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https://www.readbyqxmd.com/read/27900870/-hemosuccus-pancreaticus-rare-complication-of-chronic-pancreatitis
#1
Igor Šturdík, Martin Kužma, Zuzana Kužmová, Tomáš Koller, Vladimír Javorka, Tibor Hlavatý, Juraj Payer
Hemosuccus pancreaticus is a rare cause of upper digestive tract bleeding, it is hemorrhage to the pancreatic duct. A case report is about 56-years old man who was repeatedly hospitalized and suffered from melena and enterorrhagia during 3 years. Imaging studies did not clearly identified etiology of bleeding or source of hemorrhage was wrong identified. Finally, hemosuccus pancreaticus from collaterals of pseudoaneurysm after embolization was suspected because of repeating hemorrhage and embolization of a gastroduodenal artery in history...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27900754/ezrin-and-moesin-expression-in-canine-and-feline-osteosarcoma
#2
Juraj Hlavaty, Birgitt Wolfesberger, Marlene Hauck, Barbara Obermayer-Pietsch, Andrea Fuchs-Baumgartinger, Ingrid Miller, Ingrid Walter
Biological features of canine osteosarcomas (OS) differ markedly from those found in feline and resemble more human osteosarcomas, in particular for their high rate of metastasis and poor prognosis. Ezrin, radixin and moesin are members of the ERM protein family and link the actin cytoskeleton with the cell membrane. Ezrin and moesin have been shown to be of prognostic significance in tumor progression due to their role in the metastatic process. The objective of this study was to analyze ezrin and moesin protein expression in a series of dog (n = 16) and cat (n = 8) osteosarcoma samples using immunohistochemistry and western blot techniques...
November 30, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27782938/examination-of-ricochet-gunshot-wounds-from-commonly-encountered-surfaces
#3
Leigh Hlavaty, Sarah Avedschmidt, Kelly Root, Jeffrey Amley, LokMan Sung
Proper interpretation of gunshot wounds is vital for the forensic pathologist and requires experience and expertise, as well as consultation with a firearms and ballistics expert and careful scene investigation in cases of atypical gunshot wounds. This study is the first large-series examining ricochet gunshot wounds involving different firearm calibers. Typical gunshot wounds created from 4 handgun calibers (22 Long Rifle, 9 × 19 mm Parabellum, .40 Smith &Wesson, and .45 Automatic Colt Pistol) and 2 rifle calibers (5...
December 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27698817/stem-cell-growth-factor-receptor-in-canine-vs-feline-osteosarcomas
#4
Birgitt Wolfesberger, Andrea Fuchs-Baumgartinger, Juraj Hlavaty, Florian R Meyer, Martin Hofer, Ralf Steinborn, Christiane Gebhard, Ingrid Walter
Osteosarcoma is considered the most common bone cancer in cats and dogs, with cats having a much better prognosis than dogs, since the great majority of dogs with osteosarcoma develop distant metastases. In search of a factor possibly contributing to this disparity, the stem cell growth factor receptor KIT was targeted, and the messenger (m)RNA and protein expression levels of KIT were compared in canine vs. feline osteosarcomas, as well as in normal bone. The mRNA expression of KIT was quantified by reverse transcription-quantitative polymerase chain reaction, and was observed to be significantly higher in canine (n=14) than in feline (n=5) osteosarcoma samples (P<0...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27571170/current-analysis-of-hangings-that-deviates-from-recently-published-studies
#5
Leigh Hlavaty, William Kasper, LokMan Sung
The constellation of injuries observed in hangings is a subject receiving frequent review in forensic pathology literature. Whereas recent studies have reported high concordance between hangings and internal findings such as strap muscle hemorrhages and hyoid bone and thyroid cartilage fractures, a 2-part study examining autopsied suicidal hangings over a 9-year period at the Wayne County Medical Examiner's Office produced markedly differing results. Retrospectively and prospectively, external and internal autopsy observations were correlated with factors such as age, sex, body height, body mass index, ligature, and height of suspension...
August 26, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27340667/expression-of-progesterone-receptor-membrane-component-1-pgrmc1-progestin-and-adipoq-receptor-7-paqpr7-and-plasminogen-activator-inhibitor-1-rna-binding-protein-pairbp1-in-glioma-spheroids-in-vitro
#6
Juraj Hlavaty, Reinhard Ertl, Ingrid Miller, Cordula Gabriel
Objective. Some effects of progesterone on glioma cells can be explained through the slow, genomic mediated response via nuclear receptors; the other effects suggest potential role of a fast, nongenomic action mediated by membrane-associated progesterone receptors. Methods. The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27272202/inflammation-induced-transgene-expression-in-genetically-engineered-equine-mesenchymal-stem-cells
#7
Simone Gabner, Juraj Hlavaty, Karsten Velde, Matthias Renner, Florien Jenner, Monika Egerbacher
BACKGROUND: Osteoarthritis, a chronic and progressive degenerative joint disorder, ranks amongst the top five causes of disability. Given the high incidence, associated socioeconomic costs and the absence of effective disease-modifying therapies of osteoarthritis, cell-based treatments offer a promising new approach. Owing to their paracrine, differentiation and self-renewal abilities, mesenchymal stem cells (MSCs) have great potential for regenerative medicine, which might be further enhanced by targeted gene therapy...
