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Thomas greene

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https://www.readbyqxmd.com/read/28810708/bacteria-induced-morphogenesis-of-ulva-intestinalis-and-ulva-mutabilis-chlorophyta-a-contribution-to-the-lottery-theory
#1
Fatemeh Ghaderiardakani, Juliet C Coates, Thomas Wichard
The green marine macroalgae of the class Ulvophyceae (Ulvophytes) are common algae distributed worldwide particularly in intertidal areas, which play a key role in aquatic ecosystems. They are potentially valuable resources for food, animal feed and fuel but can also cause massive nuisance blooms. Members of Ulvaceae, like many other seaweeds, harbour a rich diversity of epiphytic bacteria with functions related to host growth and morphological development. In the absence of appropriate bacterially derived signals, germ cells of the genus Ulva develop into 'atypical' colonies consisting of undifferentiated cells with abnormal cell walls...
August 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28809455/a-nanophotonic-structure-containing-living-photosynthetic-bacteria
#2
David Coles, Lucas C Flatten, Thomas Sydney, Emily Hounslow, Semion K Saikin, Alán Aspuru-Guzik, Vlatko Vedral, Joseph Kuo-Hsiang Tang, Robert A Taylor, Jason M Smith, David G Lidzey
Photosynthetic organisms rely on a series of self-assembled nanostructures with tuned electronic energy levels in order to transport energy from where it is collected by photon absorption, to reaction centers where the energy is used to drive chemical reactions. In the photosynthetic bacteria Chlorobaculum tepidum, a member of the green sulfur bacteria family, light is absorbed by large antenna complexes called chlorosomes to create an exciton. The exciton is transferred to a protein baseplate attached to the chlorosome, before migrating through the Fenna-Matthews-Olson complex to the reaction center...
August 15, 2017: Small
https://www.readbyqxmd.com/read/28797311/risk-factors-for-adverse-outcomes-in-older-adults-with-blunt-chest-trauma-a-systematic-review
#3
Jake Sawa, Robert S Green, Brent Thoma, Mete Erdogan, Philip J Davis
OBJECTIVES: The objective of this study was to systematically review the published literature for risk factors associated with adverse outcomes in older adults sustaining blunt chest trauma. METHODS: EMBASE and MEDLINE were searched from inception until March 2017 for prognostic factors associated with adverse outcomes in older adults sustaining blunt chest trauma using a pre-specified search strategy. References were independently screened for inclusion by two reviewers...
August 11, 2017: CJEM
https://www.readbyqxmd.com/read/28794178/potential-of-high-affinity-slow-off-rate-modified-aptamer-somamer-reagents-for-mycobacterium-tuberculosis-proteins-as-tools-for-infection-models-and-diagnostic-applications
#4
Theresa Russell, Louis S Green, Taylor Rice, Nicole A Kruh-Garcia, Karen Dobos, Mary A DeGroote, Thomas Hraha, David G Sterling, Nebojsa Janjic, Urs A Ochsner
Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult, due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with adequate sensitivity. We sought to determine whether slow off-rate modified aptamer (SOMAmer) reagents with sub-nanomolar affinity for M. tuberculosis (Mtb) proteins (antigen 85A, 85B, 85C, GroES, GroEL2, DnaK, CFP10, KAD, CFP2, RplL and Tpx) could be useful to diagnose tuberculosis. When incorporated into the multiplexed, array-based proteomic SOMAscan assay, limits of detection reached the sub-picomolar range in 40% serum...
August 9, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28794177/discovery-and-validation-of-a-six-marker-serum-protein-signature-for-the-diagnosis-of-active-pulmonary-tuberculosis
#5
Mary A De Groote, David G Sterling, Thomas Hraha, Theresa Russell, Louis S Green, Kirsten Wall, Stephan Kraemer, Rachel Ostroff, Nebojsa Janjic, Urs A Ochsner
New non-sputum biomarker tests for active tuberculosis (TB) diagnostics are of highest priority for global TB control. We performed in-depth proteomic analysis using the 4000-plex SOMAscan assay on 1470 serum samples from seven TB-endemic countries. All samples were from patients with symptoms and signs suggestive of active pulmonary TB that were systematically confirmed or ruled-out for TB by culture and clinical follow-up. HIV-coinfection was present in 34%and 22% were sputum smear-negative. Serum protein biomarkers were identified by stability selection using L1-regularized logistic regression and by Kolmogorov-Smirnov (KS) statistics...
