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SIRS and sepsis

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https://www.readbyqxmd.com/read/29138874/using-il-6-concentrations-in-the-first-24%C3%A2-h-following-trauma-to-predict-immunological-complications-and-mortality-in-trauma-patients-a-meta-analysis
#1
REVIEW
Zhi Qiao, Weikang Wang, Luxu Yin, Peng Luo, Johannes Greven, Klemens Horst, Frank Hildebrand
PURPOSE: In previous studies, interleukin-6 (IL-6) has been shown to have a high predictive value for the development of complications and mortality after trauma; however, there is some uncertainty around these results. The aim of this meta-analysis was to assess the value of early IL-6 levels (within the first 24 h after trauma) for predicting post-traumatic complications [acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), sepsis, multiple organ failure (MOF), and multiple organ dysfunction syndrome (MODS)] and mortality...
November 14, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29137578/predictive-value-of-quick-sepsis-related-organ-failure-scores-following-sepsis-related-medical-emergency-team-calls-a-retrospective-cohort-study
#2
D Boulos, Y Shehabi, J A Moghaddas, M Birrell, A Choy, V Giang, J Nguyen, T Hall, S Le
We conducted a cohort study of adult ward patients who had a Medical Emergency Team (MET) call triggered by confirmed or suspected sepsis in an Australian tertiary centre to assess the predictive utility of systemic inflammatory response syndrome (SIRS) and quick Sepsis-Related Organ Failure Assessment (qSOFA) scores for 28-day mortality over a 12-month period. Sepsis was the causative aetiology in 970 MET calls for 646 patients with a mean age of 68 years and median Charlson Comorbidity score (CCS) of 3.0...
November 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29127841/comparison-of-the-performance-of-sofa-qsofa-and-sirs-for-predicting-mortality-and-organ-failure-among-sepsis-patients-admitted-to-the-intensive-care-unit-in-a-middle-income-country
#3
Bodin Khwannimit, Rungsun Bhurayanontachai, Veerapong Vattanavanit
INTRODUCTION: The Sepsis-3 definition provides a change of two or more scores from zero or a known baseline of the Sequential Organ Failure Assessment (SOFA) as criteria of sepsis. The aim of this study was to compare the SOFA score and the quick SOFA (qSOFA) to Systemic Inflammatory Response Syndrome (SIRS) criteria in predictive ability of mortality and organ failure. METHODS: A-10year retrospective cohort study was conducted in a teaching hospital in Thailand...
October 18, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29127325/acinar-injury-and-early-cytokine-response-in-human-acute-biliary-pancreatitis
#4
Aparna Jakkampudi, Ramaiah Jangala, Ratnakar Reddy, Sasikala Mitnala, G Venkat Rao, Rebala Pradeep, D Nageshwar Reddy, Rupjyoti Talukdar
Clinical acute pancreatitis (AP) is marked by an early phase of systemic inflammatory response syndrome (SIRS) with multiorgan dysfunction (MODS), and a late phase characterized by sepsis with MODS. However, the mechanisms of acinar injury in human AP and the associated systemic inflammation are not clearly understood. This study, for the first time, evaluated the early interactions of bile acid induced human pancreatic acinar injury and the resulting cytokine response. We exposed freshly procured resected human pancreata to taurolithocolic acid (TLCS) and evaluated for acinar injury, cytokine release and interaction with peripheral blood mononuclear cells (PBMCs)...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127060/granulocyte-colony-stimulating-factor-and-autologous-cd133-positive-stem-cell-therapy-in-liver-cirrhosis-realistic-an-open-label-randomised-controlled-phase-2-trial
#5
Philip Noel Newsome, Richard Fox, Andrew L King, Darren Barton, Nwe-Ni Than, Joanna Moore, Christopher Corbett, Sarah Townsend, James Thomas, Kathy Guo, Diana Hull, Heather A Beard, Jacqui Thompson, Anne Atkinson, Carol Bienek, Neil McGowan, Neil Guha, John Campbell, Dan Hollyman, Deborah Stocken, Christina Yap, Stuart John Forbes
BACKGROUND: Results of small-scale studies have suggested that stem-cell therapy is safe and effective in patients with liver cirrhosis, but no adequately powered randomised controlled trials have been done. We assessed the safety and efficacy of granulocyte colony-stimulating factor (G-CSF) and haemopoietic stem-cell infusions in patients with liver cirrhosis. METHODS: This multicentre, open-label, randomised, controlled phase 2 trial was done in three UK hospitals and recruited patients with compensated liver cirrhosis and MELD scores of 11·0-15·5...
