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SIRS and sepsis

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https://www.readbyqxmd.com/read/29771353/predictors-for-identifying-burn-sepsis-and-performance-versus-existing-criteria
#1
David M Hill, Matthew D Percy, Sai R Velamuri, Julio Lanfranco, Ivan Romero Legro, Scott E Sinclair, William L Hickerson
Sepsis is the largest cause of mortality in thermally injured patients. Traditional SIRS criteria do not aid diagnosis of sepsis in burn centers. Studies have attempted identification of the best indicators of sepsis in the thermal injured patient, but predictive variables are inconsistent across the various studies. Currently, consensus guidelines lack evidential support as to which patients will benefit most from prompt antimicrobial therapy. The purpose of our study was to evaluate novel diagnostic parameters for thermal injured patients with known sepsis and compare these parameters with existing diagnostic criteria...
May 16, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29770247/using-statistical-and-machine-learning-methods-to-evaluate-the-prognostic-accuracy-of-sirs-and-qsofa
#2
Akash Gupta, Tieming Liu, Scott Shepherd, William Paiva
Objectives: The objective of this study was to compare the performance of two popularly used early sepsis diagnostic criteria, systemic inflammatory response syndrome (SIRS) and quick Sepsis-related Organ Failure Assessment (qSOFA), using statistical and machine learning approaches. Methods: This retrospective study examined patient visits in Emergency Department (ED) with sepsis related diagnosis. The outcome was 28-day in-hospital mortality. Using odds ratio (OR) and modeling methods (decision tree [DT], multivariate logistic regression [LR], and naïve Bayes [NB]), the relationships between diagnostic criteria and mortality were examined...
April 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29760745/diagnostic-value-of-decoy-receptor-3-combined-with-procalcitonin-and-soluble-urokinase-type-plasminogen-activator-receptor-for-sepsis
#3
Jing-Jing Zhao, Xiao-Li Lou, Hong-Wei Chen, Feng-Ting Zhu, Yan-Qiang Hou
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29742943/comparison-between-presepsin-and-procalcitonin-in-early-diagnosis-of-neonatal-sepsis
#4
Agustin Iskandar, Maimun Z Arthamin, Kristin Indriana, Muhammad Anshory, Mina Hur, Salvatore Di Somma
BACKGROUND: Neonatal sepsis remains worldwide one of the leading causes of morbidity and mortality in both term and preterm infants. Lower mortality rates are related to timely diagnostic evaluation and prompt initiation of empiric antibiotic therapy. Blood culture, as gold standard examination for sepsis, has several limitations for early diagnosis, so that sepsis biomarkers could play an important role in this regard. This study was aimed to compare the value of the two biomarkers presepsin and procalcitonin in early diagnosis of neonatal sepsis...
May 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29720475/comparison-of-qsofa-with-current-emergency-department-tools-for-screening-of-patients-with-sepsis-for-critical-illness
#5
Robert M Rodriguez, John C Greenwood, Thomas J Nuckton, Bryan Darger, Frances S Shofer, Dawn Troeger, Soo Y Jung, Kelly G Speich, Joel Valencia, J Hope Kilgannon, Danny Fernandez, Brigitte M Baumann
OBJECTIVE: We sought to compare the quick sequential organ failure assessment (qSOFA) to systemic inflammatory response syndrome (SIRS), severe sepsis criteria and lactate levels for their ability to identify ED patients with sepsis with critical illness. METHODS: We conducted this multicenter retrospective cohort study at five US hospitals, enrolling all adult patients admitted to these hospitals from their EDs with infectious disease-related illnesses from 1 January 2016 to 30 April 2016...
May 2, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29717063/nuclear-pten-enhances-the-maturation-of-a-microrna-regulon-to-limit-myd88-dependent-susceptibility-to-sepsis
#6
Flavia Sisti, Soujuan Wang, Stephanie L Brandt, Nicole Glosson-Byers, Lindsey D Mayo, Young Min Son, Sarah Sturgeon, Luciano Filgueiras, Sonia Jancar, Hector Wong, Charles S Dela Cruz, Nathaniel Andrews, Jose Carlos Alves-Filho, Fernando Q Cunha, C Henrique Serezani
Sepsis-induced organ damage is caused by systemic inflammatory response syndrome (SIRS), which results in substantial comorbidities. Therefore, it is of medical importance to identify molecular brakes that can be exploited to dampen inflammation and prevent the development of SIRS. We investigated the role of phosphatase and tensin homolog (PTEN) in suppressing SIRS, increasing microbial clearance, and preventing lung damage. Septic patients and mice with sepsis exhibited increased PTEN expression in leukocytes...
