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https://www.readbyqxmd.com/read/28720139/the-golmepsa-study-protocol-an-investigator-initiated-double-blind-parallel-group-randomised-controlled-trial-of-golimumab-and-methotrexate-versus-methotrexate-in-early-diagnosed-psoriatic-arthritis-using-clinical-and-whole-body-mri-outcomes
#1
Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C Coates, Elizabeth M A Hensor, Helena Marzo-Ortega
BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of inflammation in PsA leads to improved long-term outcomes. It is postulated that prompt intervention after diagnosis using a remission-induction treatment strategy will lead to improved outcomes and optimal disease control of PsA. The aim of the present study was to compare the clinical efficacy of a treatment strategy in newly diagnosed, treatment naïve PsA subjects, using the combination of golimumab (GOL), methotrexate (MTX) and steroids versus standard care (MTX monotherapy plus steroids)...
July 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28706201/genotypic-variability-based-association-identifies-novel-non-additive-loci-dhcr7-and-irf4-in-sero-negative-rheumatoid-arthritis
#2
Wen-Hua Wei, Sebastien Viatte, Tony R Merriman, Anne Barton, Jane Worthington
Sero-negative rheumatoid arthritis (RA) is a highly heterogeneous disorder with only a few additive loci identified to date. We report a genotypic variability-based genome-wide association study (vGWAS) of six cohorts of sero-negative RA recruited in Europe and the US that were genotyped with the Immunochip. A two-stage approach was used: (1) a mixed model to partition dichotomous phenotypes into an additive component and non-additive residuals on the liability scale and (2) the Levene's test to assess equality of the residual variances across genotype groups...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705162/the-effect-of-autologous-adipose-derived-mesenchymal-stem-cell-therapy-in-the-treatment-of-a-large-osteochondral-defect-of-the-knee-following-unsuccessful-surgical-intervention-of-osteochondritis-dissecans-a-case-study
#3
Julien Freitag, Kiran Shah, James Wickham, Richard Boyd, Abi Tenen
BACKGROUND: A prospective analysis of the effect of autologous adipose derived mesenchymal stem cell (MSC) therapy in the treatment of an osteochondral defect of the knee with early progressive osteoarthritis following unsuccessful surgical intervention of osteochondritis dissecans (OCD). CASE PRESENTATION: After failed conventional management of OCD a patient undergoes intra-articular MSC therapy. Patient outcome measures included the Numeric Pain Rating Scale (NPRS), the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the Knee Injury and Osteoarthritis Outcome Score (KOOS)...
July 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28704914/impact-of-early-diagnosis-on-functional-preservation-in-patients-with-rheumatoid-arthritis-the-early-bird-catches-the-worm
#4
Yun-Hong Cheon, Sang-Il Lee
No abstract text is available yet for this article.
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28698517/the-plasticity-of-th17-cells-in-the-pathogenesis-of-rheumatoid-arthritis
#5
REVIEW
Shigeru Kotake, Toru Yago, Tsuyoshi Kobashigawa, Yuki Nanke
Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells (i.e., "nonclassic Th1 cells"), which are reported to be more pathogenic than Th17 cells per se. Thus, the association of Th cells in the pathogenesis of autoimmune disease has become more complicated. We recently reported using peripheral blood from untreated and early-onset RA patients that the ratio of CD161+Th1 cells (i.e...
July 10, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28693000/a-new-active-contours-approach-for-finger-extensor-tendon-segmentation-in-ultrasound-images-using-prior-knowledge-and-phase-symmetry
#6
Nelson Martins, Saad Sultan, Diana Veiga, Manuel Ferreira, Filipa Teixeira, Miguel Coimbra
This work proposes a new approach for the segmentation of the extensor tendon in ultrasound images of the second metacarpophalangeal joint (MCPJ). The MCPJ is known to be frequently involved in early stages of rheumatic diseases like rheumatoid arthritis. The early detection and follow up of these diseases is important to start and adapt the treatments properly and, in that way, preventing irreversible damage of the joints. This work relies on an active contours framework, preceded by a phase symmetry preprocessing and with prior knowledge energies, to automatically identify the extensor tendon...
July 5, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28692794/despite-early-improvement-patients-with-rheumatoid-arthritis-still-have-impaired-grip-force-5-years-after-diagnosis
#7
Maria Rydholm, Christina Book, Ingegerd Wikström, Lennart Jacobsson, Carl Turesson
OBJECTIVE: Objective measures of function are important in rheumatoid arthritis (RA). The objective of this study was to investigate grip strength in patients with early RA. METHODS: An inception cohort of 225 patients with early RA was followed according to a structured protocol. Average and peak grip force values (Grippit; AB Detektor, Gothenburg, Sweden) of the dominant hand were evaluated and compared to the expected, based on age- and sex-specific reference values from the literature...
