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"Celiac disease"

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https://www.readbyqxmd.com/read/29684362/characterization-of-the-small-intestinal-lesion-in-celiac-disease-by-label-free-quantitative-mass-spectrometry
#1
Astrid E V Tutturen, Siri Dørum, Trevor Clancy, Henrik M Reims, Asbjørn Christophersen, Knut E A Lundin, Ludvig M Sollid, Gustavo A de Souza, Jorunn Stamnaes
Global characterization of tissue proteomes from small amounts of biopsy material has become feasible due to advances in mass spectrometry and bioinformatics tools. In celiac disease (CD), dietary gluten induces an immune response which is accompanied by pronounced remodeling of the small intestine. Removal of gluten from the diet abrogates the immune response and the tissue architecture normalizes. In this study differences in global protein expression of small intestinal biopsies from CD patients were quantified by analyzing formalin-fixed, paraffin-embedded material using liquid-chromatography mass spectrometry and label-free protein quantitation...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29681452/risk-of-fractures-in-youths-with-celiac-disease-a-population-based-study
#2
Cristina Canova, Gisella Pitter, Loris Zanier, Lorenzo Simonato, Karl Michaelsson, Jonas F Ludvigsson
OBJECTIVE: To assess the risk of any fracture requiring hospital care in a cohort of individuals with celiac disease diagnosed in childhood/adolescence compared with reference individuals matched by age and sex. STUDY DESIGN: Our study cohort consisted of 213 635 people born and residing in Friuli-Venezia Giulia Region, Italy, in 1989-2011. We selected, through pathology reports, hospital discharge records, or co-payment exemptions, 1233 individuals with celiac disease (aged 0-17 years at diagnosis) and compared them with 6167 reference individuals matched by sex and year of birth...
April 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29674648/human-intraepithelial-lymphocytes
#3
REVIEW
Toufic Mayassi, Bana Jabri
The location of intraepithelial lymphocytes (IEL) between epithelial cells, their effector memory, cytolytic and inflammatory phenotype positions them to kill infected epithelial cells and protect the intestine against pathogens. Human TCRαβ+ CD8αβ+ IEL have the dual capacity to recognize modified self via natural killer (NK) receptors (autoreactivity) as well as foreign antigen via the T cell receptor (TCR), which is accomplished in mouse by two cell subsets, the naturally occurring TCRαβ+ CD8αα+ and adaptively induced TCRαβ+ CD8αβ+ IEL subsets, respectively...
April 20, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29672438/alterations-of-inflammatory-and-matrix-production-indices-in-celiac-disease-with-low-bone-mass-on-long-term-gluten-free-diet
#4
Michele Di Stefano, Manuela Bergonzi, Irene Benedetti, Mara De Amici, Cristina Torre, Natascia Brondino, Emanuela Miceli, Elisabetta Pagani, Gian L Marseglia, Gino R Corazza, Antonio Di Sabatino
BACKGROUND: A clinically meaningful impairment of bone mass secondary to malabsorption is frequent in untreated celiac disease. In adult patients, a rigorous gluten-free diet (GFD) significantly improves, but does not always normalize, bone mineral density (BMD). The reason for this marginal response is unclear. Accordingly, we evaluated the role of both local and systemic factors for bone loss in celiac patients on long-term GFD. STUDY: In a prospective cohort, 22 patients with low lumbar and/or femoral BMD and 22 with normal BMD underwent bone and mineral metabolism evaluation: we tested calcium, phosphate, parathyroid hormone, and vitamin D; telopeptide of type I collagen, a bone resorption index; propeptide of type I procollagen, a bone neoformation index; receptor antagonist of NF-kB ligand, an osteoclast-stimulating factor; osteoprotegerin (OPG), a decoy receptor for RANKL...
April 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29672211/increased-prevalence-of-pathogenic-bacteria-in-the-gut-microbiota-of-infants-at-risk-of-developing-celiac-disease-the-proficel-study
#5
Marta Olivares, Alfonso Benítez-Páez, Giada de Palma, Amalia Capilla, Esther Nova, Gemma Castillejo, Vicente Varea, Ascensión Marcos, José Antonio Garrote, Isabel Polanco, Ester Donat, Carmen Ribes-Koninckx, Carmen Calvo, Luis Ortigosa, Francesc Palau, Yolanda Sanz
Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk)...
