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https://www.readbyqxmd.com/read/28857762/strangulation-and-its-role-in-multiple-causes-of-death
#1
Leigh Hlavaty, LokMan Sung
Forensic pathologists have a duty to determine the cause and manner of death and are bound by international guidelines in the completion of the death certificate. Sometimes, there are complex circumstances surrounding a death that cannot be captured in the structure of the death certificate and its requirement of listing only 1 cause of death per line. Cases may have multiple causes of death with comorbid medical conditions or inflicted injuries that equally contribute to the ultimate demise. Compared with other forms of homicide, autopsy evidence of strangulation will often be found with other life-threatening traumatic injuries...
August 26, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28657908/idiopathic-megacolon-report-of-2-deaths-with-review-of-the-literature
#2
Leigh Hlavaty, LokMan Sung
Abnormal dilation of the colon and rectum can develop from a range of disease processes. When encountered at autopsy, its contribution to death requires assessment and a thorough investigation of its origins. Elimination of known causes elicits a diagnosis of idiopathic megacolon. This entity is uncommonly encountered and presents with similar gross anatomic findings as Hirschsprung disease. Although death is infrequent, it most commonly results from disruption of the bowel wall and subsequent peritonitis. The authors report 2 rare deaths from idiopathic megacolon with retained integrity of the bowel wall...
September 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28652663/drug-induced-liver-injury-in-inflammatory-bowel-disease-1-year-prospective-observational-study
#3
Tomas Koller, Martina Galambosova, Simona Filakovska, Michaela Kubincova, Tibor Hlavaty, Jozef Toth, Anna Krajcovicova, Juraj Payer
AIM: To analyze 1-year liver injury burden in inflammatory bowel disease (IBD) patients. METHODS: During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase (AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase (GGT) were measured at baseline, 3 mo prior to study entry and prospectively every 3 mo for 1 year. Liver injury patterns were predefined as: Grade 1 in ALT 1-3 × upper limit of normal (ULN), grade 2 in ALT > 3 × ULN, hepatocellular injury in ALT > 2 × ULN, cholestatic injury in simultaneous GGT and ALP elevation > ULN...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28624994/expression-of-ezrin-and-moesin-in-primary-breast-carcinoma-and-matched-lymph-node-metastases
#4
M Bartova, J Hlavaty, Y Tan, C Singer, K Pohlodek, J Luha, I Walter
Ezrin, radixin, moesin (ERM) are important membrane-cytoskeletal crosslinkers and are suggested to play important role in cancer progression and metastasis. Even though ERM proteins were generally considered to be functionally redundant and the most studied was ezrin, recent studies highlight their distinct roles in metastatic process. Little information is available regarding the role of individual ERM proteins and their phosphorylated forms in human breast cancer. Our study is the first to examine expression of ezrin, moesin and their phosphorylated forms in primary breast tumors and matched lymph node metastases (LNMs) and their correlation with clinicopathological variables...
June 17, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28605023/the-modern-compound-bow
#5
LokMan Sung, Kilak Kesha, Sarah Avedschmidt, Kelly Root, Leigh Hlavaty
Bows and arrows are ancient weapons that have risen and fallen as the preeminent armaments used by man. Because of the ubiquity of firearms, fatalities from archery injuries in the United States have radically declined. However, when deaths involving this weapon do present themselves, the paucity of reference materials can be a hurdle for forensic pathologists and other forensic scientists. This article will provide a brief history of the origins of the bow and the inception of the compound bow. Comparing and contrasting the structures comprising a traditional bow to those of the modern compound bow will provide insight into how these components function in unison to propel arrows...
June 12, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28453909/cardiotoxicity-and-cardiomyopathy-in-children-and-young-adult-survivors-of-hematopoietic-stem-cell-transplant
#6
REVIEW
Seth J Rotz, Thomas D Ryan, Joel Hlavaty, Stephen A George, Javier El-Bietar, Christopher E Dandoy
Cardiomyopathy is common in long-term survivors of pediatric hematopoietic stem cell transplant (HSCT). Events occurring before and after HSCT when combined with specific insults during HSCT likely contribute to long-term risk. Strategies for detecting subclinical cardiomyopathy prior to patients developing overt heart failure are under investigation. Changes in HSCT preparative regimens and cardioprotective medications administered during chemotherapy may alter the risk for cardiomyopathy. Interventions in long-term survivors such as lifestyle modification and cardioactive medications are of increasing importance...