August 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27256494/heterogeneity-within-domestic-violence-exposure-young-adults-retrospective-experiences
#8
Megan L Haselschwerdt, Kathleen Hlavaty, Camille Carlson, Mallory Schneider, Lauren Maddox, Megan Skipper
Using Holden's taxonomy of domestic violence (DV) exposure as a guiding framework, the current study examined young adults' diverse DV exposure experiences. Twenty-five young adults (ages 19-25) exposed to father-perpetrated DV during their childhood and adolescence were interviewed using a qualitative descriptive design. Data analyses focused on coercive control exposure through reports of non-physical abuse tactics, types of exposure (e.g., direct, indirect), physical violence exposure (e.g., severity, frequency), and child abuse and harsh parenting practices...
June 1, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27172442/-fecal-microbiota-transplantation
#9
REVIEW
Igor Šturdík, Tibor Hlavatý, Juraj Payer
Fecal microbiota transplantation (FMT) is a therapeutic method, in which the fecal microflora from healthy donors is transmitted to the patient to restore the healthy microbial composition of the gut. In the recent years, there is a growing interest in the therapeutic potential of FMT in various diseases. The standard FMT protocols do not exist. Procedures of FMT vary in several aspects such as donor selection, preparation of fecal material, preparation of the recipient and administration way. FMT appears to be the most successful in the treatment of recurrent Clostridium difficile infection (CDI), randomized controlled studies reported 90 % success rate...
February 2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27124970/-hormonal-changes-in-inflammatory-bowel-disease
#10
Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer
Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn's disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease. In the article we analyze correlation of IBD with gonadal hormone production and fertility, with adrenal function, with the function and morphology of the thyroid, with growth hormone production and growth disorders in children, and with bone mineral density reduction...
December 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27075383/relapse-rates-of-inflammatory-bowel-disease-patients-in-deep-and-clinical-remission-after-discontinuing-anti-tumor-necrosis-factor-alpha-therapy
#11
T Hlavaty, A Krajcovicova, J Letkovsky, I Sturdik, T Koller, J Toth, M Huorka
BACKGROUND AND AIMS: Relapse rates after discontinuing anti-tumor necrosis factor-α (TNFα) therapy of inflammatory bowel disease (IBD) patients in deep remission are poorly understood. This prospective single-center open-label study evaluated the relapse rates of IBD patients after stopping anti-TNFα therapy. METHODS: All IBD patients who were in clinical remission and stopped anti-TNFα therapy in 2011-2013 and were followed up for at least 12 months were enrolled...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27049661/applying-the-principles-of-homicide-by-heart-attack
#12
Leigh Hlavaty, LokMan Sung
Homicide by heart attack is a well-established model in forensic pathology that describes death elicited during or immediately after a criminal act where a threat or fear of physical injury is present. After its introduction nearly 4 decades ago, the principle has undergone a handful of modifications but still maintains its core concepts. All cases of this nature during a 20-year period at the Wayne County Medical Examiner's Office were compared and contrasted for demographics, circumstances and scene investigation, and autopsy and toxicology findings...
June 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/26955990/-hormonal-changes-in-inflammatory-bowel-disease
#13
Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer
UNLABELLED: Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn´s disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease...
2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26898415/the-physiological-expression-of-scavenger-receptor-sr-b1-in-canine-endometrial-and-placental-epithelial-cells-and-its-potential-involvement-in-pathogenesis-of-pyometra
#14
C Gabriel, A Becher-Deichsel, J Hlavaty, G Mair, I Walter
Pyometra, the purulent inflammation of the uterus, is a common uterine disease of bitches that has potentially life-threatening consequences. The opportunistic bacterial infection of the uterus often progresses into the serious systemic inflammatory response syndrome. In a previous study, we characterized epithelial foam cells in the canine endometrial surface occurring in metestrus, and we regularly observed pronounced epithelial foam-cell formations in pyometra-affected uteri. Therefore, it was assumed that the mechanism behind lipid droplet accumulation in surface epithelial cells might even increase bacterial binding capacity and promote pyometra development...
