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NAFLD fibrosis score

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https://www.readbyqxmd.com/read/27911262/magnetic-resonance-elastography-vs-transient-elastography-in-detection-of-fibrosis-and-noninvasive-measurement-of-steatosis-in-patients-with-biopsy-proven-nonalcoholic-fatty-liver-disease
#1
Charlie C Park, Phirum Nguyen, Carolyn Hernandez, Ricki Bettencourt, Kimberly Ramirez, Lynda Fortney, Jonathan Hooker, Ethan Sy, Mosab H Alquiraish, Mark A Valasek, Emily Rizo, Lisa Richards, David Brenner, Claude B Sirlin, Rohit Loomba
BACKGROUND & AIMS: Magnetic-resonance-imaging (MRI) techniques and ultrasound-based transient elastography (TE) can be used in noninvasive diagnosis of fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD). We performed a prospective study to compare the performance of magnetic resonance elastography (MRE) vs TE for in diagnosis of fibrosis, and MRI-based proton density fat fraction (MRI-PDFF) analysis vs TE-based controlled attenuation parameter (CAP) for diagnosis of steatosis in patients undergoing biopsy to assess NAFLD...
October 27, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27881858/safety-and-efficacy-of-bariatric-surgery-in-patients-with-advanced-fibrosis-bariatric-surgery-safety-in-advanced-fibrosis
#2
T Singh, G S Kochhar, G B Goh, P Schauer, S Brethauer, M Kroh, A Aminian, R Lopez, S Dasarathy, A J McCullough
BACKGROUND: Bariatric surgery is performed safely in NAFLD patients with minimal fibrosis (stage 1-2). However, the safety and potential benefits of bariatric surgery for NAFLD with advanced fibrosis (stage 3-4) remain unclear. This study was designed to compare the safety and efficacy of bariatric surgery in patients with biopsy proven advanced fibrosis to those with minimal fibrosis. METHODS: All patients who underwent bariatric surgery between 2005-2014 and had evidence of NAFLD with fibrosis score 3-4 (advanced fibrosis) based on the staging system defined by Kleiner et al...
November 24, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27872651/a-review-of-western-and-traditional-chinese-medical-approaches-to-managing-nonalcoholic-fatty-liver-disease
#3
REVIEW
Wei-Fan Hsu, Lee-Yan Sheen, Hung-Jen Lin, Hen-Hong Chang
Nonalcoholic fatty liver disease (NAFLD) is a disease of attention because of increase in prevalence from 20% to 41%. The clinical and pathological conditions in patients with NAFLD range from steatosis alone to nonalcoholic steatohepatitis (NASH) with or without fibrosis to hepatic cancer. In the United States, NAFLD was the second-leading indication for liver transplant between 2004 and 2013. Although imaging studies such as magnetic resonance elastography and the use of diagnostic panels and scoring systems can provide a fairly accurate diagnosis of NAFLD, there are few treatment options for patients with mild to moderate disease other than lifestyle modification...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27859583/external-validation-of-the-nonalcoholic-fatty-liver-disease-fibrosis-score-for-assessing-advanced-fibrosis-in-korean-patients
#4
Dae Won Jun, Sang Gyune Kim, Sang Hoon Park, So-Young Jin, Ji Sung Lee, Jin-Woo Lee, Moon Young Kim, Dae Hee Choi, Yong Kyun Cho, Jong Eun Yeon, Joo Hyun Sohn
BACKGROUND: The degree of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) is a critical predictive factor for patient prognosis. This study was intended to perform external validation of the various fibrosis prediction models for assessing advanced fibrosis in Korean NAFLD patients. METHODS: A retrospective study of 412 patients with NAFLD confirmed by liver biopsy in hospitals affiliated with the Koran NAFLD study group was conducted and the predictive ability of existing liver fibrosis prediction models including NAFLD fibrosis score (NFS), BARD, and FIB-4 were compared...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27851786/calcium-reduces-liver-injury-in-mice-on-a-high-fat-diet-alterations-in-microbial-and-bile-acid-profiles
#5
Muhammad Nadeem Aslam, Christine M Bassis, Li Zhang, Sameer Zaidi, James Varani, Ingrid L Bergin
A high-fat "Western-style" diet (HFWD) promotes obesity-related conditions including non-alcoholic steatohepatitis (NASH), the histologic manifestation of non-alcoholic fatty liver disease (NAFLD). In addition to high saturated fat and processed carbohydrates, the typical HFWD is deficient in calcium. Calcium-deficiency is an independent risk factor for many conditions associated with the Western-style diet. However, calcium has not been widely evaluated in the context of NAFLD. The goal of the present study was to determine if dietary calcium supplementation could protect mice fed a HFWD from NAFLD, specifically by decreasing non-alcoholic steatohepatitis (NASH) and its down-stream consequences...
