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https://www.readbyqxmd.com/read/28722819/self-targeting-immune-transparent-plasma-protein-coated-nanocomplex-for-noninvasive-photothermal-anticancer-therapy
#1
Fwu-Long Mi, Thierry Burnouf, Shih-Yuan Lu, Yu-Jen Lu, Kun-Ying Lu, Yi-Cheng Ho, Chang-Yi Kuo, Er-Yuan Chuang
Cancer cells exhibit specific physiological differences compared to normal cells. Most surface membranes of cancer cells are characterized by high expression of given protein receptors, such as albumin, transferrin, and growth factors that are also present in the plasma of patients themselves, but are lacking on the surface of normal cells. These distinct features between cancer and normal cells can serve as a niche for developing specific treatment strategies. Near-infrared (NIR)-light-triggered therapy platforms are an interesting novel avenue for use in clinical nanomedicine...
July 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28717755/innovative-breast-cancer-awareness-and-advocacy-campaign
#2
Omolola Salako, Alero A Roberts, Victor I Isibor, Oluwatimilehin Babatunde, Omolara Fatiregun, Chukwumere N Nwogu
Breast cancer is a major disease in Nigeria; in 2012, 27,304 new occurrences were diagnosed, and the number of mortalities was 13,960. Greater than 70% of patients present with advanced disease, which has a poor survival outcome. The mortality rates are high mainly because of a lack of awareness about breast health, screening guidelines, and treatment centers, and because of sociocultural barriers. In Nigeria, health care professionals remain the backbone for the provision of medical information to the public...
April 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28714017/targeting-vegfr-and-fgfr-in-head-and-neck-squamous-cell-carcinoma-in-vitro
#3
Roman C Brands, Luise M Knierim, Francesco De Donno, Valentin Steinacker, Stefan Hartmann, Axel Seher, Alexander C Kübler, Urs D A Müller-Richter
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease characterized by a tumor microenvironment (TME) that overexpresses vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR), which can lead to neovascularization, tumor growth and metastasis. Therapeutic strategies inhibiting these signaling pathways might lead to innovative HNSCC treatments. Five HNSCC cell lines were characterized based on VEGFR1-3 and FGFR1-4 expression by sqRT-PCR and treated with three different tyrosine kinase inhibitors (TKIs) (nintedanib, dovitinib and pazopanib), all of which are effective against VEGFR and FGFR family members...
July 10, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28708956/the-power-of-combining-adoptive-cell-therapy-act-and-pathogen-boosted-vaccination-to-treat-solid-tumors
#4
Ryan Zander, Weiguo Cui
Recent advancements in adoptive cell therapy (ACT) are opening up new frontiers for cancer immunotherapy. CAR T cells targeting CD19 have emerged as a remarkable T cell-based therapy for the successful treatment of certain types of leukemia and lymphomas. Despite these clinical successes, as well as significant breakthroughs in T cell engineering, the treatment of solid tumors with ACT remains a relentless challenge. Thus, the current consensus of the field is that an urgent need exists for the design of innovative approaches that can improve the efficacy of ACT in treating solid cancers while maintaining a high degree of reliability and safety...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28704211/how-to-emerge-from-the-conservatism-in-clinical-research-methodology
#5
Nuria Kotecki, Nicolas Penel, Ahmad Awada
PURPOSE OF REVIEW: Despite recent changes in clinical research methodology, many challenges remain in drug development methodology. RECENT FINDINGS: Advances in molecular biology and cancer treatments have changed the clinical research landscape. Thus, we moved from empirical clinical oncology to molecular and immunological therapeutic approaches. Along with this move, adapted dose-limiting toxicities definitions, endpoints, and dose escalation methods have been proposed...
