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https://www.readbyqxmd.com/read/28222393/caffeine-prevents-changes-in-muscle-caused-by-high-intensity-interval-training
#1
Juliano M Vieira, Jessié M Gutierres, Fabiano B Carvalho, Luciane B Pereira, Liziele S Oliveira, Vera Maria Morsch, Maria Rosa C Schetinger, Marília V Rodrigues, Jossiele Leitemperger, Vânia Loro, Cristina C Krewer, Marina S Vencato, Roselia M Spanevello
The use of ergogenic substances such as caffeine has become a strategy to enhance sports performance. In the present study we evaluated the effects of high-intensity interval training (HIIT) associated with caffeine intake on acetylcholinesterase (AChE) and Ca(2+)ATPase activity and glycogen levels in the muscles of rats were evaluated. The animals were divided in groups: control, caffeine 4 or 8mg/kg, HIIT, HIIT plus caffeine 4 or caffeine 8mg/kg. Our results showed a decrease in glycogen levels in muscle in all trained groups after acute session exercise, while that an increase in glycogen levels was observed in all groups in relation to control in chronic exercise protocol...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222365/the-cessation-of-the-long-term-exposure-to-low-doses-of-mercury-ameliorates-the-increase-in-systolic-blood-pressure-and-vascular-damage-in-rats
#2
Danize Aparecida Rizzetti, João Guilherme Dini Torres, Alyne Goulart Escobar, Taiz Martins da Silva, Paola Zambelli Moraes, Raquel Hernanz, Franck Maciel Peçanha, Marta Miguel Castro, Dalton Valentim Vassallo, Mercedes Salaices, Maria Jesús Alonso, Giulia Alessandra Wiggers
This study aimed to verify whether a prolonged exposure to low-level mercury promotes haemodynamic disorders and studied the reversibility of this vascular damage. Rats were divided into seven groups: three control groups received saline solution (im) for 30, 60 or 90 days; two groups received HgCl2 (im, first dose, 4.6μg/kg, subsequent doses 0.07μg/kg/day) for 30 or 60 days; two groups received HgCl2 for 30 or 60 days (im, same doses) followed by a 30-day washout period. Systolic blood pressure (SBP) was measured, along with analysis of vascular response to acetylcholine (ACh) and phenylephrine (Phe) in the absence and presence of endothelium, a nitric oxide (NO) synthase inhibitor, an NADPH oxidase inhibitor, superoxide dismutase, a non-selective cyclooxygenase (COX) inhibitor and an AT1 receptor blocker...
February 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28222221/elastase-2-an-angiotensin-ii-generating-enzyme-contributes-to-increased-ang-ii-in-resistance-arteries-of-mice-with-myocardial-infarction
#3
Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II-generation in resistance arteries are unknown. We hypothesized that ELA-2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI...
February 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28222055/ex-situ-perfusion-of-human-limb-allografts-for-24-hours
#4
Nicole L Werner, Fares Alghanem, Stephanie L Rakestraw, Dylan C Sarver, Bruce Nicely, Richard E Pietroski, Paul Lange, Steven M Rudich, Christopher L Mendias, Alvaro Rojas-Pena, John C Magee, Robert H Bartlett, Kagan Ozer
BACKGROUND: Vascularized composite allografts, particularly hand and forearm, have limited ischemic tolerance after procurement. In bilateral hand transplantations, this demands a 2 team approach and expedited transfer of the allograft, limiting the recovery to a small geographic area. Ex situ perfusion may be an alternative allograft preservation method to extend allograft survival time. This is a short report of 5 human limbs maintained for 24 hours with ex situ perfusion. METHODS: Upper limbs were procured from brain-dead organ donors...
