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https://www.readbyqxmd.com/read/28711737/subthalamic-deep-brain-stimulation-sweet-spots-and-hyperdirect-cortical-connectivity-in-parkinson-s-disease
#1
Harith Akram, Stamatios N Sotiropoulos, Saad Jbabdi, Dejan Georgiev, Philipp Mahlknecht, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Marjan Jahanshahi, Marwan Hariz, John Ashburner, Tim Behrens, Ludvic Zrinzo
OBJECTIVES: Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdirect pathways which predict maximum efficacy. METHODS: High angular resolution diffusion imaging in twenty patients with advanced Parkinson's disease was acquired prior to bilateral subthalamic nucleus deep brain stimulation...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28693744/changes-in-use-of-anticoagulation-in-patients-with-atrial-fibrillation-within-a-primary-care-network-associated-with-the-introduction-of-direct-oral-anticoagulants
#2
Jeffrey M Ashburner, Daniel E Singer, Steven A Lubitz, Leila H Borowsky, Steven J Atlas
Atrial fibrillation (AF) and the decision to anticoagulate is a common problem faced by primary care physicians. Oral anticoagulation (OAC) is underused, despite its clear benefits with regard to stroke prevention. We examined OAC usage between 2010 and 2015, following the introduction of direct oral anticoagulants (DOACs) and specifically assessed whether more patients were anticoagulated over time. The study cohort included adult patients aged 18 and older with AF cared for in an 18-practice primary care network between 2010 and 2015...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28681450/-the-optimization-of-superficial-planning-target-volumes-ptvs-with-helical-tomotherapy-jacmp-15-6-2014
#3
M Ashburner, G S Tudor
No abstract text is available yet for this article.
July 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28649492/relationship-between-brainstem-neurodegeneration-and-clinical-impairment-in-traumatic-spinal-cord-injury
#4
Patrick Grabher, Claudia Blaiotta, John Ashburner, Patrick Freund
BACKGROUND: Brainstem networks are pivotal in sensory and motor function and in recovery following experimental spinal cord injury (SCI). OBJECTIVE: To quantify neurodegeneration and its relation to clinical impairment in major brainstem pathways and nuclei in traumatic SCI. METHODS: Quantitative MRI data of 30 chronic traumatic SCI patients (15 with tetraplegia and 15 with paraplegia) and 23 controls were acquired. Patients underwent a full neurological examination...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28645842/opennft-an-open-source-python-matlab-framework-for-real-time-fmri-neurofeedback-training-based-on-activity-connectivity-and-multivariate-pattern-analysis
#5
Yury Koush, John Ashburner, Evgeny Prilepin, Ronald Sladky, Peter Zeidman, Sergei Bibikov, Frank Scharnowski, Artem Nikonorov, Dimitri Van De Ville
Neurofeedback based on real-time functional magnetic resonance imaging (rt-fMRI) is a novel and rapidly developing research field. It allows for training of voluntary control over localized brain activity and connectivity and has demonstrated promising clinical applications. Because of the rapid technical developments of MRI techniques and the availability of high-performance computing, new methodological advances in rt-fMRI neurofeedback become possible. Here we outline the core components of a novel open-source neurofeedback framework, termed Open NeuroFeedback Training (OpenNFT), which efficiently integrates these new developments...
June 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28619310/dance-for-parkinson-s-the-effects-on-whole-body-co-ordination-during-turning-around
#6
RANDOMIZED CONTROLLED TRIAL
Sophia Hulbert, Ann Ashburn, Lisa Roberts, Geert Verheyden
OBJECTIVE: To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. DESIGN: This study employed a randomised, controlled, experimental design. SETTING: Dance classes were performed in a community dance centre in Southern England and all assessments took place a gait laboratory. PARTICIPANTS: Twenty-seven people with mild-moderate Parkinson's participated. INTERVENTION: Participants were randomly allocated to receive either 20, 1-h dancing classes over 10 weeks (n=15), or a 'usual care' control group (n=12)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28597560/l-dopa-responsiveness-is-associated-with-distinctive-connectivity-patterns-in-advanced-parkinson-s-disease
#7
Harith Akram, Chengyuan Wu, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Tarek Yousry, Marjan Jahanshahi, Marwan Hariz, Timothy Behrens, John Ashburner, Ludvic Zrinzo
BACKGROUND: Neuronal loss and dopamine depletion alter motor signal processing between cortical motor areas, basal ganglia, and the thalamus, resulting in the motor manifestations of Parkinson's disease. Dopamine replacement therapy can reverse these manifestations with varying degrees of improvement. METHODS: To evaluate functional connectivity in patients with advanced Parkinson's disease and changes in functional connectivity in relation to the degree of response to l-dopa, 19 patients with advanced Parkinson's disease underwent resting-state functional magnetic resonance imaging in the on-medication state...