2016: PloS One
https://www.readbyqxmd.com/read/27830836/long-term-lifestyle-interventions-in-middle-aged-and-elderly-men-with-nonalcoholic-fatty-liver-disease-a-randomized-controlled-trial
#6
Fangyuan Dong, Yan Zhang, Yiqin Huang, Yiqian Wang, Gansheng Zhang, Xiaona Hu, Jiaofeng Wang, Jie Chen, Zhijun Bao
Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of long-term lifestyle interventions in middle-aged and elderly men with NAFLD. All 280 eligible patients were randomized to the control or test group...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27797398/hepatic-chemerin-mrna-expression-is-reduced-in-human-nonalcoholic-steatohepatitis
#7
Rebekka Pohl, Elisabeth M Haberl, Lisa Rein-Fischboeck, Sebastian Zimny, Maximilian Neumann, Charalampos Aslanidis, Doris Schacherer, Sabrina Krautbauer, Kristina Eisinger, Thomas S Weiss, Christa Buechler
BACKGROUND: Chemerin is associated with insulin resistance and is expressed in the liver. Nonalcoholic fatty liver disease (NAFLD) is related to impaired insulin sensitivity, but studies evaluating hepatic and serum chemerin in NAFLD resulted in discordant data. MATERIALS AND METHODS: Chemerin mRNA was determined in the liver tissue obtained from 33 controls and 76 NAFLD patients. Chemerin serum levels were measured in a different cohort of patients with ultrasound-diagnosed NAFLD and the respective controls...
October 31, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27795938/noninvasive-markers-of-fibrosis-and-inflammation-in-nonalcoholic-fatty-liver-disease
#8
Saumya Jayakumar, Stephen A Harrison, Rohit Loomba
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Nonalcoholic steatohepatitis (NASH) and fibrosis are associated with elevated morbidity and mortality, and a means of differentiating these diseases from simple steatosis (SS) is needed. Liver biopsy in all patients with NAFLD is not feasible, thus necessitating a noninvasive method for discerning the presence of inflammation and fibrosis. Of the various serum markers, cytokeratin-18 seems to best predict NASH, the NAFLD Fibrosis Score is most closely correlated with fibrosis, and transient elastography can be used for diagnosis of cirrhosis, or to exclude cirrhosis, although its utility is limited by obesity...
June 2016: Current Hepatology Reports
https://www.readbyqxmd.com/read/27778429/multi-parametric-magnetic-resonance-imaging-for-the-assessment-of-non-alcoholic-fatty-liver-disease-severity
#9
Michael Pavlides, Rajarshi Banerjee, Elizabeth M Tunnicliffe, Catherine Kelly, Jane Collier, Lai Mun Wang, Kenneth A Fleming, Jeremy F Cobbold, Matthew D Robson, Stefan Neubauer, Eleanor Barnes
BACKGROUND AND AIMS: The diagnosis of non-alcoholic steatohepatitis (NASH) and fibrosis staging are central to non-alcoholic fatty liver disease (NAFLD) assessment. We evaluated multi-parametric magnetic resonance (MR) in the assessment of NASH and fibrosis using histology as standard in NAFLD. METHODS: Seventy one patients with suspected NAFLD were recruited within one month of liver biopsy. MR data were used to define the liver inflammation and fibrosis score (LIF 0-4)...
October 25, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27764892/association-between-plasminogen-activator-inhibitor-1-and-severity-of-liver-injury-and-cardiovascular-risk-in-children-with-non-alcoholic-fatty-liver-disease
#10
R Jin, A Krasinskas, N-A Le, J V Konomi, J Holzberg, R Romero, M B Vos
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of the endogenous fibrinolytic system and is known to be increased in obesity, insulin resistance and non-alcoholic fatty liver disease (NAFLD). We previously demonstrated that PAI-1 levels were closely related to the amount of hepatic steatosis in children. OBJECTIVES: The aim of this study was to characterize plasma PAI-1 in relationship to severity of inflammation and fibrosis, as well as to plasma lipids in children with NAFLD...
October 20, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27753194/performance-of-transient-elastography-in-japanese-patients-with-non-alcoholic-fatty-liver-disease
#11
Kojiro Seki, Toshihide Shima, Hirohisa Oya, Yasuhide Mitsumoto, Masayuki Mizuno, Takeshi Okanoue
AIM: Transient elastography (TE) is a noninvasive method for predicting liver fibrosis. However, there is limited data regarding the performance of TE in Japanese patients with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the association between liver stiffness measurement (LSM) by TE and liver fibrosis stage, and define a cut-off value for predicting liver fibrosis. METHODS: A total of 171 Japanese patients with biopsy-proven NAFLD underwent LSM using TE with FibroScan®...
