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MULTICENTER STUDY
Paola Ilaria Bianchi, Marco Vincenzo Lenti, Clarissa Petrucci, Giulia Gambini, Nicola Aronico, Matteo Varallo, Carlo Maria Rossi, Elena Pozzi, Elena Groppali, Francesca Siccardo, Giulia Franchino, Gian Vincenzo Zuccotti, Grazia Di Leo, Chiara Zanchi, Fernanda Cristofori, Ruggiero Francavilla, Marina Aloi, Giulia Gagliostro, Monica Montuori, Sara Romaggioli, Caterina Strisciuglio, Marco Crocco, Noemi Zampatti, Angela Calvi, Renata Auricchio, Costantino De Giacomo, Silvia Maria Elena Caimmi, Carolina Carraro, Annamaria Staiano, Sabrina Cenni, Mauro Congia, Enrico Schirru, Francesca Ferretti, Carolina Ciacci, Nicoletta Vecchione, Mario Andrea Latorre, Semela Resuli, Giusy Cinzia Moltisanti, Giulia Maria Abruzzese, Andrea Quadrelli, Simone Saglio, Pietro Canu, Damiano Ruggeri, Annalisa De Silvestri, Catherine Klersy, Gian Luigi Marseglia, Gino Roberto Corazza, Antonio Di Sabatino
IMPORTANCE: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood. OBJECTIVES: To investigate the diagnostic delay of CD in childhood, and to assess factors associated with this delay. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective, cross-sectional study (2010-2019) of pediatric (aged 0-18 years) patients with CD from 13 pediatric tertiary referral centers in Italy...
April 1, 2024: JAMA Network Open
#22
REVIEW
Alessio Danilo Inchingolo, Gianna Dipalma, Fabio Viapiano, Anna Netti, Irene Ferrara, Anna Maria Ciocia, Antonio Mancini, Daniela Di Venere, Andrea Palermo, Angelo Michele Inchingolo, Francesco Inchingolo
INTRODUCTION: This systematic review aims to elucidate the intricate correlation between celiac disease (CD) and dental enamel defects (DED), exploring pathophysiological mechanisms, oral health implications, and a dentist's role in early diagnosis. MATERIALS AND METHODS: Following PRISMA guidelines, a comprehensive search from 1 January 2013 to 1 January 2024 across PubMed, Cochrane Library, Scopus, and Web of Science identified 153 publications. After exclusions, 18 studies met the inclusion criteria for qualitative analysis...
February 28, 2024: Journal of Clinical Medicine
#23
Megan Elizabeth Moore, Fawad Talat, Michael Talanian, Harmony Allison
Celiac disease (CD) is associated with several neurological diseases. We report a case of a 25-year-old man with CD that was discovered during hospitalization for acute transverse myelitis. The diagnosis of CD was suspected after positive serological tests and was confirmed with duodenal biopsy. Steroid pulse therapy and plasma exchange stabilized the patient's condition. The patient started a gluten-free diet and rituximab therapy before discharge. Although the association of CD with various neurological diseases is well established, this case report describes a less explored association between CD and transverse myelitis...
April 2024: ACG Case Reports Journal
#24
JOURNAL ARTICLE
Rasha Alradadi, Daliah M Alharbi, Maram S Alrehely, Samah F Alraddadi, May Almouteri, Muna Mohammad AlSuhaimi, Maram Abdullah Alaofi, Noha Farouk Tashkandi, Fatimah A Aljohani
BACKGROUND: Type 1 diabetes mellitus (T1DM) in children, a significant public health concern, often leads to diabetic ketoacidosis (DKA). The prevalence of T1DM is increasing globally, with Saudi Arabia recording high rates of DKA at T1DM onset. This study aimed to evaluate the characteristics and risk factors of pediatric T1DM patients presenting with DKA in the emergency room in Saudi Arabia and quantify intensive care unit (ICU) admission incidences reflecting DKA severity. METHODS: This retrospective chart review, conducted at Medina Maternity and Children's Hospital, Saudi Arabia, analyzed data from 2017 to 2022...