March 2017: Transplantation
https://www.readbyqxmd.com/read/28221218/underactive-bladder-detrusor-underactivity-definition-symptoms-epidemiology-etiopathogenesis-and-risk-factors
#5
Reem Aldamanhori, Christopher R Chapple
PURPOSE OF REVIEW: Lower urinary tract symptoms are bothersome and significantly impair patient's quality of life. Incomplete bladder emptying affects both men and women, and has shown to increase in incidence with aging. Incomplete bladder emptying is consequent upon an inability of the detrusor muscle to adequately contract to completely empty the bladder, with or without an increased bladder outlet resistance; this can be defined urodynamically as detrusor underactivity (DUA). The symptom complex consequent upon DUA is referred to as underactive bladder (UAB)...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28221193/normal-gallbladder-ejection-fraction-occurring-unexpectedly-obviates-need-for-sincalide-stimulation
#6
Samir Hadi, Mark Tulchinsky
A 25-year-old man was referred for chronic right upper quadrant abdominal pain for hepatobiliary scintigraphy to evaluate the gallbladder (GB) function. An unexpected GB contraction with ejection fraction (EF) of 90% was observed during the first hour of baseline imaging. Subsequent stimulation with sincalide produced GB EF of 99%. A similar case previously reported also showed normal unexpected GB EF that predicted similar post-sincalide GB EF. These examples support what should be evident: A normal unexpected GB EF is a sufficient evidence for a normal GB function and should obviate need for sincalide stimulation...
February 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28221166/prevalence-of-needlestick-injuries-attitude-changes-and-prevention-practices-over-12-years-in-an-urban-academic-hospital-surgery-department
#7
Jessica M Hasak, Christine B Novak, Jennifer Megan M Patterson, Susan E Mackinnon
OBJECTIVE: Needlestick injury prevalence, protection practices, and attitudes were assessed. Current medical students were compared with 2003 data to assess any changes that occurred with engineered safety feature implementation. BACKGROUND: Risk of occupational exposure to bloodborne pathogens is elevated in the operating room particularly with surgeons in training and nurses. METHODS: A cross-sectional survey was distributed to medical students (n = 358) and Department of Surgery staff (n = 247)...
February 17, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28220906/experiences-with-preventing-carpal-tunnel-syndrome-in-an-automotive-plant
#8
Věra Žídková, Marie Nakládalová, Jana Zapletalová, Zdeněk Nakládal, Helena Kollárová
OBJECTIVES: Carpal tunnel syndrome (CTS) is a common occupational disease. The aim was to assess the effect of preventive measures in automotive assembly workers. MATERIAL AND METHODS: The analysis summarizes data from annual crosssectional studies. The 7-year analysis of data was based on medical records obtained from an occupational physician and inspections carried out at the workplace where targeted preventive measures were introduced, including better ergonomic arrangement of the workplace, technical adjustments facilitating the work, preventive nerve conduction studies (NCS) testing of the median nerve once a year, switching of workers and their targeted rotation within the workplace...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220890/clinical-investigation-of-the-posterior-scleral-contraction-to-treat-macular-traction-maculopathy-in-highly-myopic-eyes
#9
An-Peng Pan, Ting Wan, Shuang-Qian Zhu, Liang Dong, An-Quan Xue
Myopic traction maculopathy (MTM) can cause vision disabilities in highly myopic eyes. This retrospective case series investigated the clinical outcomes of posterior scleral contraction (PSC) using genipin-cross-linked sclera as the material to treat MTM in highly myopic eyes. In total, 32 eyes from 29 highly myopic patients who underwent PSC for MTM were recruited. The changes in best-corrected visual acuity (BCVA) and axial length were evaluated, macular reattachment and macular hole (MH) closure was assessed by optical coherence tomography, and complications were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220794/flucrypyrim-a-novel-uterine-relaxant-has-antinociceptive-and-anti-inflammatory-effects-in-vivo
#10
Zhongtang Li, Limei Wang, Yue Cong, Lin Guo, Xiaohui Lin, Zuyin Yu, Xingan Wu, Junxing Dong, Rifang Yang, Yuwen Cong
Consequences of primary dsysmenorrhea (PD) can be severe. Increased prostaglandin production leads to uterine contraction and insufficient blood flow to the endometrium causing ischemia and pain symptoms. Protein tyrosine kinase/phosphatase activities contribute to the modulation of uterine contraction. In our previous study, we found the synthetic β-methoxyacrylates compound Fluacrypyrim (FAPM), significantly increased protein tyrosine phosphatases (PTPs) activity, resulting in dephosphorylation of tyrosine kinases...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220541/validation-of-ultrasonography-for-assessment-of-gastric-emptying-time-in-healthy-cats-by-radionuclide-scintigraphy
#11
R Husnik, J M Fletcher, L Gaschen, F P Gaschen
BACKGROUND: The prevalence of gastric emptying (GE) disorders in cats is unknown due to lack of clinically applicable diagnostic tests. OBJECTIVES: The principal aim of this study was to assess correlation between scintigraphic and ultrasonographic measurements of GE time (GET) in healthy cats. Additionally, variability of ultrasonographic GET, and correlation between scintigraphy and ultrasonographic parameters of gastric motility were evaluated. ANIMALS: Eight healthy domestic shorthair cats...