June 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28594729/regarding-the-clinical-practice-guidelines-for-the-surgical-treatment-of-patients-with-lynch-syndrome
#8
James Michael Church, Jean H Ashburn
No abstract text is available yet for this article.
July 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28554210/can-primary-care-physicians-accurately-predict-the-likelihood-of-hospitalization-in-their-patients
#9
Andrew S Hwang, Jeffrey M Ashburner, Clemens S Hong, Wei He, Steven J Atlas
No abstract text is available yet for this article.
April 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28534070/total-abdominal-colectomy-vs-restorative-total-proctocolectomy-as-the-initial-approach-to-medically-refractory-ulcerative-colitis
#10
Jinyu Gu, Luca Stocchi, Jeanie Ashburn, Feza H Remzi
PURPOSE: There is scant data assessing the consequences of staging restorative proctocolectomy for ulcerative colitis. The aim of the study is to compare outcomes of initial vs. staged restorative proctocolectomy. METHODS: Patients completing restorative proctocolectomy, including ileostomy reversal, during 2006-2012 were identified from an IRB-approved database. Demographics, treatment variables, and perioperative outcomes were assessed. RESULTS: Out of 521 patients, 322 (62%) underwent initial total abdominal colectomy before restorative proctectomy...
August 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28505562/ultra-fast-electronic-detection-of-antimicrobial-resistance-genes-using-isothermal-amplification-and-thin-film-transistor-sensors
#11
Chunxiao Hu, Sumit Kalsi, Ioannis Zeimpekis, Kai Sun, Peter Ashburn, Carrie Turner, J Mark Sutton, Hywel Morgan
A low cost thin-film transistor (TFT) nanoribbon (NR) sensor has been developed for rapid real-time detection of DNA amplification using an isothermal Recombinase Polymerase Amplification (RPA) method. The semiconductor chip measures DNA amplification through a pH change, rather than via fluorescence. The utility of the method was demonstrated by amplifying CTX-M and NDM, two genes that confer bacterial resistance to cephalosporins and carbapenems, respectively. It is shown that this approach provides extremely fast and sensitive detection...
May 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28482703/it-takes-two-the-influence-of-dance-partners-on-the-perceived-enjoyment-and-benefits-during-participation-in-partnered-ballroom-dance-classes-for-people-with-parkinson-s
#12
Dorit Kunkel, Judy Robison, Carolyn Fitton, Sophia Hulbert, Lisa Roberts, Rose Wiles, Ruth Pickering, Helen Roberts, Ann Ashburn
PURPOSE: To explore the views of people with Parkinson's and their dance partners on the influence and issues surrounding dancing with an able-bodied dance partner during partnered ball room dance classes. METHODS: In depth, semi-structured interviews explored purposively selected participants' experiences and views about dance classes. Fourteen people with Parkinson's and their dance partners (six spouses, two friends/relatives, five volunteers) were interviewed within a month of completing the 10-week dance class program...
May 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28481467/restorative-proctocolectomy-an-example-of-how-surgery-evolves-in-response-to-paradigm-shifts-in-care
#13
Feza H Remzi, Olga A Lavryk, Jean H Ashburn, Tracy L Hull, Ian C Lavery, David W Dietz, Hermann Kessler, James M Church
BACKGROUND: Surgical technique constantly evolves in response to the pressure of progress. Ileal pouch anal anastomosis (IPAA) is a good example. We analyzed the effect of changes in practice on the technique of IPAA and its outcomes. METHODS: Patients undergoing primary IPAA at this institution were divided into three groups by date of IPAA: those operated from 1983-1993, 1994-2004, and 2005 - 2015. Demographics, patient comorbidity, surgical techniques, post-operative outcomes, pouch function and quality of life were analyzed...
May 8, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28383450/long-term-outcomes-after-continent-ileostomy-creation-in-patients-with-crohn-s-disease
#14
Erman Aytac, David W Dietz, Jean Ashburn, Feza H Remzi
BACKGROUND: Patients with Crohn's disease have a higher failure rate after ileal pouch surgery compared with their counterparts with ulcerative colitis. OBJECTIVE: We hypothesized that risk of continent ileostomy failure can be stratified based on the timing of Crohn's disease diagnosis and aimed to assess long-term outcomes. DESIGN: This was a retrospective cohort study. SETTINGS: The investigation took place in a high-volume, specialized colorectal surgery department...
