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Thomas greene

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https://www.readbyqxmd.com/read/28075408/time-course-exo-metabolomic-profiling-in-the-green-marine-macroalga-ulva-chlorophyta-for-identification-of-growth-phase-dependent-biomarkers
#1
Taghreed Alsufyani, Anne Weiss, Thomas Wichard
The marine green macroalga Ulva (Chlorophyta) lives in a mutualistic symbiosis with bacteria that influence growth, development, and morphogenesis. We surveyed changes in Ulva's chemosphere, which was defined as a space where organisms interact with each other via compounds, such as infochemicals, nutrients, morphogens, and defense compounds. Thereby, Ulva mutabilis cooperates with bacteria, in particular, Roseovarius sp. strain MS2 and Maribacter sp. strain MS6 (formerly identified as Roseobacter sp. strain MS2 and Cytophaga sp...
January 10, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28074648/mispacking-and-the-fitness-landscape-of-the-green-fluorescent-protein-chromophore-milieu
#2
Shounak Banerjee, Christian D Schenkelberg, Thomas B Jordan, Julia M Reimertz, Emily E Crone, Donna E Crone, Christopher Bystroff
The auto-catalytic maturation of the chromophore in green fluorescent protein (GFP) was thought to require the precise positioning of the side chains surrounding it in the core of the protein, many of which are strongly conserved among homologous fluorescent proteins. In this study, we screened for green fluorescence in an exhaustive set of point mutations of seven residues that make up the chromophore microenvironment, excluding R96 and E222 because mutations of these positions have been previously characterized...
January 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28073397/identification-of-new-members-of-the-escherichia-coli-k-12-mg1655-slya-regulon
#3
Thomas Curran, Fatima Abacha, Stephen Hibberd, Matthew Rolfe, Melissa Lacey, Jeffrey Green
SlyA is a member of the MarR family of bacterial transcriptional regulators. Previously, SlyA has been shown to directly regulate only two operons in Escherichia coli K-12 MG1655, fimB and hlyE (clyA). In both cases SlyA activates gene expression by antagonizing repression by the nucleoid associated protein H-NS. Here the transcript profiles of aerobic glucose-limited steady-state chemostat cultures of E. coli K-12 MG1655, slyA mutant and slyA over-expression strains are reported. The transcript profile of the slyA mutant was not significantly different to that of the parent; however, that of the slyA expression strain was significantly different from that of the vector control...
January 10, 2017: Microbiology
https://www.readbyqxmd.com/read/28070454/marine-turtles-are-not-fussy-nesters-a-novel-test-of-small-scale-nest-site-selection-using-structure-from-motion-beach-terrain-information
#4
Ilana Kelly, Javier X Leon, Ben L Gilby, Andrew D Olds, Thomas A Schlacher
BACKGROUND: Nest selection is widely regarded as a key process determining the fitness of individuals and viability of animal populations. For marine turtles that nest on beaches, this is particularly pivotal as the nesting environment can significantly control reproductive success.The aim of this study was to identify the environmental attributes of beaches (i.e., morphology, vegetation, urbanisation) that may be associated with successful oviposition in green and loggerhead turtle nests...
2017: PeerJ
https://www.readbyqxmd.com/read/28053218/singleton-st382-an-emerging-clonal-group-of-listeria-monocytogenes-associated-with-three-multistate-outbreaks-linked-to-contaminated-stone-fruit-caramel-apples-and-leafy-green-salad
#5
Yi Chen, Yan Luo, James Pettengill, Ruth Timme, David Melka, Matthew Doyle, Alikeh Jackson, Mickey Parish, Thomas S Hammack, Marc Allard, Eric W Brown, Errol A Strain
Three multistate outbreaks between 2014 and 2016, involving case patients in and outside the United States, were linked to stone fruit, caramel apples and packaged leafy green salad contaminated with Listeria monocytogenes singleton ST382. Isolates from these outbreaks and other ST382 isolates not associated with these outbreaks were analyzed by whole genome sequencing (WGS) analysis. The primary difference among these three ST382 outbreak strains were single nucleotide polymorphisms (SNPs). WGS analysis using these SNPs differentiated ST382 from a clonal complex 1 outbreak strain co-contaminating the caramel apples...
