcolm J Low
Mice deficient in proopiomelanocortin peptides (Pomc(-/-)) generated on a 129 (A(w)/ A(w)) genetic background were back-crossed onto the C57BL/6 (a/a) genetic background. These mice exhibited most of the phenotypic characteristics previously reported on the 129 genetic background (Yaswen et al. 1999. Nat. Med. 5: 1066-1070). Adult mice became obese, their adrenals were atrophied, and they had undetectable plasma corticosterone in basal and stressed states. The partial perinatal lethality previously reported was also present on the C57BL/6 background...
June 2003: Annals of the New York Academy of Sciences
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