July 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28690235/-diagnosis-and-treatment-for-one-case-of-elderly-diabetes-complicated-with-still-s-disease
#8
Tuanyu Fang, Kaining Chen, Eryuan Liao
Adult onset Still's disease (AOSD) is a clinical syndrome with multiple organ failure. The patients normally show intermittent high fever for a long time, a transient rash, arthritis or joint pain as the main performance, accompanied by an increase in granulocytes and enlargement in liver, spleen and lymph node. A 71-years-old female patient with type 2 diabetes admitted hospital because of high fever, skin rash, joint pain and increased granulocyte. After review of the iron protein, she was diagnosed as AOSD...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28688467/prediction-of-response-to-targeted-treatment-in-rheumatoid-arthritis
#9
REVIEW
C A Wijbrandts, P P Tak
Rheumatoid arthritis is an autoimmune syndrome presenting with chronic inflammation of the joints. Patients with the same diagnosis can present with different phenotypes. In some patients severe joint inflammation and early joint destruction are observed, whereas a milder phenotype can be seen in others. Conversely, patients with the same signs and symptoms may exhibit different immunological and molecular abnormalities. Since the introduction of early treatment in clinical practice, the treat to target principle, and new medicines such as biologic disease-modifying antirheumatic drugs, clinical remission can be achieved early in the disease course, albeit not in all patients...
July 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28688058/a-retrospective-study-of-joint-infections-in-patients-with-systemic-lupus-erythematosus
#10
Lin Qiao, Dong Xu, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
The aim of this study was to analyze the clinical characteristics of systemic lupus erythematosus (SLE) patients with joint infections. We retrospectively reviewed the medical records of 11,734 SLE patients admitted to Peking Union Medical College Hospital (PUMCH) from January 1990 to December 2016. Twenty patients who developed joint infections were identified. Subjects without joint infections (designated as control patients) were selected from the pool of SLE patients using a 1:4 systematic sampling method...
July 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28685724/role-of-contrast-enhanced-ultrasound-in-the-evaluation-of-inflammatory-arthritis
#11
REVIEW
Chen-Yang Zhao, Yu-Xin Jiang, Jian-Chu Li, Zhong-Hui Xu, Qing Zhang, Na Su, Meng Yang
OBJECTIVE: Contrast-enhanced ultrasound (CEUS) is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices, and its applications in the assessment of inflammatory arthritis, such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have provoked abundant discussion and researches among radiologists and rheumatologists. To summarize the achievements of clinical studies on CEUS in the application of arthritis, and to keep up with the latest progresses of the imaging technique, we reviewed the literature in recent years, hoping to establish the role of CEUS in joint diseases...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28679990/myelodysplastic-syndrome-with-neutrophilic-dermatosis-successfully-treated-with-azacitidine
#12
Daisuke Kudo, Misayo Shimizu, Akihiro Kuroda, Takuya Suyama, Atsushi Shinagawa, Syusaku Ito
A 66-year-old male underwent prednisolone (PSL) therapy of 13 mg/day for rheumatoid arthritis (RA). Antiphospholipid antibody syndrome, neutrophilic dermatosis (ND), and myelodysplastic syndrome (MDS) developed. Treatment of MDS required red cell concentrate transfusion, and second courses of azacitidine therapy (75 mg/m(2) daily, intravenous injection for 7 consecutive days) led to hematologic remission. Furthermore, ND improved early after the start of azacitidine therapy, making it possible to decrease the dose of PSL...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28679392/factors-associated-with-initial-or-subsequent-choice-of-biologic-disease-modifying-antirheumatic-drugs-for-treatment-of-rheumatoid-arthritis
#13
Yinzhu Jin, Rishi J Desai, Jun Liu, Nam-Kyong Choi, Seoyoung C Kim
BACKGROUND: Biologic disease-modifying antirheumatic drugs (DMARDs) are increasingly used for rheumatoid arthritis (RA) treatment. However, little is known based on contemporary data about the factors associated with DMARDs and patterns of use of biologic DMARDs for initial and subsequent RA treatment. METHODS: We conducted an observational cohort study using claims data from a commercial health plan (2004-2013) and Medicaid (2000-2010) in three study groups: patients with early untreated RA who were naïve to any type of DMARD and patients with prevalent RA with or without prior exposure to one biologic DMARD...
July 5, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28676912/clinical-characteristics-of-methotrexate-associated-lymphoproliferative-disorders-relationship-between-absolute-lymphocyte-count-recovery-and-spontaneous-regression
#14
Satoshi Takanashi, Yoshinobu Aisa, Chisako Ito, Hideki Arakaki, Yuki Osada, Yuichiro Amano, Motoharu Hirano, Tomonori Nakazato
Several reports have shown that patients with rheumatoid arthritis (RA) are at increased risk of developing lymphoproliferative disorders (LPD). Methotrexate (MTX) has been recognized as a major cause of LPD. Sometimes spontaneous regression (SR) occurs after withdrawal of MTX. Recent studies suggest that the early recovery of the absolute lymphocyte count (ALC) after withdrawal of MTX is associated with the spontaneous regression of MTX-LPD. We retrospectively analyzed 26 patients with MTX-LPD to identify predictive factors for spontaneous regression...
