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https://www.readbyqxmd.com/read/27918189/mentalization-based-therapy-for-parents-in-entrenched-conflict-a-random-allocation-feasibility-study
#1
Leezah Hertzmann, Mary Target, David Hewison, Polly Casey, Pasco Fearon, Dana Lassri
To explore the effectiveness of a mentalization-based therapeutic intervention specifically developed for parents in entrenched conflict over their children. To the best of our knowledge, this is the first randomized controlled intervention study in the United Kingdom to work with both parents postseparation, and the first to focus on mentalization in this situation. Using a mixed-methods study design, 30 parents were randomly allocated to either mentalization-based therapy for parental conflict-Parenting Together, or the Parents' Group, a psycho-educational intervention for separated parents based on elements of the Separated Parents Information Program-part of the U...
December 2016: Psychotherapy
https://www.readbyqxmd.com/read/27914236/disentangling-the-mental-health-impact-of-childhood-abuse-and-neglect
#2
Charlotte A M Cecil, Essi Viding, Pasco Fearon, Danya Glaser, Eamon J McCrory
It is unclear whether maltreatment types exert common or specific effects on mental health. In the current study, we aimed to systematically characterize the unique, shared and cumulative effects of maltreatment types on psychiatric symptoms, using data drawn from a community sample of high-risk youth (n=204, M=18.85). Analyses controlled for a range of potentially confounding variables, including socio-demographic variables, neighbourhood deprivation and levels of community violence exposure. Outcome measures included multi-informant reports of internalizing difficulties, as well as data on externalizing problems and trauma-related symptoms...
November 30, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27913080/foreword-primary-care-and-the-promotion-of-children-s-mental-health
#3
EDITORIAL
John M Pascoe
No abstract text is available yet for this article.
November 29, 2016: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27896942/mid-childhood-outcomes-of-infant-siblings-at-familial-high-risk-of-autism-spectrum-disorder
#4
Elizabeth Shephard, Bosiljka Milosavljevic, Greg Pasco, Emily J H Jones, Teodora Gliga, Francesca Happé, Mark H Johnson, Tony Charman
Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling with an ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-risk infants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age 7, high-risk children without ASD, and low-risk control children...
November 29, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27885036/visionary-medicine-speculative-fiction-racial-justice-and-octavia-butler-s-bloodchild
#5
John Carlo Pasco, Camille Anderson, Sayantani DasGupta
Medical students across the USA have increasingly made the medical institution a place for speculating racially just futures. From die-ins in Fall 2014 to silent protests in response to racially motivated police brutality, medical schools have responded to the public health crisis that is racial injustice in the USA. Reading science fiction may benefit healthcare practitioners who are already invested in imagining a more just, healthier futurity. Fiction that rewrites the future in ways that undermine contemporary power regimes has been termed 'visionary fiction'...
December 2016: Medical Humanities
https://www.readbyqxmd.com/read/27884954/impact-of-external-pneumatic-compression-target-inflation-pressure-on-transcriptome-wide-rna-expression-in-skeletal-muscle
#6
Jeffrey S Martin, Wesley C Kephart, Cody T Haun, Anna E McCloskey, Joshua J Shake, Christopher B Mobley, Michael D Goodlett, Andreas Kavazis, David D Pascoe, Lee Zhang, Michael D Roberts
Next-generation RNA sequencing was employed to determine the acute and subchronic impact of peristaltic pulse external pneumatic compression (PEPC) of different target inflation pressures on global gene expression in human vastus lateralis skeletal muscle biopsy samples. Eighteen (N = 18) male participants were randomly assigned to one of the three groups: (1) sham (n = 6), 2) EPC at 30-40 mmHg (LP-EPC; n = 6), and 3) EPC at 70-80 mmHg (MP-EPC; n = 6). One hour treatment with sham/EPC occurred for seven consecutive days...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27883255/genome-wide-association-of-functional-traits-linked-with-campylobacter-jejuni-survival-from-farm-to-fork
#7
Koji Yahara, Guillaume Méric, Aidan J Taylor, Stefan P W de Vries, Susan Murray, Ben Pascoe, Leonardos Mageiros, Alicia Torralbo, Ana Vidal, Anne Ridley, Sho Komukai, Helen Wimalarathna, Alison J Cody, Frances M Colles, Noel McCarthy, David Harris, James E Bray, Keith A Jolley, Martin C J Maiden, Stephen D Bentley, Julian Parkhill, Christopher D Bayliss, Andrew Grant, Duncan Maskell, Xavier Didelot, David J Kelly, Samuel K Sheppard
Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, primarily associated with the consumption of contaminated poultry. C. jejuni lineages vary in host range and prevalence in human infection, suggesting differences in survival throughout the poultry processing chain. From 7,343 MLST-characterised isolates, we sequenced 600 C. jejuni and C. coli isolates from various stages of poultry processing and clinical cases. A genome-wide association study (GWAS) in C. jejuni ST-21 and ST-45 complexes identified genetic elements over-represented in clinical isolates that increased in frequency throughout the poultry processing chain...
