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https://www.readbyqxmd.com/read/29785682/the-modified-memorial-symptom-assessment-scale-short-form-a-modified-response-format-and-rational-scoring-rules
#1
J L Sharp, K Gough, M C Pascoe, A Drosdowsky, V T Chang, P Schofield
PURPOSE: The Memorial Symptom Assessment Scale Short Form (MSAS-SF) is a widely used symptom assessment instrument. Patients who self-complete the MSAS-SF have difficulty following the two-part response format, resulting in incorrectly completed responses. We describe modifications to the response format to improve useability, and rational scoring rules for incorrectly completed items. METHODS: The modified MSAS-SF was completed by 311 women in our Peer and Nurse support Trial to Assist women in Gynaecological Oncology; the PeNTAGOn study...
May 21, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29782186/excessive-erythrocytosis-and-cardiovascular-risk-in-andean-highlanders
#2
Noemí Corante, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L Gamboa, Fabiola León-Velarde, Francisco C Villafuerte
Cardiovascular diseases are the main cause of death worldwide. Life under high-altitude (HA) hypoxic conditions is believed to provide highlanders with a natural protection against cardiovascular and metabolic diseases compared with sea-level inhabitants. However, some HA dwellers become intolerant to chronic hypoxia and develop a progressive incapacitating syndrome known as chronic mountain sickness (CMS), characterized by excessive erythrocytosis (EE; Hb ≥21 g/dL in men, Hb ≥19 g/dL in women). Evidence from HA studies suggests that, in addition to CMS typical signs and symptoms, these highlanders may also suffer from metabolic and cardiovascular disorders...
May 21, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29781701/intervention-for-bilingual-speech-sound-disorders-a-case-study-of-an-isixhosa-english-speaking-child
#3
Kate Rossouw, Michelle Pascoe
 Bilingualism is common in South Africa, with many children acquiring isiXhosa as a home language and learning English from a young age in nursery or crèche. IsiXhosa is a local language, part of the Bantu language family, widely spoken in the country. Aims: To describe changes in a bilingual child's speech following intervention based on a theoretically motivated and tailored intervention plan. Methods and procedures: This study describes a female isiXhosa-English bilingual child, named Gcobisa (pseudonym) (chronological age 4 years and 2 months) with a speech sound disorder...
March 19, 2018: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/29778345/health-literacy-and-uptake-of-anti-fracture-medications-in-a-population-based-sample-of-australian-women
#4
Sarah M Hosking, Sharon L Brennan-Olsen, Alison Beauchamp, Rachelle Buchbinder, Lana J Williams, Julie A Pasco
This study investigated associations between health literacy and use of anti-fracture medications in women with osteoporosis. Data were collected for women participating in the population-based Geelong Osteoporosis Study in Australia. Health literacy was ascertained using the Health Literacy Questionnaire (HLQ) and bone mineral density by dual x-ray absorptiometry. Self-reported current medications were classified using MIMS codes, with the category 'Agent affecting calcium and bone metabolism' indicating osteoporosis treatment...
May 9, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29777786/photoselective-vaporisation-of-the-bladder-for-the-management-of-radiation-cystitis-technique-and-initial-outcomes
#5
Claire Pascoe, Daniel Christidis, Todd Manning, Benjamin W Lamb, Declan G Murphy, Nathan Lawrentschuk
Objective To describe our technique utilising photoselective vaporisation of the bladder (PVB) for the management of haemorrhagic cystitis and initial results of 12 patients. Materials and Method An audit of theatre records of a single surgeon was performed to identify patients who had undergone PVB for management of radiation-cystitis. TECHNIQUE: Rigid cystoscopy was performed. Ureteric catheters were placed and active bleeding sites targeted to optimise vision. Ablation was commenced using the vaporize function...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29762893/retrobulbar-vs-peribulbar-regional-anesthesia-techniques-using-bupivacaine-in-dogs
#6
Yael Shilo-Benjamini, Peter J Pascoe, David J Maggs, Steven R Hollingsworth, Ann R Strom, Kathryn L Good, Sara M Thomasy, Philip H Kass, Erik R Wisner
OBJECTIVE: To compare the effectiveness of retrobulbar anesthesia (RBA) and peribulbar anesthesia (PBA) in dogs. ANIMAL STUDIED: Six adult mixed-breed dogs (18-24 kg). PROCEDURES: In a randomized, masked, crossover trial with a 10-day washout period, each dog was sedated with intravenously administered dexmedetomidine and administered 0.5% bupivacaine:iopamidol (4:1) as RBA (2 mL via a ventrolateral site) or PBA (5 mL divided equally between ventrolateral and dorsomedial sites)...