October 18, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27740518/%C3%A2-most-overweight-and-obese-indian-children-have-nonalcoholic-fatty-liver-disease
#12
Sunil V Pawar, Vinay G Zanwar, Ajay S Choksey, Ashok R Mohite, Samit S Jain, Ravindra G Surude, Qais Q Contractor, Pravin M Rathi, Ravi U Verma, Premlata K Varthakavi
:  Background and rationale. Nonalcoholic fatty liver disease (NAFLD) is the most common cause of pediatric liver disease in western countries. Its prevalence in Indian subcontinent is not well studied. MATERIAL AND METHODS: In a school based cross sectional study we have screened overweight and obese children in the age group of 11 to 15 years for NAFLD. Ultrasonography, elevated serum transaminases, fibroscan were used for defining NAFLD. Dietary habits, blood pressure, serum lipid profile, blood counts and insulin resistance were recorded...
November 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27739482/serum-ykl-40-as-a-marker-of-liver-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#13
Erina Kumagai, Yohei Mano, Sachiyo Yoshio, Hirotaka Shoji, Masaya Sugiyama, Masaaki Korenaga, Tsuyoshi Ishida, Taeang Arai, Norio Itokawa, Masanori Atsukawa, Hideyuki Hyogo, Kazuaki Chayama, Tomohiko Ohashi, Kiyoaki Ito, Masashi Yoneda, Takumi Kawaguchi, Takuji Torimura, Yuichi Nozaki, Sumio Watanabe, Masashi Mizokami, Tatsuya Kanto
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic non-viral liver disease. YKL-40, chitinase-like protein expressed in multiple tissues including liver, is involved in cell proliferation, inflammation and remodeling of the extracellular matrix. The aim of this study was to assess whether serum YKL-40 levels are associated with liver fibrosis in NAFLD patients. Serum YKL-40 levels were quantified in 111 NAFLD patients and 23 HCC patients with NAFLD. To identify the source of YKL-40, immunofluorescence staining of liver specimens from NAFLD patients was performed...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725647/age-as-a-confounding-factor-for-the-accurate-non-invasive-diagnosis-of-advanced-nafld-fibrosis
#14
Stuart McPherson, Tim Hardy, Jean-Francois Dufour, Salvatore Petta, Manuel Romero-Gomez, Mike Allison, Claudia P Oliveira, Sven Francque, Luc Van Gaal, Jörn M Schattenberg, Dina Tiniakos, Alastair Burt, Elisabetta Bugianesi, Vlad Ratziu, Christopher P Day, Quentin M Anstee
OBJECTIVES: Non-invasive fibrosis scores are widely used to identify/exclude advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). However, these scores were principally developed and validated in patients aged between 35 and 65 years of age. The objective of this study was to assess the effect of age on the performance of non-invasive fibrosis tests in NAFLD. METHODS: Patients were recruited from European specialist hepatology clinics. The cohort was divided into five age-based groups: ≤35 (n=74), 36-45 (n=96), 46-55 (n=197), 56-64 (n=191), and ≥65 years (n=76), and the performance of the aspartate aminotransferase (AST)/alanine transaminase (ALT) ratio, fibrosis 4 (FIB-4), and NAFLD fibrosis score (NFS) for advanced fibrosis (stage F3-F4) for each group was assessed using liver biopsy as the standard...
October 11, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27706836/identifying-nonalcoholic-fatty-liver-disease-patients-with-active-fibrosis-by-measuring-extracellular-matrix-remodeling-rates-in-tissue-and-blood
#15
Martin L Decaris, Kelvin W Li, Claire L Emson, Michelle Gatmaitan, Shanshan Liu, Yenny Wang, Edna Nyangau, Marc Colangelo, Thomas E Angel, Carine Beysen, Jeffrey Cui, Carolyn Hernandez, Len Lazaro, David A Brenner, Scott M Turner, Marc K Hellerstein, Rohit Loomba
: Excess collagen synthesis (fibrogenesis) in the liver plays a causal role in the progression of nonalcoholic fatty liver disease (NAFLD). Methods are needed to identify patients with more rapidly progressing disease and to demonstrate early response to treatment. We describe here a novel method to quantify hepatic fibrogenesis flux rates both directly in liver tissue and noninvasively in blood. Twenty-one patients with suspected NAFLD ingested heavy water ((2) H2 O, 50-mL aliquots) two to three times daily for 3-5 weeks prior to a clinically indicated liver biopsy...