July 12, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28703890/targeted-therapies-in-pancreatic-cancer-promises-and-failures
#6
Matineh Barati Bagherabad, Fahimeh Afzaljavan, Soodabeh ShahidSales, Seyed Mahdi Hassanian, Amir Avan
Pancreatic ductal adenocarcinoma (PDAC) is an incidence rate nearly equal to its mortality rate. The poor prognosis of the disease can be explained by the absence of effective biomarkers for screening and early detection, together with the aggressive behavior and resistance to the currently available chemotherapy. The therapeutic failure can also be attributed to the inter-/intra- tumor genetic heterogeneity and the abundance of tumor stroma that occupies the majority of the tumor mass. Gemcitabine is used in the treatment of PDAC, however, the response rate is less than 12%...
July 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28703084/case-study-on-an-ipilimumab-cost-containment-strategy-in-an-italian-hospital
#7
Alberto Russi, Vanna Chiarion-Sileni, Vera Damuzzo, Francesca Di Sarra, Jacopo Pigozzo, Angelo Claudio Palozzo
OBJECTIVES: Ipilimumab is the first licensed immune checkpoint inhibitor for treatment of melanoma. The promising results of the registration clinical study need confirmation in real practice and its clinical success comes together with a relevant budget impact due to the high price of this drug. The aim of this work is to describe a new model of economical sustainability of ipilimumab developed in an Italian reference center for melanoma treatment. METHODS: This retrospective, observational, and monocentric study was carried out at the Veneto Institute of Oncology...
July 13, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28692951/identifying-critical-steps-towards-improved-access-to-innovation-in-cancer-care-a-european-cancer-organisation-position-paper
#8
Matti Aapro, Alain Astier, Riccardo Audisio, Ian Banks, Pierre Bedossa, Etienne Brain, David Cameron, Paolo Casali, Arturo Chiti, Leticia De Mattos-Arruda, Daniel Kelly, Denis Lacombe, Per J Nilsson, Martine Piccart, Philip Poortmans, Katrine Riklund, Gunnar Saeter, Martin Schrappe, Riccardo Soffietti, Luzia Travado, Hein van Poppel, Suzanne Wait, Peter Naredi
In recent decades cancer care has seen improvements in the speed and accuracy of diagnostic procedures; the effectiveness of surgery, radiation therapy and medical treatments; the power of information technology; and the development of multidisciplinary, specialist-led approaches to care. Such innovations are essential if we are to continue improving the lives of cancer patients across Europe despite financial pressures on our healthcare systems. Investment in innovation must be balanced with the need to ensure the sustainability of healthcare budgets, and all health professionals have a responsibility to help achieve this balance...
July 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28691331/scaling-up-proven-innovative-cervical-cancer-screening-strategies-challenges-and-opportunities-in-implementation-at-the-population-level-in-low-and-lower-middle-income-countries
#9
Francesca Holme, Sharon Kapambwe, Ashrafun Nessa, Partha Basu, Raul Murillo, Jose Jeronimo
The problem of cervical cancer in low- and lower-middle-income countries (LLMICs) is both urgent and important, and calls for governments to move beyond pilot testing to population-based screening approaches as quickly as possible. Experiences from Zambia, Bangladesh, Guatemala, Honduras, and Nicaragua, where scale-up of evidence-based screening strategies is taking place, may help other countries plan for large-scale implementation. These countries selected screening modalities recommended by the WHO that are within budgetary constraints, improve access for women, and reduce health system bottlenecks...
July 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28690673/professor-umberto-veronesi-a-physician-a-researcher-a-brilliant-man
#10
Ketti Mazzocco, Chiara Marzorati, Gabriella Pravettoni
Many of those who work in oncology or deal with cancer patients know of Prof. Umberto Veronesi and none of them could deny the importance of his battle against cancer. He devoted his life to improving cancer treatment and quality of life for patients. He was a physician, and a politician, but above all he was a researcher. He embodied the true spirit of research, i.e., to believe in something and investigate every aspect of it until all the questions about it have been satisfactorily answered. He never gave up when faced with challenges, and he never stopped being curious...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28689023/profiling-of-cytokines-chemokines-and-other-soluble-proteins-as-a-potential-biomarker-in-colorectal-cancer-and-polyps
#11
Nor Adzimah Johdi, Luqman Mazlan, Ismail Sagap, Rahman Jamal
Soluble proteins including cytokines, chemokines and growth factors are small proteins that mediate and regulate immunity. They involved in the pathogenesis of many diseases including cancers. The concentration of these proteins in biological fluids (serum or plasma) and tissues in diseases may suggest pathway activation that leads to inflammatory response or disease progression. Therefore, these soluble proteins may be useful as a tool for screening, diagnosis classification between stages of disease or surveillance for therapy...
