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Exacerbations of chronic obstructive pulmonary disease

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https://www.readbyqxmd.com/read/29679365/influence-of-gaseous-pollutants-on-copd-exacerbations-in-patients-with-cardiovascular-comorbidities
#1
Michal Zielinski, Mariusz Gasior, Dariusz Jastrzebski, Aneta Desperak, Dariusz Ziora
Exacerbations of chronic obstructive pulmonary disease (COPD) are a serious public health issue. Ambient pollution and meteorological factors are considered among precipitating factors. There are few data concerning the impact of ambient pollutants other than particulates on COPD exacerbations. Among gaseous pollutants four main groups of substances are primarily monitored: nitrogen oxides (NOx), sulphur dioxide (SO2 ), carbon monoxide (CO), and ozone (O3 ). In this study, 12,889 hospitalizations in the years 2006-2014 due to exacerbations of COPD in patients having a co-existing cardiovascular pathology were retrospectively analyzed...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29676627/effect-of-world-trade-center-dust-exposure-and-chronic-intermittent-hypoxia-on-macrophage-matrix-metalloproteinase-12-expression-in-mice
#2
Jared Radbel, Oanh Le-Hoang, Kinal N Vayas, Kaiwal Patel, Michael Goedken, Vasanthi R Sunil, Debra Laskin, Jag Sunderram
RATIONALE: The pathophysiologic mechanisms by which World Trade Center (WTC) dust exposure leads to pulmonary disease have not been established. Matrix metalloproteinase-12 (MMP-12) is involved in the development of pulmonary fibrosis and chronic obstructive pulmonary disease. We have previously shown that exposure of mice to WTC dust results in increased expression of matrix metalloproteinase 12 by alveolar macrophages. Matrix metalloproteinase 12 expression is regulated, in part, by oxidative stress, which is also increased after WTC dust exposure...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676069/perceptions-of-severe-asthma-and-asthma-copd-overlap-syndrome-among-specialists-a-questionnaire-survey
#3
Sang Heon Kim, Ji Yong Moon, Jae Hyun Lee, Ga Young Ban, Sujeong Kim, Mi Ae Kim, Joo Hee Kim, Min Hye Kim, Chan Sun Park, So Young Park, Hyouk Soo Kwon, Jae Woo Kwon, Jae Woo Jung, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, You Sook Cho, Kwang Ha Yoo, Yeon Mok Oh, Byung Jae Lee, An Soo Jang, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon
PURPOSE: Severe asthma and asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) are difficult to control and are often associated with poor clinical outcomes. However, much is not understood regarding the diagnosis and treatment of severe asthma and ACOS. To evaluate the current perceptions of severe asthma and COPD among asthma and COPD specialists, we designed an e-mail and internet-based questionnaire survey. METHODS: Subjects were selected based on clinical specialty from among the members of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Academy of Tuberculosis and Respiratory Diseases...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29673263/why-are-copd-patients-unable-to-complete-the-outpatient-pulmonary-rehabilitation-program
#4
Hulya Sahin, Ilknur Naz
This study aims to compare demographic and clinical characteristics of chronic obstructive pulmonary disease (COPD) patients who complete and fail to complete outpatient pulmonary rehabilitation (PR) program and to determine the reasons for not completing the program. Patients with COPD referred to the PR program were divided into two groups: Those who completed the program were classified as group 1 and those who did not complete were classified as group 2, and their data were compared. Patients who failed to complete the program were contacted through phone and asked why they ceased their participation in the program...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29672122/pruning-of-the-pulmonary-vasculature-in-asthma-the-sarp-cohort
#5
Samuel Y Ash, Farbod N Rahaghi, Carolyn E Come, James C Ross, Alysha G Colon, Juan Carlos Cardet-Guisasola, Eleanor M Dunican, Eugene R Bleecker, Mario Castro, John V Fahy, Sean B Fain, Benjamin M Gaston, Eric A Hoffman, Nizar N Jarjour, David T Mauger, Sally E Wenzel, Bruce D Levy, Raul San Jose Estepar, Elliot Israel, George R Washko
RATIONALE: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is associated with disease severity in patients with chronic obstructive pulmonary disease. OBJECTIVES: To determine if pulmonary vascular pruning is associated with asthma severity and exacerbations. METHODS: We measured the total pulmonary blood vessel volume (TBV) and the blood vessel volume of vessels less than 5mm2 in cross sectional area (BV5) and of vessels less than 10mm2 (BV10) in cross sectional area on non-contrast computed tomographic scans of participants from the Severe Asthma Research Program...
