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"Celiac disease"

Elizabeth Heavey, Joan Stoltman
No abstract text is available yet for this article.
November 2016: Nursing
Andrew J Irvine, William D Chey, Alexander C Ford
OBJECTIVES: Celiac disease (CD) and irritable bowel syndrome (IBS) share similar symptoms, leading to confusion between the two and diagnostic delay. International guidelines recommend screening individuals with IBS for CD, via serological testing. However, studies published recently have cast doubt on the utility of this. We updated a previous meta-analysis examining this issue. METHODS: MEDLINE, EMBASE, and EMBASE Classic were searched through to May 2016. Eligible studies recruited adults with IBS according to symptom-based criteria, physician's opinion, or questionnaire data...
October 18, 2016: American Journal of Gastroenterology
Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
BACKGROUND: Ghrelin levels and obestatin/ghrelin ratio have been proposed as activity markers in ulcerative colitis, but no data are available in celiac disease (CD) and irritable bowel syndrome (IBS). Our aims were as follows: (a) to assess obestatin and ghrelin concentrations in adult active CD patients, diarrhea-predominant IBS (IBS-d), and healthy controls (HC) in relation to intestinal permeability; (b) to evaluate the ghrelin-obestatin profile in CD patients after a 1-year gluten-free diet (GFD); and (c) to establish the impact of ghrelin genetics...
October 12, 2016: European Journal of Gastroenterology & Hepatology
Maria Teresa Bardella, Luca Elli, Francesca Ferretti
PURPOSE OF REVIEW: A new syndrome responding to gluten-free diet and defined non-celiac gluten sensitivity entered the spectrum of gluten-related disorders, together with celiac disease and wheat allergy. However, its definition, prevalence, diagnosis, pathogenesis, treatment, and follow up are still controversial. The purpose of the review is to summarize the evidence and problems emerging from the current literature. RECENT FINDINGS: Direct implication of gluten in the onset of symptoms is often unproved as a low fermentable oligo-, di- and mono-saccharides and polyols diet or other components of cereals as wheat amylase trypsin inhibitor could be similarly involved...
December 2016: Current Gastroenterology Reports
Lijun Du, John J Kim, Jinhua Shen, Ning Dai
The barrier function of the intestine is essential for maintaining the normal homeostasis of the gut and mucosal immune system. Abnormalities in intestinal barrier function expressed by increased intestinal permeability have long been observed in various gastrointestinal disorders such as Crohn's disease (CD), ulcerative colitis (UC), celiac disease, and irritable bowel syndrome (IBS). Imbalance of metabolizing junction proteins and mucosal inflammation contributes to intestinal hyperpermeability. Emerging studies exploring in vitro and in vivo model system demonstrate that Rho-associated coiled-coil containing protein kinase- (ROCK-) and myosin light chain kinase- (MLCK-) mediated pathways are involved in the regulation of intestinal permeability...
2016: Gastroenterology Research and Practice
Francesco Esposito, Evelina Fasano, Gelsomina Scognamiglio, Antonio Nardone, Maria Triassi, Teresa Cirillo
Fumonisins are mycotoxins produced by Fusarium species and affecting maize crops. Some analogues of fumonisins are known for their toxic and possible carcinogenic effects on humans and animals. Because of their occurrence in corn-based food, diet is the main source of exposure to these mycotoxins, especially among people affected by celiac disease. Hence, the purpose of this paper was to evaluate the amount of fumonisins B1, B2 and B3 in maize-based products and to assess the exposure of people affected by celiac disease to fumonisins...
October 13, 2016: Food and Chemical Toxicology
Maria C Cenit, Pilar Codoñer-Franch, Yolanda Sanz
Gut microbiota shapes the development of the mucosal immune system and may provide protection against immune-mediated diseases. Celiac disease (CD) is a chronic inflammatory condition triggered by dietary gluten proteins, recently associated with gut microbiota alterations in cross-sectional studies comparing patients and controls. Whether or not these differences are causally related to the disease has yet to be elucidated, but evaluation of specific bacteria isolated from CD patients in experimental models suggests that they can promote an adverse response to dietary gluten, whereas other commensal bacteria can be protective...
November 2016: Journal of Clinical Gastroenterology
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo
Celiac disease (CD) is the most common autoimmune enteropathy, triggered by a deregulated immune response to gliadin. It has been hypothesized that human intestinal microbiota may interfere with the pathogenesis of the disease and in the clinical course of CD. In the present review, we analyzed the microbiota alterations observed in the course of CD, how they may influence the pathogenesis of CD, and the possible applications for a microbiota modulation in CD. In detail, most of the current literature underlined that the dysbiosis in CD is hallmarked by an increase in gram-negative and Bacteroidetes species, and by a decrease in Bifidobacteria and Lactobacilli...
November 2016: Journal of Clinical Gastroenterology
Ahmed Sarkhy, Mohammad I El Mouzan, Elshazaly Saeed, Aziz Alanazi, Sharifa Alghamdi, Shirin Anil, Asaad Assiri
PURPOSE: To determine the socio-economic impact of gluten free diet (GFD) on Saudi children and their families. METHODS: A cross-sectional study was conducted in which an online questionnaire was sent to all families registered in the Saudi celiac patients support group. We included only children (age 18 years of age and younger) with biopsy-confirmed celiac disease (CD). RESULTS: A total of 113 children were included in the final analysis, the median age was 9...