April 19, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29670007/prevalence-of-self-reported-gluten-related-disorders-and-adherence-to-a-gluten-free-diet-in-salvadoran-adult-population
#6
Noé Ontiveros, Cecilia Ivonne Rodríguez-Bellegarrigue, Gerardo Galicia-Rodríguez, Marcela de Jesús Vergara-Jiménez, Elia María Zepeda-Gómez, Jesús Gilberto Arámburo-Galvez, Martina Hilda Gracia-Valenzuela, Francisco Cabrera-Chávez
Gluten-related disorders are not considered of relevance at public health level in Central America. The prevalence of gluten-related disorders, and adherence to a gluten-free diet, remain unknown in the Central American region. We conducted a cross-sectional survey of the Central American population from San Salvador, El Salvador, to estimate the prevalence rates of self-reported gluten-related disorders and adherence to a gluten-free diet. 1326 individuals were surveyed. Self-reported prevalence rates were (95% Confidence Interval): gluten sensitivity 3...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29669696/doctor-why-am-i-a-celiac-if-i-m-mexican-breaking-another-paradigm-of-celiac-disease-in-mexico
#7
EDITORIAL
J M Remes-Troche
No abstract text is available yet for this article.
April 15, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29667919/assessment-of-community-pediatric-providers-approach-to-a-child-with-celiac-disease-and-available-serological-testing-associated-with-a-large-tertiary-care-center
#8
Leina S Alrabadi, Anthony F Porto
An evidence-practice gap for use of celiac disease testing can lead to poor resource utilization. False positive tests may lead to unnecessary diet changes, gastroenterology consults, parental/patient concern, and additional testing and expenses complicated by varied available celiac bundles. An understanding of pediatric provider practices according to guideline recommendations further improves this gap.
April 1, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/29666542/development-of-gluten-free-fish-pseudoplatystoma-corruscans-patties-by-response-surface-methodology
#9
Mara C Romero, Ricardo A Fogar, Fabiana Rolhaiser, Verónica V Clavero, Ana M Romero, María A Judis
The goal of this study was to develop a fish-based product suitable for people with celiac disease. Water and gluten-free flours (rice, corn, amaranth or quinoa) were added to improve cooking yield, texture parameters and as an aid in improving quality attributes such as taste and juiciness. Cooking yields of patties containing gluten-free flours were higher than control and maximum values ranged between 91 and 93%. Hardness was higher in patties made with amaranth or quinoa flour, whereas cohesiveness and springiness were higher in patties made with corn and rice flour, respectively...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29662290/extra-intestinal-manifestations-of-non-celiac-gluten-sensitivity-an-expanding-paradigm
#10
REVIEW
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Annacinzia Amoruso, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as 'foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29662164/transcription-factors-operate-across-disease-loci-with-ebna2-implicated-in-autoimmunity
#11
John B Harley, Xiaoting Chen, Mario Pujato, Daniel Miller, Avery Maddox, Carmy Forney, Albert F Magnusen, Arthur Lynch, Kashish Chetal, Masashi Yukawa, Artem Barski, Nathan Salomonis, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch
Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors (TFs) occupy multiple loci associated with individual complex genetic disorders. Application to 213 phenotypes and 1,544 TF binding datasets identified 2,264 relationships between hundreds of TFs and 94 phenotypes, including androgen receptor in prostate cancer and GATA3 in breast cancer. Strikingly, nearly half of systemic lupus erythematosus risk loci are occupied by the Epstein-Barr virus EBNA2 protein and many coclustering human TFs, showing gene-environment interaction...
April 16, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29656367/the-impact-of-coping-patterns-and-chronic-health-conditions-on-health-related-quality-of-life-among-children-and-adolescents
#12
Sabrina Oppenheimer, Orit Krispin, Sigal Levy, Maayan Ozeri, Alan Apter
This study examined the relationship among chronic disease, coping strategy patterns, and health-related quality of life (HRQOL) among children and adolescents. The cohort included 273 Israeli children and adolescents aged 8-18 years diagnosed with asthma, diabetes mellitus, or celiac disease. All completed the Coping with a Disease Questionnaire (CODI) and the DISABKIDS Chronic Generic Measure (DCGM-37). The outcome measures were as follows: association of the use of effective and non-effective coping strategies with type of disease; predictive value of coping patterns for health-related quality of life; a European sample was used for comparison...
April 14, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29649333/soluble-t-cell-receptor-design-influences-functional-yield-in-an-e-coli-chaperone-assisted-expression-system
#13
Kristin Støen Gunnarsen, Lene Støkken Høydahl, Ralf Stefan Neumann, Kaare Bjerregaard-Andersen, Nicolay Rustad Nilssen, Ludvig Magne Sollid, Inger Sandlie, Geir Åge Løset
There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted periplasmic production system and compared expression of 4 different soluble TCR formats: single-chain TCR (scTCR), two different disulfide-linked TCR (dsTCR) formats, and chimeric Fab (cFab). A stabilized version of scTCR was also included. Additionally, we evaluated the influence of host (XL1-Blue or RosettaBlueTM) and the effect of IPTG induction on expression profiles...