August 9, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28793974/corticotropin-releasing-factor-receptor-1-antagonism-is-ineffective-for-women-with-posttraumatic-stress-disorder
#6
Boadie W Dunlop, Elisabeth B Binder, Dan Iosifescu, Sanjay J Mathew, Thomas C Neylan, Julius C Pape, Tania Carrillo-Roa, Charles Green, Becky Kinkead, Dimitri Grigoriadis, Barbara O Rothbaum, Charles B Nemeroff, Helen S Mayberg
BACKGROUND: Medication and psychotherapy treatments for posttraumatic stress disorder (PTSD) provide insufficient benefit for many patients. Substantial preclinical and clinical data indicate abnormalities in the hypothalamic-pituitary-adrenal axis, including signaling by corticotropin-releasing factor, in the pathophysiology of PTSD. METHODS: We conducted a double-blind, placebo-controlled, randomized, fixed-dose clinical trial evaluating the efficacy of GSK561679, a corticotropin-releasing factor receptor 1 (CRF1 receptor) antagonist in adult women with PTSD...
July 4, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28769816/signal-reconstruction-of-pulmonary-vein-recordings-using-a-phenomenological-mathematical-model-application-to-pulmonary-vein-isolation-therapy
#7
Harry D Green, Glyn Thomas, John R Terry
Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is commonly initiated by ectopic beats originating from a small myocardial sleeve extending over the pulmonary veins. Pulmonary vein isolation therapy attempts to isolate the pulmonary veins from the left atrium by ablating tissue, commonly by using radiofrequency ablation. During this procedure, the cardiologist records electrical activity using a lasso catheter, and the activation pattern recorded is used as a guide toward which regions to ablate...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28765194/effect-of-green-tea-supplements-on-liver-enzyme-elevation-results-from-a-randomized-intervention-study-in-the-united-states
#8
Zheming Yu, Hamed Samavat, Allison Dostal, Renwei Wang, Carolyn J Torkelson, Chung S Yang, Lesley M Bulter, Thomas W Kensler, Anna H Wu, Mindy S Kurzer, Jian-Min Yuan
Liver injury effects of green tea-based products have been reported in sporadic case reports. However, no study has examined systematically such adverse effects in an unbiased manner. We examined the potential effects of a high, sustained oral dose of green tea extract (GTE) on liver injury measures in a randomized, placebo-controlled, double-blinded phase II clinical trial, which enrolled 1,075 women with the original aim to assess the effect of daily GTE consumption for 12 months on biomarkers of breast cancer risk...
August 1, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28764905/comparison-of-short-and-long-term-exposure-effects-of-cruciferous-and-apiaceous-vegetables-on-carcinogen-metabolizing-enzymes-in-wistar-rats
#9
Jae Kyeom Kim, Noemia Strapazzon, Cynthia M Gallaher, Dwight R Stoll, William Thomas, Daniel D Gallaher, Sabrina P Trudo
Cruciferous and apiaceous vegetables may be chemopreventive due to their ability to modulate carcinogen-metabolizing enzymes but whether the effects on such enzymes are sustained over time is unknown. To examine the short- and long-term effects of the vegetables, rats were fed one of four diets for 7, 30, or 60 d: AIN-93G, CRU (21% cruciferous vegetables-fresh broccoli, green cabbage, watercress), API (9% apiaceous vegetables - fresh parsnips, celery), or API + CRU (10.5% CRU + 4.5% API). Although CRU increased activity and protein expression of cytochrome P450 (CYP) 1A1 and CYP1A2 after 7 d, only activity was sustained after 30 and 60 d...
