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Stoke children

Sarah J Nevitt, Ashley P Jones, Jo Howard
BACKGROUND: Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and a reduced life expectancy. Hydroxyurea (hydroxycarbamide), an oral chemotherapeutic drug, ameliorates some of the clinical problems of SCD, in particular that of pain, by raising fetal haemoglobin. This is an update of a previously published Cochrane Review. OBJECTIVES: To assess the effects of hydroxyurea therapy in people with SCD (all genotypes), of any age, regardless of setting...
April 20, 2017: Cochrane Database of Systematic Reviews
David H Demmer, Francis Puccio, Mark A Stokes, Jane A McGillivray, Merrilyn Hooley
The aims of the current study were to (i) explore the potential bidirectional, prospective relationships between parenting and child ADHD, and (ii) explore whether these relationships differed on the basis of child gender. Data were obtained from waves 1 (children aged 4- to 5-years) to 5 (children aged 12- to 13-years) of the Longitudinal Study of Australian Child (LSAC) dataset (child cohort). In order to examine dimensions of both mothers' and fathers' parenting, a subsample of nuclear families with mothers, fathers and children present at all waves was extracted (final sample = 1932; sons = 981, daughters = 951)...
March 2, 2017: Journal of Abnormal Child Psychology
C R Stokes
At birth the piglet's immune system is immature and it is dependent upon passive maternal protection until weaning. The piglet's mucosal immune system develops over the first few weeks but has not reached maturity at weaning ages which are common on commercial farms. At weaning piglets are presented with a vast and diverse range of microbial and dietary/environmental antigens. Their ability to distinguish between antigens and mount a protective response to potential pathogens and to develop tolerance to dietary antigens is critical to their survival and failure to do so is reflected in the high incidence of morbidity and mortality in the post-weaning period...
2017: Journal of Animal Science and Biotechnology
M A Stokes, L Kornienko, A M Scheeren, H M Koot, S Begeer
PURPOSE: Children and adolescents with autism spectrum disorders (ASD) are understood to experience a reduced quality of life compared to typically developing (TD) peers. The evidence to support this has largely been derived from proxy reports, in turn which have been evaluated by Cronbach's alpha and interrater reliability, neither of which demonstrate unidimensionality of scales, or that raters use the instruments consistently. To redress this, we undertook an evaluation of the Pediatric Quality of Life Inventory™ (PedsQL), a widely used measure of children's quality of life...
December 22, 2016: Quality of Life Research
Mathew David Sewell, Johnson Platinum, Geoffrey Noel Askin, Robert Labrom, Mike Hutton, Daniel Chan, Andrew Clarke, Oliver M Stokes, Sean Molloy, Stewart Tucker, Jan Lehovsky
OBJECTIVE: To investigate whether growing rod surgery for children with progressive idiopathic early onset scoliosis (EOS) effects activity and participation, and investigate factors that may affect this. STUDY DESIGN: Multicenter retrospective cohort study using prospectively collected data on 60 children with idiopathic EOS and significant scoliosis (defined as a Cobb angle >40°). Thirty underwent brace treatment, and 30, growth rod surgery. Questionnaire and radiographic data were recorded at 1 year...
March 2017: Journal of Pediatrics
Jayne Newbury, Thomas Klee, Stephanie F Stokes, Catherine Moran
Purpose: This study explored associations between working memory and language in children aged 2-4 years. Method: Seventy-seven children aged 24-30 months were assessed on tests measuring language, visual cognition, verbal working memory (VWM), phonological short-term memory (PSTM), and processing speed. A standardized test of receptive and expressive language was used as the outcomes measure 18 months later. Results: There were moderate-to-strong longitudinal bivariate relationships between the 3 processing measures and language outcomes...
October 12, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
Kimberly-Anne Tan, Mathew D Sewell, Andrew J Clarke, Daniel Chan, Oliver M Stokes, Shahid N Khan, Michael Hutton
PURPOSE OF THE STUDY: Pacemakers are currently identified as a contraindication for the use of magnetic growth rods (MGRs). This arises from concern that magnetic fields generated by the MGR external remote controller (ERC) during lengthening procedures may induce pacemaker dysfunction. We investigated (1) whether MGR lengthening affects pacemaker function, and (2) if the magnetic field of a pacemaker affects MGR lengthening. METHODS: MGRs were tested in conjunction with an magnetic resonance imaging-compatible pacemaker, which was connected to a virtual patient under continuous cardiac monitoring...