September 2016: Pediatric Gastroenterology, Hepatology & Nutrition
Mahya Sultan Tosun, Vildan Ertekin
Pigmentary mosaicism is a term used to encompass all of these different types of pigmentary patterns. Among these mosaic patterns, there have been only a few reports of the phylloid presentation in the literature. On the other hand, autoimmune disorders can be associated with neurocutaneous markers and syndromes. A fifteen-year-old girl was presented for chronic diarrhea and abdominal pain. Her physical examination had determined multiple hypopigmented patches. Finally, she was diagnosed phylloid hypomelanosis together with partial trisomy 13 accompanying celiac disease and autoimmune thyroiditis...
November 2015: Turkish Journal of Pediatrics
Ercan Mıhçı, Banu Güzel Nur, Sibel Berker-Karaüzüm, Aygen Yılmaz, Reha Artan
Celiac disease is an autoimmune, gastrointestinal disorder characterized by intolerance to the dietary grain protein gluten. An increased prevalence of celiac disease has been reported in Down syndrome and Turner syndrome, but there has been only few previous reports with respect to the association of celiac disease in Williams-Beuren syndrome. The aim of this study was to evaluate the frequency of celiac disease in our 24 Williams-Beuren syndrome patients. Gastrointestinal problems and celiac disease symptoms of patients were noted...
November 2015: Turkish Journal of Pediatrics
Pravin M Rathi, Vinay G Zanwar
There has been increasing interest in the entity "Non-celiac gluten sensitivity" in recent years which was first of its in 1980s. This "re-discovered" disorder is characterized by intestinal and extra-intestinal symptoms which occur after ingestion of gluten containing food. The number of such patients who neither have celiac disease nor wheat allergy, but appear to benefit from gluten withdrawal is increasing substantially. However it still remains a controversial and its pathogenesis is not well understood...
March 2016: Journal of the Association of Physicians of India
Madhu Kumar Mh, Aravind Gn, Madhumathi R, Tharun Tom Oommen
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Ranjit Singh, Manish Gutch, Madukar Mittal, Sukriti Kumar, Syed Mohd Razi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Anna Pham-Short, Kim C Donaghue, Geoffrey Ambler, Sarah Garnett, Maria E Craig
OBJECTIVE: To evaluate quality of life (QoL) and glycemic control in youth with type 1 diabetes (T1D) and celiac disease vs T1D only. We hypothesized that QoL scores would be lower in youth with T1D and celiac disease and those nonadherent to the gluten-free diet (GFD). STUDY DESIGN: This case control study included 35 youth with T1D and 35 with T1D  and  celiac disease matched for age, sex, diabetes duration, and hemoglobin A1c level. QoL was assessed in participants and parents using the Pediatric Quality of Life Inventory Generic Core Scale, Pediatric Quality of Life Inventory Diabetes Module...
October 5, 2016: Journal of Pediatrics
E Kamycheva, T Goto, C A Camargo
: We investigated the association between celiac disease (CD) and bone mass density (BMD) and risk of osteoporotic fractures in the general US population. In children and men ≥18 years, CD was associated with reduced BMD, and in men ≥40 years, CD was associated with increased risk of osteoporotic fractures. INTRODUCTION: Celiac disease (CD) is an autoimmune condition, characterized by inflammation of the small intestine. CD has an increasing prevalence, and if unrecognized or untreated, CD can lead to complications from malabsorption and micronutrient deficiencies...
October 6, 2016: Osteoporosis International
Janaína Guilhem Muniz, Vera Lucia Sdepanian, Ulysses Fagundes
Background: Celiac disease is a permanent intolerance induced by gluten, which is expressed by T-cell mediated enteropathy, and has a high prevalence in the general population. There is evidence of a strong genetic predisposition to celiac disease. Objective: To determine the prevalence of genetic markers HLA-DQ2 and HLA-DQ8 in blood donors from São Paulo and measure human recombinant tissue transglutaminase antibody IgA class in HLA-DQ2 and HLA-DQ8 positive donors...
October 2016: Arquivos de Gastroenterologia
Nishant K Singh, Brian M Baker
Recognition of antigens by T cell receptors (TCRs) underlies cellular immunity. By comparing how different TCRs recognize the key antigens associated with celiac disease, Petersen et al. (2016), in this issue of Structure, show how celiac antigen properties select immunologically distinct yet structurally and physically compatible TCRs, ultimately driving autoimmunity.
October 4, 2016: Structure
Michael Schumann, Lydia Lebenheim
Celiac disease occurs as a result of a T-cell-dependent immune reaction on gluten peptides. It is a complex genetic disorder that is mediated by an unknown number of genes, of which more than 50 have been identified in whole genome association studies. The genetic component helps identify oligosymptomatic or even subclinical celiacs by screening first-degree relatives and patients suffering from other autoimmune diseases. To offer sensitive as well as specific diagnostics for celiac disease (serology and small intestinal histology) some general rules should be followed including performing diagnostics only when patients are on a gluten-containing diet or after an appropriate re-exposition...
September 2016: Deutsche Medizinische Wochenschrift
Laura Petrarca, Raffaella Nenna
No abstract text is available yet for this article.
October 2016: Headache
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