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Michael Pascoe

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https://www.readbyqxmd.com/read/29659799/exposure-of-escherichia-coli-to-human-hepcidin-results-in-differential-expression-of-genes-associated-with-iron-homeostasis-and-oxidative-stress
#1
Michael J Pascoe, Jiraporn Lueangsakulthai, Delia Ripley, Roger H Morris, Sarah E Maddocks
Hepcidin belongs to the antimicrobial peptide family but has weak activity with regards to bacterial killing. The regulatory function of hepcidin in humans serves to maintain an iron-restricted environment that limits the growth of pathogens; this study explored whether hepcidin affected bacterial iron homeostasis and oxidative stress using the model organism Escherichia coli. Using the Miller assay it was determined that under low iron availability exposure to sub-inhibitory doses of hepcidin (4 -12μM) led to 2-fold and 4-fold increases in the expression of ftnA and bfd respectively (p < 0...
April 6, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29597229/the-symbol-digit-modalities-test-in-mild-cognitive-impairment-evidence-from-parkinson-s-disease-patients
#2
Maddie Pascoe, Yassar Alamri, John Dalrymple-Alford, Tim Anderson, Michael MacAskill
BACKGROUND: The evaluation process of the performance of the symbol-digit modalities test (SDMT) has focused much on numerical scores paying only little attention to the qualitative aspects of performance. Incorporating the gaze analysis technique, we aimed to investigate the performance of Parkinson's disease (PD) patients on the written SDMT task. METHODS: Twelve patients with PD and normal cognition (PD-N), 11 with PD and mild cognitive impairment (PD-MCI), and 13 healthy participants (NC) controlled for age, sex and education were recruited...
March 29, 2018: European Neurology
https://www.readbyqxmd.com/read/29589468/response-to-pitfalls-of-big-data
#3
Joanna F Dipnall, Julie A Pasco, Michael Berk, Lana J Williams, Seetal Dodd, Felice N Jacka, Denny Meyer
No abstract text is available yet for this article.
March 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29563029/the-subjective-wellbeing-profile-of-the-pretiree-demographic-a-cross-sectional-study
#4
Julie A Pasco, Kara L Holloway, Amanda L Stuart, Lana J Williams, Sharon L Brennan-Olsen, Michael Berk
OBJECTIVES: Pretirees are a demographic interposed between the latter stages of working life and old age. We aimed to characterise subjective wellbeing and lifestyle behaviours for individuals aged in their late-fifties and sixties. STUDY DESIGN: Cross-sectional study of 233 men and 229 women aged 55-69 yr from the Geelong Osteoporosis Study. MAIN OUTCOME MEASURES: Subjective wellbeing assessed using the World Health Organization Quality of Life questionnaire (WHOQOL-BREF, Australia)...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29441424/selective-serotonin-reuptake-inhibitors-ssris-and-markers-of-bone-turnover-in-men
#5
Lana J Williams, Michael Berk, Jason M Hodge, Mark A Kotowicz, Amanda L Stuart, Vinoomika Chandrasekaran, Jasmine Cleminson, Julie A Pasco
Selective serotonin reuptake inhibitors (SSRIs) have been shown to have a clinically significant impact on bone metabolism. To explore this further, we aimed to determine whether these agents are associated with serum markers of bone turnover utilising a population-based sample of men (n = 1138; 20-96 year) participating in the Geelong Osteoporosis Study. Blood samples were obtained and the bone resorption marker, C-telopeptide (CTx) and formation marker, type 1 procollagen amino-terminal-propeptide (PINP) were measured...
February 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29421968/multiple-short-bouts-of-walking-activity-attenuate-glucose-response-in-obese-women
#6
Mynor Rodriguez-Hernandez, Jeffrey S Martin, David D Pascoe, Michael D Roberts, Danielle W Wadsworth
BACKGROUND: We sought to determine the effect of multiple walking breaks from sedentary behavior (SED) on glucose responses in sedentary obese women. MATERIALS AND METHODS: Ten women [aged = 36 (5) y, body mass index = 38.0 (1.6) kg/m2, body fat = 49.6 (1.4)%] completed 3 conditions (48-h "washout" in-between conditions) following a standardized meal in random order: 4-hour SED, 4-hour SED with 2 minutes of moderate-intensity walking every 30 minutes (SED + 2 min), and 4-hour SED with 5 minutes of moderate-intensity walking every 30 minutes (SED + 5 min)...
