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https://www.readbyqxmd.com/read/29774078/targeting-intracellular-mmps-efficiently-inhibits-tumor-metastasis-and-angiogenesis
#1
Yaqi Lv, Xiangmei Zhao, Lidan Zhu, Sijia Li, Qingqing Xiao, Wei He, Lifang Yin
Treatment for metastatic cancer is a great challenge throughout the world. Commonly, directed inhibition of extracellular matrix metalloproteinases (MMPs) secreted by cancer cells can reduce metastasis. Here, a novel nanoplatform (HPMC NPs) assembled from hyaluronic acid (HA)-paclitaxel (PTX) prodrug and marimastat (MATT)/β-casein (CN) complexes was established to cure a 4T1 metastatic cancer model via targeting CD44 and intracellular, rather than extracellular, MMPs. Methods: HPMC NPs were prepared by assembling the complexes and prodrug under ultrasonic treatment, which the interaction between them was evaluated by förster resonance energy transfer, circular dichroism and fluorescence spectra...
2018: Theranostics
https://www.readbyqxmd.com/read/29771107/design-and-synthesis-of-a-biocompatible-1d-coordination-polymer-as-anti-breast-cancer-drug-carrier-5-fu-in-vitro-and-in-vivo-studies
#2
Mahsa Rezaei, Alireza Abbasi, Rassoul Dinarvand, Mahmood Jeddi-Tehrani, Jan Janczak
Designable coordination polymers with suitable chemical diversities and biocompatible structures have been proposed as a promising class of vehicles for drug delivery systems. Here, we hydrothermally synthesized a novel one-dimensional (1D) coordination polymer, [Zn(H2 O)6 K2 (H2 BTC)2 (H2 O)4 ](H2 BTC)2 ·2H2 O, where H3 BTC = benzene-1,3,5-tricarboxylic acid (trimesic acid), cp.1. As the hydrogen bonds stabilized 1D chains in three dimensions, the cp.1 could be a good candidate for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu)...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770311/-super-active-surveillance-mri-ultrasound-fusion-biopsy-and-ablation-for-less-invasive-management-of-prostate-cancer
#3
REVIEW
Jonathan B Bloom, Samuel A Gold, Graham R Hale, Kareem N Rayn, Vikram K Sabarwal, Ivane Bakhutashvili, Vladimir Valera, Baris Turkbey, Peter A Pinto, Bradford J Wood
Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29768228/facile-synthesis-by-a-covalent-binding-reaction-for-ph-responsive-drug-release-of-carboxylated-chitosan-coated-hollow-mesoporous-silica-nanoparticles
#4
Qiang Liu, Jiao Wang, Linnan Yang, Xiaofei Xia, Mei Wang, Shengguang Chen, Rongrong Zhu, Qingxiu Wang, Xianzheng Wu, Shilong Wang
In this study, a promising drug nano-carrier system consisting of mono-dispersed and pH sensitive carboxylated chitosan-hollow mesoporous silica nanoparticles (Ccs-HMSNs) suitable for the treatment of malignant cells was synthesised and investigated. At neutral pH, the Ccs molecules are orderly aggregated state, which could effectively hinder the release of loaded drug molecules. However, in slightly acidic environment, Ccs chains are heavily and flexibly entangled in gel state, which would enhance the subsequent controlled release of the loaded drug...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29766626/co-2-laser-and-photodynamic-therapy-study-of-efficacy-in-periocular-bcc
#5
Santo Raffaele Mercuri, Pina Brianti, Annunziata Dattola, Luigi Bennardo, Martina Silvestri, Giusy Schipani, Steven Paul Nisticò
Basal cell carcinoma (BCC), the most common type of skin cancer in the world, usually arises in sun-exposed areas of the skin. The therapeutic approach to periocular BCC has changed in the last few years. Currently the treatment, considering the delicate localization of the disease, must not only ensure complete recovery from the neoplastic disease, but must also satisfy functional and aesthetic criteria. In this study we tried to evaluate the efficacy of CO2 laser and photodynamic therapy in periocular BCC...