July 5, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28674965/dual-energy-ct-iodine-map-for-delineating-inflammation-of-inflammatory-arthritis
#15
Takeshi Fukuda, Yoshinori Umezawa, Akihiko Asahina, Hidemi Nakagawa, Kazuhiro Furuya, Kunihiko Fukuda
Iodine mapping is an image-processing technique used with dual-energy computed tomography (DECT) to improve iodine contrast resolution. CT, because of its high spatial resolution and thin slice reconstruction, is well suited to the evaluation of the peripheral joints. Recent developments in the treatment of inflammatory arthritis that require early diagnosis and precise therapeutic assessment encourage radiological evaluation. To facilitate such assessment, we describe DECT iodine mapping as a novel modality for evaluating rheumatoid arthritis and psoriatic arthritis of the hands and feet...
July 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28674590/-proteus-mirabilis-septic-arthritis
#16
REVIEW
Mohammed Sbiti, Bahia Bouhamidi, Lhoussaine Louzi
Acute septic arthritis is rare. It is associated with poor prognosis in terms of mortality and morbidity. We report the case of a 61-year old patient with spontaneous Proteus mirabilis septic arthritis. He suffered from complicated diabetes associated with positive blood cultures and synovial fluid cultures. Patient's evolution was favorable thanks to early diagnosis and initiation of adequate antibiotic therapy. Proteus mirabilis septic arthritis is rare. On that basis we conducted a literature review of cases of Proteus mirabilis pyogenic arthritis to highlight the risk factors, pathogenesis, treatment and evolution of these diseases...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28674524/psoriasis-psoriatic-arthritis-and-thyroid-autoimmunity
#17
REVIEW
Ilaria Ruffilli, Francesca Ragusa, Salvatore Benvenga, Roberto Vita, Alessandro Antonelli, Poupak Fallahi, Silvia Martina Ferrari
Psoriasis (PsO) is a chronic relapsing/remitting autoimmune skin disease, associated with an increased risk of other autoimmune disorders. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis occurring approximately in 30% of PsO patients. Sporadic cases of association between PsO and autoimmune thyroid disorders (AITDs) have been reported. However, two different recent studies did not find any association between them. In patients with PsO and PsA, an association with AITD has been shown by most of the studies in adults, but not in the juvenile form...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28673200/analysis-of-functional-outcome-of-hoffa-fractures-a-retrospective-review-of-32-patients
#18
Vivek Trikha, Saubhik Das, Sahil Gaba, Prabhat Agrawal
PURPOSE: Hoffa fractures are uncommon intra-articular fractures of femoral condyle in coronal plane. The purpose of our study is to assess radiologic and functional outcome in operatively treated Hoffa fractures. METHODS: We retrospectively reviewed 32 patients of isolated Hoffa fracture from January 2010 to March 2015. All were treated with open reduction and internal fixation using lateral approach for lateral Hoffa and medial approach for medial Hoffa fracture...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28672905/severe-septic-arthritis-of-the-temporomandibular-joint-with-pyogenic-orofacial-infections-a-case-report-and-review-of-the-literature
#19
Di Xiao, Xuefeng Feng, Haitao Huang, Huixin Quan
Septic arthritis of the temporomandibular joint (SATMJ) is a rare entity that has only been reported a few dozen times worldwide. However, SATMJ is an acute infectious disease and associated with a high risk for misdiagnosis, which results in severe complications for patients. The present study reported a case of an 83-year-old female patient with severe pyogenic orofacial infections caused by right-side SATMJ, which was not cured by abscess incision drainage and anti-microbial treatment. Finally, the clinical signs were resolved by condylectomy and debridement of the erosive septic TMJ, after which the function of the TMJ was completely restored...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28668806/patient-reported-outcomes-as-predictors-of-change-in-disease-activity-and-disability-in-early-rheumatoid-arthritis-results-from-the-yorkshire-early-arthritis-register
#20
Sarah Twigg, Elizabeth M A Hensor, Paul Emery, Alan Tennant, Ann W Morgan
OBJECTIVE: To assess patient-reported variables as predictors of change in disease activity and disability in early rheumatoid arthritis (RA). METHODS: Cases were recruited to the Yorkshire Early Arthritis Register (YEAR) between 1997 and 2009 (n = 1415). Predictors of the 28-joint Disease Activity Score (DAS28) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) at baseline and change over 12 months were identified using multilevel models. Baseline predictors were sex, age, symptom duration, autoantibody status, pain and fatigue visual analog scales (VAS), duration of early morning stiffness (EMS), DAS28, and HAQ-DI...
July 1, 2017: Journal of Rheumatology
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