January 4, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28047956/tu-ab-bra-10-treatment-of-gastric-malt-lymphoma-utilizing-a-magnetic-resonance-image-guided-radiation-therapy-mr-igrt-system-evaluation-of-gating-feasibility
#6
T Mazur, H Gach, A Chundury, B Fischer-Valuck, J Huang, M Thomas, O Green
PURPOSE: To evaluate the feasibility of real-time, real-anatomy tracking and gating for gastric lymphoma patients treated with magnetic resonance image-guided radiation therapy (MR-IGRT) METHODS: Over the last 2 years, 8 patients with gastric lymphoma were treated with 0.3-T, Co-60 MR-IGRT. Post-treatment analysis of real-time cine imaging in the sagittal plane during each patient's treatment revealed significant motion of the stomach. While this motion was accounted for with generous PTV margins, the system's capability for real-time, real-anatomy tracking could be used to reduce treatment margins by gating...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040159/relative-effectiveness-of-selected-preenrichment-media-for-the-detection-of-salmonella-from-leafy-green-produce-and-herbs
#7
Andrew P Jacobson, Hua Wang, Vikas S Gill, Robert Duvall, Gabriela Arce, Stuart Chirtel, Thomas S Hammack
Four buffered preenrichment media (BAX(®) System MP Media (BAX)), Universal Preenrichment Broth (UPB), modified Buffered Peptone Water (mBPW), and Buffered Peptone Water (BPW)) were compared with lactose broth (LB) in the Bacteriological Analytical Manual's (BAM) Salmonella culture method for the analysis of 9 leafy green produce and herb types. Artificially contaminated test portions were pre-enriched in each medium and the results were analyzed statistically using Fisher's Exact 2-tailed F test (p < 0...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28012435/estimation-of-radiation-dosimetry-for-68-ga-hbed-cc-psma-11-in-patients-with-suspected-recurrence-of-prostate-cancer
#8
Mark A Green, Jacob A Eitel, James W Fletcher, Carla J Mathias, Mark A Tann, Thomas Gardner, Michael O Koch, Wendy Territo, Heather Polson, Gary D Hutchins
INTRODUCTION: This study was performed to estimate the human radiation dosimetry for [(68)Ga]Ga-HBED-CC (PSMA-11) ((68)Ga PSMA-11). METHODS: Under an RDRC-approved research protocol, we evaluated the biodistribution and pharmacokinetics of (68)Ga PSMA-11 with serial PET imaging following intravenous administration to nine prostate cancer patients in whom clinical [(11)C]acetate PET/CT exams had been independently performed under Expanded Access IND 118,204. List-mode imaging was performed over the initial 0-10min post-injection with the pelvis in the field-of-view...
November 4, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28011743/5-ht2c-receptor-knockdown-in-the-amygdala-inhibits-neuropathic-pain-related-plasticity-and-behaviors
#9
Guangchen Ji, Wei Zhang, Lenin Mahimainathan, Madhusudhanan Narasimhan, Takaki Kiritoshi, Xiuzhen Fan, Jigong Wang, Thomas A Green, Volker Neugebauer
: Neuroplasticity in the amygdala drives pain-related behaviors. The central nucleus (CeA) serves major amygdala output functions and can generate emotional-affective behaviors and modulate nocifensive responses. The CeA receives excitatory and inhibitory inputs from the basolateral nucleus (BLA), and serotonin receptor subtype 5-HT2CR in the BLA, but not CeA, has been implicated anxiogenic behaviors and anxiety disorders. Here we tested the hypothesis that 5-HT2CR in the BLA plays a critical role in CeA plasticity and neuropathic pain behaviors in the rat spinal nerve ligation (SNL) model...
December 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28007997/stimulating-at-the-right-time-phase-specific-deep-brain-stimulation
#10
Hayriye Cagnan, David Pedrosa, Simon Little, Alek Pogosyan, Binith Cheeran, Tipu Aziz, Alexander Green, James Fitzgerald, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Marwan Hariz, Karl J Friston, Timothy Denison, Peter Brown
SEE MOLL AND ENGEL DOI101093/AWW308 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Brain regions dynamically engage and disengage with one another to execute everyday actions from movement to decision making. Pathologies such as Parkinson's disease and tremor emerge when brain regions controlling movement cannot readily decouple, compromising motor function. Here, we propose a novel stimulation strategy that selectively regulates neural synchrony through phase-specific stimulation. We demonstrate for the first time the therapeutic potential of such a stimulation strategy for the treatment of patients with pathological tremor...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28007400/consequences-of-acute-nav1-1-exposure-to-deltamethrin
#11
T F James, Miroslav N Nenov, Cynthia M Tapia, Marzia Lecchi, Shyny Koshy, Thomas A Green, Fernanda Laezza
BACKGROUND: Pyrethroid insecticides are the most popular class of insecticides in the world, despite their near-ubiquity, their effects of delaying the onset of inactivation of voltage-gated sodium (Nav) channels have not been well-evaluated in all the mammalian Nav isoforms. OBJECTIVE: Here we compare the well-studied Nav1.6 isoforms to the less-understood Nav1.1 in their responses to acute deltamethrin exposure. METHODS: We used patch-clamp electrophysiology to record sodium currents encoded by either Nav1...