July 29, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28764033/genetic-and-geochemical-signatures-to-prevent-frauds-and-counterfeit-of-high-quality-asparagus-and-pistachio
#10
Carmela Zannella, Francesca Carucci, Riccardo Aversano, Thomas Prohaska, Simona Vingiani, Domenico Carputo, Paola Adamo
A fingerprinting strategy based on genetic (simple sequence repeat) and geochemical (multielement and (87)Sr/(86)Sr ratio) analysis was tested to prove the geographical origin of high-quality Italian products "White Asparagus from Bassano del Grappa" and "Green Pistachio from Bronte". Genetic analysis generated many polymorphic alleles and different specific amplified fragments in both agriproducts. In addition, a core set of markers was defined. According to variability within production soils and products, potential candidate elements linking asparagus (Zn, P, Cr, Mg, B, K) and pistachio (Mn, P, Cr, Mg, Ti, B, K, Sc, S) to the production areas were identified...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28759587/older-adults-must-hurry-at-pedestrian-lights-a-cross-sectional-analysis-of-preferred-and-fast-walking-speed-under-single-and-dual-task-conditions
#11
Patrick Eggenberger, Sara Tomovic, Thomas Münzer, Eling D de Bruin
Slow walking speed is strongly associated with adverse health outcomes, including cognitive impairment, in the older population. Moreover, adequate walking speed is crucial to maintain older pedestrians' mobility and safety in urban areas. This study aimed to identify the proportion of Swiss older adults that didn't reach 1.2 m/s, which reflects the requirements to cross streets within the green-yellow phase of pedestrian lights, when walking fast under cognitive challenge. A convenience sample, including 120 older women (65%) and men, was recruited from the community (88%) and from senior residences and divided into groups of 70-79 years (n = 59, 74...
2017: PloS One
https://www.readbyqxmd.com/read/28752787/the-xenopus-tadpole-an-in-vivo-model-to-screen-drugs-favoring-remyelination
#12
Abdelkrim Mannioui, Quentin Vauzanges, Jean Baptiste Fini, Esther Henriet, Somya Sekizar, Loris Azoyan, Jean Léon Thomas, David Du Pasquier, Carine Giovannangeli, Barbara Demeneix, Catherine Lubetzki, Bernard Zalc
BACKGROUND: In multiple sclerosis, development of screening tools for remyelination-promoting molecules is timely. OBJECTIVE: A Xenopus transgenic line allowing conditional ablation of myelinating oligodendrocytes has been adapted for in vivo screening of remyelination-favoring molecules. METHODS: In this transgenic, the green fluorescent protein reporter is fused to E. coli nitroreductase and expressed specifically in myelinating oligodendrocytes...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28746851/the-unique-protein-to-protein-carotenoid-transfer-mechanism
#13
Eugene G Maksimov, Nikolai N Sluchanko, Yury B Slonimskiy, Kirill S Mironov, Konstantin E Klementiev, Marcus Moldenhauer, Thomas Friedrich, Dmitry A Los, Vladimir Z Paschenko, Andrew B Rubin
Orange Carotenoid Protein (OCP) is known as an effector and regulator of cyanobacterial photoprotection. This 35 kDa water-soluble protein provides specific environment for blue-green light absorbing keto-carotenoids, which excitation causes dramatic but fully reversible rearrangements of the OCP structure, including carotenoid translocation and separation of C- and N-terminal domains upon transition from the basic orange to photoactivated red OCP form. Although recent studies greatly improved our understanding of the OCP photocycle and interaction with phycobilisomes and the fluorescence recovery protein, the mechanism of OCP assembly remains unclear...
July 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28746741/rigorous-field-experiments-are-essential-to-understand-the-genuine-severity-of-light-pollution-and-to-identify-possible-solutions
#14
Thomas Raap, Rianne Pinxten, Marcel Eens
Ouyang et al. (2017; hereafter O2017) claim to have offered evidence that light pollution affects the health of free-living great tits (Parus major). Since 2012, they illuminated forests with either white, green, red or no artificial light at night (ALAN; Figure 1). Individuals in the white light treatment showed an increase in nightly activity in March 2014, which was linked to changes in health and physiology from March to May 2014. This article is protected by copyright. All rights reserved.
