Chuwa Tei, Teruhiko Imamura, Koichiro Kinugawa, Teruo Inoue, Tohru Masuyama, Hiroshi Inoue, Hirofumi Noike, Toshihiro Muramatsu, Yasuchika Takeishi, Keijiro Saku, Kazumasa Harada, Hiroyuki Daida, Youichi Kobayashi, Nobuhisa Hagiwara, Masatoshi Nagayama, Shinichi Momomura, Kazuya Yonezawa, Hiroshi Ito, Satoshi Gojo, Makoto Akaishi, Masaaki Miyata, Mitsuru Ohishi
BACKGROUND: Waon therapy improves heart failure (HF) symptoms, but further evidence in patients with advanced HF remains uncertain. METHODS AND RESULTS: In 19 institutes, we prospectively enrolled hospitalized patients with advanced HF, who had plasma levels of B-type natriuretic peptide (BNP) >500 pg/ml on admission and BNP >300 pg/ml regardless of more than 1 week of medical therapy. Enrolled patients were randomized into Waon therapy or control groups...
2016: Circulation Journal: Official Journal of the Japanese Circulation Society