December 19, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/28005676/en-face-optical-coherence-tomography-and-optical-coherence-tomography-angiography-of-multiple-evanescent-white-dot-syndrome-new-insights-into-pathogenesis
#12
Francesco Pichi, Sunil K Srvivastava, Saradha Chexal, Andrea Lembo, Luiz H Lima, Piergiorgio Neri, Andrea Saitta, Jay Chhablani, Thomas A Albini, Paolo Nucci, K Bailey Freund, Hyewon Chung, Careen Y Lowder, David Sarraf
PURPOSE: To localize the various levels of abnormalities in multiple evanescent white dot syndrome by comparing "en face" optical coherence tomography (OCT) and OCT angiography with various conventional imaging modalities. METHODS: In this retrospective case series, multimodal imaging was performed in 9 retinal centers on 36 patients with multiple evanescent white dot syndrome and included widefield fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography, and B-scan and "en face" C-scan enhanced depth imaging and spectral domain OCT...
December 2016: Retina
https://www.readbyqxmd.com/read/28002709/shortened-antimicrobial-treatment-for-acute-otitis-media-in-young-children
#13
RANDOMIZED CONTROLLED TRIAL
Alejandro Hoberman, Jack L Paradise, Howard E Rockette, Diana H Kearney, Sonika Bhatnagar, Timothy R Shope, Judith M Martin, Marcia Kurs-Lasky, Susan J Copelli, D Kathleen Colborn, Stan L Block, John J Labella, Thomas G Lynch, Norman L Cohen, MaryAnn Haralam, Marcia A Pope, Jennifer P Nagg, Michael D Green, Nader Shaikh
Background Limiting the duration of antimicrobial treatment constitutes a potential strategy to reduce the risk of antimicrobial resistance among children with acute otitis media. Methods We assigned 520 children, 6 to 23 months of age, with acute otitis media to receive amoxicillin-clavulanate either for a standard duration of 10 days or for a reduced duration of 5 days followed by placebo for 5 days. We measured rates of clinical response (in a systematic fashion, on the basis of signs and symptomatic response), recurrence, and nasopharyngeal colonization, and we analyzed episode outcomes using a noninferiority approach...
22, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28000325/breast-conservation-in-ductal-carcinoma-in-situ-dcis-what-defines-optimal-margins
#14
REVIEW
Michael S Toss, Sarah E Pinder, Andrew R Green, Jeremy Thomas, David A L Morgan, John F R Robertson, Ian O Ellis, Emad A Rakha
The introduction of mammographic screening has resulted in a rise in the detection rate of ductal carcinoma in situ (DCIS), currently accounting for one-fifth of screen-detected breast cancers. Although 60-70% of DCIS are treated with breast-conserving surgery (BCS) with or without radiotherapy, the frequency of subsequent surgery to re-excise positive margins in order to reduce the probability of recurrences remains high. DCIS recurrence is associated not only with financial, health and psychological implications; approximately half these recurrences are invasive disease...
November 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27995588/fabrication-and-characterization-of-biosilver-nanoparticles-loaded-calcium-pectinate-nano-micro-dual-porous-antibacterial-wound-dressings
#15
Robin Augustine, Anitha Augustine, Nandakumar Kalarikkal, Sabu Thomas
Development of materials for medical applications using biologically derived materials by green approaches is emerging as an important focus in the present healthcare scenario. Herein the first time, we report the plant extract mediated ultra-rapid biosynthesis of silver nanoparticles using whole plant extracts of Biophytum sensitivum. Synthesized nanoparticles were immobilized in nano-micro dual-porous calcium pectinate scaffolds for wound dressing application. Pectinate wound dressings containing silver nanoparticles have shown excellent antibacterial property and exudate uptake capacity while being biocompatible to the human cells...
