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NAFLD fibrosis score

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https://www.readbyqxmd.com/read/28520503/serum-alanine-aminotransferase-trends-and-their-relationship-with-obesity-and-metabolic-syndrome-in-united-states-adolescents-1999-2014
#1
Cyrelle R Fermin, Arthur M Lee, Stephanie L Filipp, Matthew J Gurka, Mark D DeBoer
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD), characterized by hepatocyte dysfunction, fat accumulation, and fibrosis, is the most common cause of chronic liver disease in children. Elevated levels of serum alanine aminotransferase (ALT) are used clinically to identify potential liver dysfunction. Our goal was to assess for changes in the national prevalence of elevated ALT over time and potential relationship to trends in the metabolic syndrome (MetS) severity and elevated body mass index (BMI)...
May 18, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28489307/non-alcoholic-fatty-liver-nafl-and-advanced-fibrosis-in-the-elderly-results-from-a-community-based-polish-survey
#2
Marek Hartleb, Kamil Barański, Jan Zejda, Jerzy Chudek, Andrzej Więcek
INTRODUCTION & AIM: Development of non-alcoholic fatty liver (NAFL) is dependent on metabolic factors occurring at an increased frequency with advancing age. Until now, few studies have explored the prevalence of NAFL in aged populations. Our study aimed to determine the prevalence of NAFL and advanced fibrosis in the elderly population participating in a national survey of a community-based elderly cohort. METHODS: A total of 3003 participants (mean age 79.6 years, 46...
May 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28479500/histologic-scores-for-fat-and-fibrosis-associate-with-development-of-type-2-diabetes-in-patients-with-non-alcoholic-fatty-liver-disease
#3
Karl Björkström, Per Stål, Rolf Hultcrantz, Hannes Hagström
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a strong risk factor for development of type 2 diabetes, but little is known about how long-term NAFLD or its histologic features affect risk. We aimed to investigate the cumulative incidence of type 2 diabetes in patients with NAFLD, and to identify histologic factors that affect risk of diabetes. METHODS: We performed a retrospective study of 396 patients in Sweden diagnosed with NAFLD by biopsy analysis from 1971 through 2009 who did not have type 2 diabetes at baseline...
May 4, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28470881/concentration-dependent-response-to-pioglitazone-in-nonalcoholic-steatohepatitis
#4
M Kawaguchi-Suzuki, F Bril, S Kalavalapalli, K Cusi, R F Frye
BACKGROUND: Pioglitazone is a safe and effective option to manage patients with type 2 diabetes and nonalcoholic steatohepatitis (NASH). However, there is marked variability in treatment response. AIM: To evaluate the relationship between concentrations of pioglitazone and its active metabolites and treatment outcomes in patients with NASH. METHODS: Pioglitazone concentrations were measured in patients with NASH treated with pioglitazone 45 mg/day for 18 months; liver biopsy samples were obtained at baseline and after treatment...
May 3, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28469366/liver-test-abnormalities-in-patients-with-hiv-mono-infection-assessment-with-simple-noninvasive-fibrosis-markers
#5
Rosa Lombardi, Robert Lever, Colette Smith, Neal Marshall, Alison Rodger, Sanjay Bhagani, Emmanuel Tsochatzis
BACKGROUND: Patients with HIV mono-infection may develop chronic liver disease due to a number of factors including hepatic steatosis. We estimated the prevalence and predictors of hepatic steatosis and fibrosis in a cohort of HIV-mono-infected patients with persistently deranged liver function tests. METHODS: Of 2398 consecutive patients at one UK clinical center, 156 (6.5%) had persistently abnormal transaminases in at least two measurements six months apart. We used APRI and FIB4 scores to determine the presence of significant and/or advanced fibrosis in this group as well as its potential associations...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28452101/combined-low-dose-spironolactone-plus-vitamin-e-vs-vitamin-e-monotherapy-on-insulin-resistance-noninvasive-indices-of-steatosis-and-fibrosis-and-adipokine-levels-in-nonalcoholic-fatty-liver-disease-a-randomized-controlled-trial
#6
Stergios A Polyzos, Jannis Kountouras, Christos S Mantzoros, Vaia Polymerou, Panagiotis Katsinelos
The beneficial effects of mineralocorticoid receptor blockade by spironolactone have been shown in animal models of nonalcoholic fatty liver disease (NAFLD). The aim of this 52-week randomized controlled trial was to compare the efficacy of low-dose spironolactone and vitamin E combination vs. vitamin E monotherapy on insulin resistance, noninvasive indices of hepatic steatosis and fibrosis, liver tests, circulating adipokines and hormones in patients with histologically confirmed NAFLD. Homeostasis model of assessment-insulin resistance (HOMA-IR) and noninvasive indices of steatosis and fibrosis were calculated...
