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NAFLD fibrosis score

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https://www.readbyqxmd.com/read/29045180/quantitative-liver-mri-biopsy-correlation-in-pediatric-and-young-adult-patients-with-nonalcoholic-fatty-liver-disease-can-one-be-used-to-predict-the-other
#1
Jonathan R Dillman, Andrew T Trout, Emma N Costello, Suraj D Serai, Kristin S Bramlage, Rohit Kohli, Stavra A Xanthakos
OBJECTIVE: The purpose of this study is to determine the relationships between quantitative liver MRI measurements and liver biopsy findings in pediatric and young adult patients with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: Data were obtained from a registry that prospectively enrolls pediatric and young adult patients with biopsy-confirmed NAFLD at our tertiary medical center with parent or guardian and subject informed consent, as appropriate...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29028281/usefulness-of-the-index-of-nash-ion-for-the-diagnosis-of-steatohepatitis-in-patients-with-non-alcoholic-fatty-liver-an-external-validation-study
#2
Ramy Younes, Chiara Rosso, Salvatore Petta, Monica Cucco, Milena Marietti, Gian Paolo Caviglia, Alessia Ciancio, Maria Lorena Abate, Carlo Cammà, Antonina Smedile, Antonio Craxì, Giorgio Maria Saracco, Elisabetta Bugianesi
BACKGROUND & AIMS: The non-invasive identification of steatohepatitis (NASH) in patients with Non-Alcoholic Fatty Liver Disease is an unmet need in clinical practice. Index of NASH (ION) is a new tool for the prediction of NASH. We aimed to externally validate ION and to compare it with CK-18. Since necroinflammation precedes fibrosis, we also tested ION in combination with non-invasive tools for fibrosis. METHODS: We analyzed data from 292 Italian patients (169 Southern cohort, and 123 Northern cohort) with an histological diagnosis of NAFLD...
October 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29025245/hepatic-chemerin-mrna-in-morbidly-obese-patients-with-nonalcoholic-fatty-liver-disease
#3
Maciej Kajor, Michał Kukla, Marek Waluga, Łukasz Liszka, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Mateusz Chapuła, Anna Kostrząb-Zdebel, Rafał J Bułdak, Tomasz Sawczyn, Marek Hartleb
The aim of this study was to investigate hepatic chemerin mRNA, serum chemerin concentration, and immunohistochemical staining for chemerin and and chemokine receptor-like 1 (CMKLR1) in hepatic tissue in 56 morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to search for a relationship with metabolic and histopathological features. Chemerin mRNA was assessed by quantitative real-time PCR, chemerin, and CMKLR1 immunohistochemical expression with specific antibodies, while serum chemerin concentration was assessed with commercially available enzyme-linked immunosorbent assays...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28990251/waist-to-calf-ratio-is-an-independent-predictor-of-hepatic-steatosis-and-fibrosis-patients-with-type-2-diabetes
#4
Eun Yeong Choe, Yong-Ho Lee, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Soo-Kyung Kim, Eun Seok Kang, Bong-Soo Cha, Eun Jig Lee, Kap Bum Huh, Zobair M Younossi
BACKGROUND: Although a combination of central obesity and decreased skeletal muscle mass have been associated with various cardiometabolic disorders, its influence on the presence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D) is unclear. AIM: We investigated whether waist-to-calf circumference ratio (WCR) predicts NAFLD or hepatic fibrosis in T2D. METHODS: Patients with T2D (n=5,507) were enrolled in this study. Hepatic steatosis was diagnosed using abdominal ultrasound and predicting score...
