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"Celiac disease"

Donald Duerksen, Maria Ines Pinto-Sanchez, Alexandra Anca, Joyce Schnetzler, Shelley Case, Jenni Zelin, Adrianna Smallwood, Justine Turner, Elena Verdú, J Decker Butzner, Mohsin Rashid
OBJECTIVE: To describe clinical issues related to bone health in patients with celiac disease (CD) and to provide guidance on monitoring bone health in these patients. SOURCES OF INFORMATION: A PubMed search was conducted to review literature relevant to CD and bone health, including guidelines published by professional gastroenterological organizations. MAIN MESSAGE: Bone health can be negatively affected in both adults and children with CD owing to the inflammatory process and malabsorption of calcium and vitamin D...
June 2018: Canadian Family Physician Médecin de Famille Canadien
Hilary Jericho, Stefano Guandalini
The aim of this literature review is to discuss the extra-intestinal manifestations of celiac disease within the pediatric celiac population.
June 12, 2018: Nutrients
Anette Tønnes Pedersen, Line Cleemann, Katharina M Main, Anders Juul
Hypogonadism may be suspected if puberty is delayed. Pubertal delay may be caused by a normal physiological variant, by primary ovarian insufficiency (Turner syndrome), or reflect congenital hypogonadotropic hypogonadism (HH; genetic) or acquired HH (brain lesions). Any underlying chronic disease like inflammatory bowel disease, celiac disease, malnutrition (anorexia or orthorexia), or excessive physical activity may also result in functional HH. Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated...
2018: Endocrine Development
Amanda Liu, Margaret Marcon, Esther Assor, Farid H Mahmud, Justine Turner, Diana Mager
The study purpose was to describe dietary intake and the factors influencing micronutrient supplements (MS) use in Celiac Disease (CD) ± Type 1 Diabetes (T1D). Three-day food records collected from parents of youth (3-18 years) with CD (n = 14) ± T1D (n = 10) were assessed for macro and micronutrient intake, diet quality (DQ), glycemic index (GI), glycemic load (GL), and food group intake. Focus group methodology and thematic concept analysis were conducted to determine factors influencing adolescent MS use...
June 12, 2018: Canadian Journal of Dietetic Practice and Research
Sara Ebrahimi, Gholamreza Khademi, Seyed Ali Jafari, Nona Zaboli Nejad, Abdolreza Norouzy, Bahareh Imani
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian female neonate presented with severe bloody diarrhea, poor feeding, abdominal distention, and dehydration suggesting severe proctocolitis due to an allergy to the protein in cow's milk...
May 2018: Iranian Journal of Medical Sciences
Georgina Rubal-Peace, Caroline Sepp
No abstract text is available yet for this article.
June 5, 2018: Journal of the Academy of Nutrition and Dietetics
Annalise N vonderEmbse, Jamie C DeWitt
Immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes have been on the rise over the past decades. As a result, the use of developmental immunotoxicity (DIT) testing to identify potential environmental risk factors contributing to these and other diseases has become a priority for scientists across sectors. This chapter serves to provide insight into the scientific basis for DIT and determining the necessity of DIT testing and offers recommendations for DIT testing parameters to optimize sensitivity, power, and concordance among DIT assays...
2018: Methods in Molecular Biology
Valma Fuchs, Kalle Kurppa, Heini Huhtala, Markku Mäki, Leila Kekkonen, Katri Kaukinen
Background: Celiac disease is challenging to recognize, predisposing to long diagnostic delay. Currently, associated factors and significance of the delay remain obscure. Objective: The objective of this article is to investigate associated sociodemographic risk factors and health consequences of diagnostic delay in celiac disease. Methods: Altogether 611 patients were surveyed at diagnosis and after one year on a gluten-free diet regarding sociodemographic variables, well-being and use of medicines and health care services...
May 2018: United European Gastroenterology Journal
Sarah Moretti, Simona Mrakic-Sposta, Leda Roncoroni, Alessandra Vezzoli, Cinzia Dellanoce, Erika Monguzzi, Federica Branchi, Francesca Ferretti, Vincenza Lombardo, Luisa Doneda, Alice Scricciolo, Luca Elli
INTRODUCTION: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) and tissue injury in different intestinal and extra intestinal conditions, including celiac disease (CD). The aim of the present study was to investigate the role and potential use of ROS and other biomarkers of OxS in the clinical management of CD. METHODS: We collected duodenal specimens and blood samples from naïve patients (N-CD), patients on a gluten free diet (GFD) including responders (CD-GFD) and non-responders (NRCD)...
June 8, 2018: Clinical and Translational Gastroenterology
Gergely Bodis, Victoria Toth, Andreas Schwarting
The aim of this review is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behcet's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.
2018: Methods in Molecular Biology
Brian P McAllister, Emmanuelle Williams, Kofi Clarke
Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases drastically from 1:133 in patients not-at-risk, to 1:56 in symptomatic patients, to 1:39 in patients with a second-degree relative with the diagnosis, and to 1:22 in patients with a first-degree relative with the diagnosis...
