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N Hollingshead, L Ashburn-Nardo, J Stewart, G Maupomé, A Hirsh
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
Loraine J Bacchus, Manuela Colombini, Manuel Contreras Urbina, Emma Howarth, Frances Gardner, Jeannie Annan, Kim Ashburn, Bernadette Madrid, Ruti Levtov, Charlotte Watts
Intimate partner violence (IPV) and child maltreatment (CM) by a parent or caregiver are prevalent and overlapping issues with damaging consequences for those affected. This scoping review aimed to identify opportunities for greater coordination between IPV and CM programmes in low- and middle-income countries (LMIC). Nine bibliographic databases were searched and grey literature was identified through the scoping review team. Eligible studies were published in English; described primary prevention programmes in LMIC that addressed IPV and CM, or addressed one form of violence, but reported outcomes for the other; reported IPV and CM outcomes; and evaluated with any study design...
February 2, 2017: Psychology, Health & Medicine
Gabriel Ziegler, Gerard R Ridgway, Sarah-Jayne Blakemore, John Ashburner, Will Penny
Here we introduce a multivariate framework for characterising longitudinal changes in structural MRI using dynamical systems. The general approach enables modelling changes of states in multiple imaging biomarkers typically observed during brain development, plasticity, ageing and degeneration, e.g. regional gray matter volume of multiple regions of interest (ROIs). Structural brain states follow intrinsic dynamics according to a linear system with additional inputs accounting for potential driving forces of brain development...
February 15, 2017: NeuroImage
Jessica Philpott, Jean Ashburn, Bo Shen
No abstract text is available yet for this article.
January 2017: Inflammatory Bowel Diseases
Catherine E Callinan, Mark D Neuman, Kim E Lacy, Claudia Gabison, Michael A Ashburn
: This study reports the results of a researcher-administered survey with 115 patients receiving chronic opioid therapy (>90 days) to obtain information regarding how chronic opioid therapy was started. Chronic opioids were started after surgery (27.0%, 95% confidence interval [CI], 18.5-35.5) or for the treatment of acute injury-related pain (27.0%, 95% CI, 18.5-35.5). Many who initiated opioid therapy after surgery reported postoperative complications (61.3%, 95% CI, 50.8-71.8) and many with injury-related pain reported follow-up corrective surgery (58...
December 3, 2016: Journal of Pain: Official Journal of the American Pain Society
Jeffrey M Ashburner, Alan S Go, Yuchiao Chang, Margaret C Fang, Lisa Fredman, Katie M Applebaum, Daniel E Singer
OBJECTIVES: To provide greater understanding of the "real world" effect of anticoagulation on stroke risk over several years. DESIGN: Cohort study. SETTING: Anticoagulation and Risk Factors in Atrial Fibrillation Study community-based cohort. PARTICIPANTS: Adults with nonvalvular atrial fibrillation (AF) between 1996 and 2003 (13,559). MEASUREMENTS: All events were clinician adjudicated. Extended Cox regression with longitudinal warfarin exposure was used to estimate cause-specific hazard ratios (HRs) for thromboembolism and the competing risk event (all cause death)...
January 2017: Journal of the American Geriatrics Society
Gemma L Holliday, Rebecca Davidson, Eyal Akiva, Patricia C Babbitt
The Gene Ontology (GO) (Ashburner et al., Nat Genet 25(1):25-29, 2000) is a powerful tool in the informatics arsenal of methods for evaluating annotations in a protein dataset. From identifying the nearest well annotated homologue of a protein of interest to predicting where misannotation has occurred to knowing how confident you can be in the annotations assigned to those proteins is critical. In this chapter we explore what makes an enzyme unique and how we can use GO to infer aspects of protein function based on sequence similarity...
2017: Methods in Molecular Biology
Andrew S Hwang, Steven J Atlas, Johan Hong, Jeffrey M Ashburner, Adrian H Zai, Richard W Grant, Clemens S Hong
BACKGROUND: A better understanding of the attributes of patients who require more effort to manage may improve risk adjustment approaches and lead to more efficient resource allocation, improved patient care and health outcomes, and reduced burnout in primary care clinicians. OBJECTIVE: To identify and characterize high-effort patients from the physician's perspective. DESIGN: Cohort study. PARTICIPANTS: Ninety-nine primary care physicians in an academic primary care network...
October 21, 2016: Journal of General Internal Medicine
Kim Ashburn, Brad Kerner, Dickens Ojamuge, Rebecka Lundgren
Violence against women and violence against children in Uganda are recognized as significant public health concerns. Exposure to violence at home as a child can increase the likelihood of perpetrating or experiencing violence later in life. These two forms of violence share similar risk factors and often, but not always, co-occur at the household level. Parenting programs have shown promise in reducing physical child punishment. Targeting men has also been proven effective in transforming attitudes related to gender roles and expectations and intimate partner violence (IPV) against women...
October 13, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
Catherine Bowen, Ann Ashburn, Mark Cole, Margaret Donovan-Hall, Malcolm Burnett, Judy Robison, Louis Mamode, Ruth Pickering, Dan Bader, Dorit Kunkel
BACKGROUND: Ill-fitting shoes have been implicated as a risk factor for falls but research to date has focused on people with arthritis, diabetes and the general older population; little is known about people with neurological conditions. This survey for people with stroke and Parkinson's explored people's choice of indoor and outdoor footwear, foot problems and fall history. METHODS: Following ethical approval, 1000 anonymous postal questionnaires were distributed to health professionals, leads of Parkinson's UK groups and stroke clubs in the wider Southampton area, UK...