April 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29671615/patient-reported-outcomes-for-the-detection-quantification-and-evaluation-of-chronic-obstructive-pulmonary-disease-exacerbations
#6
Alex J Mackay, Konstantinos Kostikas, Lindsey Murray, Fernando J Martinez, Marc Miravitlles, Gavin Donaldson, Donald Banerji, Francesco Patalano, Jadwiga A Wedzicha
An exacerbation of Chronic Obstructive Pulmonary Disease (COPD) is an acute worsening of respiratory symptoms, accompanied by a variable degree of physiological deterioration. The traditional assessment of an exacerbation consists of the reporting of symptoms directly by the patient to a clinician and subsequent clinical assessment. It would be valuable to also gather symptom reports directly from patients and thus patient-reported outcome (PRO) tools should be ideally suited to the evaluation of COPD exacerbations...
April 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29669774/transient-immune-mediated-agranulocytosis-following-mycoplasma-pneumoniae-infection
#7
Luani Barge, Gail Pahn, Nicholas Weber
Mycoplasma pneumoniae is a common respiratory pathogen which may cause haematological manifestations including haemolytic anaemia and thrombocytopaenia. Severe neutropaenia is rare with very few cases reported in the literature. An 85-year-old man was transferred to our facility with agranulocytosis in the context of an infective exacerbation of chronic obstructive pulmonary disease with positive serological testing for M. pneumoniae. No alternative infective, autoimmune or lymphoproliferative cause of the neutropaenia was identified...
April 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29668352/once-daily-single-inhaler-triple-versus-dual-therapy-in-patients-with-copd
#8
David A Lipson, Frank Barnhart, Noushin Brealey, Jean Brooks, Gerard J Criner, Nicola C Day, Mark T Dransfield, David M G Halpin, MeiLan K Han, C Elaine Jones, Sally Kilbride, Peter Lange, David A Lomas, Fernando J Martinez, Dave Singh, Maggie Tabberer, Robert A Wise, Steven J Pascoe
Background The benefits of triple therapy for chronic obstructive pulmonary disease (COPD) with an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β2 -agonist (LABA), as compared with dual therapy (either inhaled glucocorticoid-LABA or LAMA-LABA), are uncertain. Methods In this randomized trial involving 10,355 patients with COPD, we compared 52 weeks of a once-daily combination of fluticasone furoate (an inhaled glucocorticoid) at a dose of 100 μg, umeclidinium (a LAMA) at a dose of 62...
April 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29663403/smoke-induced-neuromuscular-junction-degeneration-precedes-the-fibre-type-shift-and-atrophy-in-copd
#9
Sophia Kapchinsky, Madhusudanarao Vuda, Kayla Miguez, Daren Elkrief, Angela R de Souza, Carolyn J Baglole, Sudhakar Aare, Norah J MacMillan, Jacinthe Baril, Paul Rozakis, Vita Sonjak, Charlotte Pion, Mylène Aubertin-Leheudre, Jose A Morais, R Thomas Jagoe, Jean Bourbeau, Tanja Taivassalo, Russell T Hepple
A neurological basis for the fast fibre shift and atrophy seen in limb muscle of patients with chronic obstructive pulmonary disease (COPD) has not been considered previously. The objective of our study was: (i) to determine if denervation contributes to fast fibre shift and muscle atrophy in COPD; and (ii) to assess using a preclinical smoking mouse model whether chronic tobacco smoke (TS) exposure could initiate denervation by causing neuromuscular junction (NMJ) degeneration. Vastus lateralis muscle biopsies were obtained from severe COPD patients (n = 10 with low fat free mass index [FFMI], 65 y; n = 15 normal FFMI, 65 y) and healthy age- and activity-matched non-smoker control subjects (CON; n = 11, 67 y), to evaluate morphological and transcriptional markers of denervation...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29661670/-community-acquired-pneumonia-in-patients-with-chronic-obstructive-pulmonary-disease-treated-with-inhaled-corticosteroids-or-other-bronchodilators-study-pneumocort
#10
Rosa Morros, Cristina Vedia, Maria Giner-Soriano, Aina Casellas, Ester Amado, Jose Miguel Baena
OBJECTIVES: To analyse the risk of pneumonia and/or exacerbations in patients with chronic obstructive pulmonary disease (COPD) who receive treatment with inhaled corticosteroids (CI), in comparison with those who are not treated with inhaled corticosteroids (NCI). To estimate the risk of pneumonia according to CI dose. DESIGN: Population-based cohort study. SETTING: Primary Healthcare. Institut Català de la Salut. PARTICIPANTS: Patients ≥45 years-old diagnosed with COPD between 2007 and 2009 in the Information System for Research in Primary Care (SIDIAP)...