October 8, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28989092/advanced-liver-fibrosis-but-not-steatosis-is-independently-associated-with-albuminuria-in-chinese-patients-with-type-2-diabetes
#5
Ming-Wai Yeung, Grace Lai-Hung Wong, Kai Chow Choi, Andrea On-Yan Luk, Raymond Kwok, Sally She-Ting Shu, Anthony Wing-Hung Chan, Eric Siu Him Lau, Ronald Ching Wan Ma, Henry Lik-Yuen Chan, Juliana Chung-Ngor Chan, Vincent Wai-Sun Wong, Alice Pik-Shan Kong
BACKGROUND & AIMS: Increasing evidence suggests that non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for chronic kidney disease (CKD). Given the high prevalence of NAFLD among patients with diabetes who are also at risk for CKD, we aimed to investigate the association between NAFLD and albuminuria, a marker commonly found in diabetic nephropathy. METHODS: This study included a cohort of Chinese patients with type 2 diabetes from the Hong Kong Diabetes Registry recruited between March 2013 and May 2014...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28981521/nonalcoholic-fatty-liver-disease-is-associated-with-an-increased-risk-of-heart-block-in-hospitalized-patients-with-type-2-diabetes-mellitus
#6
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Stefano Bonapace, Giovanni Morani, Giacomo Zoppini, Enzo Bonora, Giovanni Targher
Recent studies suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiac tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus. The aim of this study was to examine whether an association also exists between NAFLD and heart block. We have retrospectively evaluated a hospital-based cohort of 751 patients with type 2 diabetes discharged from our Division of Diabetes and Endocrinology during years 2007-2014. Standard electrocardiograms were performed on all patients...
2017: PloS One
https://www.readbyqxmd.com/read/28975533/association-of-single-nucleotide-polymorphism-at-pnpla3-with-fatty-liver-steatohepatitis-and-cirrhosis-of-liver
#7
Shahinul Alam, Mohammad Shaiful Islam, Saiful Islam, Golam Mustafa, Ahmed Abu Saleh, Nooruddin Ahmad
BACKGROUND/PURPOSE: The aim of this study was to determine the association of single nucleotide polymorphism (SNP) in patatin-like phospholipase domain-containing 3 (PNPLA3) at I148 with histological severity of non-alcoholic fatty liver disease (NAFLD). METHODS: Patients were selected for the study if they had histological evidence of NAFLD and clinical evidence of non-alcoholic steatohepatits (NASH) cirrhosis. We included 50 NASH cirrhosis, 99 patients of NAFLD including 36 non-NASH fatty liver (NNFL) along with 63 NASH and 75 healthy controls...
October 4, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28962213/effects-of-telmisartan-on-improving-leptin-resistance-and-inhibiting-hepatic-fibrosis-in-rats-with-non-alcoholic-fatty-liver-disease
#8
Qiu-Zan Zhang, Ying-Li Liu, Yan-Rong Wang, Li-Na Fu, Jing Zhang, Xiu-Ru Wang, Bang-Mao Wang
The present study aimed to investigate the impacts of telmisartan (TEL) on hepatic fibrosis, serum leptin, leptin protein in liver tissue and its mRNA expression level in rats with non-alcoholic fatty liver disease (NAFLD). Male Sprague Dawley rats were randomly divided into the control (N), model (M), polyene phosphatidylcholine (P) and TEL (T) groups. Group M and the intervention groups were given a high-fat diet for 12 weeks to induce NAFLD, followed by 4 weeks of intragastric administration of normal saline (1...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28948665/performance-of-fibrosis-prediction-scores-in-paediatric-non-alcoholic-fatty-liver-disease
#9
Jasmine A Jackson, Juna V Konomi, Michael V Mendoza, Alyssa Krasinskas, Ran Jin, Shelley Caltharp, Marialena Mouzaki, Miriam B Vos
AIM: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. The phenotype of NAFLD varies widely, and non-invasive predictors of disease severity are scarce and are needed to tailor clinical management. METHODS: We compared liver fibrosis by histology with proposed non-invasive predictors of fibrosis, including alanine transaminase (ALT), aspartate transaminase (AST), AST/ALT ratio, AST to platelet ratio index, fibrosis-4, paediatric NAFLD fibrosis index and paediatric NAFLD fibrosis score...