June 2, 2018: Clinical Reviews in Allergy & Immunology
Cristina Oana Mărginean, Lorena Elena Meliţ, Vlăduţ Stefănuţ Săsăran, Cristian Dan Mărginean, Maria Oana Mărginean
RATIONALE: Celiac disease is a chronic, immune-mediated, multiorgan disorder that affects susceptible individuals, and it is triggered by gluten and other prolamins. PATIENT CONCERNS: We present the case of a 1-year-old male child, with a history of idiopathic pericardial effusion, admitted in our clinic for severe abdominal bloating, irritability, loss of appetite and intermittent diarrheic stools. The clinical findings were: influenced general status, irritability, distended abdomen, and diffuse abdominal tenderness...
June 2018: Medicine (Baltimore)
Imad Absah, Rok Seon Choung, Joseph A Murray
No abstract text is available yet for this article.
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
Anna Fábián, Mariann Rutka, Tamás Ferenci, Renáta Bor, Anita Bálint, Klaudia Farkas, Ágnes Milassin, Kata Szántó, Zsuzsanna Lénárt, Ferenc Nagy, Zoltán Szepes, Tamás Molnár
Background and Aims: Complementary and alternative medicine (CAM) is commonly used among patients with inflammatory bowel diseases (IBD), but evidence about its real-life use is limited. We aimed to assess and compare CAM use in outpatients with IBD and other gastrointestinal diseases. Materials and Methods: The use of herbs and botanicals, lifestyle modifications and mind/body therapies, patient satisfaction, and continuous use of conventional medicine were assessed with an anonymous questionnaire at a tertiary IBD unit in Hungary...
2018: Gastroenterology Research and Practice
Juan Lasa, Astrid Rausch, Luis Florez Bracho, Josefina Altamirano, Daniela Speisky, María Teresa García de Dávila, Alejandro Iotti, Ignacio Zubiaurre
Background: The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims: To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods: A retrospective case-control study was undertaken...
2018: Gastroenterology Research and Practice
Sarah Micozzi, Sonsoles Infante, Victoria Fuentes-Aparicio, Alberto Álvarez-Perea, Lydia Zapatero
INTRODUCTION: Celiac disease and wheat allergy (WA) are infrequent diseases in the general population, and a combination of the 2 is particularly rare. Celiac disease occurs in around 1% of the general population and WA in around 1% of all children. CASE REPORT: We report 2 patients with celiac disease and a gluten-free diet who developed WA consistent in anaphylaxis and an eyelid angioedema, respectively, through accidental wheat exposure. A serum study and an intestinal biopsy confirmed celiac disease...
May 30, 2018: International Archives of Allergy and Immunology
Rinaldo Pellicano, Marilena Durazzo
No abstract text is available yet for this article.
July 2018: European Journal of Gastroenterology & Hepatology
Julián Rodríguez Almagro, David Rodríguez Almagro, Carmen Solano Ruiz, José Siles González, Antonio Hernández Martínez
Celiac disease represents a problem in our society, not only because of its interest in terms of healthcare, but also because of its increasing prevalence in recent years and the impact it has on sufferers and their families. This integrative review investigated current knowledge about the experience of living with a gluten-free diet, as well as social support and the role played by nurses and/or associations in the process. A total of 18 articles were selected. Results revealed greater family support is needed to deal with the day-to-day issues of a gluten-free diet...
May 2018: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
Britta Eggenreich, Elke Scholz, David Johannes Wurm, Florian Forster, Oliver Spadiut
BACKGROUND: Celiac disease (CD) is one of the most common food-related chronic disorders. It is mediated by the dietary consumption of prolamins, which are storage proteins of different grains. So far, no therapy exists and patients are bound to maintain a lifelong diet to avoid symptoms and long-term complications. To support those patients we developed a tandem single chain Fragment variable (tscFv) acting as a neutralizing agent against prolamins. We recombinantly produced this molecule in E...
May 29, 2018: BMC Biotechnology
Luigina De Leo, Vincenzo Villanacci, Fabiana Ziberna, Serena Vatta, Stefano Martelossi, Grazia Di Leo, Chiara Zanchi, Matteo Bramuzzo, Fabiola Giudici, Alessandro Ventura, Tarcisio Not
BACKGROUND AND AIMS: Anti-tissue transglutaminase antibodies (anti-tTG) have simplified celiac disease (CD) diagnosis. However, in atypical forms of CD, intestinal biopsy is still required. This prospective study investigates whether histological analysis of the duodenal bulb combined with intestinal IgA anti-tTG deposit immunoassay makes CD diagnosis possible in at-risk children with low concentrations of serum anti-tTG. METHODS: Histological and intestinal IgA anti-tTG deposit immunoassays were used...
May 25, 2018: Gastrointestinal Endoscopy
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