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https://www.readbyqxmd.com/read/28619310/dance-for-parkinson-s-the-effects-on-whole-body-co-ordination-during-turning-around
#1
Sophia Hulbert, Ann Ashburn, Lisa Roberts, Geert Verheyden
OBJECTIVE: To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. DESIGN: This study employed a randomised, controlled, experimental design. SETTING: Dance classes were performed in a community dance centre in Southern England and all assessments took place a gait laboratory. PARTICIPANTS: Twenty-seven people with mild-moderate Parkinson's participated. INTERVENTION: Participants were randomly allocated to receive either 20, 1-h dancing classes over 10 weeks (n=15), or a 'usual care' control group (n=12)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28597560/l-dopa-responsiveness-is-associated-with-distinctive-connectivity-patterns-in-advanced-parkinson-s-disease
#2
Harith Akram, Chengyuan Wu, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Tarek Yousry, Marjan Jahanshahi, Marwan Hariz, Timothy Behrens, John Ashburner, Ludvic Zrinzo
BACKGROUND: Neuronal loss and dopamine depletion alter motor signal processing between cortical motor areas, basal ganglia, and the thalamus, resulting in the motor manifestations of Parkinson's disease. Dopamine replacement therapy can reverse these manifestations with varying degrees of improvement. METHODS: To evaluate functional connectivity in patients with advanced Parkinson's disease and changes in functional connectivity in relation to the degree of response to l-dopa, 19 patients with advanced Parkinson's disease underwent resting-state functional magnetic resonance imaging in the on-medication state...
June 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28594729/regarding-the-clinical-practice-guidelines-for-the-surgical-treatment-of-patients-with-lynch-syndrome
#3
James Michael Church, Jean H Ashburn
No abstract text is available yet for this article.
July 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28554210/can-primary-care-physicians-accurately-predict-the-likelihood-of-hospitalization-in-their-patients
#4
Andrew S Hwang, Jeffrey M Ashburner, Clemens S Hong, Wei He, Steven J Atlas
No abstract text is available yet for this article.
April 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28534070/total-abdominal-colectomy-vs-restorative-total-proctocolectomy-as-the-initial-approach-to-medically-refractory-ulcerative-colitis
#5
Jinyu Gu, Luca Stocchi, Jeanie Ashburn, Feza H Remzi
PURPOSE: There is scant data assessing the consequences of staging restorative proctocolectomy for ulcerative colitis. The aim of the study is to compare outcomes of initial vs. staged restorative proctocolectomy. METHODS: Patients completing restorative proctocolectomy, including ileostomy reversal, during 2006-2012 were identified from an IRB-approved database. Demographics, treatment variables, and perioperative outcomes were assessed. RESULTS: Out of 521 patients, 322 (62%) underwent initial total abdominal colectomy before restorative proctectomy...
May 22, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28505562/ultra-fast-electronic-detection-of-antimicrobial-resistance-genes-using-isothermal-amplification-and-thin-film-transistor-sensors
#6
Chunxiao Hu, Sumit Kalsi, Ioannis Zeimpekis, Kai Sun, Peter Ashburn, Carrie Turner, J Mark Sutton, Hywel Morgan
A low cost thin-film transistor (TFT) nanoribbon (NR) sensor has been developed for rapid real-time detection of DNA amplification using an isothermal Recombinase Polymerase Amplification (RPA) method. The semiconductor chip measures DNA amplification through a pH change, rather than via fluorescence. The utility of the method was demonstrated by amplifying CTX-M and NDM, two genes that confer bacterial resistance to cephalosporins and carbapenems, respectively. It is shown that this approach provides extremely fast and sensitive detection...
May 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28482703/it-takes-two-the-influence-of-dance-partners-on-the-perceived-enjoyment-and-benefits-during-participation-in-partnered-ballroom-dance-classes-for-people-with-parkinson-s
#7
Dorit Kunkel, Judy Robison, Carolyn Fitton, Sophia Hulbert, Lisa Roberts, Rose Wiles, Ruth Pickering, Helen Roberts, Ann Ashburn
PURPOSE: To explore the views of people with Parkinson's and their dance partners on the influence and issues surrounding dancing with an able-bodied dance partner during partnered ball room dance classes. METHODS: In depth, semi-structured interviews explored purposively selected participants' experiences and views about dance classes. Fourteen people with Parkinson's and their dance partners (six spouses, two friends/relatives, five volunteers) were interviewed within a month of completing the 10-week dance class program...
