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NAFLD fibrosis score

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https://www.readbyqxmd.com/read/28796410/steatosis-severity-affects-the-diagnostic-performances-of-noninvasive-fibrosis-tests-in-nonalcoholic-fatty-liver-disease
#1
Sae Kyung Joo, Won Kim, Donghee Kim, Jung Ho Kim, Sohee Oh, Kook Lae Lee, Mee Soo Chang, Yong Jin Jung, Young Ho So, Myoung Seok Lee, Jeong Mo Bae, Byeong Gwan Kim
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of heterogeneous metabolic subtypes. This study compared the diagnostic performances of noninvasive fibrosis tests in predicting advanced fibrosis in patients with NAFLD and examined the effects of the subgroup on their diagnostic performances. METHODS: Three hundred fifteen patients with biopsy-proven NAFLD were prospectively enrolled. Acoustic radiation force impulse imaging (ARFI) was performed to obtain liver stiffness measurements (LSMs)...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28752524/serial-combination-of-non-invasive-tools-improves-the-diagnostic-accuracy-of-severe-liver-fibrosis-in-patients-with-nafld
#2
S Petta, V W-S Wong, C Cammà, J-B Hiriart, G L-H Wong, J Vergniol, A W-H Chan, V Di Marco, W Merrouche, H L-Y Chan, F Marra, B Le-Bail, U Arena, A Craxì, V de Ledinghen
BACKGROUND: The accuracy of available non-invasive tools for staging severe fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) is still limited. AIM: To assess the diagnostic performance of paired or serial combination of non-invasive tools in NAFLD patients. METHODS: We analysed data from 741 patients with a histological diagnosis of NAFLD. The GGT/PLT, APRI, AST/ALT, BARD, FIB-4, and NAFLD Fibrosis Score (NFS) scores were calculated according to published algorithms...
July 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28749418/the-association-between-vitamin-d-insufficiency-and-nonalcoholic-fatty-liver-disease-a-population-based-study
#3
Yeonjung Ha, Seong Gyu Hwang, Kyu Sung Rim
Previous studies have shown inconsistent results regarding the association between vitamin D insufficiency and nonalcoholic fatty liver disease (NAFLD). We attempted to demonstrate this relationship using population-based data. Vitamin D insufficiency was defined as a 25(OH)D level ≤20 ng/mL. Hepatic steatosis index was calculated to define NAFLD. Significant fibrosis was assessed using Body mass index, AST/ALT Ratio, Diabetes (BARD) score. Logistic regression analyses were performed to determine the relationship between vitamin D insufficiency and NAFLD...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28718838/phyllanthus-niruri-standardized-extract-alleviates-the-progression-of-non-alcoholic-fatty-liver-disease-and-decreases-atherosclerotic-risk-in-sprague-dawley-rats
#4
Raghdaa Hamdan Al Zarzour, Mariam Ahmad, Mohd Zaini Asmawi, Gurjeet Kaur, Mohammed Ali Ahmed Saeed, Majed Ahmed Al-Mansoub, Sultan Ayesh Mohammed Saghir, Nasiba Salisu Usman, Dhamraa W Al-Dulaimi, Mun Fei Yam
Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different extracts of Phyllanthus niruri (P. niruri). NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28716600/the-utility-of-nafld-fibrosis-score-for-prediction-of-mortality-among-patients-with-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis-of-cohort-study
#5
Veeravich Jaruvongvanich, Karn Wijarnpreecha, Patompong Ungprasert
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a common liver disorder worldwide. Several noninvasive diagnostic scoring systems have been developed to determine the severity of liver fibrosis and to predict long-term outcome of patients with NAFLD in lieu of liver biopsy. We conducted this systematic review and meta-analysis to investigate the role of NAFLD fibrosis score (NFS) for prediction of mortality from NAFLD. METHODS: MEDLINE and EMBASE databases were searched through October 2016 for studies that investigated the association between high NFS and mortality...