March 2024: Curēus
#25
JOURNAL ARTICLE
Weichen Yuan, Xiangrui Li, Guan Wang, Bo Qu, Fangkun Zhao
BACKGROUND: Many observational studies have been reported that patients with autoimmune or allergic diseases seem to have a higher risk of developing senile cataract, but the views are not consistent. In order to minimize the influence of reverse causality and potential confounding factors, we performed Mendelian Randomization (MR) analysis to investigate the genetic causal associations between autoimmune, allergic diseases and senile cataract. METHODS: Single nucleotide polymorphisms associated with ten common autoimmune and allergic diseases were obtained from the IEU Open genome-wide association studies (GWAS) database...
2024: Frontiers in Immunology
#26
REVIEW
Renato Beas, Euler Altamirano-Farfan, Diego Izquierdo-Veraza, Dalton A Norwood, Adrian Riva-Moscoso, Ambar Godoy, Eleazar E Montalvan-Sanchez, Mirian Ramirez, Daniel A Guifarro, Emily Kitchin, Monika Fischer, Satya Kurada
BACKGROUND: Celiac disease (CeD) is an immune-mediated disorder affecting the small bowel, associated with genetic factors and increasing global prevalence. AIM: This study explores the association between CeD, Systemic Lupus Erythematosus (SLE), primary Sjogren syndrome (pSS), and Systemic Sclerosis (SSc). METHODS: A systematic review and meta-analysis were conducted following PRISMA guidelines. Searches across multiple databases yielded 2728 articles, with 15 studies selected...
April 6, 2024: Digestive and Liver Disease
#27
JOURNAL ARTICLE
Ida Lindeman, Lene S Høydahl, Asbjørn Christophersen, Louise F Risnes, Jørgen Jahnsen, Knut E A Lundin, Ludvig M Sollid, Rasmus Iversen
Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific immunoglobulin (Ig) A plasma cells are abundant in gut biopsies of patients. Here, we describe the corresponding population of autoreactive B cells in blood. Circulating TG2-specific IgA cells are present in untreated patients on a gluten-containing diet but not in controls. They are clonally related to TG2-specific small intestinal plasma cells, and they express gut-homing molecules, indicating that they are plasma cell precursors...
April 4, 2024: Cell Reports
#28
JOURNAL ARTICLE
Morad Guennouni, Nysrine Mannani, Ider Oujamaa, Mohamed Echchakery, Abdelaziz Ait Melloul, Nabila Soraa, Aicha Bourrahouat, Abderraouaf Hilali, Asmae Hanchi Lamrani, Brahim Admou
BACKGROUND: The rising prevalence of gluten-related disorders such as celiac disease explains the increased consumption of gluten-free foods (GFF). However, these foods must be safe in terms of both gluten content and contamination by pathogenic microorganisms in order to avoid food poisoning. OBJECTIVE: The objective of this study was to assess the microbiological quality of gluten-free meals, naturally gluten free foods, and gluten free-labelled products. MATERIAL AND METHODS: We collected 62 GFF samples including 20 meals (M-GF), 22 naturally gluten free (N-GFF) and 20 labelled (L-GFF) products, which were investigated for microbiological contamination according to Moroccan regulations guidelines, issued by the International Organization for Standardization (ISO)...
2024: Roczniki Państwowego Zakładu Higieny
#29
REVIEW
Salvatore Oliva, Emily Clarke McGowan
Eosinophilic gastrointestinal disorders (EGIDs) are becoming more common causing significant suffering and reduced quality of life. These conditions can affect different parts of the digestive system, either individually or in combination. Recognition of their link to allergic disorders or other gastrointestinal (GI) diseases has raised questions about their shared underlying mechanisms, which has had implications for diagnosis and management. The authors critically examine the current understanding of the connection between EGIDs and allergic conditions (ie, atopic dermatitis, allergic rhinitis, asthma, and food allergy) and GI diseases (ie, inflammatory bowel disease, celiac disease, gastroesophageal reflux disease, and motility disorders)...