November 24, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27882991/print-flexible-solar-cells
#8
Yi-Bing Cheng, Alex Pascoe, Fuzhi Huang, Yong Peng
No abstract text is available yet for this article.
November 23, 2016: Nature
https://www.readbyqxmd.com/read/27879644/efficacy-of-topical-application-leaf-residue-or-soil-drench-of-blastospores-of-isaria-fumosorosea-for-citrus-root-weevil-management-laboratory-and-greenhouse-investigations
#9
Pasco B Avery, Wayne B Hunter, David G Hall, Mark A Jackson, Charles A Powell
The efficacy of topical, leaf residue, and soil drench applications with Isaria fumosorosea blastospores (Ifr strain 3581) was assessed for the management of the citrus root weevil, Diaprepes abbreviatus (L.). Blastospores of Ifr were applied topically at a rate of 10⁷ blastospores mL(-1) on both the larvae and adults, and each insect stage was incubated in rearing cups with artificial diet at 25 °C, either in the dark or in a growth chamber under a 16 h photophase for 2 weeks, respectively. Percent larval and adult mortality due to the infection of Ifr was assessed after 14 days as compared to untreated controls...
November 22, 2016: Insects
https://www.readbyqxmd.com/read/27875025/adherence-and-barriers-to-hyperinsufflation-in-children-with-congenital-muscular-dystrophy
#10
John E Pascoe, Hemant Sawnani, Oscar H Mayer, Keith McConnell, Joseph M McDonough, Cynthia White, Anne M Rutkowski, Raouf S Amin, Avani C Modi
BACKGROUND: Congenital muscular dystrophy (CMD) is a rare, inherited neuromuscular disease characterized by progressive muscle weakness, thoracic insufficiency, and ultimately respiratory failure. Adherence to respiratory therapies in children with neuromuscular disorders is unknown. This study examined the multimodal assessment of adherence and barriers to 15 min, twice daily hyperinsufflation in children with CMD. Adherence was hypothesized to be greater than 50% and discomfort, embarrassment, and difficulty finding time were hypothesized to be barriers...
November 22, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27868182/attachment-and-temperament-in-the-early-life-course-a-meta-analytic-review
#11
REVIEW
Ashley M Groh, Angela J Narayan, Marian J Bakermans-Kranenburg, Glenn I Roisman, Brian E Vaughn, R M Pasco Fearon, Marinus H van IJzendoorn
This meta-analytic review examines the association between early attachment (assessed at 1-5 years) and child temperament (assessed at birth-12 years), and compares the strength of this association with recently documented meta-analytic associations between early attachment and social competence, externalizing behavior, and internalizing symptoms. Based on 109 independent samples (N = 11,440) of diverse socioeconomic and ethnic backgrounds, temperament was weakly associated with attachment (in)security (d = ...
November 21, 2016: Child Development
https://www.readbyqxmd.com/read/27856180/sometimes-scientists-get-the-flu-wrong%C3%A2
#12
Matteo Marcantonio, Emily L Pascoe, Frédéric Baldacchino
In an international research environment, accurate communication is vital. However, the scientific literature does not always utilise consistent terminology and the misuse of some expressions in epidemiology is rife. We encourage the correct terms to be used appropriately to avoid confusion between scientists, policy makers, and members of the public.
November 14, 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/27846397/giving-the-community-a-voice-lessons-learned-from-a-comprehensive-survey-in-an-urban-neighborhood
#13
Tamar Mott Forrest, Dawn M Wallace-Pascoe, Michael D Webb, Howard Goldstein
Weinland Park, an urban neighborhood adjacent to The Ohio State University, has been targeted for revitalization following several decades of disinvestment. The goal of these efforts is to develop holistic solutions that break the cycle of poverty. Such an undertaking requires collecting baseline data to understand community needs, inform programming, and guide revitalization efforts. This paper describes the development and implementation of the Weinland Park Evaluation Project (WPEP) - a collaborative and comprehensive neighborhood survey and needs assessment...
February 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/27812135/characterization-and-genetic-analyses-of-new-genes-coding-for-nod2-interacting-proteins
#14
Raphaële Thiébaut, Sophie Esmiol, Patrick Lecine, Batoul Mahfouz, Aurelie Hermant, Cendrine Nicoletti, Stephane Parnis, Julie Perroy, Jean-Paul Borg, Leigh Pascoe, Jean-Pierre Hugot, Vincent Ollendorff
NOD2 contributes to the innate immune response and to the homeostasis of the intestinal mucosa. In response to its bacterial ligand, NOD2 interacts with RICK and activates the NF-κB and MAPK pathways, inducing gene transcription and synthesis of proteins required to initiate a balanced immune response. Mutations in NOD2 have been associated with an increased risk of Crohn's Disease (CD), a disabling inflammatory bowel disease (IBD). Because NOD2 signaling plays a key role in CD, it is important to further characterize the network of protein interacting with NOD2...