February 9, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29373967/personality-dimensions-emerging-during-adolescence-and-young-adulthood-are-underpinned-by-a-single-latent-trait-indexing-impairment-in-social-functioning
#7
Ela Polek, Peter B Jones, Pasco Fearon, Jeannette Brodbeck, Michael Moutoussis, Nspn Consortium, Ray Dolan, Peter Fonagy, Edward T Bullmore, Ian M Goodyer
BACKGROUND: Personality with stable behavioural traits emerges in the adolescent and young adult years. Models of putatively distinct, but correlated, personality traits have been developed to describe behavioural styles including schizotypal, narcissistic, callous-unemotional, negative emotionality, antisocial and impulsivity traits. These traits have influenced the classification of their related personality disorders. We tested if a bifactor model fits the data better than correlated-factor and orthogonal-factor models and subsequently validated the obtained factors with mental health measures and treatment history...
January 26, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29370389/corrigendum-crop-model-assisted-phenomics-and-genome-wide-association-study-for-climate-adaptation-of-indica-rice-2-thermal-stress-and-spikelet-sterility
#8
Michael Dingkuhn, Richard Pasco, Julie Mae Pasuquin, Jean Damo, Jean-Christophe Soulié, Louis-Marie Raboin, Julie Dusserre, Abdoulaye Sow, Baboucarr Manneh, Suchit Shrestha, Tobias Kretzschmar
No abstract text is available yet for this article.
January 23, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29370388/corrigendum-crop-model-assisted-phenomics-and-genome-wide-association-study-for-climate-adaptation-of-indica-rice-1-phenology
#9
Michael Dingkuhn, Richard Pasco, Julie M Pasuquin, Jean Damo, Jean-Christophe Soulié, Louis-Marie Raboin, Julie Dusserre, Abdoulaye Sow, Baboucarr Manneh, Suchit Shrestha, Alpha Balde, Tobias Kretzschmar
No abstract text is available yet for this article.
January 23, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29316017/a-comparison-of-graft-and-patient-outcomes-following-kidney-transplantation-in-extended-hour-and-conventional-haemodialysis-patients
#10
Emily J See, Carmel M Hawley, Yeoungjee Cho, Nigel D Toussaint, John Wm Agar, Elaine M Pascoe, Wai H Lim, Ross S Francis, Michael G Collins, David W Johnson
AIM: Differences in early graft function between kidney transplant recipients previously managed with either haemodialysis (HD) or peritoneal dialysis are well described. However, only two single-centre studies have compared graft and patient outcomes between extended hour and conventional HD patients, with conflicting results. METHODS: This study compared the outcomes of all extended hour (≥24 hours/week) and conventional HD patients transplanted in Australia and New Zealand between 2000 and 2014...
January 8, 2018: Nephrology
https://www.readbyqxmd.com/read/29175948/increased-nonhdl-cholesterol-levels-cause-muscle-wasting-and-ambulatory-dysfunction-in-the-mouse-model-of-lgmd2b
#11
Stephanie L Sellers, Nadia Milad, Zoe White, Chris Pascoe, Rayleigh Chan, Geoffrey W Payne, Chun Seow, Fabio Rossi, Michael A Seidman, Pascal Bernatchez
Progressive limb and girdle muscle atrophy leading to loss of ambulation is a hallmark of dysferlinopathies, which include limb-girdle muscular dystrophy type 2B and Miyoshi myopathy. However, animal models fail to fully reproduce the disease severity observed in humans, with dysferlin-null (Dysf-/- ) mice exhibiting minor muscle damage and weakness without dramatic ambulatory dysfunction. As we have previously reported significant Dysf expression in blood vessels, we investigated the role of vascular function in development of muscle pathology by generating a Dysf-deficient mouse model with vascular disease...