May 15, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29762138/theranostic-gold-magnetite-hybrid-nanoparticles-for-mri-guided-radiosensitization
#6
Devid Maniglio, Filippo Benetti, Luca Minati, Jorge Jovicich, Aldo Valentini, G Speranza, Claudio Migliaresi
The main limitation of drug-enhanced radiotherapy concerns the difficulty to evaluate the effectiveness of cancer targeting after drug administration hindering the standardization of therapies based on current radiosensitizing compounds. The challenge regards the development of systems able to combine imaging and radiotherapy enhancement in order to perform highly reliable cancer theragnosis. For these reasons, gold-magnetite hybrid nanoparticles are proposed as innovative theranostic nanotools for imaging-guided radiosensitization in cancer treatment...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29759594/liquid-chromatography-mass-spectrometry-based-metabolomics-and-lipidomics-reveal-toxicological-mechanisms-of-bisphenol-f-in-breast-cancer-xenografts
#7
Chao Zhao, Peisi Xie, Hailin Wang, Zongwei Cai
Bisphenol F (BPF) is a major alternative to bisphenol (BPA) and has been widely used. Although BPA exposure is known to generate various toxic effects, toxicity of BPF remains under-explored. A comprehensive method involving mass spectrometry (MS)-based global lipidomics and metabolomics, and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI)- MS imaging (MSI) was used to study toxic effects of BPF and the underlying mechanisms on tumor metastasis-related tissues (liver and kidney) in breast cancer xenografts...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29756652/laser-treatment-for-women-with-high-grade-vaginal-intraepithelial-neoplasia-a-propensity-matched-analysis-on-the-efficacy-of-ablative-versus-excisional-procedures
#8
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Lavinia Mosca, Valentina Chiappa, Diego Rossetti, Umberto Leone Roberti Maggiore, Ilaria Sabatrucci, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To investigate the long-term effectiveness of LASER treatment in women affected by high-grade vaginal intra-epithelial neoplasia. METHODS: Data of consecutive women treated for high-grade vaginal intra-epithelial neoplasia were retrieved. Efficacy and long-term effectiveness of ablative and excisional procedures were tested using a propensity-matched algorithm. Risk of recurrence over the time was assessed using Kaplan-Meier and Cox models. RESULTS: Overall, 204 patients met the inclusion criteria...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29756609/impact-of-resection-margin-status-on-oncological-outcomes-after-co2-laser-cordectomy
#9
P Aluffi Valletti, F Taranto, A Chiesa, F Pia, G Valente
The management of positive resection margins in micro-endoscopic glottic laser surgery remains a controversial and critical point. This study aims to assess the impact of margin status after transoral laser surgery on local control, survival and organ preservation rates; the decision-making process and treatment options in cases with positive margins are also discussed. We retrospectively reviewed the clinical and histological records of 308 consecutive patients with primary early glottic carcinoma (T1a, T1b, selected T2) and treated with endoscopic laser cordectomy...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29753138/multifunctional-nir-responsive-pvp-cu-sb-s-nanotheranostic-agent-for-photoacoustic-imaging-and-photothermal-photodynamic-therapy
#10
Meirong Hou, Chenggong Yan, Zelong Chen, Qingliang Zhao, Miaomiao Yuan, Yikai Xu, Bingxia Zhao
Ternary copper-based chalcogenide nanomaterials have become rather attractive due to the near-infrared (NIR) response in cancer theranostic fields. However, it is still challenging to further improve the theranostic efficiency of these nanomaterials. Herein, Cu-Sb-S nanoparticles (NPs) around 24 nm are synthesized facilely and functionalized with poly(vinylpyrrolidone) (PVP). Under the NIR irradiation, the resultant PVP-Cu-Sb-S NPs exhibit a relatively high photothermal conversion efficiency of 53.16% and a simultaneous reactive oxygen species (ROS) generation effect...
May 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29748501/proteomic-investigation-to-identify-anticancer-targets-of-nemopilema-nomurai-jellyfish-venom-in-human-hepatocarcinoma-hepg2-cells
#11
Indu Choudhary, Hyunkyoung Lee, Min Jung Pyo, Yunwi Heo, Jinho Chae, Seung Shic Yum, Changkeun Kang, Euikyung Kim
Nemopilema nomurai is a giant jellyfish that blooms in East Asian seas. Recently, N. nomurai venom (NnV) was characterized from a toxicological and pharmacological point of view. A mild dose of NnV inhibits the growth of various kinds of cancer cells, mainly hepatic cancer cells. The present study aims to identify the potential therapeutic targets and mechanism of NnV in the growth inhibition of cancer cells. Human hepatocellular carcinoma (HepG2) cells were treated with NnV, and its proteome was analyzed using two-dimensional gel electrophoresis, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF/MS)...
May 10, 2018: Toxins
https://www.readbyqxmd.com/read/29747042/synthesis-of-carbon-dots-from-hypocrella-bambusae-for-bimodel-fluorescence-photoacoustic-imaging-guided-synergistic-photodynamic-photothermal-therapy-of-cancer
#12
Qingyan Jia, Xiuli Zheng, Jiechao Ge, Weimin Liu, Haohui Ren, Shiqing Chen, Yongmei Wen, Hongyan Zhang, Jiasheng Wu, Pengfei Wang
As phototheranostic agents, carbon dots (CDs), have recently drawn considerable attention due to their excellent physicochemical properties. However, the complex synthetic route and high-cost of CDs greatly limit their practical application. To address this issue, given their nearly infinite supply from nature, Hypocrella bambusae is used as the precursor for the preparation of CDs in this study. The obtained Hypocrella bambusae CDs (HBCDs) possess good water solubility, broad absorption (350-800 nm), red-light emission (maximum peak at 610 nm), and low biotoxicity...