February 21, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28220534/electromyographic-assessment-of-women-s-pelvic-floor-what-is-the-best-place-for-a-superficial-sensor
#12
Eduarda Moretti, Alberto Galvão de Moura Filho, Judite Correia de Almeida, Camilla Medeiros Araujo, Andrea Lemos
AIMS: To compare the electromyographic signal of different surface electrodes and to identify the channel that presents the highest level of electromyographic activity through the mean and peak of Root Mean Square (RMS). METHODS: Thirty healthy women participated in this study. Each woman completed three collections (on different days) of electromyographic data. Three maximal voluntary contractions of the pelvic floor muscles were requested. The electromyographic signal was recorded by intravaginal probe and surface electrodes placed on the perianal region and on the region immediately below the labia majora...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28220257/impact-of-prior-breast-cancer-on-mode-of-delivery-and-pregnancy-associated-disorders-a-retrospective-analysis-of-subsequent-pregnancy-outcomes
#13
Louis Jacob, Matthias Kalder, Birgit Arabin, Karel Kostev
PURPOSE: The aim of this paper is to analyze the impact of prior breast cancer (BC) on mode of delivery and pregnancy-associated disorders. METHODS: A database from 262 German gynecological practices including 289,712 women between the ages of 18 and 45 with documented pregnancies between 2000 and 2014 was used to search for patients with a history of BC up to 10 years prior to pregnancy. A total of 165 patients with a history of BC were found and matched with 165 patients without a history of any cancer (1:1) by age, physician, obesity, and documented referral to a fertility center up to 12 months before the index pregnancy...
February 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28220239/sex-differences-in-variances-of-multi-channel-surface-electromyography-distribution-of-the-vastus-lateralis-muscle-during-isometric-knee-extension-in-young-adults
#14
Yuichi Nishikawa, Kohei Watanabe, Tetsuya Takahashi, Naohisa Hosomi, Naoya Orita, Yukio Mikami, Hirofumi Maruyama, Hiroaki Kimura, Masayasu Matsumoto
PURPOSE: The aim of the present study was to compare spatial electromyographic potential distribution during force production between healthy young female and male using multi-channel surface electromyography (multi-SEMG). METHODS: Thirty healthy subjects (15 females) performed sustained isometric knee extension at 10% maximal voluntary contraction (MVC) task for 120 s. Multi-SEMG signals from the vastus lateralis muscle were detected and the modified entropy, coefficient of variation (CV), and correlation coefficient determined...
February 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28220212/rho-kinase-inhibition-ameliorates-cyclophosphamide-induced-cystitis-in-rats
#15
Andrzej Wróbel, Urszula Doboszewska, Ewa Rechberger, Karol Rojek, Anna Serefko, Ewa Poleszak, Krystyna Skalicka-Woźniak, Jarosław Dudka, Piotr Wlaź
Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. The aim of the present study was to investigate whether inhibition of ROCK reduces cystometric and histopathological changes associated with CYP-induced cystitis. The rats received GSK 269962, a ROCK inhibitor, at a dose of 30 mg/kg daily, or vehicle for 7 days. Then, acute chemical cystitis leading to bladder overactivity was induced by CYP injection (200 mg/kg i...