November 7, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29100549/low-sensitivity-of-qsofa-sirs-criteria-and-sepsis-definition-to-identify-infected-patients-at-risk-of-complication-in-the-prehospital-setting-and-at-the-emergency-department-triage
#6
Selin Tusgul, Pierre-Nicolas Carron, Bertrand Yersin, Thierry Calandra, Fabrice Dami
BACKGROUND: Sepsis is defined as life-threatening organ dysfunction caused by a host response to infection. The quick SOFA (qSOFA) score has been recently proposed as a new bedside clinical score to identify patients with suspected infection at risk of complication (intensive care unit (ICU) admission, in-hospital mortality). The aim of this study was to measure the sensitivity of the qSOFA score, SIRS criteria and sepsis definitions to identify the most serious sepsis cases in the prehospital setting and at the emergency department (ED) triage...
November 3, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29076484/-features-of-cytokines-profile-in-various-forms-of-systemic-inflammatory-response-syndrome-in-patients-with-acute-calculous-cholecystitis
#7
Dzh N Gadzhiev, N Dzh Gadzhiev, Z B Mamedova
AIM: Comparative evaluation of systemic concentration of some cytokines in various forms of SIR in patients with acute calculous cholecystitis. MATERIAL AND METHODS: The study included 32 patients with acute calculous cholecystitis and SIR. According to ASSR/SCCM criteria SIR 2 was in 11, SIR 3 - in 8, SIR 4 - in 7 patients, 6 patients had sepsis. Serum TNF-α, IL-6, IL-4 and IL-10 were determined prior to surgery, in 3 and 7 days postoperatively by using of ELISA...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29068553/serum-alpha1-proteinase-inhibitor-concentrations-in-dogs-with-systemic-inflammatory-response-syndrome-or-sepsis
#8
Romy M Heilmann, Niels Grützner, Brittany E Thames, Jörg M Steiner, James W Barr
OBJECTIVE: To determine whether the concentration of serum canine alpha1 -proteinase inhibitor (cα1 -PI) has diagnostic or prognostic utility in dogs with sepsis or noninfectious systemic inflammatory response syndrome (SIRS). DESIGN: Prospective, observational study from May to December 2010. SETTING: University teaching hospital ICU. ANIMALS: Sixty-nine client-owned dogs: 19 dogs with SIRS or sepsis and 50 healthy control dogs...
October 25, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29065784/effect-of-vancomycin-initial-dosing-on-time-to-systemic-inflammatory-response-syndrome-resolution-in-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#9
Jessica Lynn Wesolek, Kelly McNorton, George Delgado, Christopher Alan Giuliano
Current guidelines suggest using vancomycin-loading doses for complicated infections despite a lack of evidence to support this practice. To address this gap, we performed a single-centre cohort study of 124 patients with sepsis due to methicillin-resistant Staphylococcus aureus bacteremia. Patients were allocated into two groups based on initial dose of vancomycin, <20 mg/kg or ≥20 mg/kg, and evaluated for time to resolution of systemic inflammatory response syndrome (SIRS). Among a cohort of 124 patients, 87 received vancomycin initial doses <20 mg/kg and 37 received ≥20 mg/kg...
