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Exacerbations of chronic obstructive pulmonary disease

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https://www.readbyqxmd.com/read/29053337/obesity-and-severity-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#1
Tadahiro Goto, Atsushi Hirayama, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
RATIONALE: Obesity is relatively common among individuals with chronic obstructive pulmonary disease (COPD). However, little is known about the association of obesity with severity of acute exacerbation of COPD (AECOPD) and in-hospital mortality. OBJECTIVES: To examine the association of obesity with severity markers of AECOPD and in-hospital mortality. METHODS: This is a retrospective cohort study using population-based data - the 2012-2013 State Inpatient Databases - of seven US states (Arkansas, Florida, Iowa, Nebraska, New York, Utah, and Washington)...
October 20, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29044160/eosinophilia-and-clinical-outcome-of-chronic-obstructive-pulmonary-disease-a-meta-analysis
#2
Jeffery Ho, Wajia He, Matthew T V Chan, Gary Tse, Tong Liu, Sunny H Wong, Czarina C H Leung, Wai T Wong, Sharon Tsang, Lin Zhang, Rose Y P Chan, Tony Gin, Joseph Leung, Benson W M Lau, William K K Wu, Shirley P C Ngai
Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles indexed in four databases using Medical Subject Heading or Title and Abstract words including COAD, COPD, eosinophil, eosinophilia, eosinopenia from inception to December 2016. Observational studies and randomized controlled trials with parallel groups comparing COPD patients with and without eosinophilia were included...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042767/effectiveness-of-treatment-with-nebulized-colistin-in-patients-with-copd
#3
Nuria Bruguera-Avila, Alicia Marin, Ignasi Garcia-Olive, Joaquim Radua, Cristina Prat, Montserrat Gil, Juan Ruiz-Manzano
OBJECTIVES: To analyze whether the introduction of nebulized colistin in patients with chronic obstructive pulmonary disease (COPD) and infection with Pseudomonas aeruginosa (PA) is associated with a decrease of the number and duration of severe exacerbations. MATERIALS AND METHODS: Thirty six patients with COPD and infection with PA treated with nebulized colistin attending a day hospital during a 5-year (January 2010-December 2014) period were prospectively included...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29042706/protective-effects-of-bisoprolol-against-acute-exacerbation-in-moderate-to-severe-chronic-obstructive-pulmonary-disease
#4
Akihiko Taniguchi, Nobuaki Miyahara, Naohiro Oda, Daisuke Morichika, Eiki Ichihara, Isao Oze, Yasushi Tanimoto, Hirohisa Ichikawa, Utako Fujii, Mitsune Tanimoto, Arihiko Kanehiro, Katsuyuki Kiura
Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29040482/strategies-to-reduce-pulmonary-complications-after-transhiatal-esophagectomy
#5
A M Gillinov, R F Heitmiller
Background: By eliminating a thoracotomy, transhiatal esophagectomy (THE) is purported to reduce postoperative pulmonary complications. However, data from many early series do not support this contention, documenting pulmonary complications in up to 50% of patients and pneumonia in 5%-20%. Since 1990, we have implemented a management strategy designed to maximize airway protection in the postoperative period. The purpose of this study was to determine the current incidence of pulmonary complications after transhiatal esophagectomy without thoracotomy...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29038519/resveratrol-therapeutics-combines-both-antimicrobial-and-immunomodulatory-properties-against-respiratory-infection-by-nontypeable-haemophilus-influenzae
#6
Begoña Euba, Nahikari López-López, Irene Rodríguez-Arce, Ariadna Fernández-Calvet, Montserrat Barberán, Nuria Caturla, Sara Martí, Roberto Díez-Martínez, Junkal Garmendia
The respiratory pathogen nontypeable Haemophilus influenzae (NTHi) is an important cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) that requires efficient treatments. A previous screening for host genes differentially expressed upon NTHi infection identified sirtuin-1, which encodes a NAD-dependent deacetylase protective against emphysema and is activated by resveratrol. This polyphenol concomitantly reduces NTHi viability, therefore highlighting its therapeutic potential against NTHi infection at the COPD airway...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038056/worldwide-prevalence-of-viral-infection-in-aecopd-patients-a-meta-analysis
#7
REVIEW
Habib Jafarinejad, Mohsen Moghoofei, Shayan Mostafaei, Jafar Salimian, Sadegh Azimzadeh, Ali Ahmadi
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. METHODS: PubMed database was systematically searched for population-based prevalence studies (1930-2017). Fixed and random effects models were used for estimation of summary effect-sizes...
October 13, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29035120/use-of-a-remote-inhaler-monitoring-device-to-measure-change-in-inhaler-use-with-chronic-obstructive-pulmonary-disease-exacerbations
#8
Kaharu Sumino, Emily R Locke, Sheryl Magzamen, Ina Gylys-Colwell, Olivier Humblet, Huong Q Nguyen, Rachel M Thomas, Vincent S Fan
BACKGROUND: Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associated with COPD exacerbations. METHODS: Thirty-five participants with COPD used an electronic inhaler sensor for 12 weeks which recorded the date and time of each albuterol actuation...