May 1, 2018: Science Signaling
https://www.readbyqxmd.com/read/29715258/comparison-of-sepsis-3-criteria-versus-sirs-criteria-in-screening-patients-for-sepsis-in-the-emergency-department
#7
Brian W Gilbert, Lanae Faires, Amber Meister, Joel Huffman, Rebecca K Faber
The objective of our study was to assess the percentage of patients who met qSOFA criteria, SIRS criteria, both, or none of either criterion and received an International Classification of Diseases, Tenth Revision (ICD-10) code for sepsis after admission from the emergency department (ED). This was a single-center retrospective chart review of medical patients admitted through the ED. Patients were included if they were older than 18 years, were admitted to an inpatient unit through the ED, and received antibiotics within 48 hr of admission...
April 2018: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29701145/a-potential-therapeutic-target-rna-binding-protein-arid5a-for-the-treatment-of-inflammatory-disease-associated-with-aberrant-cytokine-expression
#8
Kazuya Masuda, Tadamitsu Kishimoto
BACKGROUND: Infection, tissue damage and aging can cause inflammation with high levels of inflammatory cytokines. Overproduction of inflammatory cytokines often leads to systemic inflammatory response syndrome (SIRS), severe sepsis, and septic shock. However, prominent therapeutic targets have not been found, although the incidence of sepsis is likely to increase annually. Our recent studies indicate that some RNA-binding proteins, which control gene expression of inflammatory cytokines at the post-transcriptional level, may play a critical role in inflammatory diseases such as sepsis...
April 25, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29690517/fine-particulate-matter-pollution-and-risk-of-community-acquired-sepsis
#9
Elisa J Sarmiento, Justin Xavier Moore, Leslie A McClure, Russell Griffin, Mohammad Z Al-Hamdan, Henry E Wang
While air pollution has been associated with health complications, its effect on sepsis risk is unknown. We examined the association between fine particulate matter (PM2.5 ) air pollution and risk of sepsis hospitalization. We analyzed data from the 30,239 community-dwelling adults in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort linked with satellite-derived measures of PM2.5 data. We defined sepsis as a hospital admission for a serious infection with ≥2 systemic inflammatory response (SIRS) criteria...
April 21, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29683274/drug-repositioning-to-alleviate-systemic-inflammatory-response-syndrome-caused-by-gram-negative-bacterial-outer-membrane-vesicles
#10
Ji Hyun Kim, Jaewook Lee, Kyong-Su Park, Sung-Wook Hong, Yong Song Gho
Sepsis is characterized by systemic inflammatory response syndrome (SIRS) accompanied with infection. Gram-negative bacteria can evoke sepsis by activating the host immune system, such as the release of IL-6 and TNF-α, through their virulence factors. Outer membrane vesicles (OMVs), nanosized bilayered proteolipids derived from Gram-negative bacteria, harbor various virulence factors and are shown to induce SIRS. Here, drugs are repositioned to alleviate SIRS caused by Gram-negative bacterial OMVs. Using novel OMV-based drug screening systems, a total of 178 commercially available drugs are primarily screened, and a total of 18 repositioned drug candidates are found to effectively block IL-6 and TNF-α production from OMV-stimulated macrophages...
