Despina D Briana, Stavroula Gavrili, Sophia Georgantzi, Antonios Marmarinos, Konstantinos Voulgaris, Christos Christou, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
Objective: Lactation is associated with a dramatic increase of maternal bone turnover, leading to a reversible bone loss. Early life nutrition may influence later osteoporosis risk. Proteins synthesized by the group of wingless (Wnt) genes are key mediators of osteoblastogenesis and bone formation. We aimed to investigate maternal milk and serum concentrations of the inhibitors of the Wnt signaling pathway, Dickkopf-1 (DKK-1) and sclerostin. Material and methods: In 80 women, maternal milk and serum concentrations of DKK-1 and sclerostin were determined by ELISA on the 3rd-4th day postpartum...
April 2020: Journal of Maternal-fetal & Neonatal Medicine