July 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28696585/the-presence-and-severity-of-nonalcoholic-steatohepatitis-is-associated-with-specific-changes-in-circulating-bile-acids
#6
Puneet Puri, Kalyani Daita, Andrew Joyce, Faridoddin Mirshahi, Prasanna K Santhekadur, Sophie Cazanave, Velimir A Luketic, Mohammad S Siddiqui, Sherry Boyett, Hae-Ki Min, Divya P Kumar, Rohit Kohli, Huiping Zhou, Phillip B Hylemon, Melissa J Contos, Michael Idowu, Arun J Sanyal
The histologic spectrum of nonalcoholic fatty liver disease (NAFLD) includes fatty liver (NAFL) and steatohepatitis (NASH), which can progress to cirrhosis in up to 20% NASH patients. Bile acids (BA) are linked to pathogenesis and therapy of NASH. We (a) characterized plasma BA profile in biopsy proven NAFL and NASH, and compared to controls, and (b) related plasma BA profile to liver histologic features, disease activity and fibrosis. Liquid chromatography/mass spectrometry quantified BAs. Descriptive statistics, paired and multiple group comparisons, and regression analyses were performed...
July 11, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28694658/anti-steatotic-and-anti-fibrotic-effects-of-the-kca3-1-channel-inhibitor-senicapoc-in-non-alcoholic-liver-disease
#7
Latha Paka, David E Smith, Dawoon Jung, Siobhan McCormack, Ping Zhou, Bin Duan, Jing-Song Li, Jiaqi Shi, Yong-Jie Hao, Kai Jiang, Michael Yamin, Itzhak D Goldberg, Prakash Narayan
AIM: To evaluate a calcium activated potassium channel (KCa3.1) inhibitor attenuates liver disease in models of non-alcoholic fatty liver disease (NAFLD). METHODS: We have performed a series of in vitro and in vivo studies using the KCa3.1 channel inhibitor, Senicapoc. Efficacy studies of Senicapoc were conducted in toxin-, thioacetamide (TAA) and high fat diet (HFD)-induced models of liver fibrosis in rats. Efficacy and pharmacodynamic effects of Senicapoc was determined through biomarkers of apoptosis, inflammation, steatosis and fibrosis...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28694246/management-of-endocrine-disease-polycystic-ovary-syndrome-and-nonalcoholic-fatty-liver-disease
#8
REVIEW
Djuro Macut, Ivana Božić-Antić, Jelica Bjekić-Macut, Konstantinos Tziomalos
Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women, with a number of metabolic and reproductive consequences. Obesity, insulin resistance (IR) and type 2 diabetes are prominent metabolic characteristics of PCOS and common factors affecting liver function and generating nonalcoholic fatty liver disease (NAFLD). Multiple genes involved in the synthesis of androgens, cytokines and IR, as well as acquired factors, such as endocrine disruptors, could associate the etiopathogenesis of PCOS and NAFLD...
September 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28680292/effect-of-non-alcoholic-liver-disease-on-recurrence-rate-and-liver-regeneration-after-liver-resection-for-colorectal-liver-metastases
#9
N W Molla, M M Hassanain, Z Fadel, L M Boucher, A Madkhali, R M Altahan, E A Alrijraji, E B Simoneau, H Alamri, A Salman, Z Gao, P P Metrakos
BACKGROUND: Resection of metastases is the only potential cure for patients with liver metastasis from colorectal cancer (crc-lm). But despite an improved overall 5-year survival, the recurrence rate is still as high as 60%. Non-alcoholic fatty liver disease (nafld) can decrease the liver's capacity to regenerate after resection and might also affect cancer recurrence, potentially by elevating transforming growth factor β, levels of specific metalloproteinases, and oxidative stress. The objective of the present work was to determine the effect of the histologic features of nafld on cancer recurrence and liver regeneration...