May 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29745953/targeted-polypyrrole-nanoparticles-for-the-identification-and-treatment-of-hepatocellular-carcinoma
#13
Yushen Jin, Xin Yang, Jie Tian
Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29745740/co-delivery-of-gambogenic-acid-and-vegf-sirna-with-anionic-liposome-and-polyethylenimine-complexes-to-hepg2-cells
#14
Qiongfang Yu, Bian Zhang, Yali Zhou, Qin Ge, Chang Jiali, Yunna Chen, Kaiqi Zhang, Daiyin Peng, Weidong Chen
Background and Objective The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the anti-cancer efficiency in HepG2 cells. Methods The delivery system was prepared by a two-step method. Firstly, the GNA anionic liposome took shape by a solvent evaporation method, and then the liposome was bound to the PEI/siRNA complex by electrostatic interaction to form the final carrier system (lipopolyplexes)...
May 10, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29743538/which-technology-to-select-for-primary-focal-treatment-of-prostate-cancer-european-section-of-urotechnology-esut-position-statement
#15
REVIEW
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29740104/setup-errors-and-effectiveness-of-optical-laser-3d-surface-imaging-system-sentinel-in-postoperative-radiotherapy-of-breast-cancer
#16
Xiaobo Wei, Mengjiao Liu, Yun Ding, Qilin Li, Changhai Cheng, Xian Zong, Wenming Yin, Jie Chen, Wendong Gu
Breast-conserving surgery (BCS) plus postoperative radiotherapy has become the standard treatment for early-stage breast cancer. The aim of this study was to compare the setup accuracy of optical surface imaging by the Sentinel system with cone-beam computerized tomography (CBCT) imaging currently used in our clinic for patients received BCS. Two optical surface scans were acquired before and immediately after couch movement correction. The correlation between the setup errors as determined by the initial optical surface scan and CBCT was analyzed...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737551/whole-body-and-local-hyperthermia-enhances-the-photosensitizing-efficacy-of-3-1-hexyloxy-ethyl-3-devinylpyropheophorbide-a-hpph
#17
Avinash Srivatsan, Arindam Sen, Ravindra R Cheruku, Joseph R Missert, Farukh A Durrani, Khurshid Guru, Ravindra K Pandey
BACKGROUND AND OBJECTIVES: In this study, we evaluated the impact of hyperthermia in photosensitizing efficacy of 3-[(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH or Photochlor) for the treatment of cancer by photodynamic therapy (PDT). STUDY DESIGN/MATERIALS AND METHODS: The outcome of both whole body hyperthermia (WBH) and local hyperthermia (LH) in combination with HPPH-PDT was determined in BALB/c and nude mice bearing Colon26 and U87 tumors, respectively...
May 8, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29729155/-bipolar-electroexcision-and-endoscopic-laser-photocoagulation-colon-polyps
#18
Stepan S Filip, Andriy M Bratasyuk, Rudolf M Slivka
OBJECTIVE: Introduction: An important problem in the prevention of colon cancer is the diagnosis and treatment of its precancerous diseases, in particular polyps. The aim: The purpose of the study is to conduct a comparative description of the treatment outcomes using different methods of excision of polyps. PATIENTS AND METHODS: Materials and methods: The study included 134 patients with clinical manifestations of colon disease. Polyps of the colon have been diagnosed in 86 patients...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29727164/all-in-one-theranostic-nanoagent-with-enhanced-reactive-oxygen-species-generation-and-modulating-tumor-microenvironment-ability-for-effective-tumor-eradication
#19
Yang Liu, Wenyao Zhen, Longhai Jin, Songtao Zhang, Guoying Sun, Tianqi Zhang, Xia Xu, Shuyan Song, Yinghui Wang, Jianhua Liu, Hongjie Zhang
Despite regulation of the reactive oxygen species (ROS) level is an intelligent strategy for cancer therapy, the therapeutic effects of ROS-mediated therapy (including photodynamic therapy (PDT) and chemodynamic therapy (CDT)) are limited by oxygen reliance, inherent flaws of traditional photosensitizers and strict reaction conditions of effective Fenton reaction. Herein, we reported biocompatible copper ferrite nanospheres (CFNs) with enhanced ROS production under irradiation with 650 nm laser through direct electron transfer and photo-enhanced Fenton reaction and high photothermal conversion efficiency upon exposure to 808 nm laser, exhibiting a considerable improved synergistic treatment effect...
May 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29719624/distribution-of-erlotinib-in-rash-and-normal-skin-in-cancer-patients-receiving-erlotinib-visualized-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#20
Meiko Nishimura, Mitsuhiro Hayashi, Yu Mizutani, Kei Takenaka, Yoshinori Imamura, Naoko Chayahara, Masanori Toyoda, Naomi Kiyota, Toru Mukohara, Hiroaki Aikawa, Yasuhiro Fujiwara, Akinobu Hamada, Hironobu Minami
Background: The development of skin rashes is the most common adverse event observed in cancer patients treated with epidermal growth factor receptor-tyrosine kinase inhibitors such as erlotinib. However, the pharmacological evidence has not been fully revealed. Results: Erlotinib distribution in the rashes was more heterogeneous than that in the normal skin, and the rashes contained statistically higher concentrations of erlotinib than adjacent normal skin in the superficial skin layer (229 ± 192 vs...
April 6, 2018: Oncotarget
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