September 25, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28941597/immunomodulatory-liposomes-targeting-liver-macrophages-arrest-progression-of-nonalcoholic-steatohepatitis
#10
Muralidhara Rao Maradana, Suman Kumar Yekollu, Bijun Zeng, Jonathan Ellis, Andrew Clouston, Gregory Miller, Meghna Talekar, Zaied Ahmed Bhuyan, Sachin Mahadevaiah, Elizabeth E Powell, Katharine M Irvine, Ranjeny Thomas, Brendan John O'Sullivan
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic macrophage inflammation, steatosis and fibrosis. Liposomes injected intravenously passively target hepatic myeloid cells and have potential to deliver immunomodulatory compounds and treat disease. We investigated targeting, delivery, immunomodulation and efficacy of liposomes in mice with diet-induced NASH. METHODS: Liposome-encapsulated lipophilic curcumin or 1,25-dihydroxy-vitamin D3 (calcitriol) were injected intravenously into mice with diet-induced NASH...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28936407/current-modalities-of-fibrosis-assessment-in-non-alcoholic-fatty-liver-disease
#11
REVIEW
Mark Cc Cheah, Arthur J McCullough, George Boon-Bee Goh
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global health concern. In the subset of NAFLD patients with non-alcoholic steatohepatitis (NASH), the presence of significant fibrosis at index assessment is associated with poor prognosis and increased mortality. Hence, there is a growing need to accurately assess and stage fibrosis. Liver biopsy, the current gold standard, has limitations with sampling error and is invasive, with associated inherent risk. This has led to a host of non-invasive means of assessing fibrosis, which has garnered relevance in a disease that requires serial assessment of fibrosis longitudinally over time...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28936398/vitamin-d-is-associated-with-severity-and-mortality-of-non-alcoholic-fatty-liver-disease-a-us-population-based-study
#12
Hyun-Seok Kim, Laura Rotundo, Neil Kothari, Sung-Hoon Kim, Nikolaos Pyrsopoulos
Background and Aims: There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic syndrome. Since metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD), we aimed to investigate the association between vitamin D and the severity and mortality of NAFLD. Methods: Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994, with follow-up mortality data through 2011. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases and categorized as normal, mild, moderate or severe...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28927302/igfbp-1-and-igf-i-as-markers-for-advanced-fibrosis-in-nafld-a-pilot-study
#13
Hannes Hagström, Per Stål, Rolf Hultcrantz, Kerstin Brismar, Ishrath Ansurudeen
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally. Advanced fibrosis (stage 3-4) is the most robust marker for future mortality, but diagnosis requires liver biopsy. Current non-invasive scoring systems aimed to identify advanced fibrosis are imperfect. Insulin-like growth factor I (IGF-I) and its binding protein IGFBP-1 are liver derived proteins, that are involved in various liver disorders. The aim of this study was to examine the possible association between advanced fibrosis and IGF-I and IGFBP-1 in NAFLD...
September 19, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28914448/significant-burden-of-nonalcoholic-fatty-liver-disease-with-advanced-fibrosis-in-the-us-a-cross-sectional-analysis-of-2011-2014-national-health-and-nutrition-examination-survey
#14
R J Wong, B Liu, T Bhuket
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in the US. Understanding the epidemiology of NAFLD, with specific focus on individuals with hepatic fibrosis is important to guide healthcare resource planning. AIM: To evaluate prevalence and predictors of hepatic fibrosis among US adults with NAFLD. METHODS: We performed a cross-sectional study using data from the updated 2011-2014 National Health and Nutrition Examination Survey, a national, stratified, multistage sampling survey of non-institutionalised US adults age ≥ 20...
September 15, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28914407/association-of-fetuin-b-with-markers-of-liver-fibrosis-in-nonalcoholic-fatty-liver-disease
#15
Thomas Ebert, Nicolas Linder, Alexander Schaudinn, Harald Busse, Joachim Berger, Ralf Lichtinghagen, Volker Keim, Johannes Wiegand, Thomas Karlas
OBJECTIVE: The liver-derived plasma protein fetuin B is associated with nonalcoholic fatty liver disease (NAFLD) and impaired glucose homeostasis in mice. However, its association with non-invasive ultrasound- and magnetic resonance (MR)-based markers of liver fibrosis and steatosis, the enhanced liver fibrosis (ELF) score, liver biopsy, as well as rs738409 in PNPLA3, has not been elucidated in NAFLD, so far. DESIGN AND METHODS: The association of circulating fetuin B and transient elastography (TE), controlled attenuation parameter (CAP), (1)H-MR-spectroscopy, the ELF score, liver biopsy, as well as risk alleles in rs738409 in PNPLA3, was studied in 101 NAFLD patients as compared to 15 healthy controls...