April 13, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29661354/fatal-hypermagnesemia-due-to-laxative-use
#11
REVIEW
Syed Rizwan Bokhari, Ravi Siriki, Federico J Teran, Vecihi Batuman
We report a case of fatal hypermagnesemia in a 53-year-old woman admitted for acute exacerbation of chronic obstructive pulmonary disease and with a history of chronic constipation treated regularly with magnesium-containing laxatives. On admission, her magnesium level was 2.0mg/dL, which rose to a peak of 10.8mg/dL despite hydration and diuresis in the presence of a normal kidney function. Continuous renal replacement therapy was promptly initiated, which reduced her serum magnesium levels, but her condition continued to deteriorate precipitously progressing to shock leading to oligoanuric renal failure, and she died 2 days later...
April 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29656319/nlrp3-inflammasome-involves-in-the-acute-exacerbation-of-patients-with-chronic-obstructive-pulmonary-disease
#12
Huaying Wang, Chun'er Lv, Shi Wang, Huajuan Ying, Yuesong Weng, Wanjun Yu
The NLR pyrin domain-containing protein 3 (NLRP3) inflammasome, a multi-protein complex, produces the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which may contribute to the development of airway inflammation in chronic obstructive pulmonary disease (COPD). The aim of this study was to explore the correlation between circulating and local airway NLRP3 inflammasome activation with acute exacerbation of COPD (AECOPD). mRNA levels of NLRP3, Caspase (Casp)-1, apoptosis-associated speck-like protein containing CARD (ASC), IL-18, and IL-1β in peripheral blood mononuclear cells (PBMCs) and bronchial tissues were determined by real-time PCR in 32 smokers, 65 patients with AECOPD, 50 COPD patients in recovery stage, and 30 COPD patients in stable stage...
April 14, 2018: Inflammation
https://www.readbyqxmd.com/read/29650284/-home-non-invasive-ventilation-for-chronic-obstructive-pulmonary-disease
#13
S Toujani, S Dabboussi, H Snene, M Mjid, S Kamoun, A Hedhli, S Cheikh Rouhou, R Cheikh, M Beji, Y Ouahchi, J Cherif
INTRODUCTION: The benefits of long-term non-invasive ventilation (NIV) in the management of chronic obstructive pulmonary disease (COPD) patients remain controversial. AIM: To analyze the characteristics of COPD patients under home NIV and to evaluate its impact among this population. METHODS: We carried out a retrospective study between January 2002 and April 2016 of COPD patients under long-term NIV at "la Rabta" and the Military Hospital...
April 9, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29649405/economic-impact-of-early-inpatient-palliative-care-intervention-in-a-community-hospital-setting
#14
James Fitzpatrick, Matthew Mavissakalian, Tisha Luciani, Yijing Xu, Amber Mazurek
BACKGROUND: Inpatient palliative care programs have demonstrated financial benefit for the hospital and improved quality of care for patients with advanced disease. Previous studies on this subject have focused on comparisons between palliative and traditional care. The financial and clinical effects of early versus late palliative care intervention are less well documented. OBJECTIVE: The aims of this study are to review the financial and quality outcomes that early palliative care intervention has on appropriate inpatients in the community hospital setting...