February 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29097149/emotional-eating-and-instructed-food-cue-processing-in-adolescents-an-erp-study
#12
Jia Wu, Cynthia J Willner, Claire Hill, Pasco Fearon, Linda C Mayes, Michael J Crowley
We examined the P3 (250-500ms) and Late Positive Potential (LPP; 500-2000ms) event-related potentials (ERPs) to food vs. nonfood cues among adolescents reporting on emotional eating (EE) behavior. Eighty-six adolescents 10-17 years old were tested using an instructed food versus nonfood cue viewing task (imagine food taste) during high-density EEG recording. Self-report data showed that EE increased with age in girls, but not in boys. Both P3 and LPP amplitudes were greater for food vs. nonfood cues (food-cue bias)...
February 2018: Biological Psychology
https://www.readbyqxmd.com/read/29075862/concomitant-external-pneumatic-compression-treatment-with-consecutive-days-of-high-intensity-interval-training-reduces-markers-of-proteolysis
#13
Cody T Haun, Michael D Roberts, Matthew A Romero, Shelby C Osburn, James C Healy, Angelique N Moore, Christopher B Mobley, Paul A Roberson, Wesley C Kephart, Petey W Mumford, Michael D Goodlett, David D Pascoe, Jeffrey S Martin
PURPOSE: To compare the effects of external pneumatic compression (EPC) and sham when used concurrently with high intensity interval training (HIIT) on performance-related outcomes and recovery-related molecular measures. METHODS: Eighteen recreationally endurance-trained male participants (age: 21.6 ± 2.4 years, BMI: 25.7 ± 0.5 kg/m2 , VO2peak : 51.3 ± 0.9 mL/kg/min) were randomized to balanced sham and EPC treatment groups. Three consecutive days of HIIT followed by EPC/sham treatment (Days 2-4) and 3 consecutive days of recovery (Days 5-7) with EPC/sham only on Days 5-6 were employed...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28963127/molecular-neuromuscular-and-recovery-responses-to-light-versus-heavy-resistance-exercise-in-young-men
#14
Cody T Haun, Petey W Mumford, Paul A Roberson, Matthew A Romero, Christopher B Mobley, Wesley C Kephart, Richard G Anderson, Ryan J Colquhoun, Tyler W D Muddle, Michael J Luera, Cameron S Mackey, David D Pascoe, Kaelin C Young, Jeffrey S Martin, Jason M DeFreitas, Nathaniel D M Jenkins, Michael D Roberts
Recent evidence suggests that resistance training with light or heavy loads to failure results in similar adaptations. Herein, we compared how both training modalities affect the molecular, neuromuscular, and recovery responses following exercise. Resistance-trained males (mean ± SE: 22 ± 2 years, 84.8 ± 9.0 kg, 1.79 ± 0.06 m; n = 15) performed a crossover design of four sets of leg extensor exercise at 30% (light RE) or 80% (heavy RE) one repetition maximum (1RM) to repetition failure, and heavy RE or light RE 1 week later...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28959158/effects-of-a-pre-workout-supplement-on-hyperemia-following-leg-extension-resistance-exercise-to-failure-with-different-resistance-loads
#15
Jeffrey S Martin, Petey W Mumford, Cody T Haun, Micheal J Luera, Tyler W D Muddle, Ryan J Colquhoun, Mary P Feeney, Cameron S Mackey, Paul A Roberson, Kaelin C Young, David D Pascoe, Jason M DeFreitas, Nathaniel D M Jenkins, Michael D Roberts
BACKGROUND: We sought to determine if a pre-workout supplement (PWS), containing multiple ingredients thought to enhance blood flow, increases hyperemia associated with resistance training compared to placebo (PBO). Given the potential interaction with training loads/time-under-tension, we evaluated the hyperemic response at two different loads to failure. METHODS: Thirty males participated in this double-blinded study. At visit 1, participants were randomly assigned to consume PWS (Reckless™) or PBO (maltodextrin and glycine) and performed four sets of leg extensions to failure at 30% or 80% of their 1-RM 45-min thereafter...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28922774/crop-model-assisted-phenomics-and-genome-wide-association-study-for-climate-adaptation-of-indica-rice-1-phenology
#16
Michael Dingkuhn, Richard Pasco, Julie M Pasuquin, Jean Damo, Jean-Christophe Soulié, Louis-Marie Raboin, Julie Dusserre, Abdoulaye Sow, Baboucarr Manneh, Suchit Shrestha, Alpha Balde, Tobias Kretzschmar