October 25, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29046941/-sepsis-3-what-has-been-confirmed-in-therapy
#10
REVIEW
S David, F M Brunkhorst
Hugo Schottmüller realized already over 100 years ago that sepsis is a syndrome that occurs as a consequence of an infection defined by a systemic overreaction to a periodic invasion of bacilli. Consistent with this old concept, the term "systemic inflammatory response syndrome" (SIRS) was coined about 25 years ago and has been regularly used ever since. In 2016, a sepsis task force was formed to re-evaluate the current definition on a scientific basis. The task force suggested a third definition (sepsis-3) of the disease that now focuses both on the pathological host response and on organ dysfunction as obligatory key features to diagnose sepsis...
October 18, 2017: Der Internist
https://www.readbyqxmd.com/read/29037526/sirs-in-the-time-of-sepsis-3
#11
Steven Q Simpson
Severe sepsis is a common, deadly, and diagnostically vexing condition. Recent recommendations for diagnosing sepsis, referred to as consensus guidelines, provide a definition of sepsis and remove the Systemic Inflammatory Response Syndrome (SIRS) as a component of the diagnostic process. A concise definition of sepsis is welcomed. However, the approach to developing these guidelines, while thorough, had weaknesses. Emphasis is placed on mortality prediction, rather than on early diagnosis. Diagnostic criteria are recommended to replace current criteria without evidence of any effect that their use would have on mortality...
October 13, 2017: Chest
https://www.readbyqxmd.com/read/29035701/does-sofa-predict-outcomes-better-than-sirs-in-brazilian-icu-patients-with-suspected-infection-a-retrospective-cohort-study
#12
Regis Goulart Rosa, Rafael Barberena Moraes, Thiago Costa Lisboa, Daniel Pretto Schunemann, Cassiano Teixeira
We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points)...
October 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29021726/investigating-the-relationship-between-microalbuminuria-and-prognosis-of-patients-with-severe-burns-in-the-motahari-burn-hospital
#13
M Roham, K Anbari, M J Fatemi, M Momeni
Microalbuminuria seems to be a reflection of increased vascular permeability caused by systemic inflammatory response, and is likely to be a predictor of mortality, sepsis and other outcomes of severe burn patients. We investigated the impact of microalbuminuria on the prognosis of patients with severe burns. This is a prospective study on severe burn patients (above 20%) admitted in the first 24 hours after burns to the Motahari Burn Hospital. Patients' microalbuminuria was measured at admission and 48 hours later, and its relationship with patient prognosis (sepsis, renal failure, death, inhalation injury and systemic inflammatory response syndrome) was analyzed...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28993134/sepsis-caused-by-bloodstream-infection-in-patients-in-the-intensive-care-unit-the-impact-of-inactive-empiric-antimicrobial-therapy-on-outcome
#14
Daniel Brooks, Padmaja Polubothu, D Young, M G Booth, A Smith
BACKGROUND: Sepsis is one of the leading causes of death in the UK. AIMS: The aims of this study were to identify the rate of inactive antimicrobial therapy (AMT) in the ICU and whether inactive AMT had an effect on in hospital mortality, ICU mortality, 90-day mortality and length of hospital stay. Additionally, we wanted to identify risk factors for receiving inactive AMT. METHODS: This was a retrospective observational study conducted at Glasgow Royal Infirmary ICU between January 2010 and December 2013, with 12,000 blood cultures taken over this time period, of which n=127 were deemed clinically significant...
October 6, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28988067/the-effect-of-resuscitation-strategy-on-the-longitudinal-immuno-inflammatory-response-to-blunt-trauma
#15
Alexander Bonde, Ask Tybjærg Nordestgaard, Rasmus Kirial, Peter Svenningsen, Martin Sillesen
INTRODUCTION: Resuscitation strategies following blunt trauma have been linked to immuno-inflammatory complications leading to systemic inflammatory syndrome (SIRS), sepsis and multiple organ failure (MOF). The effect of resuscitation strategy on longitudinal inflammation marker trajectories is, however, unknown. We hypothesized that the effect of resuscitation strategy extends beyond the trauma-related coagulopathy, perhaps affecting the longitudinal immuno-inflammatory response to injury...