July 6, 2017: Cytokine
https://www.readbyqxmd.com/read/28687392/characterization-and-in-vitro-anticancer-properties-of-chitosan-microencapsulated-flavan-3-ols-rich-grape-seed-extracts
#12
Michelangelo Iannone, Rosario Mare, Donatella Paolino, Agnese Gagliardi, Francesca Froiio, Donato Cosco, Massimo Fresta
Studies have fully demonstrated that a diet rich in fruit and vegetables may reduce the incidence of tumors. In particular, Grape Seed Extract (GSE) has been shown to carry on chemopreventive and antitumor activity thanks to the numerous beneficial substances it contains. The purpose of this work was to create a biocompatible matrix containing GSE in order to obtain microparticles able to modulate its biopharmaceutical parameters. The spray-drying technique was chosen in order to realize chitosan microparticles characterized by a mean diameter of 4-10μm and a positive surface charge that decreased after GSE encapsulation...
July 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28681981/ros-responsive-polyprodrug-nanoparticles-for-triggered-drug-delivery-and-effective-cancer-therapy
#13
Xiaoding Xu, Phei Er Saw, Wei Tao, Yujing Li, Xiaoyuan Ji, Sushant Bhasin, Yanlan Liu, Dana Ayyash, Jonathan Rasmussen, Marc Huo, Jinjun Shi, Omid C Farokhzad
The application of nanoparticles (NPs) to drug delivery has led to the development of novel nanotherapeutics for the treatment of various diseases including cancer. However, clinical use of NP-mediated drug delivery has not always translated into improved survival of cancer patients, in part due to the suboptimal properties of NP platforms, such as premature drug leakage during preparation, storage, or blood circulation, lack of active targeting to tumor tissue and cells, and poor tissue penetration. Herein, an innovative reactive oxygen species (ROS)-responsive polyprodrug is reported that can self-assemble into stable NPs with high drug loading...
July 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28681173/pro-apoptotic-effect-of-%C3%AE-2-tgz-in-claudin-1-low-triple-negative-breast-cancer-cells-involvement-of-claudin-1
#14
Geoffroy Marine, Kleinclauss Alexandra, Grandemange Stéphanie, Hupont Sébastien, Boisbrun Michel, Flament Stéphane, Grillier-Vuissoz Isabelle, Kuntz Sandra
PURPOSE: 40% of triple-negative breast cancer (TNBC) do not express claudin-1, a major constituent of tight junction. Patients with these "claudin-1-low" tumors present a higher relapse incidence. A major challenge in oncology is the development of innovative therapies for such poor prognosis tumors. In this context, we study the anticancer effects of ∆2-TGZ, a compound derived from troglitazone (TGZ), on cell models of these tumors. METHODS AND RESULTS: In MDA-MB-231 and Hs578T "claudin-1-low" TNBC cells, Δ2-TGZ treatment induced claudin-1 protein expression and triggered apoptosis as measured by FACS analysis (annexin V/PI co-staining)...
July 5, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28676102/effects-of-an-interactive-mhealth-innovation-for-early-detection-of-patient-reported-symptom-distress-with-focus-on-participatory-care-protocol-for-a-study-based-on-prospective-randomised-controlled-trials-in-patients-with-prostate-and-breast-cancer
#15
Ann Langius-Eklöf, Marie-Therése Crafoord, Mats Christiansen, Maria Fjell, Kay Sundberg
BACKGROUND: Cancer patients are predominantly treated as out-patients and as they often experience difficult symptoms and side effects it is important to facilitate and improve patient-clinician communication to support symptom management and self-care. Although the number of projects within supportive cancer care evaluating mobile health is increasing, few evidence-based interventions are described in the literature and thus there is a need for good quality clinical studies with a randomised design and sufficient power to guide future implementations...