2016: PloS One
https://www.readbyqxmd.com/read/27810617/why-so-glumm-detecting-depression-clusters-through-graphing-lifestyle-environs-using-machine-learning-methods-glumm
#15
J F Dipnall, J A Pasco, M Berk, L J Williams, S Dodd, F N Jacka, D Meyer
BACKGROUND: Key lifestyle-environ risk factors are operative for depression, but it is unclear how risk factors cluster. Machine-learning (ML) algorithms exist that learn, extract, identify and map underlying patterns to identify groupings of depressed individuals without constraints. The aim of this research was to use a large epidemiological study to identify and characterise depression clusters through "Graphing lifestyle-environs using machine-learning methods" (GLUMM). METHODS: Two ML algorithms were implemented: unsupervised Self-organised mapping (SOM) to create GLUMM clusters and a supervised boosted regression algorithm to describe clusters...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27807601/maternal-dietary-nutrient-intake-during-pregnancy-and-offspring-linear-growth-and-bone-the-vitamin-d-in-pregnancy-cohort-study
#16
Natalie K Hyde, Sharon L Brennan-Olsen, John D Wark, Sarah M Hosking, Julie A Pasco
Magnesium, phosphorus, zinc, calcium, potassium and protein all play integral roles in maintaining bone health in adults; however, less is known about the importance of these minerals in utero. We aimed to determine associations between maternal dietary consumption of these nutrients during gestation and birth measures in offspring. Of 475 pregnant women recruited from a single antenatal clinic before 16-week gestation (2002-2003) as part of the vitamin D in pregnancy study, 346 with recorded maternal dietary intakes at 28- to 32-week gestation and offspring measures at birth were included...
November 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27787845/in-vitro-assay-for-the-rap-gtpase-activating-protein-activity-of-the-purified-cytoplasmic-domain-of-plexin
#17
Heath G Pascoe, Yuxiao Wang, Xuewu Zhang
Plexins are cell surface receptors that bind semaphorins and regulate essential processes such as axon guidance and angiogenesis. The cytoplasmic regions of plexins contain a functionally essential GTPase-activating protein (GAP) domain, which initiates downstream signaling by specifically inactivating the Rap GTPase. Here we describe the methods for expression and purification of the plexin cytoplasmic region in E. coli, and characterization of its GAP activity using a photometric assay. We also provide a protocol for measuring GAP activity of single-chain constructs with Rap covalently linked to the plexin cytoplasmic region...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27747201/ageing-chronic-disease-and-injury-a-study-in-western-victoria-australia
#18
M Amber Sajjad, Kara L Holloway, Mark A Kotowicz, Patricia M Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L Dunning, Susan Brumby, Richard S Page, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Sharon L Brennan-Olsen, Lana J Williams, Julie A Pasco
Background: An increasing burden of chronic disease and associated health service delivery is expected due to the ageing Australian population. Injuries also affect health and wellbeing and have a long-term impact on health service utilisation. There is a lack of comprehensive data on disease and injury in rural and regional areas of Australia. The aim of the Ageing, Chronic Disease and Injury study is to compile data from various sources to better describe the patterns of chronic disease and injury across western Victoria...
August 19, 2016: Journal of Public Health Research
https://www.readbyqxmd.com/read/27722380/osmotic-pressures-of-lysozyme-solutions-from-gas-like-to-crystal-states
#19
Coralie Pasquier, Sylvie Beaufils, Antoine Bouchoux, Sophie Rigault, Bernard Cabane, Mikael Lund, Valérie Lechevalier, Cécile Le Floch-Fouéré, Maryvonne Pasco, Gilles Pabœuf, Javier Pérez, Stéphane Pezennec
We obtained osmotic pressure data of lysozyme solutions, describing their physical states over a wide concentration range, using osmotic stress for pressures between 0.05 bar and about 40 bar and volume fractions between 0.01 and 0.61. The osmotic pressure vs. volume fraction data consist of a dilute, gas-phase regime, a transition regime with a high-compressibility plateau, and a concentrated regime where the system is nearly incompressible. The first two regimes are shifted towards a higher protein volume fraction upon decreasing the strength or the range of electrostatic interactions...
October 19, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27717374/the-nspcc-uk-minding-the-baby%C3%A2-mtb-home-visiting-programme-supporting-young-mothers-aged-14-25-in-the-first-2%C3%A2-years-of-their-baby-s%C3%A2-life-study-protocol-for-a-randomised-controlled-trial
#20
Elena Longhi, Lynne Murray, Rachael Hunter, David Wellsted, Samantha Taylor-Colls, Kathryn MacKenzie, Gwynne Rayns, Richard Cotmore, Peter Fonagy, Richard M Pasco Fearon
BACKGROUND: Young mothers living in low-income urban settings often are exposed to significant and chronic environmental difficulties including poverty, social isolation and poor education and typically also have to cope with personal histories of abuse and depression. Minding the Baby® (MTB) is an interdisciplinary home-visiting programme developed to support first-time young mothers, which integrates primary care and mental health approaches into a single intensive intervention from the last trimester of pregnancy until the child's second birthday...
October 7, 2016: Trials
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