September 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28895242/hepatocellular-carcinoma-in-a-mouse-model-fed-a-choline-deficient-l-amino-acid-defined-high-fat-diet
#16
Ayae Ikawa-Yoshida, Saori Matsuo, Atsuhiko Kato, Yusuke Ohmori, Atsuko Higashida, Eiji Kaneko, Masahiko Matsumoto
Hepatocellular carcinoma (HCC) is a common cancer worldwide and represents the outcome of the natural history of chronic liver disease. The growing rates of HCC may be partially attributable to increased numbers of people with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). However, details of the liver-specific molecular mechanisms responsible for the NAFLD-NASH-HCC progression remain unclear, and mouse models that can be used to explore the exact factors that influence the progression of NAFLD/NASH to the more chronic stages of liver disease and subsequent HCC are not yet fully established...
August 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28875438/non-invasive-evaluation-of-nafld-with-indocyanine-green-clearance-test-a-preliminary-study-in-morbidly-obese-patients-undergoing-bariatric-surgery
#17
Pierre Eric Danin, Rodolphe Anty, Stephanie Patouraux, Marc Raucoules-Aimé, Jean Gugenheim, Albert Tran, Philippe Gual, Antonio Iannelli
BACKGROUND: Overweight and obesity dramatically increased in the last years. Hepatic complication of obesity, integrated in the term of non-alcoholic fatty liver disease (NAFLD), is a spectrum of abnormality ranging from steatosis to non-alcoholic steatohepatitis (NASH), potentially leading to cirrhosis. Liver biopsy remains the gold standard to evaluate the stage of NAFLD; however, the procedure is invasive. The indocyanine green (ICG) clearance test is performed since years to assess hepatic function before partial hepatectomy, or after liver transplantation...
September 5, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28870674/development-of-chronic-kidney-disease-in-patients-with-non-alcoholic-fatty-liver-disease-a-cohort-study
#18
Dong Hyun Sinn, Danbee Kang, Hye Ryoun Jang, Seonhye Gu, Soo Jin Cho, Seung Woon Paik, Seungho Ryu, Yoosoo Chang, Mariana Lazo, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has been associated with chronic kidney disease (CKD), but cohort studies are limited. We investigated the longitudinal association of NAFLD and its severity with the development of CKD. METHODS: We performed a retrospective cohort study of 41,430 adult men and women (average age, 48.9y) without CKD at baseline who underwent repeated health check-up examinations from January 1, 2003, through December 31, 2013...
September 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28862712/enhanced-liver-fibrosis-test-as-a-reliable-tool-for-assessing-fibrosis-in-nonalcoholic-fatty-liver-disease-in-a-clinical-setting
#19
Luca Miele, Teresa De Michele, Giuseppe Marrone, Maria Antonietta Isgrò, Umberto Basile, Consuelo Cefalo, Marco Biolato, Fabio Maria Vecchio, Gian Lodovico Rapaccini, Antonio Gasbarrini, Cecilia Zuppi, Antonio Grieco
BACKGROUND: Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer's cutoff value (≥9.8) in identifying severe fibrosis for adult patients with histologically confirmed NAFLD. METHODS: We tested the ELF test in a clinical practice, prospective cohort of 82 consecutive patients who consecutively underwent percutaneous liver biopsy...
August 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28853202/ursodeoxycholic-acid-effects-on-hepatic-unfolded-protein-response-apoptosis-and-oxidative-stress-in-morbidly-obese-patients
#20
Michaela Mueller, Rui E Castro, Anders Thorell, Hanns-Ulrich Marschall, Nicole Auer, Merima Herac, Cecilia M P Rodrigues, Michael Trauner
BACKGROUND AND AIMS: Ursodeoxycholic acid (UDCA) is a secondary hydrophilic bile acid (BA) used as therapy for a range of hepatobiliary diseases. Its efficacy in non-alcoholic fatty liver disease (NAFLD) is still under debate. Here we aimed to decipher molecular mechanisms of UDCA in regulating endoplasmic reticulum (ER) homeostasis, apoptosis and oxidative stress in morbidly obese patients. METHODS: In this randomized controlled pharmacodynamic study, liver and serum samples from 40 well-matched morbidly obese NAFLD-patients were analyzed...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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