May 2024: Immunology and Allergy Clinics of North America
#30
JOURNAL ARTICLE
Federico Perez, María Luz Iribarren, Cinthia Mariel Olexen, Carolina Naymé Ruera, Andrea Emilse Errasti, Luciana Guzman, Laura Garbi, Eugenio Antonio Carrera-Silva, Fernando Gabriel Chirdo
Celiac disease (CD) is an immune-driven disease characterized by tissue damage in the small intestine of genetically-susceptible individuals. We evaluated here a crucial immune regulatory pathway involving TYRO3, AXL, and MERTK (TAM) receptors and their ligands PROS1 and GAS6 in duodenal biopsies of controls and CD patients. We found increased GAS6 expression associated with downregulation of PROS1 and variable TAM receptors levels in duodenum tissue of CD patients. Interestingly, CD3+ lymphocytes, CD68+ , CD11c+ myeloid and epithelial cells, showed differential expressions of TAM components comparing CD vs controls...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#31
JOURNAL ARTICLE
Berat Ebik, Nazım Ekin, Ferhat Bacaksiz, Ali Uzel, Mustafa Zanyar Akkuzu, Feyzullah Ucmak, Muhsin Kaya, Vedat Goral
INTRODUCTION: Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other. AIM: To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them. MATERIAL AND METHODS: In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021...
2024: Przegla̜d Gastroenterologiczny
#32
JOURNAL ARTICLE
Mélanie Lavoignat, Angéla Juhász, Utpal Bose, Thierry Sayd, Christophe Chambon, Miguel Ribeiro, Gilberto Igrejas, Sébastien Déjean, Catherine Ravel, Emmanuelle Bancel
Wheat proteins can trigger immunogenic reactions due to their resistance to digestion and immunostimulatory epitopes. Here, we investigated the peptidomic map of partially digested bread samples and the fingerprint of epitope diversity from 16 wheat genotypes grown in two environmental conditions. Flour protein content and composition were characterized; gastric and jejunal peptides were quantified using LC-MS/MS, and genotypes were classified into high or low bread protein digestibility. Differences in flour protein content and peptide composition distinguish high from low digestibility genotypes in both growing environments...
March 26, 2024: Food Chemistry
#33
JOURNAL ARTICLE
Salvatore Accomando, Ilenia Rita Piazza, Francesca Cacciatore, Veronica Notarbartolo, Giovanni Corsello, Mario Giuffrè
BACKGROUND: The aim of this study is to compare two groups of celiac patients: the first one, in which diagnosis was based on a "biopsy sparing" approach according to the 2012 ESPGHAN criteria, and the second one, based on the biopsy approach like the one of the 1991 Revised Criteria, in order to find relevant difference for sex, M/F ratio, age at diagnosis, clinical features at the onset, presence and prevalence of concomitant autoimmune disorders. METHODS: Our study involves 61 patients having the Celiac Disease (CD) onset from February 2013 to February 2020...
April 1, 2024: Italian Journal of Pediatrics
#34
JOURNAL ARTICLE
Lakshmimathy Subramanian, Helen Coo, Alanna Jane, Jennifer A Flemming, Amy Acker, Benjamin Hoggan, Rebecca Griffiths, Anupam Sehgal, Daniel Mulder
BACKGROUND: Previous national registry studies have reported an increased risk of eating disorders in immune-mediated conditions (inflammatory bowel disease [IBD] and celiac disease). Our objective was to examine the association between immune-mediated GI diseases and incident eating disorders in Ontario. METHODS: This was a retrospective matched cohort study of individuals <50 years of age with a diagnosis of an immune-mediated GI disease between 2002 and 2020 ("cases")...