September 28, 2017: Injury
https://www.readbyqxmd.com/read/28965741/novel-biomarkers-for-sepsis-a-narrative-review
#16
Frederik Fruergaard Larsen, J Asger Petersen
BACKGROUND: Sepsis is a prevalent condition among hospitalized patients that carries a high risk of morbidity and mortality. Rapid recognition of sepsis as the cause of deterioration is desirable, so effective treatment can be initiated rapidly. Traditionally, diagnosis was based on presence of two or more positive SIRS criteria due to infection. However, recently published sepsis-3 criteria put more emphasis on organ dysfunction caused by infection in the definition of sepsis. Regardless of this, no gold standard for diagnosis exist, and clinicians still rely on a number of traditional and novel biomarkers to discriminate between patients with and without infection, as the cause of deterioration...
September 28, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28916973/myeloperoxidase-can-differentiate-between-sepsis-and-non-infectious-sirs-and-predicts-mortality-in-intensive-care-patients-with-sirs
#17
Irene T Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu, Dylan W de Lange
BACKGROUND: Systemic inflammatory response syndrome (SIRS) is a clinical syndrome following inflammation. Clinically, it is difficult to distinguish SIRS following an infection, i.e., sepsis, from non-infectious SIRS. Myeloperoxidase is a hemeprotein stored in the neutrophil azurophilic granules and is one of the main pillars of neutrophil attack. Therefore, we hypothesized that myeloperoxidase can differentiate between sepsis and non-infectious SIRS in patients with systemic inflammatory response syndrome in the intensive care unit (ICU)...
September 15, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28876643/the-role-of-il17-a-in-the-second-hit-of-acute-pancreatitis
#18
J T Thomson, M B Brand, P FruFonteh
BACKGROUND: Acute pancreatitis is characterised by distinct clinical phases. An initial systemic inflammation response syndrome (SIRS) and occasional subsequent 'second hit' usually initiated by systemic sepsis. The pro-inflammatory T-helper 17 pathway has been shown to be an initiator of early SIRS in AP; however, to date, interleukin-17A has not been evaluated as a marker of the septic second hit in severe acute pancreatitis (SAP). METHOD: Twenty-five (aged 22-78) with mild (n = 12), moderate (n = 5) and severe (n = 8) acute pancreatitis were enrolled...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876574/holding-the-torch-up-high-a-medical-historical-evaluation-of-surgical-advances-during-the-great-war-1914-1918-in-memory-of-those-that-served-and-fell
#19
G Scharf
"How wide and varied is the experience of the battlefield and how fertile the blood of warriors in raising good surgeons" Sir Clifford Allbutt (1898). With these sentiments of the medical lessons learned in war and conflict, with the background of the poem of "In Flanders Field", written by a doctor who had South African War connections, reasons (the Somme and third Ypres battles) will be given that this was indeed a "GREAT WAR" as the world history, weapons, strategy, tactics and wounding patterns had changed dramatically...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28872708/validation-of-an-automated-immune-turbidimetric-assay-for-serum-gelsolin-and-its-possible-clinical-utility-in-sepsis
#20
Zoltán Horváth-Szalai, Péter Kustán, Balázs Szirmay, Ágnes Lakatos, Per H Christensen, Tamás Huber, Beáta Bugyi, Diána Mühl, Andrea Ludány, Attila Miseta, Gábor L Kovács, Tamás Kőszegi
BACKGROUND: Studies showing the potential predictive value of the actin-binding protein gelsolin, in critically ill patients are scarce. Moreover, even up to now a rapid automated measurement of gelsolin has still remained a challenge. Therefore, we developed and validated an automated serum gelsolin immune turbidimetric assay for possible clinical use. METHODS: Validation of serum gelsolin assay was performed on a Cobas 8000/c502 analyzer (Roche) according to the second edition of Eurachem guidelines...
September 5, 2017: Journal of Clinical Laboratory Analysis
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