April 28, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28446050/smoking-is-associated-with-severity-of-liver-fibrosis-but-not-with-histological-severity-in-nonalcoholic-fatty-liver-disease-results-from-a-cross-sectional-study
#7
Isabelle D Munsterman, Mark M Smits, Rene Andriessen, Carin M J van Nieuwkerk, Elisabeth Bloemena, Chris J J Mulder, Eric T T L Tjwa, Erwin J M van Geenen
OBJECTIVES: To assess the influence of smoking on histological disease severity and fibrosis in real-world NAFLD patients. MATERIAL AND METHODS: Consecutive NAFLD patients were identified with liver biopsies performed between 2008 and 2015. Characteristics such as smoking status and total number of pack years were collected. Biopsies were revised and BRUNT fibrosis and NAFLD activity score (NAS) determined. Patients with a high NAS (≥5) were compared to patients with a low NAS (<5) and with advanced fibrosis (stage 3-4) to patients with no-early fibrosis (stage 0-2)...
April 27, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28419855/a-randomized-trial-of-silymarin-for-the-treatment-of-non-alcoholic-steatohepatitis
#8
Wah-Kheong Chan, Nik Raihan Nik Mustapha, Sanjiv Mahadeva
BACKGROUND & AIMS: Silymarin is a complex mixture of 6 major flavonolignans and other minor polyphenolic compounds derived from the milk thistle plant Silybum marianum; it has shown anti-oxidant, anti-inflammatory and anti-fibrotic effects, and may be useful in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to study the efficacy of silymarin in patients with non-alcoholic steatohepatitis (NASH)-the more severe form of NAFLD. METHODS: We performed a randomized, double-blind, placebo-controlled trial of consecutive adults with biopsy-proven NASH and a NAFLD activity score (NAS) of 4 or more at a tertiary care hospital in Kuala Lumpur, Malaysia, from November 2012 through August 2014...
April 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28369989/severity-of-nonalcoholic-fatty-liver-disease-on-sonography-and-risk-of-coronary-heart-disease
#9
Sun Hwa Lee, Seong Jong Yun, Dong Hyeon Kim, Hyeon Hwan Jo, Yong Sung Park
PURPOSE: To evaluate the relationship between nonalcoholic fatty liver disease (NAFLD) on sonography (US) and the risk of coronary heart disease (CHD) as well as the predictive value of US-diagnosed NAFLD to determine intermediate/high CHD risk compared with as well as in combination on with NAFLD fibrosis score (NFS). METHODS: This retrospective study included 1,276 patients examined between November 2015 and August 2016. NAFLD was categorized as absent, mild, moderate, or severe based on liver-to-kidney echogenicity, visibility of intrahepatic vessel walls, and the diaphragm...
March 28, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28369100/serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-in-non-alcoholic-fatty-liver-disease
#10
Lee-Lee Lai, Wah-Kheong Chan, Pavai Sthaneshwar, Nik Raihan Nik Mustapha, Khean-Lee Goh, Sanjiv Mahadeva
Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) has been suggested to be useful for the assessment of disease severity in non-alcoholic fatty liver disease (NAFLD). Consecutive adult NAFLD patients who had a liver biopsy were included. Serum WFA+-M2BP level was measured using a lectin-antibody sandwich immunoassay using a chemiluminescence enzyme immunoassay machine (HISCL-5000, Sysmex, Kobe, Japan). The measured levels were indexed using the following equation: Cut-off index (COI) = ([WFA+-M2BP]sample-[WFA+-M2BP]NC) / ([WFA+-M2BP]PC-[WFA+-M2BP]NC), where PC = positive control and NC = negative control...