April 1, 2024: Clinical and Translational Gastroenterology
#35
JOURNAL ARTICLE
Georgia Malamut, Craig R Soderquist, Govind Bhagat, Nadine Cerf-Bensussan
Non-responsive celiac disease (NRCD) is relatively common. It is generally attributed to persistent gluten exposure and resolves after correction of diet errors. However, other complications of CD and disorders clinically mimicking CD, need to be excluded. Novel therapies are being evaluated to facilitate mucosal recovery, which might benefit NRCD patients. Refractory CD (RCD) is rare and is currently divided into two types. The etiology of RCD type 1 (RCDI) is unclear, a possible switch to gluten-independent autoimmunity is suspected in some patients, while RCD type II (RCDII) represents a low-grade intraepithelial lymphoma...
March 29, 2024: Gastroenterology
#36
JOURNAL ARTICLE
Anil K Chokkalla, Margaret M Parham, Douglas S Fishman, Sridevi Devaraj
BACKGROUND: Laboratory testing for celiac disease in pediatric patients integrates serology, genetic susceptibility and duodenal biopsy examination. The 2023 American College of Gastroenterology guidelines recommend a biopsy-free approach in pediatric patients utilizing tissue transglutaminase antibody titers >10 times upper limit of normal and subsequent endomysial antibody seropositivity as sufficient for diagnosis. The objective of this study is to assess the diagnostic accuracy of biopsy-free approach at our pediatric hospital...
April 15, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#37
JOURNAL ARTICLE
Louise F Risnes, Henrik M Reims, Ronan M Doyle, Shuo-Wang Qiao, Ludvig M Sollid, Knut E A Lundin, Asbjørn Christophersen
BACKGROUND AND AIMS: The treatment of celiac disease (CeD) with gluten-free diet (GFD) normalizes gut inflammation and disease-specific antibodies. CeD patients have HLA-restricted, gluten-specific T cells persisting in the blood and gut even after decades of GFD, which are re-activated and disease driving upon gluten exposure. Our aim was to examine the transition of activated gluten-specific T cells into a pool of persisting memory T cells concurrent with normalization of clinically relevant biomarkers during the first year of treatment...
March 27, 2024: Gastroenterology
#38
JOURNAL ARTICLE
Niklas Engström, Lena Böhn, Axel Josefsson, Stine Störsrud, Nathalie Scheers
UNLABELLED: In celiac disease, intestinal transglutaminase (TG2) produces immunogenic peptides by deamidation of gluten proteins. These products drive the celiac immune response. We have previously identified an interaction between gliadin and a food additive, E304i, which prevents gliadin processing (both deamidation and transamidation) by TG2, in vitro . In this study, we investigated if E304i could prevent TG2 processing of gluten in flours and if the effect was evident after simulated gastrointestinal digestion...
2024: Frontiers in Nutrition
#39
JOURNAL ARTICLE
Noam Peleg, Yaron Niv, Ram Dickman, Doron Boltin, Alex Krauthammer, Michal Herman-Edelstein, Nidal Issa, Jacob E Ollech, Tom Konikoff, Rachel Gingold-Belfer
GOALS AND BACKGROUND: Gluten-free diet (GFD) includes a higher intake of sugars and fats. Previous studies have investigated its effect on body mass index (BMI) in celiac disease (CD) patients but had contradictive conclusions. Thus, we conducted a systematic review and meta-analysis examining the effect of GFD on BMI in CD patients. STUDY: Systematically, we conducted literature research using Medline, Scopus, and Embase, and we identified 1565 potential studies/abstracts...
March 27, 2024: Journal of Clinical Gastroenterology
#40
REVIEW
Patrizia Garbati, Cristiana Picco, Raffaella Magrassi, Paolo Signorello, Ludovica Cacopardo, Mauro Dalla Serra, Maria Grazia Faticato, Maria De Luca, Francesco Balestra, Maria Principia Scavo, Federica Viti
The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical-chemical strategies...
March 21, 2024: Pharmaceutics
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