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"Celiac disease"

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https://www.readbyqxmd.com/read/28210247/genome-insight-and-comparative-pathogenomic-analysis-of-nesterenkonia-jeotgali-strain-cd08_7-isolated-from-duodenal-mucosa-of-celiac-disease-patient
#1
Atul M Chander, Ramesan G Nair, Gurwinder Kaur, Rakesh Kochhar, Devinder K Dhawan, Sanjay K Bhadada, Shanmugam Mayilraj
Species of the genus Nesterenkonia have been isolated from different ecological niches, especially from saline habitats and reported as weak human pathogens causing asymptomatic bacteraemia. Here, for the first time we are reporting the genome sequence and pathogenomic analysis of a strain designated as CD08_7 isolated from the duodenal mucosa of a celiac disease patient, identified as Nesterenkonia jeotgali. To date, only five strains of the genus Nesterenkonia (N. massiliensis strain NP1(T), Nesterenkonia sp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28209962/characterization-of-celiac-disease-related-oat-proteins-bases-for-the-development-of-high-quality-oat-varieties-suitable-for-celiac-patients
#2
María J Giménez, Ana Real, M Dolores García-Molina, Carolina Sousa, Francisco Barro
Some studies have suggested that the immunogenicity of oats depends on the cultivar. RP-HPLC has been proposed as a useful technique to select varieties of oats with reduced immunogenicity. The aim of this study was to identify both the avenin protein patterns associated with low gluten content and the available variability for the development of new non-toxic oat cultivars. The peaks of alcohol-soluble avenins of a collection of landraces and cultivars of oats have been characterized based on the RP-HPLC elution times...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209104/impact-of-gluten-free-diet-on-quality-of-life-in-celiac-patients
#3
R Borghini, M Di Tola, E Salvi, C Isonne, M Puzzono, M Marino, G Donato, A Picarelli
BACKGROUND AND AIM: Celiac disease (CD) is a common gluten-related disorder, whose only treatment is a gluten-free diet (GFD). Since a unique view on psychological consequences of a GFD still lacks, our aim was to assess the quality of life (QoL) and the depression state in symptomatic CD patients after GFD. Socio-demographic features were considered. PATIENTS AND METHODS: 210 adult CD patients were recruited and divided into 3 groups : 70 newly diagnosed patients (​Group A​),70 patients who have been on GFD for 6-12 months (​Group B​), and 70 patients who have been on GFD for more than 12 months (​Group C​)...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28208686/identification-of-autophagy-related-genes-and-their-regulatory-mirnas-associated-with-celiac-disease-in-children
#4
Sergio Comincini, Federico Manai, Cristina Meazza, Sara Pagani, Carolina Martinelli, Noemi Pasqua, Gloria Pelizzo, Marco Biggiogera, Mauro Bozzola
Celiac disease (CD) is a severe genetic autoimmune disorder, affecting about one in 100 people, where the ingestion of gluten leads to damage in the small intestine. Diagnosing CD is quite complex and requires blood tests and intestinal biopsy examinations. Controversy exists regarding making the diagnosis without biopsy, due to the large spectrum of manifesting symptoms; furthermore, small-intestinal gastroscopy examinations have a relatively complex management in the pediatric population. To identify novel molecular markers useful to increase the sensitivity and specificity in the diagnosis of pediatric CD patients, the expression levels of two key autophagy executor genes (ATG7 and BECN1) and their regulatory validated miRNAs (miR-17 and miR-30a, respectively) were analyzed by relative quantitative real-time-PCR on a cohort of confirmed CD patients compared to age-related controls...
February 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208589/association-of-lpp-and-tagap-polymorphisms-with-celiac-disease-risk-a-meta-analysis
#5
Shi-Qi Huang, Na Zhang, Zi-Xing Zhou, Chui-Can Huang, Cheng-Li Zeng, Di Xiao, Cong-Cong Guo, Ya-Jing Han, Xiao-Hong Ye, Xing-Guang Ye, Mei-Ling Ou, Bao-Huan Zhang, Yang Liu, Eddy Y Zeng, Guang Yang, Chun-Xia Jing
Background: Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074...