2018: PloS One
https://www.readbyqxmd.com/read/29644516/correction-to-hypervigilance-to-a-gluten-free-diet-and-decreased-quality-of-life-in-teenagers-and-adults-with-celiac-disease
#14
Randi L Wolf, Benjamin Lebwohl, Anne R Lee, Patricia Zybert, Norelle R Reilly, Jennifer Cadenhead, Chelsea Amengual, Peter H R Green
The original version of the article unfortunately contained formatting errors in Table 3. The correct version of Table 3 is given below.
April 11, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29622363/overlap-between-functional-abdominal-pain-disorders-and-organic-diseases-in-children
#15
A H Langshaw, J M Rosen, L Pensabene, O Borrelli, S Salvatore, N Thapar, D Concolino, M Saps
Functional abdominal pain disorders are highly prevalent in children. These disorders can be present in isolation or combined with organic diseases, such as celiac disease and inflammatory bowel diseases. Intestinal inflammation (infectious and non-infectious) predisposes children to the development of visceral hypersensitivity that can manifest as functional abdominal pain disorders, including irritable bowel syndrome. The new onset of irritable bowel syndrome symptoms in a patient with an underlying organic disease, such as inflammatory bowel disease, is clinically challenging, given that the same symptomatology may represent a flare-up of the inflammatory bowel disease or an overlapping functional abdominal pain disorder...
April 2, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29622097/not-all-that-flattens-villi-is-celiac-disease-a-review-of-enteropathies
#16
REVIEW
Claire L Jansson-Knodell, Isabel A Hujoel, Alberto Rubio-Tapia, Joseph A Murray
Enteropathies can be overwhelming for clinicians. There is a wide spectrum of diseases involved; their effect on patients can be severe; and their underlying cause can be obscure. In this article, we outline a practical approach to enteropathies that are most common and not to be missed and is applicable to general and specialist physicians.
April 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29620596/celiac-disease-30-years-after-diagnosis-struggling-with-gluten-free-adherence-or-gaining-gluten-tolerance
#17
Lorenzo Norsa, Federica Branchi, Marianna Bravo, Francesca Ferretti, Leda Roncoroni, Francesco Somalvico, Dario Conte, Maria Teresa Bardella, Sabrina Fabiano, Giulio Barigelletti, Luca Elli
OBJECTIVES: Studies investigating patients with coeliac disease (CD) on very long-term follow-up are limited. We aimed to evaluate the characteristics of patients with CD diagnosed more than 30 years ago. METHODS: Clinical, histologic, genetic and demographic data of patients with CD diagnosis made before 1985 were collected and their standardised mortality ratio (SMR) calculated. According to the gluten free diet (GFD) status, CD patients were divided into three groups and a specific questionnaire on GFD awareness and gluten-free products was administered to patients and caregivers...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29619399/celiac-disease-and-secondary-amyloidosis-a-possible-causal-association
#18
Ankit Chhoda, Deepanshu Jain, Mradul Kumar Daga, Vineeta Batra
We report a rare case of secondary renal amyloidosis in a patient with probable celiac disease presenting as nephrotic syndrome. A 30-year-old man with chronic diarrhea presented with progressive anasarca for 2 years. On further evaluation, he had hypoalbuminemia, significant nephrotic-range proteinuria, and elevated levels of anti-tissue transglutaminase. Renal biopsy suggested deposition of amorphous Congo red-positive material in the glomerular mesangium, positive for amyloid A amyloidosis. Endoscopic duodenal biopsy suggested blunting of the villous architecture and chronic inflammation of the lamina propria...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29616378/diagnosis-of-celiac-disease-taking-a-bite-out-of-the-controversy
#19
REVIEW
Justine M Turner
Celiac disease is a common autoimmune disorder of the small intestine, triggered by an immunological response to the gluten present in wheat, barley, and rye in individuals who are genetically at risk. A key to reducing the complications of this disease is early diagnosis, preferably in childhood, and consuming a lifelong gluten-free diet once diagnosis is confirmed. Yet, the diagnosis of celiac disease is often considerably delayed, exposing patients to needless suffering and morbidity. It is also difficult to confirm histologically if dietary gluten has been restricted prior to obtaining a diagnostic biopsy, a significant problem given the current growing popularity of gluten-free diets...
April 3, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29615946/development-and-validation-of-a-specific-self-efficacy-scale-in-adherence-to-a-gluten-free-diet
#20
Ricardo Fueyo-Díaz, Rosa Magallón-Botaya, Santiago Gascón-Santos, Ángela Asensio-Martínez, Guillermo Palacios-Navarro, Juan J Sebastián-Domingo
The aim of this study was to develop a scale to assess the levels of specific self-efficacy in order to enhance adherence to a gluten-free diet and the life quality of celiac patients. Celiac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed people. The only treatment is a strict lifelong gluten-free diet. Within the framework of Social Cognitive Theory, expectation of self-efficacy is understood as the degree in which a person believes himself to be capable of performing a certain task (e...
2018: Frontiers in Psychology
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