2016: Journal of Foot and Ankle Research
Brownsyne Tucker Edmonds, Fatima McKenzie, MacKenzie B Austgen, Leslie Ashburn-Nardo, Marianne S Matthias, Adam T Hirsh
OBJECTIVE: Describe obstetrical providers' management of a hypothetical case on chronic pain in pregnancy and determine whether practices differ based on patient race. DESIGN AND SETTING: This was a self-administered survey at a clinical conference. SUBJECTS: Seventy-six obstetrician-gynecologists and one nurse practitioner were surveyed. METHODS: A case-vignette described a pregnant patient presenting with worsening chronic lower back pain, requesting an opioid refill and increased dosage...
August 14, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Sachin J Shah, Patrick Cronin, Clemens S Hong, Andrew S Hwang, Jeffrey M Ashburner, Benjamin I Bearnot, Calvin A Richardson, Blair W Fosburgh, Alexandra B Kimball
BACKGROUND: No-shows, or missed appointments, are a problem for many medical practices. They result in fragmented care and reduce access for all patients. OBJECTIVE: To determine whether telephone reminder calls targeted to patients at high risk of no-show can reduce no-show rates. DESIGN: Single-center randomized controlled trial. PARTICIPANTS: A total of 2247 primary care patients in a hospital-based primary care clinic at high risk of no-show (>15 % risk) for their appointment in 7 days...
December 2016: Journal of General Internal Medicine
Sanja Percac-Lima, Jeffrey M Ashburner, Adrian H Zai, Yuchiao Chang, Sarah A Oo, Erica Guimaraes, Steven J Atlas
IMPORTANCE: Patient navigation (PN) to improve cancer screening in low-income and racial/ethnic minority populations usually focuses on navigating for single cancers in community health center settings. OBJECTIVE: We evaluated PN for breast, cervical, and colorectal cancer screening using a population-based information technology (IT) system within a primary care network. DESIGN, SETTING, AND PARTICIPANTS: Randomized clinical trial conducted from April 2014 to December 2014 in 18 practices in an academic primary care network...
July 1, 2016: JAMA Internal Medicine
K Sun, I Zeimpekis, C Hu, N M J Ditshego, O Thomas, M R R de Planque, H M H Chong, H Morgan, P Ashburn
In this work, we investigate how the sensitivity of a nanowire or nanoribbon sensor is influenced by the subthreshold slope of the sensing transistor. Polysilicon nanoribbon sensors are fabricated with a wide range of subthreshold slopes and the sensitivity is characterized using pH measurements. It is shown that there is a strong relationship between the sensitivity and the device subthreshold slope. The sensitivity is characterized using the current sensitivity per pH, which is shown to increase from 1.2% ph(-1) to 33...
July 15, 2016: Nanotechnology
Jean H Ashburn, Matthew F Kalady
Radiotherapy not only plays a pivotal role in the cancer care pathways of many patients with pelvic malignancies, but can also lead to significant injury of normal tissue in the radiation field (pelvic radiation disease) that is sometimes as challenging to treat as the neoplasms themselves. Acute symptoms are usually self-limited and respond to medical therapy. Chronic symptoms often require operative intervention that is made hazardous by hostile surgical planes and unforgiving tissues. Management of these challenging patients is best guided by the utmost caution and humility...
June 2016: Clinics in Colon and Rectal Surgery
Michael A Ashburn
No abstract text is available yet for this article.
July 2016: Pharmacoepidemiology and Drug Safety
Perry G Fine, Michael A Ashburn
No abstract text is available yet for this article.
June 2016: Anesthesiology Clinics
Pam Enderby, Anand Pandyan, Audrey Bowen, David Hearnden, Ann Ashburn, Paul Conroy, Pip Logan, Carl Thompson, Jacqueline Winter
AIM: To explore the use, meaning and value of the term "rehabilitation potential". METHOD: The authors of this commentary met to discuss concerns relating to the pressure on health service staff created by reduced length of stay in acute settings of those who have suffered a stroke and the need to determine the potential of a patient for rehabilitation in order to inform discharge arrangements. Points raised at this meeting were shared with an email group who over a 12-month period contributed to this paper...
April 30, 2016: Disability and Rehabilitation
Patrick Freund, Karl Friston, Alan J Thompson, Klaas E Stephan, John Ashburner, Dominik R Bach, Zoltan Nagy, Gunther Helms, Bogdan Draganski, Siawoosh Mohammadi, Martin E Schwab, Armin Curt, Nikolaus Weiskopf
No abstract text is available yet for this article.
June 2016: Brain: a Journal of Neurology
Marco Crescentini, Michele Rossi, Peter Ashburn, Marta Lombardini, Enrico Sangiorgi, Hywel Morgan, Marco Tartagni
Silicon nanowires are label-free sensors that allow real-time measurements. They are economical and pave the road for point-of-care applications but require complex readout and skilled personnel. We propose a new model and technique for sensing nanowire sensors using alternating currents (AC) to capture both magnitude and phase information from the sensor. This approach combines the advantages of complex impedance spectroscopy with the noise reduction performances of lock-in techniques. Experimental results show how modifications of the sensors with different surface chemistries lead to the same direct-current (DC) response but can be discerned using the AC approach...
April 19, 2016: Biosensors
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