June 2017: Current Oncology
https://www.readbyqxmd.com/read/28658094/multimorbidity-and-polypharmacy-in-diabetic-patients-with-nafld-implications-for-disease-severity-and-management
#10
Preya Janubhai Patel, Kelly Lee Hayward, Rathiga Rudra, Leigh Ula Horsfall, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Nigel Neil Brown, Nivene Saad, Andrew Donald Clouston, Katherine Anne Stuart, Patricia Casarolli Valery, Katharine Margaret Irvine, Anthony William Russell, Elizabeth Ellen Powell
An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28644356/low-hepatic-tissue-copper-in-pediatric-nonalcoholic-fatty-liver-disease
#11
Michael Mendoza, Shelley Caltharp, Ming Song, Lindsay Collin, Juna V Konomi, Craig J McClain, Miriam B Vos
OBJECTIVE: Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in nonalcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children. METHODS: This was a retrospective study of pediatric patients who had a liver biopsy including a hepatic copper quantitation. The primary outcome compared hepatic copper concentration in NAFLD versus non-NAFLD...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28641784/ultrasonographic-fatty-liver-indicator-detects-mild-steatosis-and-correlates-with-metabolic-histological-parameters-in-various-liver-diseases
#12
Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Alessandra Marrazzo, Dante Romagnoli, Giovanni Targher, Amedeo Lonardo
BACKGROUND AND AIMS: Fatty liver is a common feature of different types of liver diseases. The sensitivity and specificity of ultrasonography for diagnosing fatty liver are variable. A semi-quantitative ultrasound score, i.e., the ultrasonographic fatty liver indicator (US-FLI), is closely associated with metabolic/histological variables in patients with nonalcoholic fatty liver disease (NAFLD). The main aims of this study were to assess the diagnostic performance of US-FLI in detecting varying degrees of histological steatosis, and to examine the association of US-FLI with metabolic/histological parameters in 352 biopsied patients with various chronic liver diseases (173 with hepatitis C [HCV], 23 with hepatitis B [HBV], 123 with NAFLD and 33 with other etiologies)...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28641782/high-prevalence-of-apolipoprotein-b-dyslipoproteinemias-in-non-alcoholic-fatty-liver-disease-the-lifelines-cohort-study
#13
Karlijn J Nass, Eline H van den Berg, Klaas Nico Faber, Tim C M A Schreuder, Hans Blokzijl, Robin P F Dullaart
OBJECTIVE: Cardiovascular disease (CVD) is a major adverse consequence of non-alcoholic fatty liver disease (NAFLD). The association of NAFLD with various apolipoprotein B (apoB) dyslipoproteinemias is unclear. We determined the prevalence of specific apoB dyslipoproteinemias in subjects with suspected NAFLD. METHODS: This study was conducted among 22,865 fasting adults living in the northern part of the Netherlands (Lifelines Cohort Study). Six apoB dyslipoproteinemias were defined using an algorithm derived from apoB, total cholesterol and triglycerides...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28606575/good-adherence-to-the-mediterranean-diet-reduces-the-risk-for-nash-and-diabetes-in-pediatric-patients-with-obesity-the-results-of-an-italian-study
#14
Claudia Della Corte, Antonella Mosca, Andrea Vania, Arianna Alterio, Salvatore Iasevoli, Valerio Nobili
OBJECTIVE: In the last decade, it was demonstrated that the Mediterranean diet (MD) represents an ideal diet for all age groups and has an important role in the prevention of metabolic and cardiovascular diseases, as well as nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to analyze the association between adherence to the MD and NAFLD, with laboratory and histologic evaluation, in a group of children and adolescents with obesity. METHODS: We enrolled 243 patients with obesity referred to our department from March 2014 to November 2015...
July 2017: Nutrition
https://www.readbyqxmd.com/read/28600126/chemokine-cc-motif-receptor-like-2-mrna-is-expressed-in-hepatic-stellate-cells-and-is-positively-associated-with-characteristics-of-non-alcoholic-steatohepatitis-in-mice-and-men
#15
Sebastian Zimny, Rebekka Pohl, Lisa Rein-Fischboeck, Elisabeth M Haberl, Sabrina Krautbauer, Thomas S Weiss, Christa Buechler
Chemokine (CC-motif) receptor-like 2 (CCRL2) is a decoy receptor and regulates the local responses of the chemokine chemerin. Recently our group has shown that the functional chemerin receptor, chemokine-like receptor 1 (CMKLR1), correlates with fibrosis and non-alcoholic steatohepatitis (NASH) score in males only. In our current study, we wanted to know whether CCRL2 shows similar correlations as CMKLR1. Therefore, we analyzed the hepatic expression of CCRL2 in murine NASH and in liver tissues obtained from 85 patients with non-alcoholic fatty liver disease (NAFLD) and 33 controls...