2017: PloS One
https://www.readbyqxmd.com/read/28362682/genetic-determinants-of-circulating-lipoproteins-in-nonalcoholic-fatty-liver-disease
#11
Zhenghui G Jiang, Elliot B Tapper, Misung Kim, Margery A Connelly, Sarah A Krawczyk, Eric U Yee, Mark A Herman, Kenneth J Mukamal, Michelle Lai
BACKGROUND: Recent genome-wide association studies have identified 2 genetic polymorphisms in association with nonalcoholic fatty liver disease (NAFLD): patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), both of which appear to influence the production of very low density lipoprotein (VLDL). The impact of these genetic variations on lipoprotein metabolism in the setting of nonalcoholic steatohepatitis and liver fibrosis are not fully characterized...
March 30, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28359548/serum-cytokeratin-18-fragment-levels-as-noninvasive-marker-of-nonalcoholic-steatohepatitis-in-the-chilean-population
#12
Juan Pablo Arab, Cristián Hernández-Rocha, Carolina Morales, José Ignacio Vargas, Nancy Solís, Margarita Pizarro, Camila Robles, Daniela Sandoval, Simon Ponthus, Carlos Benítez, Francisco Barrera, Alejandro Soza, Arnoldo Riquelme, Marco Arrese
Nonalcoholic steatohepatitis (NASH) is the most aggressive form of nonalcoholic fatty liver disease (NAFLD) and involves the risk of progression to more advanced stages of liver disease. Non-invasive methods are needed to identify patients with NASH. OBJECTIVE: To evaluate the diagnostic performance of the determination of serum levels of cytokeratin-18 (CK-18) as a non-invasive marker of NASH in the Chilean population. METHODS: Serum CK-18 levels were determined in a group of 41 patients with biopsy-proven NAFLD...
March 27, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28352941/easl-easd-easo-clinical-practice-guidelines-for-the-management-of-non-alcoholic-fatty-liver-disease-in-severely-obese-people-do-they-lead-to-over-referral
#13
Emilie Blond, Emmanuel Disse, Charlotte Cuerq, Jocelyne Drai, Pierre-Jean Valette, Martine Laville, Charles Thivolet, Chantal Simon, Cyrielle Caussy
AIMS/HYPOTHESIS: We aimed to assess the application of the recent European Association for the Study of the Liver (EASL)-European Association for the Study of Diabetes (EASD)-European Association for the Study of Obesity (EASO) clinical practice guidelines for the management of non-alcoholic fatty liver disease (NAFLD) in severely obese individuals in routine clinical practice. METHODS: We performed a single-centre retrospective observational study of 385 patients referred for severe obesity (BMI ≥ 35 kg/m(2)) to our Endocrinology, Diabetes and Nutrition department, between 1 November 2014 and 31 December 2015...
March 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/28346543/prevalence-of-non-alcoholic-fatty-liver-disease-and-risk-factors-for-advanced-fibrosis-and-mortality-in-the-united-states
#14
Michael H Le, Pardha Devaki, Nghiem B Ha, Dae Won Jun, Helen S Te, Ramsey C Cheung, Mindie H Nguyen
In the United States, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and associated with higher mortality according to data from earlier National Health and Nutrition Examination Survey (NHANES) 1988-1994. Our goal was to determine the NAFLD prevalence in the recent 1999-2012 NHANES, risk factors for advanced fibrosis (stage 3-4) and mortality. NAFLD was defined as having a United States Fatty Liver Index (USFLI) > 30 in the absence of heavy alcohol use and other known liver diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28319602/low-hepatic-tissue-copper-in-pediatric-non-alcoholic-fatty-liver-disease
#15
Michael Mendoza, Shelley Caltharp, Ming Song, Lindsay Collin, Juna V Konomi, Craig J McClain, Miriam B Vos
OBJECTIVE: Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in non-alcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children. METHODS: This was a retrospective study of pediatric patients who had a liver biopsy including a hepatic copper quantitation. The primary outcome compared hepatic copper concentration in NAFLD versus non-NAFLD...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28318912/less-liver-fibrosis-in-metabolically-healthy-compared-with-metabolically-unhealthy-obese-patients-with-non-alcoholic-fatty-liver-disease
#16
Y Gutiérrez-Grobe, E Juárez-Hernández, B A Sánchez-Jiménez, M H Uribe-Ramos, M H Ramos-Ostos, M Uribe, N C Chávez-Tapia
AIM: This cross-sectional study evaluated liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), and compared the characteristics of metabolically healthy obese (MHO) with metabolically unhealthy obese (MUHO) patients. METHODS: The study was nested within a randomized clinical trial (RCT) and included obese patients with NAFLD, as determined by liver ultrasonography. Fibrosis was assessed by transient elastography, and AST-to-platelet ratio index (APRI) and NAFLD score...