November 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28401673/morphology-of-modern-arrowhead-tips-on-human-skin-analog
#7
LokMan Sung, Kilak Kesha, Jeffrey Hudson, Kelly Root, Leigh Hlavaty
Archery has experienced a recent resurgence in participation and has seen increases in archery range attendance and in children and young adults seeking archery lessons. Popular literature and movies prominently feature protagonists well versed in this form of weaponry. Periodic homicide cases in the United States involving bows are reported, and despite this and the current interest in the field, there are no manuscripts published on a large series of arrow wounds. This experiment utilizes a broad selection of modern arrowheads to create wounds for comparison...
April 12, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28397143/tropism-intracerebral-distribution-and-transduction-efficiency-of-hiv-and-siv-based-lentiviral-vectors-after-injection-into-the-mouse-brain-a-qualitative-and-quantitative-in-vivo-study
#8
Juraj Hlavatý, Zbyněk Tonar, Matthias Renner, Sylvia Panitz, Helga Petznek, Matthias Schweizer, Silke Schüle, Björn-Philipp Kloke, Rudolf Moldzio, Kirsti Witter
Lentiviruses are suitable to transfer potential therapeutic genes into non-replicating cells such as neurons, but systematic in vivo studies on transduction of neural cells within the complete brain are missing. We analysed the distribution of transduced cells with respect to brain structure, virus tropism, numbers of transduced neurons per brain, and influence of the Vpx or Vpr accessory proteins after injection of vectors based on SIVsmmPBj, HIV-2, and HIV-1 lentiviruses into the right striatum of the mouse brain...
September 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28394368/the-injured-heart-early-cardiac-effects-of-hematopoietic-stem-cell-transplantation-in-children-and-young-adults
#9
S J Rotz, T D Ryan, S Jodele, J L Jefferies, A Lane, A Pate, R Hirsch, J Hlavaty, A E Levesque, M D Taylor, M Cash, K C Myers, J A El-Bietar, S M Davies, C E Dandoy
We hypothesized that subclinical cardiac injury in the peri-transplant period is more frequent than currently appreciated in children and young adults. We performed echocardiographic screening on 227 consecutive patients prior to hematopoietic stem cell transplantation (HSCT), and 7, 30 and 100 days after transplant. We measured cardiac biomarkers cardiac troponin-I (cTn-I), and soluble suppressor of tumorigenicity 2 (sST2) prior to transplant, during conditioning, and days +7, +14, +28 and +49 in 26 patients...
August 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28172944/p567-cross-sectional-study-of-the-low-serum-concentrations-of-testosterone-in-ibd-and-the-influence-on-disease-activity
#10
T Hlavaty, A Krajcovicova, J Kollerova, T Koller, Z Leskova, I Sturdik, J Payer
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172883/p750-prevalence-and-risk-factors-of-cholelithiasis-in-patients-with-crohn-s-disease
#11
I Sturdik, A Krajcovicova, Z Leskova, R Decka, V Cernotova, T Koller, M Huorka, T Hlavaty
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172845/p312-trabecular-bone-score-in-patients-with-inflammatory-bowel-diseases
#12
A Krajcovicova, T Hlavaty, Z Killinger, M Kuzma, I Sturdik, Z Leskova, J Payer
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172718/p595-the-influence-of-vitamin-d-on-expression-of-cytokines-mrna-in-ibd
#13
Z Leskova, A Krajčovičová, K Šoltys, S Stuchlík, I Šturdík, T Koller, M Huorka, T Hlavatý
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27991890/pericardial-effusion-requiring-surgical-intervention-after-stem-cell-transplantation-a-case-series
#14
T M Pfeiffer, S J Rotz, T D Ryan, R Hirsch, M Taylor, R Chima, A Pate, J Hlavaty, M Grimley, K Myers, J El-Bietar, S M Davies, S Jodele, C Dandoy
No abstract text is available yet for this article.