May 15, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29740805/examining-ecological-constraints-on-the-intergenerational-transmission-of-attachment-via-individual-participant-data-meta-analysis
#7
Marije L Verhage, R M Pasco Fearon, Carlo Schuengel, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg, Sheri Madigan, Glenn I Roisman, Mirjam Oosterman, Kazuko Y Behrens, Maria S Wong, Sarah Mangelsdorf, Lynn E Priddis, Karl-Heinz Brisch
Parents' attachment representations and child-parent attachment have been shown to be associated, but these associations vary across populations (Verhage et al., 2016). The current study examined whether ecological factors may explain variability in the strength of intergenerational transmission of attachment, using individual participant data (IPD) meta-analysis. Analyses on 4,396 parent-child dyads (58 studies, child age 11-96 months) revealed a combined effect size of r = .29. IPD meta-analyses revealed that effect sizes for the transmission of autonomous-secure representations to secure attachments were weaker under risk conditions and weaker in adolescent parent-child dyads, whereas transmission was stronger for older children...
May 9, 2018: Child Development
https://www.readbyqxmd.com/read/29733741/age-related-modifications-of-type-i-collagen-impair-ddr1-induced-apoptosis-in-non-invasive-breast-carcinoma-cells
#8
Saby Charles, Rammal Hassan, Magnien Kevin, Buache Emilie, Brassart-Pasco Sylvie, Van-Gulick Laurence, Jeannesson Pierre, Maquoi Erik, Morjani Hamid
Type I collagen and DDR1 axis has been described to decrease cell proliferation and to initiate apoptosis in non-invasive breast carcinoma in three-dimensional cell culture matrices. Moreover, MT1-MMP down-regulates these effects. Here, we address the effect of type I collagen aging and MT1-MMP expression on cell proliferation suppression and induced-apoptosis in non-invasive MCF-7 and ZR-75-1 breast carcinoma. We provide evidence for a decrease in cell growth and an increase in apoptosis in the presence of adult collagen when compared to old collagen...
May 7, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29724389/blood-eosinophil-levels-as-a-biomarker-in-copd
#9
REVIEW
Guy Brusselle, Ian D Pavord, Sarah Landis, Steven Pascoe, Sally Lettis, Nikhil Morjaria, Neil Barnes, Emma Hilton
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder and patients respond differently to treatment. Blood eosinophils are a potential biomarker to stratify patient subsets for COPD therapy. We reviewed the value of blood eosinophils in predicting exacerbation risk and response to corticosteroid treatment in the available literature (PubMed articles in English; keywords: "COPD" and "eosinophil"; published prior to May 2017). Overall, clinical data suggest that in patients with a history of COPD exacerbations, a higher blood eosinophil count predicts an increased risk of future exacerbations and is associated with improved response to treatment with inhaled corticosteroids (in combination with long-acting bronchodilator[s])...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29717343/identification-of-the-achilles-heels-of-the-laurel-wilt-pathogen-and-its-beetle-vector
#10
Yonghong Zhou, Pasco B Avery, Daniel Carrillo, Rita H Duncan, Alison Lukowsky, Ronald D Cave, Nemat O Keyhani
Ambrosia beetles harbor fungal symbionts that serve as food sources for larvae and adults. These beetles lay their eggs along tunnels in xylem sapwood, which is the substrate for fungal growth. Symbiotic fungi of the genus Raffaelea found in invasive and indigenous ambrosia beetles include the highly virulent plant pathogen Raffaelea lauricola affecting members of the Lauraceae family. R. lauricola is responsible for the deaths of > 500 million trees since 2005. Infection by as few as 100 spores can kill a healthy tree within months...