February 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28204873/dysbiosis-a-risk-factor-for-celiac-disease
#6
REVIEW
Anamaria Girbovan, Genel Sur, Gabriel Samasca, Iulia Lupan
Celiac disease remains one of the most challenging pathologies of the small intestine. It involves multiple pathogenic pathways and there are no disease-changing pharmacological agents available against it yet. The term microbiota refers to the community of microorganisms that inhabit a particular region of the body. Normal gut microbiota has a vital role in maintaining the intestinal homeostasis and promoting health. Celiac disease is associated with microbiota alteration, especially with an increase in the number of Gram-negative bacteria and a decrease in the number of Gram-positive bacteria...
February 15, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28196682/mode-of-delivery-and-risk-of-celiac-disease-risk-of-celiac-disease-and-age-at-gluten-introduction-cohort-study
#7
Elena Lionetti, Stefania Castellaneta, Ruggiero Francavilla, Alfredo Pulvirenti, Carlo Catassi
OBJECTIVE: To determine whether the mode of delivery is associated with the risk of celiac disease (CD) in a cohort of children genetically predisposed to CD prospectively followed from birth. STUDY DESIGN: By telephone interview, we recorded information on the mode of delivery of children participating in the Risk of Celiac Disease and Age at Gluten Introduction study, a multicenter, prospective intervention trial that compared early and delayed introduction of gluten in infants with at least 1 first-degree relative affected with CD...
February 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28194597/celiac-disease-treatment-is-it-the-chicken-or-the-egg-yolk
#8
EDITORIAL
Valentina Discepolo, Stefano Guandalini
No abstract text is available yet for this article.
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28191721/small-intestinal-bacterial-overgrowth-and-celiac-disease-a%C3%A2-systematic-review-with-pooled-data-analysis
#9
G Losurdo, A Marra, E Shahini, B Girardi, F Giorgio, A Amoruso, A Pisani, D Piscitelli, M Barone, M Principi, A Di Leo, E Ierardi
BACKGROUND: A link between small intestinal bacterial overgrowth (SIBO) and celiac disease (CD) has been hypothesized. METHODS: Literature search was performed in main medical databases. Methods of analysis/inclusion criteria were based on Preferred Reporting Items for Systematic reviews and Meta-Analyses recommendations. The end-point was to estimate, by a pooled-data analysis, SIBO prevalence in CD. Proportions/percentages and their 95% confidence intervals (CI) were calculated by inverse variance method, whereas odd ratios (OR) and their 95% CI were estimated, where available, based on the Mantel-Haenszel method...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28188747/high-incidence-of-celiac-disease-in-a-long-term-study-of-adolescents-with-susceptibility-genotypes
#10
Edwin Liu, Fran Dong, Anna E Barón, Iman Taki, Jill M Norris, Brigitte I Frohnert, Edward J Hoffenberg, Marian Rewers
BACKGROUND & AIMS: Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. METHODS: We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA)...
February 7, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28187197/genetic-variants-alter-t-bet-binding-and-gene-expression-in-mucosal-inflammatory-disease
#11
Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that may be causative for autoimmune diseases. The majority of these polymorphisms are located within non-coding distal regulatory elements...
February 10, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28186337/impaired-intestinal-cholecystokinin-secretion-a-fascinating-but-overlooked-link-between-celiac-disease-and-cholesterol-gallstone-disease
#12
REVIEW
Helen H Wang, Min Liu, Xiaodan Li, Piero Portincasa, David Q-H Wang
BACKGROUND: Celiac disease is a chronic, small intestinal, immune-mediated enteropathy caused by a permanent intolerance to dietary gluten in genetically predisposed individuals. Clinical studies have found that intestinal cholecystokinin secretion and gallbladder emptying in response to a fatty meal are impaired before celiac patients start the gluten-free diet (GFD). DESIGN: However, it was never really appreciated whether celiac disease is associated with gallstones because there were very few studies investigating the mechanism underlying the impact of celiac disease on the pathogenesis of gallstones...
February 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28185175/blood-levels-of-lead-and-mercury-and-celiac-disease-seropositivity-the-us-national-health-and-nutrition-examination-survey
#13
Elena Kamycheva, Tadahiro Goto, Carlos A Camargo
Celiac disease (CD) is an autoimmune disease with increasing prevalence in the USA. CD leads to decreased absorption of many nutrients including certain divalent metals. On the other hand, recent cross-sectional studies suggest the associations between trace heavy metal exposure and autoimmunity. We aimed to determine if there is an association between CD autoimmunity and blood levels of heavy metals in the general US population. We used nationally representative data from National Health and Nutrition Examination Survey, 2009-2012...