May 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28339890/pennsylvania-state-core-competencies-for-education-on-opioids-and-addiction
#15
Michael A Ashburn, Rachel L Levine
Objective.:  The objective of this project was to develop core competencies for education on opioids and addiction to be used in all Pennsylvania medical schools. Methods.:  The Pennsylvania Physician General created a task force that was responsible for the creation of the core competencies. A literature review was completed, and a survey of graduating medical students was conducted. The task force then developed, reviewed, and approved the core competencies...
March 2, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28286318/spinal-cord-grey-matter-segmentation-challenge
#16
Ferran Prados, John Ashburner, Claudia Blaiotta, Tom Brosch, Julio Carballido-Gamio, Manuel Jorge Cardoso, Benjamin N Conrad, Esha Datta, Gergely Dávid, Benjamin De Leener, Sara M Dupont, Patrick Freund, Claudia A M Gandini Wheeler-Kingshott, Francesco Grussu, Roland Henry, Bennett A Landman, Emil Ljungberg, Bailey Lyttle, Sebastien Ourselin, Nico Papinutto, Salvatore Saporito, Regina Schlaeger, Seth A Smith, Paul Summers, Roger Tam, Marios C Yiannakas, Alyssa Zhu, Julien Cohen-Adad
An important image processing step in spinal cord magnetic resonance imaging is the ability to reliably and accurately segment grey and white matter for tissue specific analysis. There are several semi- or fully-automated segmentation methods for cervical cord cross-sectional area measurement with an excellent performance close or equal to the manual segmentation. However, grey matter segmentation is still challenging due to small cross-sectional size and shape, and active research is being conducted by several groups around the world in this field...
May 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28238216/impact-of-a-restrictive-versus-liberal-transfusion-strategy-on-anastomotic-leakage-and-infectious-complications-after-restorative-surgery-for-rectal-cancer
#17
Volkan Ozben, Luca Stocchi, Jean Ashburn, Xiaobo Liu, Emre Gorgun
AIM: The aim of this study was to investigate the impact of restrictive versus liberal transfusion strategy on anastomotic leakage and infectious complications after rectal cancer surgery. METHODS: Patients undergoing restorative proctectomy for rectal cancer between 01/2008 and 12/2013 were divided into four groups according to the perioperative lowest haemoglobin (Hgb) level and transfusion status: Group 1 with Hgb level ≥10 g/dL, Group 2 ≥7 and <10 g/dL, who did not receive transfusion, and Group 3 with Hgb level ≥7 and <10 g/dL and Group 4 <7 g/dL, both of which received a transfusion...
February 26, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28162750/-499-examining-the-influence-of-hispanic-ethnicity-and-ethnic-bias-on-medical-students-pain-management-decisions
#18
N Hollingshead, L Ashburn-Nardo, J Stewart, G Maupomé, A Hirsh
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28150500/exploring-opportunities-for-coordinated-responses-to-intimate-partner-violence-and-child-maltreatment-in-low-and-middle-income-countries-a-scoping-review
#19
Loraine J Bacchus, Manuela Colombini, Manuel Contreras Urbina, Emma Howarth, Frances Gardner, Jeannie Annan, Kim Ashburn, Bernadette Madrid, Ruti Levtov, Charlotte Watts
Intimate partner violence (IPV) and child maltreatment (CM) by a parent or caregiver are prevalent and overlapping issues with damaging consequences for those affected. This scoping review aimed to identify opportunities for greater coordination between IPV and CM programmes in low- and middle-income countries (LMIC). Nine bibliographic databases were searched and grey literature was identified through the scoping review team. Eligible studies were published in English; described primary prevention programmes in LMIC that addressed IPV and CM, or addressed one form of violence, but reported outcomes for the other; reported IPV and CM outcomes; and evaluated with any study design...
February 2, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27979788/multivariate-dynamical-modelling-of-structural-change-during-development
#20
Gabriel Ziegler, Gerard R Ridgway, Sarah-Jayne Blakemore, John Ashburner, Will Penny
Here we introduce a multivariate framework for characterising longitudinal changes in structural MRI using dynamical systems. The general approach enables modelling changes of states in multiple imaging biomarkers typically observed during brain development, plasticity, ageing and degeneration, e.g. regional gray matter volume of multiple regions of interest (ROIs). Structural brain states follow intrinsic dynamics according to a linear system with additional inputs accounting for potential driving forces of brain development...
February 15, 2017: NeuroImage
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