May 2, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29710276/the-prevalence-of-speech-and-language-disorders-in-french-speaking-preschool-children-from-yaound%C3%A3-cameroon
#11
Lilly Tchoungui Oyono, Michelle Pascoe, Shajila Singh
Purpose: The purpose of this study was to determine the prevalence of speech and language disorders in French-speaking preschool-age children in Yaoundé, the capital city of Cameroon. Method: A total of 460 participants aged 3-5 years were recruited from the 7 communes of Yaoundé using a 2-stage cluster sampling method. Speech and language assessment was undertaken using a standardized speech and language test, the Evaluation du Langage Oral (Khomsi, 2001), which was purposefully renormed on the sample...
April 18, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29707150/structural-characterization-and-in-vivo-pro-tumor-properties-of-a-highly-conserved-matrikine
#12
Jordan Da Silva, Pedro Lameiras, Abdelilah Beljebbar, Alexandre Berquand, Matthieu Villemin, Laurent Ramont, Sylvain Dukic, Jean-Marc Nuzillard, Michael Molinari, Mathieu Gautier, Sylvie Brassart-Pasco, Bertrand Brassart
Elastin-derived peptides (EDPs) exert protumor activities by increasing tumor growth, migration and invasion. A number of studies have highlighted the potential of VGVAPG consensus sequence-derived elastin-like polypeptides whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. However, among the EDPs, the influence of elastin-derived nonapeptides (xGxPGxGxG consensus sequence) remains unknown. Here, we show that the AGVPGLGVG elastin peptide (AG-9) present in domain-26 of tropoelastin is more conserved than the VGVAPG elastin peptide (VG-6) from domain-24 in mammals...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29702049/adverse-childhood-experiences-among-a-community-of-resilient-centenarians-and-seniors-implications-for-a-chronic-disease-prevention-framework
#13
Rhonda Spencer-Hwang, Xochitl Torres, Johanny Valladares, Marco Pasco-Rubio, Molly Dougherty, Wonha Kim
CONTEXT: Research has linked adverse childhood experiences (ACEs) with chronic disease in adults and diminished life span. Adverse biological embedding of ACEs potentially occurs through inflammatory mechanisms; inflammatory marker alterations are identified as candidate biomarkers for mediating health consequences. Lifestyle practices of residents of California's Loma Linda Blue Zone, one of five worldwide longevity hotspots, may provide insight into inflammation remediation and chronic disease prevention...
March 11, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29701327/vitamin-d-during-pregnancy-and-offspring-body-composition-a-prospective-cohort-study
#14
N K Hyde, S L Brennan-Olsen, J D Wark, S M Hosking, K L Holloway-Kew, J A Pasco
BACKGROUND: Evidence regarding the association between gestational vitamin D status and offspring body composition during childhood is inconsistent. Therefore, we aimed to determine the association between maternal vitamin D and offspring lean and fat mass in the Vitamin D in Pregnancy birth cohort. METHODS: Subjects were mother-child pairs recruited from the Australian-based Vitamin D in Pregnancy cohort study. Mothers were recruited before 16 weeks' gestation and provided a blood sample at both recruitment and at 28-32 weeks' gestation...
April 27, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29693636/spore-acquisition-and-survival-of-ambrosia-beetles-associated-with-the-laurel-wilt-pathogen-in-avocados-after-exposure-to-entomopathogenic-fungi
#15
Pasco B Avery, Verónica Bojorque, Cecilia Gámez, Rita E Duncan, Daniel Carrillo, Ronald D Cave
Laurel wilt is a disease threatening the avocado industry in Florida. The causative agent of the disease is a fungus vectored by ambrosia beetles that bore into the trees. Until recently, management strategies for the vectors of the laurel wilt fungus relied solely on chemical control and sanitation practices. Beneficial entomopathogenic fungi (EPF) are the most common and prevalent natural enemies of pathogen vectors. Laboratory experiments demonstrated that commercial strains of EPF can increase the mortality of the primary vector, Xyleborus glabratus , and potential alternative vectors, Xylosandrus crassiusculus , Xyleborus volvulus and Xyleborus bispinatus (Coleoptera: Curculionidae: Scolytinae)...