April 23, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29680395/plasma-procalcitonin-concentration-in-healthy-calves-and-those-with-septic-systemic-inflammatory-response-syndrome
#11
F Bonelli, V Meucci, T J Divers, A Boccardo, D Pravettoni, M Meylan, A G Belloli, M Sgorbini
The diagnosis of sepsis in calves is challenging. Blood culture and clinical signs combined with a complete blood count have been used for the diagnosis of sepsis. Recent literature in humans and animal species has been focused on sepsis-specific biomarkers, such as procalcitonin (PCT), that may more accurately and efficiently diagnose sepsis. The aim of this study was to evaluate plasma PCT concentrations in healthy and septic calves. Twenty healthy control calves and 58 sick calves with septic systemic inflammatory response syndrome (SIRS) based on SIRS score and clinical findings were included...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29680262/clinical-implications-of-intravenous-drug-incompatibilities-in-critically-ill-patients
#12
REVIEW
Malik Benlabed, Maxime Perez, Romain Gaudy, Stéphanie Genay, Damien Lannoy, Christine Barthélémy, Pascal Odou, Gilles Lebuffe, Bertrand Décaudin
OBJECTIVE: The aim of this review is to analyse the clinical consequences of intravenous drug incompatibilities in critically ill patients, especially the incidence of organ dysfunctions and mortality. METHODS: A review of literature was conducted according to the PRISMA statement in June 2017, using Medline, ISI Web of Science and Clinicaltrials.gov. DATA EXTRACTION: Eligible studies were case reports and randomised controlled trials (RCTs) that assessed the effects of drug incompatibilities in critically ill patients on morbidity or mortality as primary or secondary outcomes, or adverse events...
April 19, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29678851/improved-diagnostic-and-prognostic-power-of-combined-delta-neutrophil-index-and-mean-platelet-volume-in-pediatric-sepsis
#13
Minjeong Nam, Byeong Hei Son, Jung Eun Seo, Il Ry Kim, Chee Kyoung Park, Hyun Kyung Kim
This study aims to evaluate the diagnostic and prognostic significance of white blood cell (WBC) and platelet parameters measured by automated hematology analyzers in pediatric sepsis. The study included 232 pediatric patients whose C-reactive protein test had been requested for evaluation of infection or inflammation at a pediatric tertiary hospital. The patients were allocated to control, systemic inflammatory response syndrome (SIRS) without infection, and sepsis groups. An ADVIA 2120i hematology system was used to measure the delta neutrophil index (DN) and platelet parameters including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and immature platelet fraction (IPF)...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29666944/macrophages-play-an-essential-role-in-trauma-induced-sterile-inflammation-and-tissue-repair
#14
REVIEW
Moritz Peiseler, Paul Kubes
Severe trauma is accompanied by a profound activation of the immune system. Patients with polytrauma develop systemic inflammatory response syndrome (SIRS) and often sepsis, which contributes substantially to high mortality of this condition. On a cellular level, necrosis and loss of plasma membrane integrity lead to the release of endogenous "damage-associated molecular patterns" (DAMPs) as danger signals, which in turn activate innate immune cells. Inflammation that occurs in the absence of invading pathogens has been termed sterile inflammation and trauma with tissue damage represents an acute form of sterile inflammation...
April 17, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29664014/rip-kinase-1-dependent-endothelial-necroptosis-underlies-systemic-inflammatory-response-syndrome
#15
Matija Zelic, Justine E Roderick, Joanne A O'Donnell, Jesse Lehman, Sung Eun Lim, Harish P Janardhan, Chinmay M Trivedi, Manolis Pasparakis, Michelle A Kelliher
Receptor interacting protein kinase 1 (RIPK1) has important kinase-dependent and kinase-independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell context-dependent manner. The kinase activity of RIPK1 mediates hypothermia and lethality in a mouse model of TNF-induced shock, reflecting the hyperinflammatory state of systemic inflammatory response syndrome (SIRS), where the proinflammatory "cytokine storm" has long been viewed as detrimental. Here, we demonstrate that cytokine and chemokine levels did not predict survival and, importantly, that kinase-inactive Ripk1D138N/D138N hematopoietic cells afforded little protection from TNF- or TNF/zVAD-induced shock in reconstituted mice...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29660669/the-systemic-inflammatory-response-syndrome-criteria-and-their-differential-association-with-mortality
#16
Kirsi-Maija Kaukonen, Michael Bailey, David Pilcher, D James Cooper, Rinaldo Bellomo
PURPOSE: Despite the recent Sepsis-3 consensus, the Systemic Inflammatory Response Syndrome (SIRS) criteria continue to be assessed and recommended. Such use implies equivalence and interchangeability of criteria. Thus, we aimed to test whether such criteria are indeed equivalent and interchangeable. MATERIALS AND METHODS: From 2000 to 2015, we identified patients with infection, organ failure, and at least one SIRS criterion in 179 Intensive Care Units in Australia and New...