March 20, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29643168/fatigue-in-patients-with-chronic-obstructive-pulmonary-disease-protocol-of-the-dutch-multicentre-longitudinal-observational-fantastigue-study
#15
Yvonne M J Goërtz, Milou Looijmans, Judith B Prins, Daisy J A Janssen, Melissa S Y Thong, Jeannette B Peters, Chris Burtin, Yvonne Meertens-Kerris, Arnold Coors, Jean W M Muris, Mirjam A G Sprangers, Emiel F M Wouters, Jan H Vercoulen, Martijn A Spruit
INTRODUCTION: Fatigue is the second most common symptom in patients with chronic obstructive pulmonary disease (COPD). Despite its high prevalence, fatigue is often ignored in daily practice. For this reason, little is known about the underlying determinants of fatigue in patients with COPD. The primary objectives of this study are to chart the course of fatigue in patients with COPD, to identify the physical, systemic, psychological and behavioural factors that precipitate and perpetuate fatigue in patients with COPD, to evaluate the impact of exacerbation-related hospitalisations on fatigue and to better understand the association between fatigue and 2-year all-cause hospitalisation and mortality in patients with COPD...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29643055/findings-of-the-chronic-obstructive-pulmonary-disease-sitting-and-exacerbations-trial-copd-seat-in-reducing-sedentary-time-using-wearable-and-mobile-technologies-with-educational-support-randomized-controlled-feasibility-trial
#16
Mark W Orme, Amie E Weedon, Paula M Saukko, Dale W Esliger, Mike D Morgan, Michael C Steiner, John W Downey, Lauren B Sherar, Sally J Singh
BACKGROUND: Targeting sedentary time post exacerbation may be more relevant than targeting structured exercise for individuals with chronic obstructive pulmonary disease. Focusing interventions on sitting less and moving more after an exacerbation may act as a stepping stone to increase uptake to pulmonary rehabilitation. OBJECTIVE: The aim of this paper was to conduct a randomized trial examining trial feasibility and the acceptability of an education and self-monitoring intervention using wearable technology to reduce sedentary behavior for individuals with chronic obstructive pulmonary disease admitted to hospital for an acute exacerbation...
April 11, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29642882/assessing-the-healthcare-resource-use-associated-with-inappropriate-prescribing-of-inhaled-corticosteroids-for-people-with-chronic-obstructive-pulmonary-disease-copd-in-gold-groups-a-or-b-an-observational-study-using-the-clinical-practice-research-datalink
#17
James D Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson, Alicia Gayle
BACKGROUND: Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencing exacerbations (≥ 2 or ≥ 1 requiring hospitalisation); i.e. GOLD groups C and D. However, it is known that ICS is frequently prescribed for patients with less severe COPD. Potential drivers of inappropriate ICS use may be historical clinical guidance or a belief among physicians that intervening early with ICS would improve outcomes and reduce resource use...
April 11, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29630123/il-33-induced-inflammation-exacerbated-the-development-of-chronic-obstructive-pulmonary-disease-through-oxidative-stress
#18
S-C Zou, J Jiang, J Song
OBJECTIVE: We aimed at exploring the role of IL-33 in mouse chronic obstructive pulmonary disease and its potential molecular mechanism. MATERIALS AND METHODS: The chronic obstructive pulmonary disease (COPD) mice model was established by cigarette smoking (CS). COPD mice were randomly assigned into PBS group and IL-33 antibody group. The peripheral blood and lung tissues of mice from two groups were collected for the following experiments. Pathological changes of the lung tissues in both groups were analyzed by hematoxylin and eosin (HE) staining...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629405/evaluation-of-systemic-corticosteroids-in-patients-with-an-acute-exacerbation-of-copd-and-a-diagnosis-of-pneumonia
#19
Tyler Scholl, Tyree H Kiser, Sheryl F Vondracek
Background: Chronic obstructive pulmonary disease (COPD) and pneumonia are leading causes of morbidity and mortality and are frequently comorbid. Studies of systemic corticosteroids in pneumonia have shown conflicting outcomes, whereas studies in acute exacerbations of COPD (AECOPD) have shown significant benefits. No studies have evaluated systemic corticosteroids in patients with both an AECOPD and pneumonia. Purpose: To evaluate the use of systemic corticosteroids in patients with both an AECOPD and pneumonia...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29629403/effectiveness-of-umeclidinium-vilanterol-for-protocolized-management-of-chronic-obstructive-pulmonary-disease-exacerbation-in-hospitalized-patients-a-sequential-period-analysis
#20
Todd W Chapin, Michael A Mann, Gary L Brown, Traci L Leitheiser, Becky Anderson, David D Leedahl
Background: Bronchodilator therapy is a foundation of chronic obstructive pulmonary disease (COPD) exacerbation treatment. Although international guidelines recommend short-acting formulations given multiple times per day, long-acting formulations have not been adequately evaluated. The objective of our study was to determine the effectiveness of umeclidinium-vilanterol (UME/VIL), long-acting beta2-agonist/long-acting muscarinic antagonist (LABA/LAMA) as a once-daily alternative for treating COPD exacerbations in hospitalized patients...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
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