July 26, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28742498/subthalamic-nucleus-gamma-activity-increases-not-only-during-movement-but-also-during-movement-inhibition
#15
Petra Fischer, Alek Pogosyan, Damian M Herz, Binith Cheeran, Alexander L Green, James Fitzgerald, Tipu Z Aziz, Jonathan Hyam, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Peter Brown, Huiling Tan
Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson's disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in ~50% of all trials...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28740889/oncoplastic-breast-surgery-in-the-setting-of-breast-conserving-therapy-a-systematic-review
#16
REVIEW
Jennifer J Yoon, William Ross Green, Sinae Kim, Thomas Kearney, Bruce G Haffty, Firas Eladoumikdachi, Sharad Goyal
Breast-conserving therapy (BCT), or breast-conserving surgery with adjuvant radiation therapy, has become a standard treatment alternative to mastectomy for women with early-stage breast cancer after many long-term studies have reported comparable rates of overall survival and local control. Oncoplastic breast surgery in the setting of BCT consists of various techniques that allow for an excision with a wider margin and a simultaneous enhancement of cosmetic sequelae, making it an ideal breast cancer surgery...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740147/recent-warming-and-cooling-in-the-antarctic-peninsula-region-has-rapid-and-large-effects-on-lichen-vegetation
#17
Leopoldo G Sancho, Ana Pintado, Francisco Navarro, Miguel Ramos, Miguel Angel De Pablo, Jose Manuel Blanquer, Jose Raggio, Fernando Valladares, Thomas George Allan Green
The Antarctic Peninsula has had a globally large increase in mean annual temperature from the 1951 to 1998 followed by a decline that still continues. The challenge is now to unveil whether these recent, complex and somewhat unexpected climatic changes are biologically relevant. We were able to do this by determining the growth of six lichen species on recently deglaciated surfaces over the last 24 years. Between 1991 and 2002, when mean summer temperature (MST) rose by 0.42 °C, five of the six species responded with increased growth...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28734937/longitudinal-examination-of-resilience-after-traumatic-brain-injury-a-traumatic-brain-injury-model-systems-study
#18
Jennifer H Marwitz, Adam P Sima, Jeffrey S Kreutzer, Laura E Dreer, Thomas F Bergquist, Ross Zafonte, Douglas Johnson-Greene, Elizabeth R Felix
OBJECTIVE: To evaluate the trajectory of resilience during the first year following a moderate-severe TBI, factors associated with resilience at 3, 6 and 12-months post-injury, and changing relationships over time between resilience and other factors. DESIGN: Longitudinal analysis of an observational cohort. SETTING: Five inpatient rehabilitation centers. PARTICIPANTS: Patients with TBI (N = 195) enrolled in the resilience module of the TBI Model Systems study with data collected at 3, 6, and 12-month follow-up...
July 19, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28733924/cellular-mechanosensitivity-to-substrate-stiffness-decreases-with-increasing-dissimilarity-to-cell-stiffness
#19
Tamer Abdalrahman, Laura Dubuis, Jason Green, Neil Davies, Thomas Franz
Computational modelling has received increasing attention to investigate multi-scale coupled problems in micro-heterogeneous biological structures such as cells. In the current study, we investigated for a single cell the effects of (1) different cell-substrate attachment (2) and different substrate modulus [Formula: see text] on intracellular deformations. A fibroblast was geometrically reconstructed from confocal micrographs. Finite element models of the cell on a planar substrate were developed. Intracellular deformations due to substrate stretch of [Formula: see text], were assessed for: (1) cell-substrate attachment implemented as full basal contact (FC) and 124 focal adhesions (FA), respectively, and [Formula: see text]140 KPa and (2) [Formula: see text], 140, 1000, and 10,000 KPa, respectively, and FA attachment...
July 21, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28726810/a-randomized-controlled-trial-of-disclosing-genetic-risk-information-for-alzheimer-disease-via-telephone
#20
Kurt D Christensen, Wendy R Uhlmann, J Scott Roberts, Erin Linnenbringer, Peter J Whitehouse, Charmaine D M Royal, Thomas O Obisesan, L Adrienne Cupples, Melissa B Butson, Grace-Ann Fasaye, Susan Hiraki, Clara A Chen, Uwe Siebert, Robert Cook-Deegan, Robert C Green
PurposeTelephone disclosure of genetic test results can improve access to services. To date, studies of its impact have focused on return of Mendelian risk information, principally hereditary cancer syndromes.MethodsIn a multisite trial of Alzheimer disease genetic risk disclosure, asymptomatic adults were randomized to receive test results in person or via telephone. Primary analyses examined patient outcomes 12 months after disclosure.ResultsData from 257 participants showed that telephone disclosure occurred 7...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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