Phenology and time of flowering are crucial determinants of rice adaptation to climate variation. A previous study characterized flowering responses of 203 diverse indica rices (the ORYTAGE panel) to ten environments in Senegal (six sowing dates) and Madagascar (two years and two altitudes) under irrigation in the field. This study used the physiological phenology model RIDEV V2 to heuristically estimate component traits of flowering such as cardinal temperatures (base temperature (Tbase) and optimum temperature), basic vegetative phase, photoperiod sensitivity and cold acclimation, and to conduct a genome-wide association study for these traits using 16 232 anonymous single-nucleotide polymorphism (SNP) markers...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922773/crop-model-assisted-phenomics-and-genome-wide-association-study-for-climate-adaptation-of-indica-rice-2-thermal-stress-and-spikelet-sterility
#17
Michael Dingkuhn, Richard Pasco, Julie Mae Pasuquin, Jean Damo, Jean-Christophe Soulié, Louis-Marie Raboin, Julie Dusserre, Abdoulaye Sow, Baboucarr Manneh, Suchit Shrestha, Tobias Kretzschmar
Low night and high day temperatures during sensitive reproductive stages cause spikelet sterility in rice. Phenotyping of tolerance traits in the field is difficult because of temporal interactions with phenology and organ temperature differing from ambient. Physiological models can be used to separate these effects. A 203-accession indica rice diversity panel was phenotyped for sterility in ten environments in Senegal and Madagascar and climate data were recorded. Here we report on sterility responses while a companion study reported on phenology...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28888138/personality-disorder-is-an-excess-risk-factor-for-physical-multimorbidity-among-women-with-mental-state-disorders
#18
Shae E Quirk, Amanda L Stuart, Michael Berk, Julie A Pasco, Sharon L Brennan Olsen, Heli Koivumaa-Honkanen, Risto Honkanen, Pyry S Lukkala, Andrew M Chanen, Mark Kotowicz, Lana J Williams
We examined whether mental state disorders (lifetime mood, anxiety, eating, substance misuse) with comorbid personality disorder are associated with physical multimorbidity in a population-based sample of women. Mental state and personality disorders were assessed using semi-structured diagnostic interviews. Clinical measures were performed and medical conditions, medication use and lifestyle factors were documented by questionnaire. Mental state disorders were associated with higher odds of physical multimorbidity; risk was especially high for those with comorbid personality disorder...
August 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28869573/effects-of-whey-soy-or-leucine-supplementation-with-12-weeks-of-resistance-training-on-strength-body-composition-and-skeletal-muscle-and-adipose-tissue-histological-attributes-in-college-aged-males
#19
C Brooks Mobley, Cody T Haun, Paul A Roberson, Petey W Mumford, Matthew A Romero, Wesley C Kephart, Richard G Anderson, Christopher G Vann, Shelby C Osburn, Coree D Pledge, Jeffrey S Martin, Kaelin C Young, Michael D Goodlett, David D Pascoe, Christopher M Lockwood, Michael D Roberts
We sought to determine the effects of L-leucine (LEU) or different protein supplements standardized to LEU (~3.0 g/serving) on changes in body composition, strength, and histological attributes in skeletal muscle and adipose tissue. Seventy-five untrained, college-aged males (mean ± standard error of the mean (SE); age = 21 ± 1 years, body mass = 79.2 ± 0.3 kg) were randomly assigned to an isocaloric, lipid-, and organoleptically-matched maltodextrin placebo (PLA, n = 15), LEU (n = 14), whey protein concentrate (WPC, n = 17), whey protein hydrolysate (WPH, n = 14), or soy protein concentrate (SPC, n = 15) group...
September 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28856902/getting-rid-of-the-blues-formulating-a-risk-index-for-depression-rid-using-structural-equation-modeling
#20
Joanna F Dipnall, Julie A Pasco, Michael Berk, Lana J Williams, Seetal Dodd, Felice N Jacka, Denny Meyer
OBJECTIVE: While risk factors for depression are increasingly known, there is no widely utilised depression risk index. Our objective was to develop a method for a flexible, modular, Risk Index for Depression using structural equation models of key determinants identified from previous published research that blended machine-learning with traditional statistical techniques. METHODS: Demographic, clinical and laboratory variables from the National Health and Nutrition Examination Study (2009-2010, N = 5546) were utilised...
August 1, 2017: Australian and New Zealand Journal of Psychiatry
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