June 2016: Theriogenology
https://www.readbyqxmd.com/read/26800471/-hormonal-changes-in-inflammatory-bowel-disease
#15
Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer
UNLABELLED: Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn´s disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease...
2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26701143/transforming-growth-factor-beta-1-delivery-from-microporous-scaffolds-decreases-inflammation-post-implant-and-enhances-function-of-transplanted-islets
#16
Jeffrey M H Liu, Jesse Zhang, Xiaomin Zhang, Kelan A Hlavaty, Christine F Ricci, Joshua N Leonard, Lonnie D Shea, R Michael Gower
Biomaterial scaffolds are central to many regenerative strategies as they create a space for infiltration of host tissue and provide a platform to deliver growth factors and progenitor cells. However, biomaterial implantation results in an unavoidable inflammatory response, which can impair tissue regeneration and promote loss or dysfunction of transplanted cells. We investigated localized TGF-β1 delivery to modulate this immunological environment around scaffolds and transplanted cells. TGF-β1 was delivered from layered scaffolds, with protein entrapped within an inner layer and outer layers designed for cell seeding and host tissue integration...
February 2016: Biomaterials
https://www.readbyqxmd.com/read/26680477/association-of-plasma-lipids-fatty-acid-composition-with-metabolic-profile-of-czech-adolescents
#17
P Hlavaty, E Tvrzicka, B Stankova, H Zamrazilova, B Sedlackova, L Dusatkova, V Hainer, M Kunesova
Obesity in childhood increases the risk of obesity in adulthood and is predictive for the development of metabolic disorders. The fatty acid composition is associated with obesity and obesity-associated disorders. We investigated the relationship between serum fatty acids composition, adiposity, lipids profile, parameters of glucose metabolism and leptin. The study subjects were 380 adolescents aged 15.0-17.9 years. The study's variables included anthropometric measurements, levels of serum lipids and hormonal parameters...
2015: Physiological Research
https://www.readbyqxmd.com/read/26680476/fatty-acid-composition-of-adipose-tissue-triglycerides-in-obese-diabetic-women-after-bariatric-surgery-a-2-year-follow-up
#18
M Kunešová, B Sedláčková, O Bradnová, E Tvrzická, B Staňková, P Šrámková, K DoleŽalová, P Kalousková, P Hlavatý, M Hill, B Bendlová, M Fried, V Hainer, J Vrbíková
Bariatric surgery is the most effective method in the treatment of obesity and type 2 diabetes (T2DM). The aim of this study was to evaluate the effects of different types of bariatric procedures on remission of T2DM and on the fatty acid composition in subcutaneous adipose tissue. Patients included obese diabetic women who underwent bariatric surgery: biliopancreatic diversion (BPD), n=8, laparoscopic gastric banding (LAGB), n=9 or laparoscopic greater curvature plication (LGCP), n=12. Anthropometric characteristics and fatty acid composition of adipose tissue (FA AT) were analyzed before surgery, then 6 months and 2 years after surgery...
2015: Physiological Research
https://www.readbyqxmd.com/read/26513216/tolerance-induction-using-nanoparticles-bearing-hy-peptides-in-bone-marrow-transplantation
#19
Kelan A Hlavaty, Derrick P McCarthy, Eiji Saito, Woon Teck Yap, Stephen D Miller, Lonnie D Shea
Allogeneic cell therapies have either proven effective or have great potential in numerous applications, though the required systemic, life-long immunosuppression presents significant health risks. Inducing tolerance to allogeneic cells offers the potential to reduce or eliminate chronic immunosuppression. Herein, we investigated antigen-loaded nanoparticles for their ability to promote transplant tolerance in the minor histocompatibility antigen sex-mismatched C57BL/6 model of bone marrow transplantation. In this model, the peptide antigens Dby and Uty mediate rejection of male bone marrow transplants by female CD4+ and CD8+ T cells, respectively, and we investigated the action of nanoparticles on these T cell subsets...
January 2016: Biomaterials
https://www.readbyqxmd.com/read/26332646/companion-cases-in-a-large-urban-medical-examiner-s-office
#20
Leigh Hlavaty, Chantel Njiwaji, LokMan Sung
Companion death cases, as defined in this study, include 2 or more deaths that occur at the same location or 1 death at a specific location combined with 1 or more individuals transported from that same location to a hospital where death was pronounced within 1 hour of arrival. These types of cases can have multiple causes and manners of death. The Wayne County Medical Examiner's Office conducted a retrospective study of companion death cases that came into the office from mid 2007 to the end of 2014. The purpose of the study was to identify and examine patterns of companion death cases in a large urban area that would assist future companion death case investigations...
December 2015: American Journal of Forensic Medicine and Pathology
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