October 5, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27680752/nonalcoholic-fatty-liver-disease-one-entity-multiple-impacts-on-liver-health
#16
Carmen Fierbinteanu-Braticevici, Crina Sinescu, Alexandru Moldoveanu, Ana Petrisor, Sorina Diaconu, Dragos Cretoiu, Bogdan Braticevici
Nonalcoholic fatty liver disease (NAFLD) is very prevalent and now considered the most common cause of chronic liver disease. Staging the severity of liver damage is very important because the prognosis of NAFLD is highly variable. The long-term prognosis of patients with NAFLD remains incompletely elucidated. Even though the annual fibrosis progression rate is significantly higher in patients with nonalcoholic hepatitis (NASH), both types of NAFLD (nonalcoholic fatty liver and nonalcoholic steatohepatitis) can lead to fibrosis...
September 28, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27649410/renin-angiotensin-system-inhibitors-type-2-diabetes-and-fibrosis-progression-an-observational-study-in-patients-with-nonalcoholic-fatty-liver-disease
#17
Serena Pelusi, Salvatore Petta, Chiara Rosso, Vittorio Borroni, Anna Ludovica Fracanzani, Paola Dongiovanni, Antonio Craxi, Elisabetta Bugianesi, Silvia Fargion, Luca Valenti
BACKGROUND: The clinical determinants of fibrosis progression in nonalcoholic fatty liver disease (NAFLD) are still under definition. AIM: To assess the clinical determinants of fibrosis progression rate (FPR) in NAFLD patients with baseline and follow-up histological evaluation, with a special focus on the impact of pharmacological therapy. METHODS: In an observational cohort of 118 Italian patients from tertiary referral centers, liver histology was evaluated according to Kleiner...
2016: PloS One
https://www.readbyqxmd.com/read/27642348/fibroscan-compared-to-fib-4-apri-and-ast-alt-ratio-for-assessment-of-liver-fibrosis-in-saudi-patients-with-nonalcoholic-fatty-liver-disease
#18
Hind I Fallatah, Hisham O Akbar, Alyaa M Fallatah
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a cause of chronic liver disease. It has also been associated with devastating outcomes such as decompensated liver cirrhosis and hepatocellular carcinoma, as well as diabetes and metabolic syndrome. OBJECTIVES: This study was conducted in order to assess liver fibrosis using Fibroscan, and to compare these results to the use of Fibrosis-4 (FIB-4) scores, AST platelet ratio index (APRI scores), and the AST/ALT ratios on NAFLD patients...
July 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27639088/improved-noninvasive-prediction-of-liver-fibrosis-by-liver-stiffness-measurement-in-patients-with-nonalcoholic-fatty-liver-disease-accounting-for-controlled-attenuation-parameter-values
#19
Salvatore Petta, Vincent Wai-Sun Wong, Calogero Cammà, Jean-Baptiste Hiriart, Grace Lai-Hung Wong, Fabio Marra, Julien Vergniol, Anthony Wing-Hung Chan, Vito Di Marco, Wassil Merrouche, Henry Lik-Yuen Chan, Marco Barbara, Brigitte Le-Bail, Umberto Arena, Antonio Craxì, Victor de Ledinghen
BACKGROUND AND AIMS: Liver stiffness measurement (LSM) frequently overestimates the severity of liver fibrosis In Nonalcoholic Fatty Liver Disease (NAFLD). Controlled Attenuation Parameter (CAP) is a new parameter provided by the same machine used for LSM, and associated with both steatosis and BMI, the two factors mostly affecting LSM peformance in NAFLD. We aimed to determine wheter prediction of liver fibrosis by LSM in NAFLD patients is affected by CAP values. METHODS: Patients (n=324) were assessed by clinical and histological (Kleiner score) features...
September 17, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27635163/hepatic-artery-resistive-index-hari-and-non-alcoholic-fatty-liver-disease-nafld-fibrosis-score-in-nafld-patients-cut-off-suggestive-of-non-alcoholic-steatohepatitis-nash-evolution
#20
Claudio Tana, Marco Tana, Stefano Rossi, Mauro Silingardi, Cosima Schiavone
PURPOSE OF THE STUDY: Conventional ultrasound (US) is reliable to reveal the presence of non-alcoholic fatty liver disease (NAFLD), but it is neither sensitive nor specific to reveal fibrosis clues, except in advanced stages where signs of cirrhosis are evident. NALFD fibrosis score is a non-invasive parameter that predicts well the presence of significant fibrosis, but correlations with US parameters are lacking. The aim of this study was, therefore, to compare resistive index of hepatic artery (HARI) of NAFLD patients with different severity degrees of diffuse fatty liver disease vs HARI of controls, and to compare HARI of NAFLD patients with different NAFLD fibrosis scores vs HARI of controls...
September 2016: Journal of Ultrasound
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