December 2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27995453/laparoscopic-glissonean-pedicle-transection-takasaki-for-negative-fluorescent-counterstaining-of-segment-6
#16
Takashi Mizuno, Rahul Sheth, Masakazu Yamamoto, Hyun Seon C Kang, Suguru Yamashita, Thomas A Aloia, Yun Shin Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, C Conrad
BACKGROUND: The portal pedicles are wrapped in connective tissue known as the Walaeus sheath, which abut Laennec's capsule covering the liver parenchyma. Precise knowledge of this anatomic relationship allows for dissection of this interspace and early control of the segmental portal pedicle (Glissonean pedicle transection method [GPTM], Takasaki approach). (1,2) Subsequent systemic administration of indocyanine green (ICG) leads to negative counterstaining of the segment to be resected...
December 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27994558/epigallocatechin-3-gallate-accelerates-relaxation-and-ca-2-transient-decay-and-desensitizes-myofilaments-in-healthy-and-mybpc3-targeted-knock-in-cardiomyopathic-mice
#17
Felix W Friedrich, Frederik Flenner, Mahtab Nasib, Thomas Eschenhagen, Lucie Carrier
Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac muscle disease with left ventricular hypertrophy, interstitial fibrosis and diastolic dysfunction. Increased myofilament Ca(2+) sensitivity could be the underlying cause of diastolic dysfunction. Epigallocatechin-3-gallate (EGCg), a catechin found in green tea, has been reported to decrease myofilament Ca(2+) sensitivity in HCM models with troponin mutations. However, whether this is also the case for HCM-associated thick filament mutations is not known...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27993732/fast-therapeutic-dna-internalization-a-high-potential-transfection-system-based-on-a-peptide-mimicking-cationic-lipid
#18
Christopher Janich, Shashank Reddy Pinnapireddy, Frank Erdmann, Thomas Groth, Andreas Langner, Udo Bakowsky, Christian Wölk
The delivery of nucleic acids into cells is a determining factor for successful gene therapy. In this study we investigate the uptake and time dependent processing of a lipid-based non-viral nucleic acid delivery system composed of a peptide-mimicking cationic lipid (N-{6-amino-1-[N-(9Z)-octadec-9-enylamino]-1-oxohexan-(2S)-2-yl}-N'-{2-[N,N-bis(2-aminoethyl)amino]ethyl}-2-hexadecylpropandiamide - OH4) and a phospholipid (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine - DOPE). Studies by confocal laser scanning microscopy (CLSM) indicate a rapid internalization of fluorescent labelled DNA within 1h...
December 18, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27993560/step-changes-in-leaf-oil-accumulation-via-iterative-metabolic-engineering
#19
Thomas Vanhercke, Uday K Divi, Anna El Tahchy, Qing Liu, Madeline Mitchell, Matthew C Taylor, Peter J Eastmond, Fiona Bryant, Anna Mechanicos, Cheryl Blundell, Yao Zhi, Srinivas Belide, Pushkar Shrestha, Xue-Rong Zhou, Jean-Philippe Ral, Rosemary G White, Allan Green, Surinder P Singh, James R Petrie
Synthesis and accumulation of plant oils in the entire vegetative biomass offers the potential to deliver yields surpassing those of oilseed crops. However, current levels still fall well short of those typically found in oilseeds. Here we show how transcriptome and biochemical analyses pointed to a futile cycle in a previously established Nicotiana tabacum line, accumulating up to 15% (dry weight) of the storage lipid triacylglycerol in leaf tissue. To overcome this metabolic bottleneck, we either silenced the SDP1 lipase or overexpressed the Arabidopsis thaliana LEC2 transcription factor in this transgenic background...
January 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/27991927/caspase-2-mediated-cell-death-is-required-for-deleting-aneuploid-cells
#20
S Dawar, Y Lim, J Puccini, M White, P Thomas, L Bouchier-Hayes, D R Green, L Dorstyn, S Kumar
Caspase-2, one of the most evolutionarily conserved of the caspase family, has been implicated in maintenance of chromosomal stability and tumour suppression. Caspase-2 deficient (Casp2(-/-)) mice develop normally but show premature ageing-related traits and when challenged by certain stressors, succumb to enhanced tumour development and aneuploidy. To test how caspase-2 protects against chromosomal instability, we utilized an ex vivo system for aneuploidy where primary splenocytes from Casp2(-/-) mice were exposed to anti-mitotic drugs and followed up by live cell imaging...
December 19, 2016: Oncogene
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