May 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28481467/restorative-proctocolectomy-an-example-of-how-surgery-evolves-in-response-to-paradigm-shifts-in-care
#8
Feza H Remzi, Olga A Lavryk, Jean H Ashburn, Tracy L Hull, Ian C Lavery, David W Dietz, Hermann Kessler, James M Church
BACKGROUND: Surgical technique constantly evolves in response to the pressure of progress. Ileal pouch anal anastomosis (IPAA) is a good example. We analyzed the effect of changes in practice on the technique of IPAA and its outcomes. METHODS: Patients undergoing primary IPAA at this institution were divided into three groups by date of IPAA: those operated from 1983-1993, 1994-2004, and 2005 - 2015. Demographics, patient comorbidity, surgical techniques, post-operative outcomes, pouch function and quality of life were analyzed...
May 8, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28383450/long-term-outcomes-after-continent-ileostomy-creation-in-patients-with-crohn-s-disease
#9
Erman Aytac, David W Dietz, Jean Ashburn, Feza H Remzi
BACKGROUND: Patients with Crohn's disease have a higher failure rate after ileal pouch surgery compared with their counterparts with ulcerative colitis. OBJECTIVE: We hypothesized that risk of continent ileostomy failure can be stratified based on the timing of Crohn's disease diagnosis and aimed to assess long-term outcomes. DESIGN: This was a retrospective cohort study. SETTINGS: The investigation took place in a high-volume, specialized colorectal surgery department...
May 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28339890/pennsylvania-state-core-competencies-for-education-on-opioids-and-addiction
#10
Michael A Ashburn, Rachel L Levine
Objective.:  The objective of this project was to develop core competencies for education on opioids and addiction to be used in all Pennsylvania medical schools. Methods.:  The Pennsylvania Physician General created a task force that was responsible for the creation of the core competencies. A literature review was completed, and a survey of graduating medical students was conducted. The task force then developed, reviewed, and approved the core competencies...
March 2, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28286318/spinal-cord-grey-matter-segmentation-challenge
#11
Ferran Prados, John Ashburner, Claudia Blaiotta, Tom Brosch, Julio Carballido-Gamio, Manuel Jorge Cardoso, Benjamin N Conrad, Esha Datta, Gergely Dávid, Benjamin De Leener, Sara M Dupont, Patrick Freund, Claudia A M Gandini Wheeler-Kingshott, Francesco Grussu, Roland Henry, Bennett A Landman, Emil Ljungberg, Bailey Lyttle, Sebastien Ourselin, Nico Papinutto, Salvatore Saporito, Regina Schlaeger, Seth A Smith, Paul Summers, Roger Tam, Marios C Yiannakas, Alyssa Zhu, Julien Cohen-Adad
An important image processing step in spinal cord magnetic resonance imaging is the ability to reliably and accurately segment grey and white matter for tissue specific analysis. There are several semi- or fully-automated segmentation methods for cervical cord cross-sectional area measurement with an excellent performance close or equal to the manual segmentation. However, grey matter segmentation is still challenging due to small cross-sectional size and shape, and active research is being conducted by several groups around the world in this field...
May 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28238216/impact-of-a-restrictive-versus-liberal-transfusion-strategy-on-anastomotic-leakage-and-infectious-complications-after-restorative-surgery-for-rectal-cancer
#12
Volkan Ozben, Luca Stocchi, Jean Ashburn, Xiaobo Liu, Emre Gorgun
AIM: The aim of this study was to investigate the impact of restrictive versus liberal transfusion strategy on anastomotic leakage and infectious complications after rectal cancer surgery. METHODS: Patients undergoing restorative proctectomy for rectal cancer between 01/2008 and 12/2013 were divided into four groups according to the perioperative lowest haemoglobin (Hgb) level and transfusion status: Group 1 with Hgb level ≥10 g/dL, Group 2 ≥7 and <10 g/dL, who did not receive transfusion, and Group 3 with Hgb level ≥7 and <10 g/dL and Group 4 <7 g/dL, both of which received a transfusion...
February 26, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28162750/-499-examining-the-influence-of-hispanic-ethnicity-and-ethnic-bias-on-medical-students-pain-management-decisions
#13
N Hollingshead, L Ashburn-Nardo, J Stewart, G Maupomé, A Hirsh
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28150500/exploring-opportunities-for-coordinated-responses-to-intimate-partner-violence-and-child-maltreatment-in-low-and-middle-income-countries-a-scoping-review
#14
Loraine J Bacchus, Manuela Colombini, Manuel Contreras Urbina, Emma Howarth, Frances Gardner, Jeannie Annan, Kim Ashburn, Bernadette Madrid, Ruti Levtov, Charlotte Watts
Intimate partner violence (IPV) and child maltreatment (CM) by a parent or caregiver are prevalent and overlapping issues with damaging consequences for those affected. This scoping review aimed to identify opportunities for greater coordination between IPV and CM programmes in low- and middle-income countries (LMIC). Nine bibliographic databases were searched and grey literature was identified through the scoping review team. Eligible studies were published in English; described primary prevention programmes in LMIC that addressed IPV and CM, or addressed one form of violence, but reported outcomes for the other; reported IPV and CM outcomes; and evaluated with any study design...