February 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28182308/mr-enterography-in-nonresponsive-adult-celiac-disease-correlation-with-endoscopic-pathologic-serologic-and-genetic-features
#14
Amir Reza Radmard, Amir Pejman Hashemi Taheri, Elham Salehian Nik, Soheil Kooraki, Shadi Kolahdoozan, Babak Mirminachi, Masoud Sotoudeh, Golnaz Ekhlasi, Reza Malekzadeh, Bijan Shahbazkhani
PURPOSE: To assess small bowel abnormalities on magnetic resonance enterography (MRE) in adult patients with nonresponsive celiac disease (CD) and investigate their associations with endoscopic, histopathologic, serologic, and genetic features. MATERIALS AND METHODS: This prospective study was carried out between September 2012 and August 2013. After approval by the Ethics Committee of our institution, informed consent was acquired from all participants. Forty consecutive patients with nonresponsive CD, aged 17-76 years, underwent MRE using a 1...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28178205/gluten-contamination-in-naturally-or-labeled-gluten-free-products-marketed-in-italy
#15
Anil K Verma, Simona Gatti, Tiziana Galeazzi, Chiara Monachesi, Lucia Padella, Giada Del Baldo, Roberta Annibali, Elena Lionetti, Carlo Catassi
BACKGROUND: A strict and lifelong gluten-free diet is the only treatment of celiac disease. Gluten contamination has been frequently reported in nominally gluten-free products. The aim of this study was to test the level of gluten contamination in gluten-free products currently available in the Italian market. METHOD: A total of 200 commercially available gluten-free products (including both naturally and certified gluten-free products) were randomly collected from different Italian supermarkets...
February 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28177956/optimizing-the-diagnosis-of-celiac-disease
#16
Michelle Shui Yee Lau, David Surendran Sanders
PURPOSE OF REVIEW: The diagnostic approach in celiac disease is continuously evolving as our understanding of its pathophysiology improves. This review aims to provide a summary of contemporary work that supports optimization of the diagnosis of this common yet underdiagnosed condition. RECENT FINDINGS: The recently updated National Institute of Clinical Excellence and European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines and the contentious biopsy-free diagnostic approach will be discussed...
February 7, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28176232/celiac-disease-in-children-with-severe-acute-malnutrition-sam-a-hospital-based-study
#17
Neetu Beniwal, Gaurav Ameta, Chandra Kumar Chahar
OBJECTIVES: To evaluate the prevalence and clinical features of Celiac disease among children with severe acute malnutrition (SAM). METHODS: This prospective observational study was conducted in PBM Children Hospital, Bikaner from July 2012 through December 2013. All consecutively admitted children with SAM were recruited. All subjects were screened for Celiac disease by serological test for IgA-anti tissue Transglutaminase (IgA tTG) antibodies. All seropositive children underwent upper gastrointestinal endoscopy for small bowel biopsy for the confirmation...
February 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28175271/p697-association-of-inflammatory-bowel-disease-and-celiac-disease-experience-in-a-hospital-of-the-autonomous-community-of-madrid-spain
#18
N Manceñido Marcos, R Pajares Villarroya, S Salinas Moreno, M R Arribas Lόpez, C Comas Redondo
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175022/p206-celiac-disease-and-inflammatory-bowel-disease-a%C3%A2-rare-association
#19
A Boutaleb, H Saoula, M Aissaoui, D Hamidouche, Y Aissat, H Mahiou, R Osmane, Y Zmiri, A Mitiche, M Nakmouche, F Hamchaoui
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174758/interferon-alpha-promotes-th1-response-and-epithelial-apoptosis-via-inflammasome-activation-in-human-intestinal-mucosa
#20
Anne Jarry, Florent Malard, Chantal Bou-Hanna, Guillaume Meurette, Mohamad Mohty, Jean-François Mosnier, Christian L Laboisse, Céline Bossard
BACKGOUND & AIMS: Several lines of investigation suggest that interferon (IFN) alpha can alter human intestinal mucosa homeostasis. These include the endogenous production of IFN alpha in celiac disease or inflammatory bowel diseases, as well as the occurrence of intestinal side effects of exogenous IFN alpha used as a therapeutic tool. Here, we present an ex vivo translational approach to investigate the effects of IFN alpha on the human normal intestinal mucosa, as well as its underlying mechanisms...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
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