February 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28220147/robustness-of-frequency-division-technique-for-online-myoelectric-pattern-recognition-against-contraction-level-variation
#16
Bahareh Tolooshams, Ning Jiang
Contraction-level invariant surface electromyography pattern recognition introduces the decrease of training time and decreases the limitation of clinical prostheses. This study intended to examine whether a signal pre-processing method named frequency division technique (FDT) for online myoelectric pattern recognition classification is robust against contraction-level variation, and whether this pre-processing method has an advantage over traditional time-domain pattern recognition techniques even in the absence of muscle contraction-level variation...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28219977/adrenergic-receptors-in-individual-ventricular-myocytes-the-beta-1-and-alpha-1b-are-in-all-cells-the-alpha-1a-is-in-a-subpopulation-and-the-beta-2-and-beta-3-are-mostly-absent
#17
Bat-Erdene Myagmar, James M Flynn, Patrick M Cowley, Philip Swigart, Megan Montgomery, Kevin Thai, Divya R Nair, Rumita Gupta, Chihiro Hosoda, Simon Melov, Anthony J Baker, Paul C Simpson
Rationale: It is unknown if every ventricular myocyte expresses all 5 of the cardiac adrenergic receptors (ARs), beta-1, beta-2, beta-3, alpha-1A, and alpha-1B. The beta-1 and beta-2 are thought to be the dominant myocyte ARs. Objective: Quantify the 5 cardiac ARs in individual ventricular myocytes. Methods and Results: We studied ventricular myocytes from wild type mice, mice with alpha-1A and alpha-1B knockin reporters, and beta-1 and beta-2 knockout mice. Using individual isolated cells, we measured knockin reporters, mRNAs, signaling (phosphorylation of ERK and phospholamban), and contraction...
February 20, 2017: Circulation Research
https://www.readbyqxmd.com/read/28219708/novel-technique-to-determine-the-pka-of-clonidine-at-prejunctional-%C3%AE-2-adrenoceptors-in-cardiac-and-vascular-sympathetic-transmission
#18
James A Angus, Pravin Rajasekaran, Christine E Wright
Analytical pharmacology draws heavily on the concept of equilibrium of agonist and silent antagonist concentrations competing at a specific receptor site. This condition breaks down in nerve transmission when transmitter release is inhibited by prejunctional α2-adrenoceptors activated by an agonist such as clonidine. We have developed a method that allows the agonist dissociation constant KA of clonidine to be determined in a robust isolated right atrial assay of mouse, rat and guinea pig. By applying low numbers of field pulses 1-4 to prevent autoinhibitory feedback, clonidine shifted the nerve pulse stimulation-tachycardia curves to the right...
February 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28219032/analysis-of-the-semg-force-relationship-using-hd-semg-technique-and-data-fusion-a-simulation-study
#19
Mariam Al Harrach, Vincent Carriou, Sofiane Boudaoud, Jeremy Laforet, Frederic Marin
The relationship between the surface Electromyogram (sEMG) signal and the force of an individual muscle is still ambiguous due to the complexity of experimental evaluation. However, understanding this relationship should be useful for the assessment of neuromuscular system in healthy and pathological contexts. In this study, we present a global investigation of the factors governing the shape of this relationship. Accordingly, we conducted a focused sensitivity analysis of the sEMG/force relationship form with respect to neural, functional and physiological parameters variation...
February 16, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28218814/mr-elastography-measurement-of-the-effect-of-passive-warmup-prior-to-eccentric-exercise-on-thigh-muscle-mechanical-properties
#20
Paul Kennedy, Lewis J Macgregor, Eric Barnhill, Curtis L Johnson, Michael Perrins, Angus Hunter, Colin Brown, Edwin J R van Beek, Neil Roberts
PURPOSE: To investigate the effect of warmup by application of the thermal agent Deep Heat (DH) on muscle mechanical properties using magnetic resonance elastography (MRE) at 3T before and after exercise-induced muscle damage (EIMD). MATERIALS AND METHODS: Twenty male participants performed an individualized protocol designed to induce EIMD in the quadriceps. DH was applied to the thigh in 50% of the participants before exercise. MRE, T2 -weighted MRI, maximal voluntary contraction (MVC), creatine kinase (CK) concentration, and muscle soreness were measured before and after the protocol to assess EIMD effects...
February 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
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