February 2, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27979788/multivariate-dynamical-modelling-of-structural-change-during-development
#15
Gabriel Ziegler, Gerard R Ridgway, Sarah-Jayne Blakemore, John Ashburner, Will Penny
Here we introduce a multivariate framework for characterising longitudinal changes in structural MRI using dynamical systems. The general approach enables modelling changes of states in multiple imaging biomarkers typically observed during brain development, plasticity, ageing and degeneration, e.g. regional gray matter volume of multiple regions of interest (ROIs). Structural brain states follow intrinsic dynamics according to a linear system with additional inputs accounting for potential driving forces of brain development...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27930413/efficacy-of-vedolizumab-in-patients-with-antibiotic-and-anti-tumor-necrosis-alpha-refractory-pouchitis
#16
Jessica Philpott, Jean Ashburn, Bo Shen
No abstract text is available yet for this article.
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27919771/the-initiation-of-chronic-opioids-a-survey-of-chronic-pain-patients
#17
Catherine E Callinan, Mark D Neuman, Kim E Lacy, Claudia Gabison, Michael A Ashburn
This study reports the results of a researcher-administered survey with 115 patients receiving chronic opioid therapy (>90 days) to obtain information regarding how chronic opioid therapy was started. Chronic opioids were started after surgery (27.0%, 95% confidence interval [CI], 18.5-35.5) or for the treatment of acute injury-related pain (27.0%, 95% CI, 18.5-35.5). Many who initiated opioid therapy after surgery reported postoperative complications (61.3%, 95% CI, 50.8-71.8) and many with injury-related pain reported follow-up corrective surgery (58...
April 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27861698/influence-of-competing-risks-on-estimating-the-expected-benefit-of-warfarin-in-individuals-with-atrial-fibrillation-not-currently-taking-anticoagulants-the-anticoagulation-and-risk-factors-in-atrial-fibrillation-study
#18
Jeffrey M Ashburner, Alan S Go, Yuchiao Chang, Margaret C Fang, Lisa Fredman, Katie M Applebaum, Daniel E Singer
OBJECTIVES: To provide greater understanding of the "real world" effect of anticoagulation on stroke risk over several years. DESIGN: Cohort study. SETTING: Anticoagulation and Risk Factors in Atrial Fibrillation Study community-based cohort. PARTICIPANTS: Adults with nonvalvular atrial fibrillation (AF) between 1996 and 2003 (13,559). MEASUREMENTS: All events were clinician adjudicated. Extended Cox regression with longitudinal warfarin exposure was used to estimate cause-specific hazard ratios (HRs) for thromboembolism and the competing risk event (all cause death)...
January 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27812939/evaluating-functional-annotations-of-enzymes-using-the-gene-ontology
#19
Gemma L Holliday, Rebecca Davidson, Eyal Akiva, Patricia C Babbitt
The Gene Ontology (GO) (Ashburner et al., Nat Genet 25(1):25-29, 2000) is a powerful tool in the informatics arsenal of methods for evaluating annotations in a protein dataset. From identifying the nearest well annotated homologue of a protein of interest to predicting where misannotation has occurred to knowing how confident you can be in the annotations assigned to those proteins is critical. In this chapter we explore what makes an enzyme unique and how we can use GO to infer aspects of protein function based on sequence similarity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27770385/defining-team-effort-involved-in-patient-care-from-the-primary-care-physician-s-perspective
#20
Andrew S Hwang, Steven J Atlas, Johan Hong, Jeffrey M Ashburner, Adrian H Zai, Richard W Grant, Clemens S Hong
BACKGROUND: A better understanding of the attributes of patients who require more effort to manage may improve risk adjustment approaches and lead to more efficient resource allocation, improved patient care and health outcomes, and reduced burnout in primary care clinicians. OBJECTIVE: To identify and characterize high-effort patients from the physician's perspective. DESIGN: Cohort study. PARTICIPANTS: Ninety-nine primary care physicians in an academic primary care network...
March 2017: Journal of General Internal Medicine
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