April 25, 2018: Insects
https://www.readbyqxmd.com/read/29690329/a-synopsis-of-the-genus-dorcasta-pascoe-1858-coleoptera-cerambycidae-lamiinae-apomecynini
#16
Larry G Bezark, Antonio Santos-Silva, Francisco E de L Nascimento
Three new species of Dorcasta Pascoe, 1858 are described: D. birai, from Brazil (Goiás); D. parkeri, from Mexico, Nicaragua and Costa Rica; and D. rifkindi, from Mexico and Panama. Additionally, D. dasycera, D. borealis, and D. crassicornis are redescribed. Dorcasta crassicornis is recorded from Mexico, Guatemala and Costa Rica, and D. borealis is recorded from Costa Rica. New state records for Mexico are provided for Dorcasta cinerea. A key to the known species of Dorcasta is provided.
March 20, 2018: Zootaxa
https://www.readbyqxmd.com/read/29690203/division-of-the-genera-sparna-thomson-1864-and-carterica-pascoe-1858-coleoptera-cerambycidae-lamiinae-colobotheini-with-description-of-six-new-genera-and-eight-new-species
#17
Antonio Santos-Silva, Maria Helena M Galileo, Jim Mcclarin
Sparna Thomson, 1864 and Carterica Pascoe, 1858 are divided into seven genera: Sparna, Carterica, Francisparna gen. nov., Batesparna gen. nov., Allocarterica gen. nov., Piriana gen. nov., Miguellus gen. nov., and Confluentia gen. nov. From the species currently placed in Sparna, only S. lycoides Thomson, 1864 is maintained in the genus, and only Carterica mucronata (Olivier, 1795) is considered a true Carterica. Sparna bosqi Gilmour, 1954 is revalidated and included in a new genus. The following new species are described: Sparna tavakiliani, from Colombia; Piriana birai, and P...
April 9, 2018: Zootaxa
https://www.readbyqxmd.com/read/29682995/efficacy-and-safety-of-the-combination-of-isosorbide-dinitrate-spray-and-chitosan-gel-for-the-treatment-of-diabetic-foot-ulcers-a-double-blind-randomized-clinical-trial
#18
Sylvia Elena Totsuka Sutto, Yunuen Itzet Rodríguez Roldan, Ernesto German Cardona Muñoz, Teresa Arcelia Garcia Cobian, Sara Pascoe Gonzalez, Abril Martínez Rizo, Miriam Mendez Del Villar, Leonel García Benavides
AIM: To evaluate whether a combination of isosorbide dinitrate spray and chitosan gel (10%) topically applied can have additive benefits for management of diabetic foot ulcers. METHODS: In a randomized, placebo-controlled, double-blinded clinical trial, 68 patients were divided into four groups: Group 1: treated with chitosan gel; Group 2: isosorbide dinitrate spray; Group 3: combination of isosorbide dinitrate spray and chitosan gel; Group 4: placebo. RESULTS: Histological analyses showed a significant regeneration in all groups ( p < 0...
April 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29680797/xp11-translocation-renal-cell-carcinoma-paraneoplastic-syndrome-presenting-as-cutaneous-vasculitis-first-reported-case-of-yet-another-mask
#19
Claire Pascoe, Daniel Christidis, David Clouston, Nathan Lawrentschuk
Renal cell carcinoma is historically known as the 'great masquerader' with 40% of patients experiencing a paraneoplastic syndrome. Translocation carcinoma represents one-third of renal cancer in paediatric patients but less than 3% of renal cancers in patients aged 18-45 years where the clinical course is often rapidly terminal. There are less than 10 reported cases of leucoclastic vasculitis associated with clear cell carcinoma reported in the literature and 10 case reports of translocation carcinoma in adults...
April 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29676921/straightforward-entry-toward-highly-substituted-2-3-dihydrobenz-b-oxepines-by-ring-expansion-of-benzopyryliums-with-donor-acceptor-diazo-compounds
#20
Thibaut Courant, Morgane Pasco, Thomas Lecourt
Ylide-type reactivity of diazo compounds is exploited in a new way to prepare benzo[ b]oxepines thanks to the formation of three chemical bonds and two contiguous and highly substituted stereocenters in a single pot. This cationic reaction cascade first involves addition of a donor-acceptor-substituted diazo compound to a benzopyrylium. Selective 1,2 migration of the endocyclic C-C bond then results in a ring-expansion and generates a second oxocarbenium that is trapped by a nucleophile added sequentially.
April 20, 2018: Organic Letters
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