April 7, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29656714/epidemiology-of-sepsis-in-intensive-care-units-in-turkey-a-multicenter-point-prevalence-study
#17
Nur Baykara, Halis Akalın, Mustafa Kemal Arslantaş, Volkan Hancı, Çiğdem Çağlayan, Ferda Kahveci, Kubilay Demirağ, Canan Baydemir, Necmettin Ünal
BACKGROUND: The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in Turkey. METHODS: A total of 132 ICUs from 94 hospitals participated. All patients (aged > 18 years) present at the participating ICUs or admitted for any duration within a 24-h period (08:00 on January 27, 2016 to 08:00 on January 28, 2016) were included...
April 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29624409/validation-of-a-host-response-assay-septicyte%C3%A2-lab-for-discriminating-sepsis-from-sirs-in-the-icu
#18
Russell R Miller Iii, Bert K Lopansri, John P Burke, Mitchell Levy, Steven Opal, Richard E Rothman, Franco R D'Alessio, Venkataramana K Sidhaye, Neil R Aggarwal, Robert Balk, Jared A Greenberg, Mark Yoder, Gourang Patel, Emily Gilbert, Majid Afshar, Jorge P Parada, Greg S Martin, Annette M Esper, Jordan A Kempker, Mangala Narasimhan, Adey Tsegaye, Stella Hahn, Paul Mayo, Tom van der Poll, Marcus J Schultz, Brendon P Scicluna, Peter Klein Klouwenberg, Antony Rapisarda, Therese A Seldon, Leo C McHugh, Thomas D Yager, Silvia Cermelli, Dayle Sampson, Victoria Rothwell, Richard Newman, Shruti Bhide, James T Kirk, Krupa Navalkar, Roy F Davis, Roslyn A Brandon, Richard B Brandon
RATIONALE: A molecular test to distinguish between sepsis and systemic inflammation of non-infectious etiology could potentially have clinical utility. OBJECTIVES: This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte™ LAB) designed to distinguish between sepsis and non-infectious systemic inflammation in critically ill adults. METHODS: The study employed a prospective, observational, non-interventional design, and recruited a heterogeneous cohort of adult critical care patients from seven sites in the USA (N=249)...
April 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29610604/correlation-of-procalcitonin-and-c-reactive-protein-with-intra-abdominal-hypertension-in-intra-abdominal-infections-their-predictive-role-in-the-progress-of-the-disease
#19
Bedri Braha, Dafina Mahmutaj, Mehmet Maxhuni, Burim Neziri, Shaip Krasniqi
AIM: To analyse the correlation of procalcitonin (PCT) and C-reactive protein (CRP) values with increased intra-abdominal pressure and to evaluate their predictive role in the progression of Intra-abdominal infections. MATERIALS AND METHODS: A non-randomized prospective study conducted in the group of 80 patients. We have measured the PCT, CRP and intra-abdominal pressure (IAP). RESULTS: According to IAH grades (G), there was a significant difference of PCT values: G I 3...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29609531/metformin-associated-lactic-acidosis-a-case-series-of-28-patients-treated-with-sustained-low-efficiency-dialysis-sled-and-long-term-follow-up
#20
Andrea Angioi, Gianfranca Cabiddu, Maura Conti, Gianfranco Pili, Alice Atzeni, Valeria Matta, Riccardo Cao, Matteo Floris, Marco Songini, Maria Franca Mulas, Mitchell Rosner, Antonello Pani
BACKGROUND: Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant increase in hospitalizations for MALA to our Center. We report the outcomes of our clinical and therapeutic approach. METHODS: This is a single-center case series. Twenty-eight patients affected with MALA and acute kidney failure admitted between January 2000 and September 2014 were included...
April 2, 2018: BMC Nephrology
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