September 15, 2016: Journal of Pediatric Orthopedics
Michael G Currier, Sujin Lee, Christopher C Stobart, Anne L Hotard, Remi Villenave, Jia Meng, Carla D Pretto, Michael D Shields, Minh Trang Nguyen, Sean O Todd, Michael H Chi, Jason Hammonds, Stefanie A Krumm, Paul Spearman, Richard K Plemper, Kaori Sakamoto, R Stokes Peebles, Ultan F Power, Martin L Moore
Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in children. In contrast to the RSV prototypic strain A2, clinical isolate RSV 2-20 induces airway mucin expression in mice, a clinically relevant phenotype dependent on the fusion (F) protein of the RSV strain. Epidermal growth factor receptor (EGFR) plays a role in airway mucin expression in other systems; therefore, we hypothesized that the RSV 2-20 F protein stimulates EGFR signaling. Infection of cells with chimeric strains RSV A2-2-20F and A2-2-20GF or over-expression of 2-20 F protein resulted in greater phosphorylation of EGFR than infection with RSV A2 or over-expression of A2 F, respectively...
May 2016: PLoS Pathogens
Suhail Al-Saleh, Paul F Kantor, Indra Narang
Sleep disordered breathing is well described in adults with heart failure but not in pediatric population. We describe a 13-year-old Caucasian male with severe heart failure related to dilated cardiomyopathy who demonstrated polysomnographic features of Cheyne-Stokes respiration, which completely resolved following cardiac transplantation. Cheyne-Stokes respiration in children with advanced heart failure and its resolution after heart transplant can be observed similar to adults.
2016: Case Reports in Pediatrics
Guillermo L Monroy, Paritosh Pande, Ryan L Shelton, Ryan M Nolan, Darold R Spillman, Ryan G Porter, Michael A Novak, Stephen A Boppart
Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity and form a middle ear effusion (MEE). MEEs can persist for weeks or months and cause hearing loss as well as speech and learning delays in young children. The ability of a physician to accurately identify and characterize the middle ear for signs of fluid and/or infection is crucial to provide the most appropriate treatment for the patient. Currently, middle ear infections are assessed with otoscopy, which provides limited and only qualitative diagnostic information...
March 2017: Journal of Biophotonics
Carly S Molloy, Sacha Stokes, Maria Makrides, Carmel T Collins, Peter J Anderson, Lex W Doyle
BACKGROUND: Children born preterm are at risk of visual-processing impairments. Several lines of evidence have contributed to the rationale that docosahexaenoic acid (DHA) supplementation of preterm infants may improve outcomes in visual processing. OBJECTIVE: The aim was to determine whether at 7 y of age children who were born very preterm and who received a high-DHA diet have better visual-processing outcomes than do infants fed a standard-DHA diet. DESIGN: This was a follow-up study in a subgroup of children from a randomized controlled trial...
January 2016: American Journal of Clinical Nutrition
Francis J Gilchrist
Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is in progress. Four research areas are discussed that are likely to contribute to the continued academic output from the unit. These are the use of selected ion flow tube mass spectrometry for the detection of biomarkers associated with pulmonary pathogens, the measurement of lung clearance index in preschool children, structured light plethysmography in children and the use of oral prednisolone for asthma exacerbations in children...
January 2016: Paediatric Respiratory Reviews
Susanna L den Boer, Koen F M Joosten, Sandra van den Berg, Ad P C M Backx, Ronald B Tanke, Gideon J du Marchie Sarvaas, Willem A Helbing, Lukas A J Rammeloo, Arend D J ten Harkel, Gabriëlle G van Iperen, Michiel Dalinghaus
In adults with heart failure, central sleep apnea (CSA), often manifested as Cheyne-Stokes respiration, is common, and has been associated with adverse outcome. Heart failure in children is commonly caused by dilated cardiomyopathy (DCM). It is unknown whether children with heart failure secondary to DCM have CSA, and whether CSA is related to the severity of heart failure. In this prospective observational study, 37 patients (<18 year) with heart failure secondary to DCM were included. They underwent polysomnography, clinical and laboratory evaluation and echocardiographic assessment...