October 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29033840/hydrogen-sulfide-inhibits-cigarette-smoke-induced-endoplasmic-reticulum-stress-and-apoptosis-in-bronchial-epithelial-cells
#9
Fan Lin, Chengcheng Liao, Yun Sun, Jinsheng Zhang, Weiwei Lu, Yu Bai, Yixuan Liao, Minxia Li, Xianqiang Ni, Yuelong Hou, Yongfen Qi, Yahong Chen
Background: Apoptosis of lung structural cells contributes to the process of lung damage and remodeling in chronic obstructive pulmonary disease (COPD). Our previous studies demonstrated that exogenous hydrogen sulfide (H2S) can reduce the lung tissue pathology score, anti-inflammation and anti-oxidation effects in COPD, but the effect of H2S in regulating cigarette smoke (CS) induced bronchial epithelial cell apoptosis and the underlying mechanisms are not clear. Objectives: To investigate the effect of H2S on CS induced endoplasmic reticulum stress (ERS) and bronchial epithelial cell apoptosis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033625/the-salford-lung-study-a-pioneering-comparative-effectiveness-approach-to-copd-and-asthma-in-clinical-trials
#10
REVIEW
Timothy E Albertson, Susan Murin, Mark E Sutter, James A Chenoweth
The Salford Lung Study (SLS) of patients with asthma and chronic obstructive pulmonary disease (COPD) is a practical, community-based, randomized, open-label pragmatic study on the efficacy and safety of the once-daily dry powder inhaler that combines the inhaled corticosteroid fluticasone furoate (FF) with the long-acting beta2 agonist vilanterol (VI). The asthma component of the SLS is not yet reported but the COPD component, done over a 12-month period, found a statistically significant 8.4% reduction in COPD exacerbations when compared to usual care...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29033560/proactive-palliative-care-for-patients-with-copd-prolong-a-pragmatic-cluster-controlled-trial
#11
R G Duenk, C Verhagen, E M Bronkhorst, Pjwb van Mierlo, Meac Broeders, S M Collard, Pnr Dekhuijzen, Kcp Vissers, Y Heijdra, Y Engels
BACKGROUND AND AIM: Patients with advanced chronic obstructive pulmonary disease (COPD) have poor quality of life. The aim of this study was to assess the effects of proactive palliative care on the well-being of these patients. TRIAL REGISTRATION: This trial is registered with the Netherlands Trial Register, NTR4037. PATIENTS AND METHODS: A pragmatic cluster controlled trial (quasi-experimental design) was performed with hospitals as cluster (three intervention and three control) and a pretrial assessment was performed...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29032197/interleukin-22-attenuates-double-stranded-rna-induced-upregulation-of-pd-l1-in-airway-epithelial-cells-via-a-stat3-dependent-mechanism
#12
Nanae Seki, Keiko Kan-O, Koichiro Matsumoto, Satoru Fukuyama, Saaka Hamano, Ken Tonai, Keiichi Ota, Hiromasa Inoue, Yoichi Nakanishi
Double-stranded RNA derived from viruses induces host immune responses. PD-L1, also known as B7-H1, is an immune-checkpoint molecule associated with the escape of viruses from host immune systems, which plays a role in the persistence of viral infection, resulting in exacerbations of underlying diseases such as asthma and chronic obstructive pulmonary disease. Interleukin (IL)-22 is produced from various immune cells and has protective properties on mucosal tissue. The binding of IL-22 to IL-22 receptor induces STAT3 activation...
October 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29028810/risk-of-exacerbation-following-pneumonia-in-adults-with-heart-failure-or-chronic-obstructive-pulmonary-disease
#13
Rebecca Bornheimer, Kimberly M Shea, Reiko Sato, Derek Weycker, Stephen I Pelton
BACKGROUND: Recent evidence demonstrates increased short-term risk of cardiac complications and respiratory failure among patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD), respectively, concurrent with an episode of community-acquired pneumonia (CAP). We evaluated patients with pre-existing HF or COPD, beginning 30 days after CAP diagnosis, to determine if CAP had a prolonged impact on their underlying comorbidity. METHODS: A retrospective matched-cohort design using US healthcare claims was employed...