April 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27921304/hyperthermia-thermal-injuries-and-death-from-a-forced-convection-heat-source-a-case-report-and-experimental-model
#15
Amanda O Fisher-Hubbard, LokMan Sung, Sean A Hubbard, Leigh Hlavaty
Heat-related deaths of children are most often encountered in the context of enclosed vehicles in summer months. Deviating from this, a 16-month-old boy was found unresponsive in a stroller that was placed adjacent to a space heater during mid-winter. The cause of death was hyperthermia and thermal injuries. Manner of death determination was difficult due to alleged surrounding circumstances. To understand the time-course of this child's injuries, a child death scene investigation was performed; the stroller and space heater were recovered...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27900870/-hemosuccus-pancreaticus-rare-complication-of-chronic-pancreatitis
#16
Igor Šturdík, Martin Kužma, Zuzana Kužmová, Tomáš Koller, Vladimír Javorka, Tibor Hlavatý, Juraj Payer
Hemosuccus pancreaticus is a rare cause of upper digestive tract bleeding, it is hemorrhage to the pancreatic duct. A case report is about 56-years old man who was repeatedly hospitalized and suffered from melena and enterorrhagia during 3 years. Imaging studies did not clearly identified etiology of bleeding or source of hemorrhage was wrong identified. Finally, hemosuccus pancreaticus from collaterals of pseudoaneurysm after embolization was suspected because of repeating hemorrhage and embolization of a gastroduodenal artery in history...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27900754/ezrin-and-moesin-expression-in-canine-and-feline-osteosarcoma
#17
Juraj Hlavaty, Birgitt Wolfesberger, Marlene Hauck, Barbara Obermayer-Pietsch, Andrea Fuchs-Baumgartinger, Ingrid Miller, Ingrid Walter
Biological features of canine osteosarcomas (OS) differ markedly from those found in feline and resemble more human osteosarcomas, in particular for their high rate of metastasis and poor prognosis. Ezrin, radixin and moesin are members of the ERM protein family and link the actin cytoskeleton with the cell membrane. Ezrin and moesin have been shown to be of prognostic significance in tumor progression due to their role in the metastatic process. The objective of this study was to analyze ezrin and moesin protein expression in a series of dog (n = 16) and cat (n = 8) osteosarcoma samples using immunohistochemistry and western blot techniques...
August 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/27782938/examination-of-ricochet-gunshot-wounds-from-commonly-encountered-surfaces
#18
Leigh Hlavaty, Sarah Avedschmidt, Kelly Root, Jeffrey Amley, LokMan Sung
Proper interpretation of gunshot wounds is vital for the forensic pathologist and requires experience and expertise, as well as consultation with a firearms and ballistics expert and careful scene investigation in cases of atypical gunshot wounds. This study is the first large-series examining ricochet gunshot wounds involving different firearm calibers. Typical gunshot wounds created from 4 handgun calibers (22 Long Rifle, 9 × 19 mm Parabellum, .40 Smith &Wesson, and .45 Automatic Colt Pistol) and 2 rifle calibers (5...
December 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27698817/stem-cell-growth-factor-receptor-in-canine-vs-feline-osteosarcomas
#19
Birgitt Wolfesberger, Andrea Fuchs-Baumgartinger, Juraj Hlavaty, Florian R Meyer, Martin Hofer, Ralf Steinborn, Christiane Gebhard, Ingrid Walter
Osteosarcoma is considered the most common bone cancer in cats and dogs, with cats having a much better prognosis than dogs, since the great majority of dogs with osteosarcoma develop distant metastases. In search of a factor possibly contributing to this disparity, the stem cell growth factor receptor KIT was targeted, and the messenger (m)RNA and protein expression levels of KIT were compared in canine vs. feline osteosarcomas, as well as in normal bone. The mRNA expression of KIT was quantified by reverse transcription-quantitative polymerase chain reaction, and was observed to be significantly higher in canine (n=14) than in feline (n=5) osteosarcoma samples (P<0...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27571170/current-analysis-of-hangings-that-deviates-from-recently-published-studies
#20
Leigh Hlavaty, William Kasper, LokMan Sung
The constellation of injuries observed in hangings is a subject receiving frequent review in forensic pathology literature. Whereas recent studies have reported high concordance between hangings and internal findings such as strap muscle hemorrhages and hyoid bone and thyroid cartilage fractures, a 2-part study examining autopsied suicidal hangings over a 9-year period at the Wayne County Medical Examiner's Office produced markedly differing results. Retrospectively and prospectively, external and internal autopsy observations were correlated with factors such as age, sex, body height, body mass index, ligature, and height of suspension...
December 2016: American Journal of Forensic Medicine and Pathology
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