June 15, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28589339/a-simple-scoring-system-using-type-iv-collagen-7s-and-aspartate-aminotransferase-for-diagnosing-nonalcoholic-steatohepatitis-and-related-fibrosis
#16
Takeshi Okanoue, Hayao Ebise, Toshihiro Kai, Masayuki Mizuno, Toshihide Shima, Junji Ichihara, Mikio Aoki
BACKGROUND: Recently we reported novel noninvasive scoring systems for diagnosing nonalcoholic steatohepatitis (NASH) and related fibrosis, namely FM-NASH index and FM-fibro index. They are highly accurate, however, they contain some items not widely used in clinical practice and require six or more items to diagnose both NASH and related fibrosis. By focusing on widely used items, we tried to identify convenient markers in common with the both diagnoses. METHODS: To explore the markers for NASH and related fibrosis in nonalcoholic fatty liver disease (NAFLD) patients, we used data of 24 clinical items in our previous report...
June 6, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28586172/comparison-of-laboratory-tests-ultrasound-or-mre-to-detect-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease-a-meta-analysis
#17
Guangqin Xiao, Sixian Zhu, Xiao Xiao, Lunan Yan, Jiayin Yang, Gang Wu
Many noninvasive methods for diagnosing liver fibrosis (LF) have been proposed. To determine the best method for diagnosing LF in nonalcoholic fatty liver disease (NAFLD), we conducted a systemic review and meta-analysis to compare the performance of APRI, FIB-4, BARD score, NAFLD fibrosis score (NFS), FibroScan, shear wave elastography (SWE) and magnetic resonance elastography (MRE) for diagnosing LF in NAFLD. We compared the sensitivity, specificity, positive predictive value, negative predictive value, and AUROC of these noninvasive methods for detecting significant fibrosis (SF), advanced fibrosis (AF), and cirrhosis...
June 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28586157/role-of-point-shear-wave-elastography-in-the-determination-of-the-severity-of-fibrosis-in-pediatric-liver-diseases-with-pathologic-correlations
#18
Mehmet Burak Özkan, Meltem Ceyhan Bilgici, Esra Eren, Gonul Caltepe, Gulay Yilmaz, Cengiz Kara, Seda Gun
OBJECTIVES: Our aims in this study were as follows: (1) to determine the cutoff value that can distinguish between advanced liver fibrosis and normal liver tissue for two different elastographic techniques; (2) to determine the cutoff value that can distinguish mild liver fibrosis from normal liver tissue for the techniques; and (3) to assess tissue stiffness in nonalcoholic fatty liver disease (NAFLD). METHODS: Seventy-five patients assessed for liver biopsy on the same day were evaluated by point shear wave elastography...
June 6, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28573069/combination-curcumin-and-vitamin-e-treatment-attenuates-diet-induced-steatosis-in-hfe-mice
#19
Mandy Heritage, Lesley Jaskowski, Kim Bridle, Catherine Campbell, David Briskey, Laurence Britton, Linda Fletcher, Luis Vitetta, V Nathan Subramaniam, Darrell Crawford
AIM: To investigate the synergistic hepato-protective properties of curcumin and vitamin E in an Hfe(-/-) high calorie diet model of steatohepatitis. METHODS: Hfe(-/-) C57BL/6J mice were fed either a high calorie diet or a high calorie diet with 1 mg/g curcumin; 1.5 mg/g vitamin E; or combination of 1 mg/g curcumin + 1.5 mg/g vitamin E for 20 wk. Serum and liver tissue were collected at the completion of the experiment. Liver histology was graded by a pathologist for steatosis, inflammation and fibrosis...
May 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28572039/ast-to-platelet-ratio-index-and-fibrosis-4-calculator-scores-for-non-invasive-assessment-of-hepatic-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#20
Noam Peleg, Assaf Issachar, Orly Sneh-Arbib, Amir Shlomai
BACKGROUND & AIMS: Liver fibrosis is the single most important prognostic factor in patients with non-alcoholic fatty liver disease (NAFLD). The predictive value of the AST to Platelet Ratio Index (APRI) score, originally developed for fibrosis assessment in hepatitis C virus (HCV) patients, is much less known in the context of NAFLD patients. METHODS: We retrospectively compared the performance of APRI and fibrosis 4 calculator (FIB-4) scores in NAFLD patients with documented liver biopsies, to their performance in chronic HCV patients...
May 11, 2017: Digestive and Liver Disease
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