July 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28670156/thyroid-radiofrequency-ablation-updates-on-innovative-devices-and-techniques
#16
REVIEW
Hye Sun Park, Jung Hwan Baek, Auh Whan Park, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
Radiofrequency ablation (RFA) is a well-known, effective, and safe method for treating benign thyroid nodules and recurrent thyroid cancers. Thyroid-dedicated devices and basic techniques for thyroid RFA were introduced by the Korean Society of Thyroid Radiology (KSThR) in 2012. Thyroid RFA has now been adopted worldwide, with subsequent advances in devices and techniques. To optimize the treatment efficacy and patient safety, understanding the basic and advanced RFA techniques and selecting the optimal treatment strategy are critical...
July 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28668512/h-pylori-infection-increases-gastric-mucosal-cox2-and-mtor-expression-in-chronic-gastritis-implications-for-cancer-progression
#17
Dalia M Badary, Mohammed Zakaria Ali Abu Rahma, Ahmed M Ashmawy, Mohamed Z Hafez
BACKGROUND: Helicobacter Pylori is a Gram-negative bacterium that infects the human stomach and plays an important role in the pathogenesis of chronic gastritis. H. pylori associated chronic gastritis affects various molecular markers related to gastric cancer development. The aim of this study to assess the effect of H. pylori infection on gastric mucosa and to explore its role in gastric carcinogenesis via COX2 and mTOR mucosal expression. MATERIALS AND METHODS: This study comprised archival blocks from 60 dyspeptic patients who underwent gastric endoscopic biopsies for histopathological examination...
June 17, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28665143/suppression-of-lipogenesis-via-ros-ampk-signaling-for-treating-malignancy-and-over-proliferative-diseases
#18
Xing-Xing Fan, Elaine Lai-Han Leung, Ying Xie, Zhong Qiu Liu, Xiao-Jun Yao, LinLin Lu, Jianglin Wu, Jian-Xing He, ZhongWen Yuan, JunJiang Fu, ChunLi Wei, Jun Huang, DaKai Xiao, LianXiang Luo, Zebo Jiang, Lynn Zhou, Richard Kam, Liang Liu
AIMS: Systemic diseases often have common characteristics. The aim of this study was to investigate the feasibility of targeting common pathological metabolism to inhibit the progression of malignant and proliferative diseases. RESULTS: Gefitinib-resistant (G-R) non-small cell lung cancer (NSCLC) and rheumatoid arthritis (RA) were studied as conditions representative of malignant and proliferative diseases respectively. Strong lipogenic activity and high expression of sterol regulatory element-binding protein 1 (SREBP-1) were found in both G-R NSCLC cells and synovial fibroblasts from RA patients (RASFs)...
June 30, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28663078/living-with-multiple-myeloma-a-continuum-based-approach-to-cancer-survivorship
#19
REVIEW
Sandra Kurtin
OBJECTIVES: To describe a tailored approach to survivorship care for health care providers (HCPs) involved in the care of patients and caregivers living with multiple myeloma (MM) and identify key transition points within the continuum of care with recommended adaptation to the survivorship care plan (SCP). DATA SOURCES: Review of the literature, web-based resources. CONCLUSION: The health care needs of cancer survivors will vary throughout the continuum of care...
June 27, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28655073/-thought-of-the-present-application-situation-and-the-future-trends-of-minimally-invasive-surgery-in-colorectal-cancer
#20
J F Ji, A W Wu
Laparoscopic surgery has been increasingly used in rectal cancer surgery. Though there are still some controversies, most of the research results support that the outcome is similar for rectal cancer patients with either laparoscopic or open surgery, in term of short-term such as safety and efficacy and long-term such as oncologic outcome. Standardization of laparoscopic training together with the comprehensive management concept are the prerequisites of laparoscopic rectal cancer surgery. Those doctors who do minimally invasive surgery should follow the rationale that smaller incision and sphincter preservation are secondary to safety and oncological result of the patients...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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