2017: PloS One
https://www.readbyqxmd.com/read/29026353/association-of-body-mass-index-and-postoperative-acute-kidney-injury-in-patients-undergoing-laparoscopic-surgery
#14
Maged Y Argalious, Natalya Makarova, Alexander Leone, Jacek Cywinski, Ehab Farag
BACKGROUND: Whether the deleterious effects of carbon dioxide pneumoperitoneum on the kidneys are exacerbated in the obese population remains unknown. We hypothesized that increased body mass index (BMI) is associated with an increased incidence of postoperative acute kidney injury (AKI) in patients undergoing noncardiac laparoscopic surgery. METHODS: Following institutional review board approval, we analyzed data on 8,543 adult patients with American Society of Anesthesiologists physical status scores of I-IV who had inpatient noncardiac laparoscopic surgery from 2005-2014...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025891/impact-and-associations-of-eosinophilic-inflammation-in-copd-analysis-of-the-aeris-cohort
#15
Viktoriya L Kim, Ngaire A Coombs, Karl J Staples, Kristoffer K Ostridge, Nicholas P Williams, Stephen A Wootton, Jeanne-Marie Devaster, Emmanuel Aris, Stuart C Clarke, Andrew C Tuck, Simon C Bourne, Tom M A Wilkinson
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) predicts response to treatment, especially corticosteroids. We studied the nature of eosinophilic inflammation in COPD prospectively to examine the stability of this phenotype and its dynamics across exacerbations, and its associations with clinical phenotype, exacerbations and infection.127 patients aged 40-85 years with moderate to very severe COPD underwent repeated blood and sputum sampling at stable visits and within 72 h of exacerbation for 1 year...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29025888/effect-of-erdosteine-on-the-rate-and-duration-of-copd-exacerbations-the-restore-study
#16
Roberto W Dal Negro, Jadwiga A Wedzicha, Martin Iversen, Giovanni Fontana, Clive Page, Arrigo F Cicero, Edoardo Pozzi, Peter M A Calverley
Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) exacerbations and antioxidants can decrease exacerbation rates, although we lack data about the effect of such drugs on exacerbation duration.The RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) study was a prospective randomised, double-blind, placebo-controlled study, enrolling patients aged 40-80 years with Global Initiative for Chronic Obstructive Lung Disease stage II/III. Patients received erdosteine 300 mg twice daily or placebo added to usual COPD therapy for 12 months...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29025886/th17-cytokines-novel-potential-therapeutic-targets-for-copd-pathogenesis-and-exacerbations
#17
REVIEW
Olivier Le Rouzic, Muriel Pichavant, Emilie Frealle, Antoine Guillon, Mustapha Si-Tahar, Philippe Gosset
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways caused mainly by cigarette smoke exposure. COPD progression is marked by exacerbations of the disease, often associated with infections. Recent data show the involvement in COPD pathophysiology of interleukin (IL)-17 and IL-22, two cytokines that are important in the control of lung inflammation and infection. During the initiation and progression of the disease, increased IL-17 secretion causes neutrophil recruitment, leading to chronic inflammation, airways obstruction and emphysema...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28994634/the-eu-project-united4health-results-and-experiences-from-automatic-health-status-assessment-in-a-norwegian-telemedicine-trial-system
#18
Martin Gerdes, Frode Gallefoss, Rune Werner Fensli
Introduction Patients with chronic obstructive pulmonary disease require help in daily life situations to increase their individual perception of security, especially under worsened medical conditions. Unnecessary hospital (re-)admissions and home visits by doctors or nurses shall be avoided. This study evaluates the results from a two-year telemedicine field trial for automatic health status assessment based on remote monitoring and analysis of a long time series of vital signs data from patients at home over periods of weeks or months...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28987858/-effectiveness-of-an-educational-program-for-respiratory-rehabilitation-of-chronic-obstructive-pulmonary-disease-patients-in-primary-care-in-improving-the-quality-of-life-symptoms-and-clinical-risk
#19
Cristina Blánquez Moreno, Cristina Colungo Francia, M Carme Alvira Balada, Belchin Kostov, Luis González-de Paz, Antoni Sisó-Almirall
AIM: To determine the impact of an educational program to improve the management of chronic obstructive pulmonary disease (COPD) that contributes to an increase of the quality of life, exercise capacity, level of dyspnoea, and clinical risk. DESIGN: Intervention study without controls. LOCATION: Primary Healthcare Centre. PARTICIPANTS: 193 patients with COPD were invited, 73 accepted and 55 participated in the educational program...
October 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28987610/heterocyclic-pharmacochemistry-of-new-rhinovirus-antiviral-agents-a-combined-computational-and-experimental-study
#20
Laurène Da Costa, Els Scheers, Antonio Coluccia, Alessia Rosetti, Manon Roche, Johan Neyts, Thierry Terme, Roberto Cirilli, Carmen Mirabelli, Romano Silvestri, Patrice Vanelle
Rhinovirus (RV), member of the Enterovirus genus, is known to be involved in more than half of the common colds. Through advances in molecular biology, rhinoviruses have also been associated with exacerbations of chronic pulmonary diseases (e.g. asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis). In the current investigation, we develop a novel series of 4,5-dimethoxybenzyl derivatives that potently inhibits rhinovirus replication. Compound (S)-7f blocks RV-B14 replication with an EC50 value of 0...
September 21, 2017: European Journal of Medicinal Chemistry
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