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28288193/nonalcoholic-fatty-liver-disease-and-increased-risk-of-1-year-all-cause-and-cardiac-hospital-readmissions-in-elderly-patients-admitted-for-acute-heart-failure
#17
Filippo Valbusa, Stefano Bonapace, Davide Agnoletti, Luca Scala, Cristina Grillo, Pietro Arduini, Emanuela Turcato, Alessandro Mantovani, Giacomo Zoppini, Guido Arcaro, Christopher Byrne, Giovanni Targher
Nonalcoholic fatty liver disease (NAFLD) is an emerging risk factor for heart failure (HF). Although some progress has been made in improving survival among patients admitted for HF, the rates of hospital readmissions and the related costs continue to rise dramatically. We sought to examine whether NAFLD and its severity (diagnosed at hospital admission) was independently associated with a higher risk of 1-year all-cause and cardiac re-hospitalization in patients admitted for acute HF. We studied 212 elderly patients who were consecutively admitted with acute HF to the Hospital of Negrar (Verona) over a 1-year period...
2017: PloS One
https://www.readbyqxmd.com/read/28286193/in-children-with-nonalcoholic-fatty-liver-disease-zone-1-steatosis-is-associated-with-advanced-fibrosis
#18
Jonathan A Africa, Cynthia A Behling, Elizabeth M Brunt, Nan Zhang, Yunjun Luo, Alan Wells, Jiayi Hou, Patricia H Belt, Rohit Kohil, Joel E Lavine, Jean P Molleston, Kimberly P Newton, Peter F Whitington, Jeffrey B Schwimmer
BACKGROUND & AIMS: Focal zone 1 steatosis, although rare in adults with nonalcoholic fatty liver disease (NAFLD), does occur in children with NAFLD. We investigated whether focal zone 1 steatosis and focal zone 3 steatosis are distinct subphenotypes of pediatric NAFLD. We aimed to determine associations between the zonality of steatosis and demographic, clinical, and histologic features in children with NAFLD. METHODS: We performed a cross-sectional study of baseline data from 813 children (age <18 years; mean age, 12...
March 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28274829/vitamin-d-and-histologic-severity-of-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#19
Veeravich Jaruvongvanich, Wasin Ahuja, Anawin Sanguankeo, Karn Wijarnpreecha, Sikarin Upala
BACKGROUND: NAFLD and vitamin D deficiency often coexist and epidemiologic evidence has shown that both of these conditions share several risk factors. Recent studies investigating the relationship between vitamin D levels and severity of NAFLD showed conflicting results. Thus we conducted a systematic review and meta-analysis to evaluate association between vitamin D and NAFLD histologic severity. METHODS: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through November 2016...
February 16, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28265826/intestinal-inflammation-does-not-predict-nonalcoholic-fatty-liver-disease-severity-in-inflammatory-bowel-disease-patients
#20
Rotonya M Carr, Arpan Patel, Hillary Bownik, Amanke Oranu, Caroline Kerner, Amy Praestgaard, Kimberly A Forde, K Rajender Reddy, Gary R Lichtenstein
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic steatosis in patients with inflammatory bowel disease (IBD). Both metabolic syndrome (MetS) and intestinal inflammation are implicated in NAFLD pathogenesis. METHODS: We performed a retrospective cohort study of patients with IBD and NAFLD seen in our health system from January 1997 to December 2011 to examine associations between IBD severity and phenotype; MetS; and NAFLD fibrosis as estimated by the NAFLD Fibrosis Score (NFS)...
May 2017: Digestive Diseases and Sciences
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