February 2016: Pediatric Cardiology
Jayne Newbury, Thomas Klee, Stephanie F Stokes, Catherine Moran
PURPOSE: This study explored whether measures of working memory ability contribute to the wide variation in 2-year-olds' expressive vocabulary skills. METHOD: Seventy-nine children (aged 24-30 months) were assessed by using standardized tests of vocabulary and visual cognition, a processing speed measure, and behavioral measures of verbal working memory and phonological short-term memory. RESULTS: Strong correlations were observed between phonological short-term memory, verbal working memory, and expressive vocabulary...
December 2015: Journal of Speech, Language, and Hearing Research: JSLHR
Andrea Reupert, Darryl Maybery, Merrilee Cox, Eileen Scott Stokes
Within the context of mental illness, there is an acknowledgement that the social environment is critical to recovery. Nonetheless, how family roles and interactions are presented in recovery frameworks is unclear. This systematic review sought to: (i) identify how family is defined in recovery models, and (ii) synthesize how family relationships and roles are incorporated into recovery models for those with a mental illness. A systematic search of electronic databases was conducted for peer reviewed, English language papers published between 1980 to April 2013, from Ovid MEDLINE, PsycINFO, Proquest, CINAHL plus and Web of Knowledge...
December 2015: International Journal of Mental Health Nursing
Daniel M Green, Thomas E Merchant, Catherine A Billups, Dennis C Stokes, Alberto Broniscer, Ute Bartels, Murali Chintagumpala, Timothy E Hassall, Sridharan Gururangan, Geoffrey B McCowage, John A Heath, Richard J Cohn, Michael J Fisher, Ashok Srinivasan, Giles W Robinson, Amar Gajjar
PURPOSE: The treatment of children with embryonal brain tumors (EBT) includes craniospinal irradiation (CSI). There are limited data regarding the effect of CSI on pulmonary function. METHODS: Protocol SJMB03 enrolled patients 3 to 21 years of age with EBT. Pulmonary function tests (PFTs) (forced expiratory volume in 1 second [FEV1] and forced vital capacity [FVC] by spirometry, total lung capacity [TLC] by nitrogen washout or plethysmography, and diffusing capacity of the lung for carbon monoxide corrected for hemoglobin [DLCO(corr)]) were obtained...
September 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Xue Ming, Ritesh Patel, Victor Kang, Sudhansu Chokroverty, Peter O Julu
INTRODUCTION: Cardiac parasympathetic hypofunction has been reported in autism spectrum disorders (ASD). This usually is linked to respiratory dysrhythmia which has been documented in some children with ASD. OBJECTIVES: This study evaluated the cardiorespiratory functions in ASD to elucidate the physiologic basis of behaviors. METHODS: Nineteen children with ASD and 18 age matched controls underwent autonomic function monitoring at a defined resting state using the NeuroScope...
February 2016: Brain & Development
Anne K Jensen, Carrie Coleman, David Stokes, Gui-shuang Ying, Jiayan Huang, Ivy Kuhn, Gil Binenbaum
This study assessed validity, reliability, and feasibility of a filter paper blood spot insulin-like growth factor 1 (IGF-1) assay for retinopathy of prematurity (ROP) research. Blood samples were collected from 45 healthy children. Half of each sample was spun to obtain serum; half was applied to filter cards and stored for varying times and at different temperatures. IGF-1 assays were performed using a commercially available kit. Intraclass correlation between blood spot and serum IGF-1 values was high (0...
August 2015: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Thóra Másdóttir, Stephanie F Stokes
PURPOSE: A developmental hierarchy of phonetic feature complexity has been proposed, suggesting that later emerging sounds have greater articulatory complexity than those learned earlier. The aim of this research was to explore this hierarchy in a relatively unexplored language, Icelandic. METHOD: Twenty-eight typically-developing Icelandic-speaking children were tested at 2;4 and 3;4 years. Word-initial and word-medial phonemic inventories and a phonemic implicational hierarchy are described...
April 2016: International Journal of Speech-language Pathology
A A Antonova, K A Absatova, A A Korneev, A V Kurgansky
The production of drawing movements was studied in 29 right-handed children of 9-to-11 years old. The movements were the sequences of horizontal and vertical linear stokes conjoined at right angle (open polygonal chains) referred to throughout the paper as trajectories. The length of a trajectory varied from 4 to 6. The trajectories were presented visually to a subject in static (linedrawing) and dynamic (moving cursor that leaves no trace) modes. The subjects were asked to draw (copy) a trajectory in response to delayed go-signal (short click) as fast as possible without lifting the pen...
March 2015: Fiziologiia Cheloveka
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